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公开(公告)号：US06416969B2
公开(公告)日：2002-07-09
申请号：US09843202
申请日：2001-04-26
申请人： Paul M. Matsumura , Jones M. Hyman , Scott R. Jeffrey , Martin J. Maresch , Thurman C. Thorpe , William G. Barron
发明人： Paul M. Matsumura , Jones M. Hyman , Scott R. Jeffrey , Martin J. Maresch , Thurman C. Thorpe , William G. Barron
IPC分类号： C12Q118
CPC分类号： C12M41/46 , C12M41/36 , C12Q1/04 , C12Q1/18 , G01N21/253 , G01N2035/0425
摘要： Disposable plates for performing microbial antibiotic susceptibility testing with multiple channels can be inoculated with a microorganism and antimicrobial agent. The antimicrobial agent may be presented as a gradient of concentrations in the plate. The susceptibility testing plates are configured to allow viewing of microbial growth, and/or to be received in an automated instrument which analyzes same.
摘要翻译： 用多个通道进行微生物抗生素敏感性试验的一次性板可以用微生物和抗微生物剂接种。 抗微生物剂可以以板中的浓度梯度表示。 敏感性测试板被配置为允许观察微生物生长，和/或被接收在分析其的自动化仪器中。
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公开(公告)号：US06197577B1
公开(公告)日：2001-03-06
申请号：US09320386
申请日：1999-05-27
IPC分类号： C12M134
摘要： A device and method allow for detecting the presence of microorganisms in clinical and non-clinical specimens. The device, a sensor, provides an environment to culture microbial organism colonies from a fluid sample, and a means to facilitate microbial detection and quantification, either manually or with an instrument. The sensor has a microorganism immobilization matrix layer and a sensor layer. Detected microbial colonies are immediately available for further testing. The sensor provides an area for accepting a fluid sample, a mechanism to immobilize the fluid sample on an interior surface of the plate, nutrients to facilitate growth of microorganisms in the sample, and a sensor for allowing the detection and/or enumeration of microorganism colonies within the sample.
摘要翻译： 一种装置和方法允许检测临床和非临床标本中微生物的存在。 该装置，传感器，提供了从流体样品培养微生物菌落的环境，以及手动或用仪器促进微生物检测和定量的手段。 传感器具有微生物固定基质层和传感器层。 检测到的微生物菌落立即可用于进一步测试。 传感器提供用于接受流体样品的区域，将流体样品固定在板的内表面上的机制，营养物质以促进样品中微生物的生长，以及用于允许微生物菌落的检测和/或计数的传感器 在样品内。
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公开(公告)号：US6153400A
公开(公告)日：2000-11-28
申请号：US267863
申请日：1999-03-12
申请人： Paul M. Matsumura , Jones M. Hyman , Scott R. Jeffrey , Martin J. Maresch , Thurman C. Thorpe , William G. Barron
发明人： Paul M. Matsumura , Jones M. Hyman , Scott R. Jeffrey , Martin J. Maresch , Thurman C. Thorpe , William G. Barron
CPC分类号： G01N21/253 , C12Q1/18
摘要： A method and apparatus for performing microbial antibiotic susceptibility testing include disposable, multi-chambered susceptibility plates and an automated plate handler and image acquisition and processing instrument. The susceptibility plates are inoculated with a microorganism (any suitable organism such as bacteria, fungi, protozoa, algae or viruses) and anti-microbial agent(s) are applied such that the microorganism is exposed to a variety of concentrations, or a gradient of each anti-microbial agent. The plates are then placed in the instrument, which monitors and measures the growth (or lack thereof) of the microorganisms. This data is used to determine the susceptibility of the microorganism to the antibiotics. Such a system automates antimicrobial susceptibility testing using solid media and Kirby-Bauer standardized result reporting. The system provides a level of automation previously associated only with broth microdilution testing, while retaining the advantages of the manual disk diffusion test.
摘要翻译： 用于进行微生物抗生素敏感性试验的方法和装置包括一次性多室敏感性板和自动板处理器和图像采集和处理仪器。 用微生物（诸如细菌，真菌，原生动物，藻类或病毒的任何合适的生物体）接种敏感性板，并施用抗微生物剂，使得微生物暴露于多种浓度或梯度 每种抗微生物剂。 然后将板放置在仪器中，其监测和测量微生物的生长（或不存在）。 该数据用于确定微生物对抗生素的敏感性。 这种系统使用固体培养基和Kirby-Bauer标准化结果报告自动化抗微生物药敏试验。 该系统提供了以前仅与肉汤微量稀释测试相关联的自动化水平，同时保留了手动盘扩散测试的优点。
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34.发明授权公开(公告)号：US09128058B2
公开(公告)日：2015-09-08
申请号：US12589985
申请日：2009-10-30
申请人： John Walsh , Jones M. Hyman , Thurman Thorpe , Bradford Clay
发明人： John Walsh , Jones M. Hyman , Thurman Thorpe , Bradford Clay
CPC分类号： C12Q1/24 , C12Q1/04 , C12Q1/37 , C12Q1/6816 , G01N21/35 , G01N21/3581 , G01N21/47 , G01N21/64 , G01N21/65 , G01N33/6848
摘要： The present invention is directed to a method for separating, characterizing and/or identifying microorganisms in a test sample. The method of the invention comprises an optional lysis step for lysing non-microorganism cells that may be present in a test sample, followed by a subsequent separation step. The method may be useful for the separation, characterization and/or identification of microorganisms from complex samples such as blood-containing culture media. The invention further provides for the use of one or more identifier agents and interrogating the microorganism sample and/or said one or more identifier agents to produce measurements which characterizing and/or identifying the microorganism based on the produced measurements and/or the presence or absence of the identifier agent or a metabolized form of the identifier agent in the microorganism sample.
摘要翻译： 本发明涉及一种用于分离，表征和/或鉴定测试样品中的微生物的方法。 本发明的方法包括用于裂解可能存在于测试样品中的非微生物细胞的任选裂解步骤，随后是随后的分离步骤。 该方法可用于从诸如含血培养基的复杂样品中分离，表征和/或鉴定微生物。 本发明进一步提供一种或多种识别剂的使用，并且询问微生物样品和/或所述一种或多种标识物以产生基于产生的测量值和/或存在或不存在来表征和/或鉴定微生物的测量结果 的识别剂或微生物样品中识别剂的代谢形式。
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35.发明申请Methods for the characterization of microorganisms on solid or semi-solid media 有权在固体或半固体培养基上表征微生物的方法公开(公告)号：US20110033847A1
公开(公告)日：2011-02-10
申请号：US12653527
申请日：2009-12-15
申请人： John Walsh , Jones M. Hyman , Thurman Thorpe
发明人： John Walsh , Jones M. Hyman , Thurman Thorpe
IPC分类号： C12Q1/04 , C12Q1/68 , G01N33/566
CPC分类号： C12Q1/04
摘要： The present invention relates to methods and systems for scanning, detecting, and monitoring microorganisms on solid or semi-solid media using intrinsic fluorescence (IF) measurements. The methods are further directed to detection, characterization and/or identification of microorganisms on a solid or semi-solid media using intrinsic fluorescence (IF) measurements that are characteristic of said microorganisms.
摘要翻译： 本发明涉及使用固有荧光（IF）测量在固体或半固体培养基上扫描，检测和监测微生物的方法和系统。 所述方法进一步涉及使用所述微生物特征的固有荧光（IF）测量法在固体或半固体培养基上检测，表征和/或鉴定微生物。
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36.发明申请Method for detection, characterization and/or identification of microorganisms in a sealed container 审中-公开在密封容器中检测，表征和/或鉴定微生物的方法公开(公告)号：US20100124763A1
公开(公告)日：2010-05-20
申请号：US12589968
申请日：2009-10-30
申请人： John Walsh , Jones M. Hyman , Thurman Thorpe , Bradford Clay
发明人： John Walsh , Jones M. Hyman , Thurman Thorpe , Bradford Clay
IPC分类号： C12Q1/04
CPC分类号： C12Q1/04 , G01N21/35 , G01N21/3577 , G01N21/3581 , G01N21/47 , G01N21/64 , G01N21/65 , G01N33/6848
摘要： The present invention provides a method and system for monitoring, detecting, and/or characterizing a biological particle that may be present in a sample. The method may be accomplished in a sealed container by utilizing a first step time-dependent spectroscopic technique to obtain at least two measurements of a growth composition comprising a sample and correlating said measurements for the detection and/or characterization of a biological particle that may be present in the sample. The method further provides for a subsequent step for the separation, characterizion and/or identification of the microorganisms in the sealed container.
摘要翻译： 本发明提供了用于监测，检测和/或表征可能存在于样品中的生物颗粒的方法和系统。 该方法可以在密封容器中通过利用第一步骤时间依赖性光谱技术来实现，以获得包含样品的生长组合物的至少两个测量值，并将所述测量结果与生物学颗粒的检测和/或表征相关联，生物颗粒可以是 存在于样品中。 该方法还提供了在密封容器中分离，表征和/或鉴定微生物的后续步骤。
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37.发明申请Separation device for use in the separation, characterization and/or identification of microorganisms 审中-公开用于分离，表征和/或鉴定微生物的分离装置公开(公告)号：US20100120133A1
公开(公告)日：2010-05-13
申请号：US12589969
申请日：2009-10-30
申请人： John Walsh , Jones M. Hyman , Christopher Ronsick , John Link , Ron Robinson , Mark Wilson
发明人： John Walsh , Jones M. Hyman , Christopher Ronsick , John Link , Ron Robinson , Mark Wilson
IPC分类号： C12M1/34
CPC分类号： C12Q1/24 , B01L3/5021 , B01L2300/042 , B01L2300/0838 , B01L2300/0861 , C12Q1/04 , C12Q1/37 , C12Q1/6816 , G01N21/03 , G01N21/35 , G01N21/3581 , G01N21/359 , G01N21/47 , G01N21/64 , G01N21/65 , G01N33/6848
摘要： The present invention is directed to a separation device or container that can be used in the separation, isolation or pelleting of microorganisms from a test samples known to contain or suspected of containing said microorganisms. Subsequently, the separated, isolated or pelleted microorganism sample can undergo one or more interrogation steps to provide measurements useful for the characterization and/or identification of microorganism. In one aspect of the present invention, the interrogation steps can occur in situ in the separation device or container described herein.
摘要翻译： 本发明涉及可用于从已知含有或怀疑含有所述微生物的测试样品中分离，分离或造粒微生物的分离装置或容器。 随后，分离的，分离的或沉淀的微生物样品可以经历一个或多个询问步骤以提供对微生物的表征和/或鉴定有用的测量。 在本发明的一个方面，询问步骤可以在本文所述的分离装置或容器中原位发生。
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公开(公告)号：US5976827A
公开(公告)日：1999-11-02
申请号：US989560
申请日：1997-12-12
摘要： A device and method allow for detecting the presence of microorganisms in clinical and non-clinical specimens. The device, a sensor, provides an environment to culture microbial organism colonies from a fluid sample, and a means to facilitate microbial detection and quantification, either manually or with an instrument. The sensor has a microorganism immobilization matrix layer and a sensor layer. Detected microbial colonies are immediately available for further testing. The sensor provides an area for accepting a fluid sample, a mechanism to immobilize the fluid sample on an interior surface of the plate, nutrients to facilitate growth of microorganisms in the sample, and a sensor for allowing the detection and/or enumeration of microorganism colonies within the sample.
摘要翻译： 一种装置和方法允许检测临床和非临床标本中微生物的存在。 该装置，传感器，提供了从流体样品培养微生物菌落的环境，以及手动或用仪器促进微生物检测和定量的手段。 传感器具有微生物固定基质层和传感器层。 检测到的微生物菌落立即可用于进一步测试。 传感器提供用于接受流体样品的区域，将流体样品固定在板的内表面上的机制，营养物质以促进样品中微生物的生长，以及用于允许微生物菌落的检测和/或计数的传感器 在样品内。
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39.发明授权Evacuated sensor device for detecting microorganisms in blood samples, and method thereof 失效用于检测血液样品中微生物的真空传感器装置及其方法
公开(公告)号：US5912115A
公开(公告)日：1999-06-15
申请号：US113929
申请日：1998-07-10
申请人： Jones M. Hyman , Thurman C. Thorpe
发明人： Jones M. Hyman , Thurman C. Thorpe
CPC分类号： C12M23/04 , C12M23/22 , C12M23/24 , C12M25/06 , C12M25/14 , C12M41/36 , C12Q1/04 , C12Q1/045 , C12Q1/24
摘要： A device and method allow for collection of a blood specimen and for detecting the presence of microorganisms in the blood specimen. The device, a sensor plate under vacuum, provides an environment to culture microbial organism colonies from a blood sample, and a means to facilitate microbial detection and quantification, either manually or with an instrument. The vacuum sensor plate has a microorganism immobilization matrix layer and a sensor layer. Detected microbial colonies are immediately available for further testing. A kit is provided having a needle assembly for direct draw of blood from a patient onto the immobilization layer within the vacuum sensor plate. The sensor plate provides an area for accepting a blood sample, a mechanism to immobilize the blood sample on an interior surface of the plate, nutrients to facilitate growth of microorganisms in the sample, and a sensor layer for allowing the detection and/or enumeration of microorganism colonies within the blood sample.
摘要翻译： 装置和方法允许收集血液样本并检测血液样本中微生物的存在。 该装置是真空下的传感器板，提供了从血液样品中培养微生物菌落的环境，以及手动或用仪器促进微生物检测和定量的手段。 真空传感器板具有微生物固定基质层和传感器层。 检测到的微生物菌落立即可用于进一步测试。 提供了一种套件，其具有用于将血液从患者直接抽吸到真空传感器板内的固定层上的针组件。 传感器板提供用于接受血液样本的区域，将血液样本固定在板的内表面上的机制，营养物质以促进样品中微生物的生长，以及传感器层，用于允许检测和/或计数 血液样品中的微生物菌落。
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公开(公告)号：US5384240A
公开(公告)日：1995-01-24
申请号：US981689
申请日：1992-11-25
申请人： Jones M. Hyman
发明人： Jones M. Hyman
IPC分类号： G01N33/531 , G01N33/53 , G01N33/536 , G01N33/569 , G01N33/574 , C12Q1/70
CPC分类号： G01N33/5306 , G01N33/536 , G01N33/56988 , Y10S435/974 , Y10S436/82 , Y10S436/825 , Y10S436/826
摘要： This invention relates to a novel reagent and a method of using the reagent in an immunoassay to detect antigens, particularly antigens immunocomplexed with their corresponding or cross-reacting antibodies. In particular, this reagent and method increase the detection of human immunodeficiency virus HIV-1 p24 core antigen.
摘要翻译： 本发明涉及一种新的试剂和在免疫测定中使用该试剂的方法来检测抗原，特别是与其相应或交叉反应抗体免疫复合的抗原。 特别地，该试剂和方法增加了人体免疫缺陷病毒HIV-1 p24核心抗原的检测。
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