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77 条记录 (耗时 0.061 秒)

    Delivery of biologically active substance to target sites in the body of patients
    36.
    发明授权
    Delivery of biologically active substance to target sites in the body of patients 有权
    将生物活性物质交付给患者体内的靶点

    公开(公告)号：US06258378B1

    公开(公告)日：2001-07-10

    申请号：US09243787

    申请日：1999-02-03

    申请人： Michel Schneider ,  Feng Yan ,  Agnés Hiver

    发明人： Michel Schneider ,  Feng Yan ,  Agnés Hiver

    IPC分类号： A61K9127

    CPC分类号： A61K9/127 ,  A61K9/0009 ,  A61K41/0028 ,  Y10S424/812 ,  Y10S436/829

    摘要： The invention concerns a method for administering bioactive substances to patients at selected sites in the body and remotely promoting delivery of said media to selected organs or tissues in the body. The method comprises providing an administrable formulation comprising, dispersed in an aqueous carrier liquid, liposomes filled with bioactive substances and gas-filled microspheres, injecting said formulation into the circulation of a patient so that it is directed to a site of interest, and applying ultrasound pulses to said site so as to make the gas-filled microbodies explode and the gas confined therein to expand in the carrier liquid, the energy of expansion of said confined gas causing the liposome vesicles to open and release the trapped substances at said site. Also disclosed are formulations for delivery of biologically active substances to selected target sites in the organism, the formulations comprising an aqueous suspension of gas-filled microvesicles and liposomes filled with active susbstances such as drugs or diagnostic agents. The formulations are available in a kit form in which the kit comprises sterile precursor components.

    摘要翻译： 本发明涉及一种用于向身体中选定部位的患者施用生物活性物质的方法，并远程促进将所述培养基递送至身体中选定的器官或组织。 该方法包括提供可施用的制剂，其包含在水性载体液体中分散有填充有生物活性物质和充气微球的脂质体，将所述制剂注射到患者的循环中，使其被引导到感兴趣的部位，并施加超声波 脉冲到所述位置，以使气体充填的微体体积膨胀，并且其中限制的气体在载体液体中膨胀，所述密闭气体的膨胀能使脂质体囊泡打开并释放所述位点处的被捕获的物质。 还公开了用于将生物活性物质递送到生物体中的选定靶位点的制剂，该制剂包含充满气体的微泡的水性悬浮液和填充有活性物质如药物或诊断剂的脂质体。 制剂可以试剂盒形式获得，其中试剂盒包含无菌前体组分。

    Gas mixtures useful as ultrasound contrast media, contrast agents containing the media and method
    37.
    发明授权
    Gas mixtures useful as ultrasound contrast media, contrast agents containing the media and method 失效
    用作超声波造影剂的气体混合物，含有介质和方法的造影剂

    公开(公告)号：US06183725B2

    公开(公告)日：2001-02-06

    申请号：US09021367

    申请日：1998-02-10

    申请人： Feng Yan ,  Michel Schneider

    发明人： Feng Yan ,  Michel Schneider

    IPC分类号： A61B813

    CPC分类号： A61K49/223 ,  A61K49/225

    摘要： The invention relates to injectable media for ultrasonic echography in the form of microbubbles or microballoons comprising at least two biocompatible substances A and B (gaseous at the body temperature) forming a mixture which when in suspension with usual surfactants, additives and stabilisers provides useful ultrasound contrast agents. At least one of the components (B) in the mixture is a gas whose molecular weight is greater than 80 daltons and whose solubility in water is below 0.0283 ml per ml of water at standard conditions. The presence of the first component (B) in the contrast medium may vary between 0.5 and 41 volume percent. The other component (A) of the ultrasound contrast media is a gas or a mixture of gases whose molecular weight is below 80 daltons. The second component is present in a proportion of between 59-99.5% by vol., and is preferably chosen from oxygen, air, nitrogen, carbon dioxide or mixtures thereof. Gas mixtures described are found to be very effective as ultrasound contrast media. The invention also comprises a method of making the ultrasound contrast medium, the contrast agent and the ultrasound agent kit.

    摘要翻译： 本发明涉及以微泡或微球形式的超声波回波成像的可注射介质，其包含至少两种生物相容性物质A和B（在体温下为气体）形成混合物，当与通常的表面活性剂悬浮时，添加剂和稳定剂提供有用的超声对比 代理商 混合物中组分（B）中的至少一种是分子量大于80道尔顿且在标准条件下其在水中的溶解度低于0.0283ml / ml水的气体。 造影剂中第一组分（B）的存在可以在0.5和41体积％之间变化。 超声造影剂的另一组分（A）是分子量低于80道尔顿的气体或气体混合物。 第二组分以59-99.5体积％的比例存在，优选选自氧气，空气，氮气，二氧化碳或其混合物。 发现所描述的气体混合物作为超声波造影剂非常有效。 本发明还包括制造超声造影剂，造影剂和超声剂试剂盒的方法。