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31.发明申请Antibodies to a polypeptide encoded by a nucleic acid underexpressed in melanoma 有权由在黑素瘤中低表达的核酸编码的多肽的抗体公开(公告)号：US20060099657A1
公开(公告)日：2006-05-11
申请号：US11101316
申请日：2005-04-06
申请人： Dan Eaton , Ellen Filvaroff , Mary Gerritsen , Audrey Goddard , Paul Godowski , J. Grimaldi , Austin Gurney , Colin Watanabe , William Wood
发明人： Dan Eaton , Ellen Filvaroff , Mary Gerritsen , Audrey Goddard , Paul Godowski , J. Grimaldi , Austin Gurney , Colin Watanabe , William Wood
IPC分类号： G01N33/574
CPC分类号： G01N33/5743
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
摘要翻译： 本发明涉及新型多肽和编码那些多肽的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。
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公开(公告)号：US20060074223A1
公开(公告)日：2006-04-06
申请号：US10218784
申请日：2002-08-12
申请人： Kevin Baker , Luc Desnoyers , Mary Gerritsen , Audrey Goddard , Paul Godowski , J. Grimaldi , Austin Gurney , Victoria Smith , Jean-Philippe Stephan , Colin Watanabe , William Wood
发明人： Kevin Baker , Luc Desnoyers , Mary Gerritsen , Audrey Goddard , Paul Godowski , J. Grimaldi , Austin Gurney , Victoria Smith , Jean-Philippe Stephan , Colin Watanabe , William Wood
IPC分类号： C07K16/18
CPC分类号： C07K14/705 , C07K14/47 , G01N33/574
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
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公开(公告)号：US20060073568A1
公开(公告)日：2006-04-06
申请号：US11290153
申请日：2005-11-30
申请人： Kevin Baker , Maureen Beresini , Laura DeForge , Luc Desnoyers , Ellen Filvaroff , Wei-Qiang Gao , Mary Gerritsen , Audrey Goddard , Paul Godowski , Austin Gurney , Steven Sherwood , Victoria Smith , Timothy Stewart , Daniel Tumas , Colin Watanabe , William Wood , Zemin Zhang
发明人： Kevin Baker , Maureen Beresini , Laura DeForge , Luc Desnoyers , Ellen Filvaroff , Wei-Qiang Gao , Mary Gerritsen , Audrey Goddard , Paul Godowski , Austin Gurney , Steven Sherwood , Victoria Smith , Timothy Stewart , Daniel Tumas , Colin Watanabe , William Wood , Zemin Zhang
CPC分类号： C07K14/4748 , A61K38/00 , A61K39/00 , A61K39/0011 , C07K1/00 , C07K14/00 , C07K14/47 , C07K14/4703 , C07K14/705 , C07K14/70578 , C07K14/82 , C07K16/18 , C07K17/00 , C07K2317/24 , C07K2319/00 , C07K2319/30 , C12N5/06 , C12N9/00 , C12N9/001 , C12N9/1051 , C12N15/00 , C12N2799/026 , C12P21/02 , C12P21/06 , C12Q1/68 , C12Q1/6886 , C12Q2600/136 , C12Q2600/158 , G01N33/5008 , G01N33/5011 , G01N33/5014 , G01N33/502 , G01N33/5044 , G01N33/505 , G01N33/5061 , G01N33/53 , G01N33/574 , G01N33/57484 , G01N33/68 , G01N33/6845 , G01N2800/042 , Y10S530/828 , Y10S530/866
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
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公开(公告)号：US20060073476A1
公开(公告)日：2006-04-06
申请号：US10233134
申请日：2002-08-29
申请人： Kevin Baker , Luc Desnoyers , Mary Gerritsen , Audrey Goddard , Paul Godowski , J. Grimaldi , Austin Gurney , Victoria Smith , Jean-Philippe Stephan , Colin Watanabe , William Wood
发明人： Kevin Baker , Luc Desnoyers , Mary Gerritsen , Audrey Goddard , Paul Godowski , J. Grimaldi , Austin Gurney , Victoria Smith , Jean-Philippe Stephan , Colin Watanabe , William Wood
CPC分类号： C07K14/47 , C07K14/435 , C12N9/00 , C12N2510/00 , C12P21/02
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
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公开(公告)号：US20060030597A1
公开(公告)日：2006-02-09
申请号：US11085982
申请日：2005-03-22
申请人： Mary Gerritsen , Xiaohua Xin
发明人： Mary Gerritsen , Xiaohua Xin
IPC分类号： A61K31/4439 , A61K31/426
CPC分类号： A61K31/427 , A61K31/00 , A61K31/426 , A61K31/4439 , A61K45/06 , C12Q1/37 , G01N33/5011 , G01N2333/515 , G01N2333/96486
摘要： Angiogenesis is inhibited and the growth of tumors is treated by administering an effective amount of a PPAR gamma ligand/agonist, optionally with an RXR receptor ligand.
摘要翻译： 通过施用有效量的任选与RXR受体配体的PPARγ配体/激动剂来治疗血管发生被抑制并且肿瘤的生长。
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公开(公告)号：US20050227342A1
公开(公告)日：2005-10-13
申请号：US10165036
申请日：2001-10-19
申请人： Avi Ashkenazi , Kevin Baker , David Botstein , Luc Desnoyers , Dan Eaton , Napoleone Ferrara , Ellen Filvaroff , Sherman Fong , Wei-Qiang Gao , Hanspeter Gerber , Mary Gerritsen , Audrey Goddard , Paul Godowski , J. Grimaldi , Austin Gurney , Kenneth Hillan , Ivar Kljavin , Sophia Kuo , Mary Napier , James Pan , Nicholas Paoni , Margaret Roy , David Shelton , Timothy Stewart , Daniel Tumas , P. Williams , William Wood
发明人： Avi Ashkenazi , Kevin Baker , David Botstein , Luc Desnoyers , Dan Eaton , Napoleone Ferrara , Ellen Filvaroff , Sherman Fong , Wei-Qiang Gao , Hanspeter Gerber , Mary Gerritsen , Audrey Goddard , Paul Godowski , J. Grimaldi , Austin Gurney , Kenneth Hillan , Ivar Kljavin , Sophia Kuo , Mary Napier , James Pan , Nicholas Paoni , Margaret Roy , David Shelton , Timothy Stewart , Daniel Tumas , P. Williams , William Wood
CPC分类号： C07K14/705
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
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37.发明申请公开(公告)号：US20050153396A1
公开(公告)日：2005-07-14
申请号：US10955952
申请日：2004-09-29
申请人： Kevin Baker , Maureen Beresini , Laura DeForge , Luc Desnoyers , Ellen Filvaroff , Wei-Qiang Gao , Mary Gerritsen , Audrey Goddard , Paul Godowski , Austin Gurney , Steven Sherwood , Victoria Smith , Timothy Stewart , Daniel Tumas , Colin Watanabe , William Wood , Zemin Zhang
发明人： Kevin Baker , Maureen Beresini , Laura DeForge , Luc Desnoyers , Ellen Filvaroff , Wei-Qiang Gao , Mary Gerritsen , Audrey Goddard , Paul Godowski , Austin Gurney , Steven Sherwood , Victoria Smith , Timothy Stewart , Daniel Tumas , Colin Watanabe , William Wood , Zemin Zhang
IPC分类号： A61K38/00 , A61K38/17 , C07H21/02 , C07H21/04 , C07K1/00 , C07K14/00 , C07K14/435 , C07K14/47 , C07K14/705 , C07K16/18 , C07K17/00 , C12N5/06 , C12N9/00 , C12N9/02 , C12N15/00 , C12N15/12 , C12P21/02 , C12P21/06 , C12Q1/68 , C12Q1/6886 , G01N33/53 , G01N33/574 , G01N33/68
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention used to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
摘要翻译： 本发明涉及新型多肽和编码那些多肽的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含用于异源多肽序列的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体和本发明的多肽的制备方法 发明。
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公开(公告)号：US20050037458A1
公开(公告)日：2005-02-17
申请号：US10805667
申请日：2004-07-23
申请人： Avi Ashkenazi , Kevin Baker , David Botstein , Luc Desnoyers , Dan Eaton , Napoleone Ferrara , Ellen Filvaroff , Sherman Fong , Wei-Qiang Gao , Hanspeter Gerber , Mary Gerritsen , Audrey Goddard , Paul Godowski , J. Grimaldi , Austin Gurney , Kenneth Hillan , Ivar Kljavin , Sophia Kuo , Mary Napier , James Pan , Nicholas Paoni , Margaret Roy , David Shelton , Timothy Stewart , Daniel Tumas , P. Williams , William Wood
发明人： Avi Ashkenazi , Kevin Baker , David Botstein , Luc Desnoyers , Dan Eaton , Napoleone Ferrara , Ellen Filvaroff , Sherman Fong , Wei-Qiang Gao , Hanspeter Gerber , Mary Gerritsen , Audrey Goddard , Paul Godowski , J. Grimaldi , Austin Gurney , Kenneth Hillan , Ivar Kljavin , Sophia Kuo , Mary Napier , James Pan , Nicholas Paoni , Margaret Roy , David Shelton , Timothy Stewart , Daniel Tumas , P. Williams , William Wood
CPC分类号： C07K14/47 , G01N33/6872
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
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39.发明申请Novel polypeptides, their nucleic acids, and methods for their use in angiogenesis and vascularization 审中-公开新型多肽，其核酸，及其用于血管生成和血管形成的方法公开(公告)号：US20050032693A1
公开(公告)日：2005-02-10
申请号：US10811080
申请日：2004-03-26
申请人： Mary Gerritsen , Audrey Goddard , J. Grimaldi , Fuad Mehraban
发明人： Mary Gerritsen , Audrey Goddard , J. Grimaldi , Fuad Mehraban
IPC分类号： G01N33/50 , A61K31/7088 , A61K38/00 , A61K39/395 , A61K45/00 , A61K48/00 , A61P7/00 , A61P9/10 , A61P17/00 , A61P35/00 , C07K14/47 , C07K16/18 , C07K16/46 , C12M1/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N7/00 , C12N15/09 , C12N15/12 , C12P21/02 , C12P21/08 , C12Q1/02 , C12Q1/68 , C12R1/91 , C12R1/93 , G01N33/15 , G01N33/53 , G01N33/566 , G01N37/00 , A61K38/17 , C07H21/04
CPC分类号： C07K14/47 , A61K38/00 , C07K2319/00 , C12N2799/027
摘要： The present invention is directed to novel polypeptides critical for angiogenesis and vascularization, and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Compositions and methods are disclosed for stimulating or inhibiting angiogenesis and/or neo- or cardio-vascularization in mammals, including humans. Pharmaceutical compositions are based on polypeptides or antagonists thereto that have been identified for one or more of these uses. Disorders that can be diagnosed, prevented, or treated by the compositions herein include trauma such as wounds; various cancers, and disorders of the vessels including atherosclerosis.
摘要翻译： 本发明涉及对血管生成和血管形成临界的新型多肽以及编码这些多肽的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。 公开了用于刺激或抑制哺乳动物（包括人）中的血管发生和/或新生血管或心脏血管形成的组合物和方法。 药物组合物基于已被鉴定为一种或多种这些用途的多肽或其拮抗剂。 可以通过本文组合物诊断，预防或治疗的疾病包括创伤，例如伤口; 各种癌症和包括动脉粥样硬化的血管紊乱。
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公开(公告)号：US07582293B2
公开(公告)日：2009-09-01
申请号：US10243425
申请日：2002-09-12
IPC分类号： A61K39/395
CPC分类号： C07K14/47 , C07K14/705
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods, for producing the polypeptides of the present invention.
摘要翻译： 本发明涉及新型多肽和编码那些多肽的核酸分子。 本文还提供了包含这些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明多肽的嵌合多肽分子，与本发明多肽结合的抗体以及用于产生本发明多肽的方法 本发明。
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