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    Polypeptides Having Protease Activity and Polynucleotides Encoding Same
    35.
    发明申请
    Polypeptides Having Protease Activity and Polynucleotides Encoding Same 审中-公开
    具有蛋白酶活性的多肽和编码相同的多核苷酸

    公开(公告)号：US20160298102A1

    公开(公告)日：2016-10-13

    申请号：US15100842

    申请日：2014-12-19

    Applicant: NOVOZYMES A/S

    Inventor： Morten Gjermansen ,  Lars Lehmann Hylling Christensen ,  Miguel Duarte Guilherme Pereira Toscano

    IPC: C12N9/54 ,  C11D3/386

    CPC classification number: C12N9/54 ,  C11D3/386 ,  C12Y304/00

    Abstract: The present invention relates to isolated polypeptides having protease activity, and polynucleotides encoding the polypeptides. The invention further relates to the use of such polypeptides in detergent and/or in cleaning processes. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing the polypeptides.

    Abstract translation: 本发明涉及具有蛋白酶活性的分离多肽和编码多肽的多核苷酸。 本发明还涉及这种多肽在洗涤剂和/或清洁方法中的用途。 本发明还涉及包含多核苷酸的核酸构建体，载体和宿主细胞以及产生多肽的方法。

    Lipase Variants for Pharmaceutical Use
    38.
    发明申请
    Lipase Variants for Pharmaceutical Use 审中-公开
    药用脂肪酶变体

    公开(公告)号：US20150209414A1

    公开(公告)日：2015-07-30

    申请号：US14679563

    申请日：2015-04-06

    Applicant: Novozymes A/S ,  Novozymes Inc.

    Inventor： Allan Svendsen ,  Michael Skjoet ,  Deborah Yaver ,  Lars Lehmann Hylling Christensen ,  Signe Eskildsen Larsen ,  Nina Lundin ,  Michael Lamsa ,  Peter Colin Gregory

    IPC: A61K38/46 ,  A61K38/48 ,  A61K38/47 ,  C12N9/20

    CPC classification number: A61K38/465 ,  A61K38/47 ,  A61K38/48 ,  C12N9/20

    Abstract: The pharmaceutical use of lipases related to the Thermomyces lanuginosus (Humicola lanuginosa) lipase comprising amino acids 1-269 of SEQ ID NO: 2, optionally in combination with a protease and/or an amylase. Examples of medical indications are: Treatment of digestive disorders, pancreatic exocrine insufficiency (PEI), pancreatitis, cystic fibrosis, diabetes type I, and/or diabetes type II. The lipases of the invention have, e.g., an improved digestion performance in vitro, an improved activity at a pH in the neutral range, an improved stability at low pH, an are stable against protease-degradation, and/or are stable in the presence of pepsin and bile salts. The invention also relates to methods of determining digestion performance in vitro of lipases, as well as to certain novel variants of the lipase of T. lanuginosus.

    Abstract translation: 与包含SEQ ID NO：2的氨基酸1-269的Thermomyces lanuginosus（Humicola lanuginosa）脂肪酶相关的脂肪酶的药物用途，任选地与蛋白酶和/或淀粉酶组合。 医学适应症的例子有：消化系统疾病，胰腺外分泌功能不全（PEI），胰腺炎，囊性纤维化，I型糖尿病和/或II型糖尿病的治疗。 本发明的脂肪酶具有例如体外改进的消化性能，在中性范围内的pH值改善的活性，在低pH下的改进的稳定性，对蛋白酶降解是稳定的，和/或在存在时是稳定的 的胃蛋白酶和胆汁盐。 本发明还涉及确定脂肪酶的体外消化性能的方法以及T.lanuginosus的脂肪酶的某些新颖变体。

    Protease Variants
    39.
    发明申请
    Protease Variants 有权
    蛋白酶变体

    公开(公告)号：US20130189732A1

    公开(公告)日：2013-07-25

    申请号：US13738490

    申请日：2013-01-10

    Applicant: Novozymes A/S

    Inventor： Leonardo De Maria ,  Carsten Andersen ,  Lars Lehmann Hylling Christensen ,  Soren Flensted Lassen ,  Peter Rahbek Ostergaard

    IPC: C12N9/48 ,  A23K1/165

    CPC classification number: C12N9/58 ,  A01K2217/05 ,  A23K20/189 ,  C12N9/48 ,  C12N9/52 ,  C12N2310/111

    Abstract: The invention relates to a novel 3D structure encoding a Nocardiopsis protease, as well as to variants of parent protease homologous to Nocardiopsis proteases, preferably of improved thermostability and/or with an amended temperature activity profile. The invention also relates to DNA sequences encoding such variants, their production in a recombinant host cell, as well as methods of using the variants, in particular within the field of animal feed and detergents. The invention furthermore relates to methods of generating and preparing protease variants of amended properties.

    Abstract translation: 本发明涉及编码诺卡氏菌蛋白酶的新型3D结构，以及与诺卡氏菌蛋白酶同源的亲本蛋白酶的变体，优选具有改善的热稳定性和/或具有修改的温度活性分布。 本发明还涉及编码这些变体的DNA序列，其在重组宿主细胞中的产生，以及使用该变体，特别是在动物饲料和洗涤剂领域中的方法。 本发明还涉及生成和制备修饰性质的蛋白酶变体的方法。

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