公开(公告)号：US09612803B2

公开(公告)日：2017-04-04

申请号：US13448111

申请日：2012-04-16

申请人： Richard P. Mousseau ,  Mark Nelson ,  Jon Richards ,  Troy Schulz ,  Keith Kelleman ,  Mark Spotswood ,  Jeff Berkowitz

发明人： Richard P. Mousseau ,  Mark Nelson ,  Jon Richards ,  Troy Schulz ,  Keith Kelleman ,  Mark Spotswood ,  Jeff Berkowitz

IPC分类号： G06F9/455 ,  G06F9/44

CPC分类号： G06F8/34 ,  G06F9/45558 ,  G06F2009/45562 ,  G06F2009/4557

摘要： A virtual assembly builder for use in virtualization environments, which can be used as a tool for virtualizing installed components in a reference environment, modifying those components if necessary, and then deploying them into another/target environment. Using the virtual assembly builder, a user (e.g., an administrator) can capture the configuration and product/component binaries of existing software components into software appliance artifacts. Appliances can be grouped, and their relationships defined, into software assembly artifacts. Logical connections between appliances within an assembly can be reconfigured by a process of assembly editing. When a desired assembly configuration has been achieved, the assembly can be prepared for, and deployed into, the target environment.

公开(公告)号：US08986606B2

公开(公告)日：2015-03-24

申请号：US12472058

申请日：2009-05-26

申请人： Mark Nelson ,  Marko Kolari ,  Juhana Ahola

发明人： Mark Nelson ,  Marko Kolari ,  Juhana Ahola

IPC分类号： A61L2/18 ,  D21F1/66 ,  C02F1/76 ,  C02F1/50 ,  C02F103/28

CPC分类号： D21F1/66 ,  C02F1/50 ,  C02F1/76 ,  C02F2103/28 ,  C02F2303/08 ,  C02F2303/20

摘要： Processes for biofilm or microorganism growth control in an aqueous system such as a pulp, paper or board manufacturing system are described in which a halogenated hydantoin is added to the aqueous system in combination with haloamine, chlorine dioxide or a combination thereof. The halogenated hydantoin is preferably a fully or partially halogenated dialkyl hydantoin, and more preferably 5,5-dimethyl hydantoin or 5-methyl-5-ethyl hydantoin. The haloamine is preferably a monohaloamine, dihaloamine, trihaloamine, or a combination thereof, and more preferably monochloramine, monobromamine, bromochloroamine or a combination thereof. The halogenated hydantoin is preferably added to the aqueous system in portions of the system susceptible to gas phase corrosion, such as the short loop of the system, and the haloamine and chlorine dioxide are preferably added to other portions of the system. The halogenated hydantoin and haloamine and/or chlorine dioxide maintain good compatibility with each other in the absence of excess free chlorine.

摘要翻译： 描述了在水系统如纸浆，纸或板制造系统中的生物膜或微生物生长控制的方法，其中将卤代乙内酰脲与卤胺，二氧化氯或其组合组合加入到水系统中。 卤化乙内酰脲优选为完全或部分卤化的二烷基乙内酰脲，更优选为5,5-二甲基乙内酰脲或5-甲基-5-乙基乙内酰脲。 卤代胺优选为单卤代胺，二卤代胺，三卤代胺或其组合，更优选一氯胺，一溴胺，溴氯胺或其组合。 卤化乙内酰脲优选在易于气相腐蚀的系统的部分系统中加入到水系统中，例如系统的短路，并且卤胺和二氧化氯优选加入系统的其它部分。 卤代乙内酰脲和卤代胺和/或二氧化氯在不存在过量游离氯的情况下保持彼此良好的相容性。

公开(公告)号：US08976003B2

公开(公告)日：2015-03-10

申请号：US12564993

申请日：2009-09-23

申请人： George E. Corbin ,  Anthony Grech ,  Thomas E. Murphy, Jr. ,  Mark Nelson ,  Kevin H. Peters

发明人： George E. Corbin ,  Anthony Grech ,  Thomas E. Murphy, Jr. ,  Mark Nelson ,  Kevin H. Peters

IPC分类号： G05B19/00 ,  G06F21/64

CPC分类号： G06F21/64

摘要： Computer-implemented methods, systems, and computer program products for document authentication and identification using a large-scale distributed system are provided. A method includes receiving a digitized document at a trusted system managed by a trusted third-party that is separate from a creator of content in the digitized document. The digitized document is compared to a set of markers to determine whether the digitized document includes one or more of the markers, and in response thereto, information associated with the one or more markers is extracted using a decoder on the trusted system according to encoding strategies. The method further includes generating a comparison registration identifier on the trusted system as a summary of the extracted information and the one or more markers, and comparing the comparison registration identifier with a stored registration identifier in an encoding history via the trusted system to authenticate and identify the received digitized document.

摘要翻译： 提供了使用大规模分布式系统进行文档认证和识别的计算机实现的方法，系统和计算机程序产品。 一种方法包括在由数字化文档中的内容的创建者分离的受信任的第三方管理的受信系统处接收数字化文档。 将数字化文档与一组标记进行比较以确定数字化文档是否包括一个或多个标记，并且响应于此，根据编码策略，使用可信系统上的解码器提取与一个或多个标记相关联的信息 。 该方法还包括在可信系统上生成比较注册标识符作为提取的信息和一个或多个标记的摘要，并且通过可信系统将比较注册标识符与编码历史中存储的注册标识符进行比较，以验证和识别 收到的数字化文件。

公开(公告)号：US08753313B2

公开(公告)日：2014-06-17

申请号：US13555470

申请日：2012-07-23

申请人： Scott Kimmel ,  Nicholas Kampa ,  Mark Nelson ,  Blane Larson

发明人： Scott Kimmel ,  Nicholas Kampa ,  Mark Nelson ,  Blane Larson

IPC分类号： A61M5/178

CPC分类号： A61M25/0043 ,  A61B17/34 ,  A61M25/0097 ,  A61M25/0668 ,  A61M29/00

摘要： An improved splittable medical device introducer designed to introduce a medical device such as a lead or catheter, into a patient's vasculature without loss of blood or introduction of air is described. The introducer assembly is designed with a notch provided at the proximal end of the introducer housing. The notch, which may comprise a multitude of cross-sectional geometries, is designed to reduce the force required to separate the housing and the introducer sheath, thereby minimizing the possibility of unintentional dislodgement during separation. The notch also increases the repeatability and consistency of the amount of force required to separate the introducer housing and sheath.

摘要翻译： 描述了一种改进的可分裂医疗装置导引器，其被设计成将诸如引线或导管的医疗装置引入病人的脉管系统中而不会损失血液或引入空气。 导引器组件设计成具有设置在导引器壳体的近端处的凹口。 可以包括多个横截面几何形状的凹口被设计成减小分离壳体和导引器鞘所需的力，从而最小化在分离期间意外移动的可能性。 切口还增加了分离导引器壳体和护套所需的力的重复性和一致性。

公开(公告)号：US08576049B2

公开(公告)日：2013-11-05

申请号：US12564982

申请日：2009-09-23

申请人： George E. Corbin ,  Anthony Grech ,  Thomas E. Murphy, Jr. ,  Mark Nelson ,  Kevin H. Peters

发明人： George E. Corbin ,  Anthony Grech ,  Thomas E. Murphy, Jr. ,  Mark Nelson ,  Kevin H. Peters

IPC分类号： H04L9/32 ,  G06F17/00 ,  G06F19/00 ,  G06F7/00 ,  G06F7/04 ,  G06K13/00 ,  H04Q9/00 ,  G05B19/00 ,  G05B23/00 ,  G08B29/00

CPC分类号： H04N1/32144 ,  G06F21/64 ,  H04N2201/3233 ,  H04N2201/327 ,  H04N2201/3277

摘要： Computer-implemented methods, systems, and computer program products for document authentication and identification using encoding and decoding are provided. A method includes receiving a digitized document and comparing the digitized document to a set of markers to determine whether the digitized document is an encoded document with one or more characters replaced. In response to determining that the digitized document is encoded, information is extracted from the set of markers using a decoder according to an encoding strategy. The extracted information and the set of markers are compared with data stored in encoding history to authenticate and identify the received digitized document. Markers in the encoded document may be hidden in plain sight, such that the encoding is not readily apparent to a casual observer.

摘要翻译： 提供了使用编码和解码的用于文档认证和识别的计算机实现的方法，系统和计算机程序产品。 一种方法包括接收数字化文档并将数字化文档与一组标记进行比较，以确定数字化文档是否是被替换了一个或多个字符的编码文档。 响应于确定数字化文档被编码，使用解码器根据编码策略从标记集合中提取信息。 将提取的信息和标记集合与存储在编码历史中的数据进行比较，以验证和识别所接收的数字化文档。 编码文档中的标记可能被隐藏在明显的视觉中，使得编码对于临时观察者来说不是显而易见的。

公开(公告)号：US08308659B2

公开(公告)日：2012-11-13

申请号：US12463570

申请日：2009-05-11

申请人： Grant A. Scheibe ,  Mark Nelson

发明人： Grant A. Scheibe ,  Mark Nelson

IPC分类号： A61B5/00 ,  A61M25/00 ,  A61M31/00 ,  A61M37/00

CPC分类号： A61M25/0136

摘要： A deflectable sheath for use in medical procedures in the vasculature is described. The sheath includes a handle supporting the sheath. Two pull wires run along opposite sides of the sheath to anchors at the deflectable distal end. The handle includes a rotatable member that moves a threaded member including wire guide in a back and forth translation. As the movement occurs, force is applied to either one or the other of the pull wires to cause deflection of distal end of the sheath in either and upwardly or a downwardly direction with respect to the longitudinal axis of the sheath.

摘要翻译： 描述了用于脉管系统中的医疗程序的可偏转护套。 鞘包括支撑鞘的手柄。 两条牵引线沿护套的相对侧延伸，以锚定在可偏转的远端。 手柄包括可旋转构件，该可旋转构件使包括导线器的螺纹构件在前后平移中移动。 当运动发生时，力被施加到牵引线中的一个或另一个以引起护套的远端相对于护套的纵向轴线向上或向下的方向偏转。

公开(公告)号：US20100269221A1

公开(公告)日：2010-10-21

申请号：US12436171

申请日：2009-05-06

申请人： Andre R. Abad ,  Hua Dong ,  Susan B. Lo ,  Mark Nelson ,  Xiaomei Shi ,  Clement W.K. Waine ,  Takashi Yamamoto

发明人： Andre R. Abad ,  Hua Dong ,  Susan B. Lo ,  Mark Nelson ,  Xiaomei Shi ,  Clement W.K. Waine ,  Takashi Yamamoto

IPC分类号： A01H1/00 ,  A01H5/00 ,  C12N15/82 ,  C07H21/04 ,  C12N1/21 ,  C12N5/10 ,  C12N15/63 ,  C12N15/79 ,  C07K14/00 ,  A01N61/00 ,  C12P21/02 ,  A01P7/04

CPC分类号： C12N15/8286 ,  C07K14/32 ,  Y02A40/162

摘要： The invention provides nucleic acids, and variants and fragments thereof, obtained from strains of Bacillus thuringiensis encoding polypeptides having pesticidal activity against insect pests, including Lepidoptera. Particular embodiments of the invention provide isolated nucleic acids encoding pesticidal proteins, pesticidal compositions, DNA constructs, and transformed microorganisms and plants comprising a nucleic acid of the embodiments. These compositions find use in methods for controlling pests, especially plant pests.

公开(公告)号：US20100231606A1

公开(公告)日：2010-09-16

申请号：US12404404

申请日：2009-03-16

申请人： Mark Nelson ,  Michael Woolf ,  Heidi Munson ,  David Bradlee, JR. ,  Evan Moran

发明人： Mark Nelson ,  Michael Woolf ,  Heidi Munson ,  David Bradlee, JR. ,  Evan Moran

IPC分类号： G09G5/00 ,  G06F9/44

CPC分类号： G06T3/20 ,  G06F3/03543 ,  G06F3/04817 ,  G06F3/0482 ,  G06F3/04842 ,  G06F3/04845 ,  G06T3/40 ,  G06T11/206

摘要： Information in a diagram is logically structured using lists, containers, and callouts without requiring the diagram author to explicitly define a structure or map any diagram contents to a structure. Logical relationships are inferred based on actions associated with shapes, groupings, and attributes of shapes/groupings taken by the author. Feedback mechanisms are provided to communicate an underlying structure to the author. Intelligent behaviors are enabled to expose manipulation of diagrams based on their logical structure.

摘要翻译： 图中的信息使用列表，容器和标注进行逻辑结构，而不需要图表作者明确定义结构或将任何图表内容映射到结构。 逻辑关系是基于与作者采取的形状，分组和形状/分组的属性相关联的动作来推断的。 提供反馈机制以向作者传达基础结构。 智能行为能够根据逻辑结构公开对图表的操纵。

公开(公告)号：US20090265818A1

公开(公告)日：2009-10-22

申请号：US12351267

申请日：2009-01-09

申请人： Rafael Herrmann ,  Michael Lassner ,  Albert L. Lu ,  Mark Nelson ,  James K. Presnail ,  Janet A. Rice

发明人： Rafael Herrmann ,  Michael Lassner ,  Albert L. Lu ,  Mark Nelson ,  James K. Presnail ,  Janet A. Rice

IPC分类号： A01H5/00 ,  C12N5/04 ,  A01N43/04 ,  A01P7/04

CPC分类号： C12N15/8286 ,  A01N65/20 ,  A01N65/44 ,  C12N15/113 ,  C12N2310/11 ,  C12N2310/14 ,  C12N2310/531 ,  C12N2320/32 ,  Y02A40/162

摘要： Methods and compositions are provided which employ a silencing element that, when ingested by a pest, such as a pest from the Lepidoptera order, they are capable of decreasing the expression of a target sequence in the pest. In specific embodiments, the decrease in expression of the target sequence controls the pest and thereby the methods and compositions are capable of limiting damage to a plant. The present invention provides target polynucleotides encoding polypeptides from specific protein families and various target polynucleotides set forth in SEQ ID NOS: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, or 50 or active variants and fragments thereof, wherein a decrease in expression of one or more the sequences in the target pest controls the pest (i.e., has insecticidal activity). Further provided are silencing elements which when ingested by the pest decrease the level of the target polypeptide and thereby control the pest. In specific embodiment, the pest is Spodoptera frugiperda. Plants, plant part, bacteria and other host cells comprising the silencing elements or an active variant or fragment thereof of the invention are also provided.

摘要翻译： 提供了使用沉积元件的方法和组合物，当沉积元件在被害虫如来自鳞翅目序列的害虫中摄取时，它们能够降低害虫中靶序列的表达。 在具体实施方案中，靶序列的表达降低控制有害生物，因此方法和组合物能够限制对植物的损害。 本发明提供编码来自特定蛋白质家族的多肽的多核苷酸和SEQ ID NO：1,2,3,4,5,6,7,8,9,10,11,12,13,14中所示的各种靶多核苷酸的靶多核苷酸 ，15，16，17，18，19，20，21，22，23，24，25，26，27，28，29，30，31，32，33，34，35，36，37，38，39 ，40,41,42,43,44,45,46,47,48,49或50个或其活性变体和片段，其中目标害虫中一个或多个序列的表达降低控制害虫（即 ，具有杀虫活性）。 进一步提供的是沉积元件，当受害虫摄入时，降低靶多肽的水平，从而控制害虫。 在具体实施方案中，害虫是草地夜蛾（Spodoptera frugiperda）。 还提供了包含本发明的沉默元件或其活性变体或片段的植物，植物部分，细菌和其它宿主细胞。

公开(公告)号：US20070167415A1

公开(公告)日：2007-07-19

申请号：US11728346

申请日：2007-03-26

申请人： Stuart Levy ,  Mark Nelson

发明人： Stuart Levy ,  Mark Nelson

IPC分类号： A61K31/65

CPC分类号： A61K31/65 ,  C07C237/26 ,  C07C2601/10 ,  Y02A50/488

摘要： Methods and compositions for treating Cryptosporidium parvum related disorders in a mammal are discussed. Several novel tetracycline compounds useful for treating Cryptosporidium parvum related disorders are also included.