公开(公告)号：US20090118532A1

公开(公告)日：2009-05-07

申请号：US12063907

申请日：2006-08-08

申请人： Martin Charles Bowden ,  Thomas Aitcheson Clark ,  Fanny Giordano ,  Beat Jau ,  Hans-Dieter Schneider ,  Gottfried Seifert ,  Martin Zeller ,  Dominik Faber ,  Juerg Wiss

发明人： Martin Charles Bowden ,  Thomas Aitcheson Clark ,  Fanny Giordano ,  Beat Jau ,  Hans-Dieter Schneider ,  Gottfried Seifert ,  Martin Zeller ,  Dominik Faber ,  Juerg Wiss

IPC分类号： C07C255/37 ,  C07C231/02 ,  C07C231/06 ,  C07C43/23 ,  C07C213/02

CPC分类号： C07C231/12 ,  C07C33/46 ,  C07C59/70 ,  C07C69/734 ,  C07C213/02 ,  C07C235/34 ,  C07C251/16 ,  C07C255/37 ,  C07C315/04 ,  C07C319/20 ,  C07C317/46 ,  C07C323/62

摘要： A process for the preparation of a compound of formula (I) wherein: R is an alkynyl group; R1 is alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkyl-alkyl, phenyl and phenylalkyl, it being possible in turn for all of the receding groups to carry one or more identical or different halogen atoms; alkoxy; alkenyloxy; alkynyloxy; alkoxyalkyl; haloalkoxy; alkylthio; haloalkylthio; alkysulfonyl; formyl; alkanoyl; hydroxy; halogen; cyano; nitro; amino; alkylamino; dialkylamino; carboxyl; alkoxycarbonyl; alkenyloxycarbonyl; or alkynyloxycarbonyl; and n is an integer from 0 to 3, said process comprising: (i) the reaction of a compound of formula (III) wherein R, R1 and n are as hereinbefore defined; m and m′ are independently 0 or 1; when m and m′ are both 0, A is an alkyl, alkenyl or alkynyl group (suitably having up to eight carbon atoms), optionally substituted by one or more groups independently selected from halogen, hydroxy, alkoxy, C1-4 dialkylamino or cyano; when one of m and m′ is 0 and the other is 1, A is an alkanediyl, alkenediyl or alkynediyl group containing at least two carbon atoms (and suitably having up to eight carbon atoms), optionally substituted by one or more groups independently selected from halogen, hydroxy, alkoxy, C1-4 dialkylamino or cyano; when m and m′ are both 1, A is an alkanetriyl, alkenetriyl or alkynetriyl group containing at least three carbon atoms (and suitably having up to eight carbon atoms), optionally substituted by one or more groups independently selected from halogen, hydroxy, alkoxy, C1-4 dialkylamino or cyano; and wherein if the group A contains three or more carbon atoms, one or more of the carbon atoms may each optionally be replaced with an oxygen atom, provided that there is at least one carbon atom between any two oxygen atoms in the molecule, with a compound of formula (IV) to give a compound of formula (II) wherein R, R1 and n are as hereinbefore defined, and (ii) the reaction of a compound of formula (II) with, wherein L is a leaving group, to give the compound of formula (I) as hereinbefore defined, is disclosed.

公开(公告)号：US06538159B2

公开(公告)日：2003-03-25

申请号：US09872576

申请日：2001-06-01

申请人： Martin Zeller ,  André Jeanguenat ,  Clemens Lamberth

发明人： Martin Zeller ,  André Jeanguenat ,  Clemens Lamberth

IPC分类号： A61K3116

CPC分类号： A01N41/06 ,  C07C307/06 ,  C07C311/06 ,  C07C311/07 ,  C07C311/11

摘要： The invention relates to &agr;-sulfin- and &agr;-sulfonamino acid amides of the general formula I including the optical isomers thereof and mixtures of such isomers, wherein n is a number zero or one; R1 is C1-C12alkyl, C1-C12alkyl substituted with C1-C4alkoxy, C1-C4alkylthio, C1-C4alkylsulfonyl, C3-C8cycloalkyl, cyano, C1-C6alkoxycarbonyl, C3-C6alkenyloxycarbonyl or C3-C6alkenyloxycarbonyl; C3-C8cycloalkyl; C2-C12alkenyl; C2-C12alkynyl; C1-C12haloalkyl; or a group NR12R13 wherein R12 and R13 are each independently of the other hydrogen or C1-C6-alkyl, or together are tetra- or penta-methylene; R2 and R3 are each independently hydrogen; C1-C8alkyl; C1-C8alkyl substituted with hydroxy, mercapto, C1-C4alkoxy or C1-C4alkylthio; C3-C8alkenyl; C3-C8alkynyl; C3-C8cycloalkyl; C3-C8cycloalkyl-C1-C4alkyl; or the two groups R2 and R3 together with the carbon atom to which they are bonded form a three- to eight-membered hydrocarbon ring; R4, R5, R6 and R7 are each independently hydrogen or C1-C4alkyl; R8 is C1-C6alkyl, C3-C6alkenyl or C3-C6alkynyl; R9, R10, R14, R15, R16 and R17 are each independently hydrogen or C1-C4alkyl; A is optionally substituted phenyl, and to the preparation of those substances and to agrochemical compositions comprising at least one of those compounds as active ingredient. The invention relates also to the preparation of the said compositions and to the use of the compounds or of the compositions in controlling or preventing the infestation of plants by phytopathogenic microorganisms, especially fungi.

摘要翻译： 本发明涉及包含其光学异构体的通式I的α-亚磺酸和α-磺氨基酰胺和这些异构体的混合物，其中n是数个零或一个; R 1是C 1 -C 12烷基，被C 1 -C 12取代的C 1 -C 12烷基， C 4烷氧基，C 1 -C 4烷硫基，C 1 -C 4烷基磺酰基，C 3 -C 8环烷基，氰基，C 1 -C 6烷氧基羰基，C 3 -C 6烯氧基羰基或C 3 -C 6烯氧基羰基; C 3 -C 8环烷基; C 2 -C 12烯基; C 2 -C 12炔基; C 1 -C 12卤代烷基; 或NR 12 R 13基团，其中R 12和R 13各自独立地为氢或C 1 -C 6 - 烷基，或一起为四或五亚甲基; R 2和R 3各自独立地为氢; C1-C8烷基; 被羟基，巯基，C 1 -C 4烷氧基或C 1 -C 4烷硫基取代的C 1 -C 8烷基; C3-C8链烯基; C3-C8炔基; C 3 -C 8环烷基; C 3 -C 8环烷基-C 1 -C 4烷基; 或两个R 2和R 3与它们所键合的碳原子一起形成三至八元烃环; R 4，R 5，R 6和R 7各自独立地为氢或C 1 -C 4烷基; R 8为C 1 -C 6烷基， C 3 -C 6烯基或C 3 -C 6炔基; R 9，R 10，R 14，R 15，R 16和R 17各自独立地为氢或C 1 -C 4烷基; A为任选取代的苯基，并且为这些物质的制备以及包含至少一种 化合物作为活性成分。 本发明还涉及所述组合物的制备以及化合物或组合物在控制或预防植物病原微生物特别是真菌侵染植物中的用途。

公开(公告)号：US06538016B2

公开(公告)日：2003-03-25

申请号：US09872577

申请日：2001-06-01

申请人： Martin Zeller ,  André Jeanguenat ,  Clemens Lamberth

发明人： Martin Zeller ,  André Jeanguenat ,  Clemens Lamberth

IPC分类号： A61K3116

CPC分类号： C07C323/12 ,  C07C307/06 ,  C07C311/06

摘要： The invention relates to &agr;-sulfin- and &agr;-sulfonamino acid amides of the general formula I including the optical isomers thereof and mixtures of such isomers, wherein n is a number zero or one; R1 is C1-C12alkyl, C1-C12alkyl substituted with C1-C4alkoxy, C1-C4alkylthio, C1-C4alkylsulfonyl, C3-C8cycloalkyl, cyano, C1-C6alkoxycarbonyl, C3-C6alkenyloxycarbonyl or C3-C6alkynyloxycarbonyl; C3-C8cycloalkyl; C2-C12alkenyl; C2-C12alkynyl; C1-C12haloalkyl; or a group NR12R13 wherein R12 and R13 are each independently of the other hydrogen or C1-C6-alkyl, or together are tetra- or penta-methylene; R2 and R3 are each independently hydrogen; C1-C8alkyl; C1-C8alkyl substituted with hydroxy, mercapto, C1-C4alkoxy or C1-C4alkylthio; C3-C8alkenyl; C3-C8alkynyl; C3-C8cycloalkyl; C3-C8cycloalkyl-C1-C4alkyl; or the two groups R2 and R3 together with the carbon atom to which they are bonded form a three- to eight-membered hydrocarbon ring; R4, R5, R6 and R7 are each independently hydrogen or C1-C4alkyl; R8 is C1-C6alkyl, C3-C6alkenyl or C3-C6alkynyl; R9 and R10 are each independently hydrogen or C1-C4alkyl; and R11 is either  in wherein R14, R,15, R16 and R17 are each independently hydrogen or C1-C4alkyl, X is oxygen, sulfur or —NR18—, wherein R18 is hydrogen or C1-C4alkyl, and A is optionally substituted mono- or polycylic aryl or heteroaryl, and to the preparation of those substances and to agrochemical compositions comprising at least one of those compounds as active ingredient. The invention relates also to the preparation of compositions and to the use of the compounds or of the compositions in controlling or preventing the infestation of plants by phytopathogenic microorganisms, especially fungi.

摘要翻译： 本发明涉及包含其光学异构体的通式I的α-亚磺酸和α-磺氨基酰胺和这些异构体的混合物，其中n是数个零或一个; R 1是C 1 -C 12烷基，被C 1 -C 12取代的C 1 -C 12烷基， C4烷氧基，C1-C4烷硫基，C1-C4烷基磺酰基，C3-C8环烷基，氰基，C1-C6烷氧基羰基，C3-C6烯氧基羰基或C3-C6炔氧基羰基; C 3 -C 8环烷基; C 2 -C 12烯基; C 2 -C 12炔基; C 1 -C 12卤代烷基; 或NR 12 R 13基团，其中R 12和R 13各自独立地为氢或C 1 -C 6 - 烷基，或一起为四或五亚甲基; R 2和R 3各自独立地为氢; C1-C8烷基; 被羟基，巯基，C 1 -C 4烷氧基或C 1 -C 4烷硫基取代的C 1 -C 8烷基; C3-C8链烯基; C3-C8炔基; C 3 -C 8环烷基; C 3 -C 8环烷基-C 1 -C 4烷基; 或两个R 2和R 3与它们所键合的碳原子一起形成三至八元烃环; R 4，R 5，R 6和R 7各自独立地为氢或C 1 -C 4烷基; R 8为C 1 -C 6烷基， C 3 -C 6烯基或C 3 -C 6炔基; R 9和R 10各自独立地为氢或C 1 -C 4烷基; 并且R 11在其中R 14，R 15，R 16和R 17各自独立地为氢或C 1 -C 4烷基，X为氧，硫或-NR 18 - ，其中R 18为氢或C 1 -C 4烷基，A为任选取代的单或多环芳基 或杂芳基，以及这些物质的制备以及包含这些化合物中的至少一种作为活性成分的农药组合物。 本发明还涉及组合物的制备以及化合物或组合物在通过植物病原微生物特别是真菌控制或预防植物感染中的用途。

公开(公告)号：US06482859B1

公开(公告)日：2002-11-19

申请号：US09485280

申请日：2000-02-04

申请人： Martin Zeller ,  André Jeanguenat

发明人： Martin Zeller ,  André Jeanguenat

IPC分类号： A61K3118

CPC分类号： C07C311/06 ,  A01N41/06 ,  A01N43/10 ,  C07C217/60 ,  C07C237/08 ,  C07C307/06 ,  C07C311/11 ,  C07C313/06 ,  C07C2601/14 ,  C07D333/16

摘要： The invention relates to novel pesticidally active compounds of the general formula I as well as possible isomers and mixtures of isomers thereof, wherein n is a number zero or one; and R1 is C1-C12alkyl that is unsubstituted or may be substituted by C1-C4alkoxy, C1-C4alkylthio, C1-C4alkylsulfonyl, C3-C8cycloalkyl, cyano, C1C6alkoxycarbonyl, C3-C6alkenyloxycarbonyl or by C3-C6alkynyloxycarbonyl; C3-C8cycloalkyl; C2-C12alkenyl; C2-C12alkynyl; C1-C12haloalkyl: or a group NR11R12 wherein R11 and R12 are each independently of the other hydrogen or C1-C8alkyl, or together are tetra- or penta-methylene; R2 and R3 are each independently of the other hydrogen; C1-C8alkyl; C1-C8alkyl substituted by hydroxy, C1-C4alkoxy, mercapto or by C1-C4alkylthio; C3-C8alkenyl; C3-C8alkynyl; C3-C8cycloalkyl; C3-C8cycloalkyl-C1-C4alkyl; or the two groups R2 and R3 together with the carbon atom to which they are bonded form a three- to eight-membered ring; R4, R5, R6 and R7 are identical or different and are each independently of the others hydrogen or C1-C4alkyl; R8 is C1-C6alkyl, C3-C6alkenyl or C3-C6alkynyl; A is C1-C6alkylene; and B is optionally mono- or poly-nuclear, unsubstituted or substituted aryl; optionally mono- or poly-nuclear, unsubstituted or substituted heteroaryl; C4-C12alkyl; or C3-C8cycloalkyl. The novel compounds have plant-protecting properties and are suitable for protecting plants against infestation by phytopathogenic microorganisms.

摘要翻译： 本发明涉及具有通式的新的杀虫活性化合物，以及可能的异构体及其异构体的混合物，其中n为数个零或一; 并且R 1是未被取代或可以被C 1 -C 4烷氧基，C 1 -C 4烷硫基，C 1 -C 4烷基磺酰基，C 3 -C 8环烷基，氰基，C 1 -C 6烷氧基羰基，C 3 -C 6炔氧基羰基或C 3 -C 6炔氧基羰基取代的C 1 -C 12烷基; C 3 -C 8环烷基; C 2 -C 12烯基; C 2 -C 12炔基; C 1 -C 12卤代烷基或NR 11 R 12基团，其中R 11和R 12各自独立地为氢或C 1 -C 8烷基，或一起为四或五亚甲基; R 2和R 3各自独立地为氢; C1-C8烷基; 由羟基，C 1 -C 4烷氧基，巯基或被C 1 -C 4烷硫基取代的C 1 -C 8烷基; C3-C8链烯基; C3-C8炔基; C 3 -C 8环烷基; C 3 -C 8环烷基-C 1 -C 4烷基; 或两个R 2和R 3与它们所键合的碳原子一起形成三至八元环; R 4，R 5，R 6和R 7相同或不同，各自独立地为氢或C 1 -C 4烷基 ; R 8为C 1 -C 6烷基，C 3 -C 6烯基或C 3 -C 6炔基; A为C 1 -C 6亚烷基; 和B是任选的单核或多核，未取代或取代的芳基; 任选的单核或多核，未取代或取代的杂芳基; C4-C12烷基; 或C3-C8环烷基。新化合物具有植物保护性质，并且适合于保护植物免受植物病原微生物侵扰。

公开(公告)号：US06469005B1

公开(公告)日：2002-10-22

申请号：US09903651

申请日：2001-07-11

申请人： Martin Zeller ,  André Jeanguenat ,  Clemens Lamberth ,  Walter Kunz

发明人： Martin Zeller ,  André Jeanguenat ,  Clemens Lamberth ,  Walter Kunz

IPC分类号： A01N4358

CPC分类号： A01N43/40 ,  A01N37/36 ,  A01N37/38 ,  A01N37/42 ,  A01N37/50 ,  A01N43/08 ,  A01N43/10 ,  A01N43/28 ,  A01N43/30 ,  A01N43/32 ,  A01N43/54 ,  A01N47/12 ,  C07C235/34 ,  C07C235/80 ,  C07C251/40 ,  C07C271/22 ,  C07C323/62

摘要： Propargylether derivatives of formula I including the optical isomers thereof and mixtures of such isomers, wherein R1 is hydrogen, alkyl, cycloalkyl or optionally substituted aryl, R2 and R3 are each independently hydrogen or alkyl, R4 is alkyl, alkenyl or alkynyl, R5, R6, R7, and R8 are each independently hydrogen or alkyl and R9 is a group R10 is optionally substituted aryl or optionally substituted heteroaryl, R11 is hydrogen or optionally substituted alkyl, alkenyl or alkynyl, Z is hydrogen —CO—R16, —COOR16, —CO—COOR16 or —CONR16R17, R12 is hydrogen, or optionally substituted alkyl, alkenyl or alkynyl, R13 is hydrogen or alkyl, R14 is hydrogen, alkyl, cycloalkyl or cycloalkyl-alkyl, R15 is alkyl, alkenyl, alkynyl, optionally substituted aryl or optionally substituted aryl-alkyl, and R16 and R17 are independently of each other hydrogen, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted aryl or optionally substituted heteroaryl, have been found to be useful for controlling or preventing the infestation of plants by phytopathogenic microorganisms, especially fungi. The invention relates the novel compounds and also to the preparation thereof and to the use of the compounds for plant protection, and to compositions suitable for applying the novel compounds in agricultural techniques.

摘要翻译： 式I的丙酰醚衍生物包括其光学异构体和这些异构体的混合物，其中R 1是氢，烷基，环烷基或任选取代的芳基，R 2和R 3各自独立地是氢或烷基，R 4是烷基，烯基或炔基，R 5，R 6，R 7 ，和R 8各自独立地为氢或烷基，R 9为基团R 10为任选取代的芳基或任选取代的杂芳基，R 11为氢或任选取代的烷基，烯基或炔基，Z为氢-CO-R 16，-COOR 16，-CO-COOR 16或 -CONR 16 R 17，R 12是氢或任选取代的烷基，烯基或炔基，R 13是氢或烷基，R 14是氢，烷基，环烷基或环烷基 - 烷基，R 15是烷基，烯基，炔基，任选取代的芳基或任选取代的芳基 - 烷基，R16和R17彼此独立地为氢，任选取代的烷基，任选取代的环烷基，任选取代的芳基或任选取代的杂芳基，已被发现是有用的 用于控制或防止由植物病原微生物，特别是真菌侵染植物。本发明涉及新化合物以及其制备方法以及本发明化合物用于植物保护的用途，以及适用于农业技术中的新型化合物的组合物 。

公开(公告)号：US06316389B1

公开(公告)日：2001-11-13

申请号：US09202887

申请日：1997-06-16

申请人： Henry Szczepanski ,  Martin Zeller ,  Ottmar Franz Hüter

发明人： Henry Szczepanski ,  Martin Zeller ,  Ottmar Franz Hüter

IPC分类号： A01N3708

CPC分类号： C07D213/30 ,  A01N37/38 ,  A01N37/50 ,  A01N43/40 ,  A01N43/80 ,  C07C69/736 ,  C07C251/42 ,  C07C251/54 ,  C07C255/62 ,  C07C323/60 ,  C07C2601/10 ,  C07D213/61 ,  C07D213/69 ,  C07D239/26 ,  C07D241/12 ,  C07D261/08 ,  C07D263/32 ,  C07D277/24 ,  C07D317/22 ,  C07D333/16

摘要： Compounds of the formula I in which: where: X is CH or N; Y is O; S, S═O or NR5; Z is OR2, SR2, N(R3)R4; or Y and Z together form 5- to 7-membered ring which contains, 2 or 3 hetero atoms O and/or N and which is unsubstituted or substituted by C1-C4alkyl, halo-C1-C4alkyl, halogen, ═O or cyclopropyl; V is a direct bond or C1-C6alkylene, which is unsubstituted or substituted by C1-C3alkyl, C2-C3alkylidene or C3-C6cycloalkylidene; U is O, S, NR7, SO or SO2; W is substituted or unsubstituted aryl or substituted or unsubstituted heteroaryl; R1 is cyclopropyl, C1C6alkyl or halo-C1-C6alkyl; R2 and R3 independently of one another are C1-C6alkyl or halo-C1-C6alkyl; R4 and R5 independently of one another are hydrogen, C1-C6alkyl or C1-C6alkoxy; R7 is hydrogen, C1-C6alkyl, benzyl, C1-C6alkylcarbonyl, halo-C1-C6alkylcarbonyl, halo-C2-C6alkenylcarbonyl; R21 and R22 independently of one another are hydrogen, halogen, C1-C8alkyl or C1-C8alkoxy or C1-C8alkylthio; R23, R24, R25, R26 independently of one another are hydrogen, halogen, C1-C8alkyl or C1-C8alkoxy; are pesticidally active. They can be used for pest control, in particular as fungicides, acaricides and insecticides in crop protection.

摘要翻译： 式Iin的化合物，其中：其中：X为CH或N; Y为O; S，S = O或NR5; Z是OR2，SR2，N（R3）R4; 或Y和Z一起形成5-至7-元环，其含有2或3个杂原子O和/或N，并且其未被取代或被C 1 -C 4烷基，卤代-C 1 -C 4烷基，卤素，O或环丙基取代; V C 1 -C 3亚烷基或C 3 -C 6亚烷基; U是O，S，NR 7，SO或SO 2; W是取代或未取代的芳基或取代或未取代的杂芳基 R 1和R 2各自独立地为C 1 -C 6烷基或卤代-C 1 -C 6烷基; R 4和R 5彼此独立地为氢，C 1 -C 6烷基或C 1 -C 6烷氧基; R 7为 R 2和R 22彼此独立地是氢，卤素，C 1 -C 8烷基或C 1 -C 8烷氧基或C 1 -C 8烷硫基; R 23是氢，C 1 -C 6烷基，苄基，C 1 -C 6烷基羰基，卤代C 1 -C 6烷基羰基 R 24，R 25，R 26彼此独立地是氢，卤素，C 1 -C 8烷基或C 1 -C 8烷氧基; 具有杀虫活性，可用于防治害虫，特别是杀虫剂，杀螨剂和作物保护中的杀虫剂。

公开(公告)号：US5585519A

公开(公告)日：1996-12-17

申请号：US431230

申请日：1995-04-28

申请人： Martin Zeller

发明人： Martin Zeller

IPC分类号： C07D275/02 ,  A01N41/06 ,  C07C303/36 ,  C07C307/06 ,  C07C311/06 ,  C07C311/07 ,  C07C311/11 ,  C07C311/14 ,  C07C311/20 ,  C07C313/06 ,  C07C313/20 ,  C07C317/04 ,  C07C323/60 ,  C07C323/65 ,  C07D295/26 ,  C07C233/76

CPC分类号： C07D295/26 ,  C07C307/06 ,  C07C311/06 ,  C07C311/07 ,  C07C311/11 ,  C07C311/14 ,  C07C313/06 ,  C07C313/20 ,  C07C317/04 ,  C07C323/60 ,  C07C2101/08 ,  C07C2101/14

摘要： .alpha.-Amino acid amides of the formula I ##STR1## in which n is the number zero or one;R.sub.1 is C.sub.1 -C.sub.12 alkyl, which is unsubstituted or can be substituted by C.sub.1 -C.sub.4 alkoxy, C.sub.1 -C.sub.4 alkylthio, C.sub.1 -C.sub.4 alkylsulfonyl, C.sub.3 -C.sub.8 cycloalkyl, cyano, C.sub.1 -C.sub.6 alkoxycarbonyl, C.sub.3 -C.sub.6 alkenyloxycarbonyl or C.sub.3 -C.sub.6 alkynyloxycarbonyl; C.sub.3 -C.sub.8 cycloalkyl; C.sub.2 -C.sub.12 alkenyl; C.sub.2 -C.sub.12 alkynyl; C.sub.1 -C.sub.12 halogenoalkyl or a group NR.sub.13 R.sub.14 ; in whichR.sub.13 and R.sub.14 independently of one another are hydrogen or C.sub.1 -C.sub.6 alkyl or together are tetra- or pentamethylene;R.sub.2 and R.sub.3 independently of one another are hydrogen; C.sub.1 -C.sub.8 alkyl; C.sub.1 -C.sub.8 alkyl which is substituted by hydroxyl, C.sub.1 -C.sub.4 alkoxy, mercapto or C.sub.1 -C.sub.4 alkylthio; C.sub.3 -C.sub.8 alkenyl; C.sub.3 -C.sub.8 alkynyl; C.sub.3 -C.sub.8 cycloalkyl or C.sub.3 -C.sub.8 cycloalkyl-C.sub.1 -C.sub.4 alkyl, or in which the two groups R.sub.2 and R.sub.3, together with the carbon atom to which they are bonded, form a three- to eight-membered carbocyclic ring;R.sub.4 is hydrogen or C.sub.1 -C.sub.6 alkyl;R.sub.5 is hydrogen; C.sub.1 -C.sub.6 alkyl or phenyl, which is unsubstituted or can be substituted by halogen, nitro, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 halogenoalkyl, C.sub.1 -C.sub.4 alkoxy or C.sub.1 -C.sub.4 alkylthio; andR.sub.6 is a group G ##STR2## in which R.sub.7 and R.sub.8 independently of one another are hydrogen or C.sub.1 -C.sub.6 alkyl;p is the number zero or one; andR.sub.9, R.sub.10 and R.sub.11 independently of one another are hydrogen, C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.6 halogenoalkyl, C.sub.3 -C.sub.6 alkenyl, C.sub.3 -C.sub.6 alkynyl, C.sub.1 -C.sub.6 alkoxy, C.sub.3 -C.sub.6 alkenyloxy, C.sub.3 -C.sub.6 alkynyloxy, C.sub.1 -C.sub.6 alkylthio, halogen or nitro are valuable microbicides. They can be employed in crop protection in the form of suitable compositions, for example for controlling fungal diseases.

摘要翻译： α型氨基酰胺，其中n是数字0或1; R 1是未被取代或可以被C 1 -C 4烷氧基，C 1 -C 4烷硫基，C 1 -C 4烷基磺酰基，C 3 -C 8环烷基，氰基，C 1 -C 6烷氧基羰基，C 3 -C 6烯氧基羰基或C 3 -C 6炔氧基羰基取代的C 1 -C 12烷基; C 3 -C 8环烷基; C 2 -C 12烯基; C 2 -C 12炔基; C 1 -C 12卤代烷基或NR 13 R 14基团; 其中R 13和R 14彼此独立地是氢或C 1 -C 6烷基或一起是四或五亚甲基; R2和R3彼此独立地是氢; C1-C8烷基; 被羟基，C 1 -C 4烷氧基，巯基或C 1 -C 4烷硫基取代的C 1 -C 8烷基; C3-C8链烯基; C3-C8炔基; C 3 -C 8环烷基或C 3 -C 8环烷基-C 1 -C 4烷基，或其中两个基团R 2和R 3与它们所键合的碳原子一起形成三至八元碳环; R4是氢或C1-C6烷基; R5是氢; 硝基，C 1 -C 4烷基，C 1 -C 4卤代烷基，C 1 -C 4烷氧基或C 1 -C 4烷硫基取代的C 1 -C 6烷基或苯基; 并且R 6是基团G G，其中R 7和R 8彼此独立地是氢或C 1 -C 6烷基; p是数字0或1; 并且R 9，R 10和R 11彼此独立地是氢，C 1 -C 6烷基，C 1 -C 6卤代烷基，C 3 -C 6烯基，C 3 -C 6炔基，C 1 -C 6烷氧基，C 3 -C 6烯氧基，C 3 -C 6炔氧基，C 1 -C 6烷硫基，卤素或硝基是有价值的 杀菌剂 它们可以以合适的组合物的形式用于作物保护，例如用于防治真菌疾病。

公开(公告)号：US20120065239A1

公开(公告)日：2012-03-15

申请号：US13198739

申请日：2011-08-05

申请人： Hans Tobler ,  Harald Walter ,  Josef Ehrenfreund ,  Camilla Corsi ,  Fanny Giordano ,  Martin Zeller ,  Gottfried Seifert ,  Shailesh Shah ,  Neil George ,  Ian Kevin Jones ,  Paul Edward Bonnett

发明人： Hans Tobler ,  Harald Walter ,  Josef Ehrenfreund ,  Camilla Corsi ,  Fanny Giordano ,  Martin Zeller ,  Gottfried Seifert ,  Shailesh Shah ,  Neil George ,  Ian Kevin Jones ,  Paul Edward Bonnett

IPC分类号： A01N43/56 ,  A01P3/00 ,  C07D231/14

CPC分类号： C07C211/61 ,  A01N43/56 ,  C07C205/06 ,  C07C209/325 ,  C07C209/70 ,  C07C2603/66 ,  C07D231/14

摘要： The present invention relates to a process for the preparation of compounds of formula I wherein R1 and R2 are each independently of the other hydrogen or C1-C5alkyl and R3 is CF3 or CF2H, by a) reaction of a compound of formula II wherein R1 and R2 are as defined for formula I, with at least one reducing agent to form a compound of formula wherein R1 and R2 are as defined for formula I, and b) reaction of that compound with at least one reducing agent to form a compound of formula IV wherein R1 and R2 are as defined for formula I, and (c) reaction of that compound with a compound of formula V wherein Q is chlorine, fluorine, bromine, iodine, hydroxy or C1-C6alkoxy and R3 is as defined for formula I, to form the compound of formula I; and to novel intermediates for use in that process.

摘要翻译： 本发明涉及一种制备式Ⅰ化合物的方法，其中R1和R2分别独立地为氢或C1-C5烷基，R3为CF3或CF2H，通过a）式II化合物的反应其中R 1和 R 2如式I所定义，与至少一种还原剂形成下式化合物，其中R 1和R 2如式I所定义，和b）该化合物与至少一种还原剂的反应形成式 IV其中R1和R2如式I所定义，和（c）该化合物与式V化合物的反应，其中Q是氯，氟，溴，碘，羟基或C 1 -C 6烷氧基，R 3如式I所定义 ，形成式I化合物; 以及用于该过程的新型中间体。

公开(公告)号：US20100145100A1

公开(公告)日：2010-06-10

申请号：US12443082

申请日：2007-09-26

申请人： Harald Walter ,  Hans Tobler ,  Fanny Giordano ,  Martin Zeller

发明人： Harald Walter ,  Hans Tobler ,  Fanny Giordano ,  Martin Zeller

IPC分类号： C07C209/36

CPC分类号： C07C209/36 ,  C07C2603/66 ,  C07C211/61

摘要： The present invention relates to a process for the preparation of syn-enriched 5-amino-9-isopropyl-benzonorbomene in which the ratio of compounds of formula (Ia(syn)) to compounds of formula (Ib(anti)) is from 70:30 to 99:1, which process comprises reacting a compound of formula (Il) in a pressure vessel with hydrogen in the presence of a palladium catalyst and a solvent, at a pressure of at least 2 bar and a temperature of from 00 C to 45° C., to form syn-enriched 5-amino-9-isopropyl-benzonorbomene.

摘要翻译： 本发明涉及制备合成富集的5-氨基-9-异丙基 - 苯并异戊烯的方法，其中式（Ia（顺式））化合物与式（Ib（反））化合物的比例为70 ：30至99:1，该方法包括在钯催化剂和溶剂存在下，将压力容器中的式（II）化合物与氢气在至少2巴的压力和0℃的温度下反应 至45℃，以形成合成富集的5-氨基-9-异丙基 - 苯并异戊烯。

公开(公告)号：US07521579B2

公开(公告)日：2009-04-21

申请号：US10495257

申请日：2002-11-15

申请人： Martin Zeller ,  Dominik Faber ,  Thomas Vettiger ,  Clemens Lamberth

发明人： Martin Zeller ,  Dominik Faber ,  Thomas Vettiger ,  Clemens Lamberth

IPC分类号： C07C233/05 ,  C07C231/02

CPC分类号： C07C233/22

摘要： The invention concerns a novel process for the preparation of 2-phenyl-2-hydroxy-N-[2-(3-alkoxy-4-hydroxyphenyl)-ethyl]-acetamides of the formula (I), wherein R1 is alkyl, R2 and R3 are each independently hydrogen or alkyl, and R4 is optionally substituted aryl or optionally substituted heteroaryl, which process comprises reacting a 2-(3-alkoxy-4-hydroxyphenyl)-ethylamine of the formula (II), wherein R1 R2 and R3 are as defined above with a α-hydoxycarboxylic acid ester of the formula (III) or a dioxolanone of the formula (III)a, wherein R4 is as defined above, and R5, R6 and R7 independently of each other are lower alkyl. The compounds of formula (I) are important intermediates for a novel group of fungicides derived from mandelic acid amides.

摘要翻译： 本发明涉及制备式（I）的2-苯基-2-羟基-N- [2-（3-烷氧基-4-羟基苯基） - 乙基] - 乙酰胺的新方法，其中R1是烷基，R2 和R 3各自独立地为氢或烷基，R 4为任选取代的芳基或任选取代的杂芳基，该方法包括使式（II）的2-（3-烷氧基-4-羟基苯基） - 乙胺反应，其中R1R2和R3 （III）的α-羟基羧酸酯或式（III）a的二氧戊环酮，其中R 4如上所定义，R 5，R 6和R 7彼此独立地为低级烷基。 式（I）化合物是衍生自扁桃酸酰胺的新型杀真菌剂组的重要中间体。