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公开(公告)号：US20090263322A1
公开(公告)日：2009-10-22
申请号：US12494754
申请日：2009-06-30
申请人： Richard Apodaca , Nicholas I. Carruthers , John R. Carson , Wenying Chai , Annette K. Kwok , Xiaobing Li , Timothy W. Lovenberg , Dale A. Rudolph , Chandravadan R. Shah
发明人： Richard Apodaca , Nicholas I. Carruthers , John R. Carson , Wenying Chai , Annette K. Kwok , Xiaobing Li , Timothy W. Lovenberg , Dale A. Rudolph , Chandravadan R. Shah
IPC分类号： A61K31/437 , C07D221/04 , C07D401/14 , A61K31/496 , A61K51/00 , A61P11/00 , A61P25/00
CPC分类号： C07D487/04 , A61K51/0455 , A61K51/0459 , C07D455/00 , C07D471/04
摘要： The invention features substituted fused bicyclic compounds, pharmaceutical compositions containing them, and methods of using them to treat or prevent histamine-mediated diseases and conditions.
摘要翻译： 本发明具有取代的稠合双环化合物，含有它们的药物组合物，以及使用它们治疗或预防组胺介导的疾病和病症的方法。
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公开(公告)号：US07186732B2
公开(公告)日：2007-03-06
申请号：US09922631
申请日：2001-08-06
申请人： Richard Apodaca , Nicholas I. Carruthers , Curt A. Dvorak , Dale A. Rudolph , Chandravadan R. Shah , Wei Xiao
发明人： Richard Apodaca , Nicholas I. Carruthers , Curt A. Dvorak , Dale A. Rudolph , Chandravadan R. Shah , Wei Xiao
IPC分类号： A61K31/445 , C07D211/08
CPC分类号： C07D207/325 , A61K31/4402 , A61K31/4465 , A61K45/06 , C07C217/22 , C07C323/25 , C07C335/32 , C07D207/335 , C07D211/22 , C07D211/46 , C07D211/58 , C07D213/36 , C07D213/74 , C07D215/06 , C07D231/12 , C07D233/42 , C07D233/54 , C07D233/56 , C07D233/84 , C07D233/88 , C07D235/06 , C07D235/26 , C07D239/34 , C07D249/08 , C07D257/04 , C07D277/36 , C07D295/088 , C07D295/096 , C07D295/112 , C07D295/135 , C07D295/205 , C07D307/52 , C07D317/28 , C07D333/20 , C07D401/04 , C07D401/12 , C07D401/14 , C07D471/08 , A61K2300/00
摘要： Substituted aryloxyalkylamines of formula (I), compositions containing them, and methods of making and using them to treat histamine-mediated conditions.
摘要翻译： 式（I）的取代的芳氧基烷基胺，含有它们的组合物，以及制备和使用它们来治疗组胺介导的病症的方法。
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公开(公告)号：US07041828B2
公开(公告)日：2006-05-09
申请号：US10960363
申请日：2004-10-07
申请人： J. Guy Breitenbucher , Nicholas I. Carruthers , Xiaobing Li , Laura C. McAtee , Chandravadan R. Shah , Ronald L. Wolin
发明人： J. Guy Breitenbucher , Nicholas I. Carruthers , Xiaobing Li , Laura C. McAtee , Chandravadan R. Shah , Ronald L. Wolin
IPC分类号： C07D47/04
CPC分类号： C07D401/12 , A61K31/423 , C07D209/12 , C07D403/12 , C07D471/04
摘要： The invention features pharmaceutically-active imidazopyridines and derivatives that are substituted with phenyl, methods of making them, and methods of using them.
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公开(公告)号：US07041827B2
公开(公告)日：2006-05-09
申请号：US10960200
申请日：2004-10-07
申请人： J. Guy Breitenbucher , Nicholas I. Carruthers , Xiaobing Li , Laura C. McAtee , Chandravadan R. Shah , Ronald L. Wolin
发明人： J. Guy Breitenbucher , Nicholas I. Carruthers , Xiaobing Li , Laura C. McAtee , Chandravadan R. Shah , Ronald L. Wolin
IPC分类号： C07D471/04
CPC分类号： C07D401/12 , A61K31/423 , C07D209/12 , C07D403/12 , C07D471/04
摘要： The invention features pharmaceutically-active imidazopyridines and derivatives that are substituted with phenyl, methods of making them, and methods of using them.
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公开(公告)号：US07279491B2
公开(公告)日：2007-10-09
申请号：US10692080
申请日：2003-10-23
IPC分类号： A61K31/445 , C07D401/10
CPC分类号： C07D401/12 , C07D207/09 , C07D211/26 , C07D211/46 , C07D211/58 , C07D413/10
摘要： Substituted phenylpiperidines and phenylpyrrolidines of formula (I), compositions containing them, and methods of making and using them to treat histamine-mediated conditions.
摘要翻译： 取代的苯基哌啶和式（I）的苯基吡咯烷酮，含有它们的组合物，以及制备和使用它们来治疗组胺介导的病症的方法。
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36.发明授权公开(公告)号：US07544698B2
公开(公告)日：2009-06-09
申请号：US11731047
申请日：2007-03-30
IPC分类号： A61K31/437 , A61K31/404 , A61K31/4184 , C07D471/04 , C07D235/04 , C07D487/08 , C07D209/04
CPC分类号： C07D403/14 , C07D403/06 , C07D471/04 , C07D487/08
摘要： Benzoimidazole and indole compounds are described, which are useful as H4 receptor modulators. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by H4 receptor activity, such as allergy, asthma, autoimmune diseases, and pruritis.
摘要翻译： 描述了苯并咪唑和吲哚化合物，其可用作H 4受体调节剂。 这些化合物可用于治疗由H 4受体活性介导的疾病状态，病症和病症的药物组合物和方法，例如过敏，哮喘，自身免疫性疾病和瘙痒症。
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37.发明申请PIPERAZINYL DERIVATIVES USEFUL AS MODULATORS OF THE NEUROPEPTIDE Y2 RECEPTOR 审中-公开作为神经元Y2受体的调节剂有用的哌嗪衍生物公开(公告)号：US20120129870A1
公开(公告)日：2012-05-24
申请号：US12809023
申请日：2008-12-17
申请人： Wenying Chai , Jill A. Jablonowski , Dale A. Rudolph , Chandravadan R. Shah , Devin M. Swanson , Victoria D. Wong
发明人： Wenying Chai , Jill A. Jablonowski , Dale A. Rudolph , Chandravadan R. Shah , Devin M. Swanson , Victoria D. Wong
IPC分类号： A61K31/496 , C07D295/135 , A61K31/495 , C07D405/12 , C07D401/06 , C07D417/06 , C07D403/06 , A61K31/506 , C07D413/14 , C07D405/06 , A61P25/22 , A61P25/24 , A61P9/00 , A61P19/10 , A61P5/00 , A61P25/32 , A61P3/04 , A61P15/08 , A61P25/00 , A61P29/00 , C07D409/06 , C07D401/14 , C07D295/15 , C07D413/06
CPC分类号： C07D271/06 , C07D213/38 , C07D233/64 , C07D239/26 , C07D263/16 , C07D263/32 , C07D263/56 , C07D271/10 , C07D277/28 , C07D277/64 , C07D295/073 , C07D295/135 , C07D295/15 , C07D295/155 , C07D307/14 , C07D307/54 , C07D333/20 , C07D413/04 , C07D413/12
摘要： The present invention is directed to piperidinyl and piperazinyl derivatives of formula (II) useful as inhibitors of the NPY Y2 receptor, pharmaceutical compositions comprising said compounds, processes for the preparation of said compounds and the use of said compounds for the treatment and/or prevention of disorders, diseases and conditions mediated by the NPY Y2 receptor.
摘要翻译： 本发明涉及可用作NPY Y2受体的抑制剂的式（II）的哌啶基和哌嗪基衍生物，包含所述化合物的药物组合物，所述化合物的制备方法和所述化合物用于治疗和/或预防的用途 由NPY Y2受体介导的疾病，疾病和病症。
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38.发明申请PIPERAZINYL DERIVATIVES USEFUL AS MODULATORS OF THE NEUROPEPTIDE Y2 RECEPTOR 审中-公开作为神经元Y2受体的调节剂有用的哌嗪衍生物公开(公告)号：US20120015957A1
公开(公告)日：2012-01-19
申请号：US12809010
申请日：2008-12-17
申请人： Wenying Chai , Curt A. Dvorak , Jill A. Jablonowski , Dale A. Rudolph , Chandravadan R. Shah , Victoria D. Wong
发明人： Wenying Chai , Curt A. Dvorak , Jill A. Jablonowski , Dale A. Rudolph , Chandravadan R. Shah , Victoria D. Wong
IPC分类号： A61K31/496 , C07D403/10 , C07D413/14 , C07D295/15 , A61K31/495 , C07D401/10 , C07D417/10 , A61P25/22 , A61P25/24 , A61P25/00 , A61P19/08 , A61P9/00 , A61P25/30 , A61P3/04 , A61P5/00 , A61P15/08 , A61P25/32 , C07D413/10
CPC分类号： C07D271/06 , C07D207/335 , C07D213/38 , C07D231/12 , C07D231/20 , C07D249/08 , C07D263/16 , C07D263/32 , C07D263/34 , C07D271/07 , C07D271/10 , C07D275/02 , C07D285/08 , C07D295/15
摘要： The present invention is directed to piperidinyl and piperazinyl derivatives of formula (I) useful as inhibitors of the NPY Y2 receptor, pharmaceutical compositions comprising said compounds, processes for the preparation of said compounds and the use of said compounds for the treatment and/or prevention of disorders, diseases and conditions mediated by the NPY Y2 receptor.
摘要翻译： 本发明涉及可用作NPY Y2受体的抑制剂的式（I）的哌啶基和哌嗪衍生物，包含所述化合物的药物组合物，所述化合物的制备方法和所述化合物用于治疗和/或预防的用途 由NPY Y2受体介导的疾病，疾病和病症。
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公开(公告)号：US20070238771A1
公开(公告)日：2007-10-11
申请号：US11731047
申请日：2007-03-30
IPC分类号： A61K31/4184 , A61K31/405 , C07D403/14
CPC分类号： C07D403/14 , C07D403/06 , C07D471/04 , C07D487/08
摘要： Benzoimidazole and indole compounds are described, which are useful as H4 receptor modulators. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by H4 receptor activity, such as allergy, asthma, autoimmune diseases, and pruritis.
摘要翻译： 描述了苯并咪唑和吲哚化合物，其可用作H 4 S 5受体调节剂。 这样的化合物可以用于治疗由H 4 S受体活性介导的疾病状态，病症和病症的药物组合物和方法，例如过敏，哮喘，自身免疫疾病和瘙痒症。
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