公开(公告)号：US20100280352A1

公开(公告)日：2010-11-04

申请号：US12770850

申请日：2010-04-30

申请人： Razvan Ioan Ionasec ,  Puneet Sharma ,  Bogdan Georgescu ,  Andrey Torzhkov ,  Fabian Moerchen ,  Gayle M. Wittenberg ,  Dmitriy Fradkin ,  Dorin Comaniciu

发明人： Razvan Ioan Ionasec ,  Puneet Sharma ,  Bogdan Georgescu ,  Andrey Torzhkov ,  Fabian Moerchen ,  Gayle M. Wittenberg ,  Dmitriy Fradkin ,  Dorin Comaniciu

IPC分类号： A61B5/05 ,  A61B5/00 ,  G06F17/50 ,  G06G7/60 ,  G06N5/02

CPC分类号： A61B5/0263 ,  G01R33/56 ,  G01R33/5608 ,  G06F19/00 ,  G06F19/321 ,  G06T17/00 ,  G16H50/20 ,  G16H50/50

摘要： A method and system for generating a patient specific anatomical heart model is disclosed. Volumetric image data, such as computed tomography (CT), echocardiography, or magnetic resonance (MR) image data of a patient's cardiac region is received. Individual models for multiple heart components, such as the left ventricle (LV) endocardium, LV epicardium, right ventricle (RV), left atrium (LA), right atrium (RA), mitral valve, aortic valve, aorta, and pulmonary trunk, are estimated in said volumetric cardiac image data. A multi-component patient specific anatomical heart model is generated by integrating the individual models for each of the heart components. Fluid Structure Interaction (FSI) simulations are performed on the patient specific anatomical model, and patient specific clinical parameters are extracted based on the patient specific heart model and the FSI simulations. Disease progression modeling and risk stratification are performed based on the patient specific clinical parameters.

摘要翻译： 公开了一种用于产生患者特异性解剖心脏模型的方法和系统。 接收患者心脏区域的体积图像数据，例如计算机断层摄影（CT），超声心动图或磁共振（MR）图像数据。 用于多个心脏组件的单独模型，例如左心室（LV）心内膜，LV心外膜，右心室（RV），左心房（LA），右心房（RA），二尖瓣，主动脉瓣，主动脉和肺动脉干， 在所述体积心脏图像数据中估计。 通过对每个心脏组件的各个模型进行整合，产生多组分患者特异性解剖心脏模型。 对患者特异性解剖模型进行流体结构相互作用（FSI）模拟，并根据患者特异性心脏模型和FSI模拟提取患者特异性临床参数。 疾病进展模型和风险分层是根据患者的具体临床参数进行的。

公开(公告)号：US20110060576A1

公开(公告)日：2011-03-10

申请号：US12825905

申请日：2010-06-29

申请人： Puneet Sharma ,  Bogdan Georgescu ,  Razvan Ioan Ionasec ,  Dorin Comaniciu

发明人： Puneet Sharma ,  Bogdan Georgescu ,  Razvan Ioan Ionasec ,  Dorin Comaniciu

IPC分类号： G06G7/60

CPC分类号： G06T17/00 ,  G06F19/00 ,  G06T7/0012 ,  G06T2207/10072 ,  G06T2207/30048 ,  G16H50/20 ,  G16H50/50

摘要： A method and system for generating a patient specific anatomical heart model is disclosed. A sequence of volumetric image data, such as computed tomography (CT), echocardiography, or magnetic resonance (MR) image data of a patient's cardiac region is received. A multi-component patient specific 4D geometric model of the heart and aorta estimated from the sequence of volumetric cardiac imaging data. A patient specific 4D computational model based on one or more of personalized geometry, material properties, fluid boundary conditions, and flow velocity measurements in the 4D geometric model is generated. Patient specific material properties of the aortic wall are estimated using the 4D geometrical model and the 4D computational model. Fluid Structure Interaction (FSI) simulations are performed using the 4D computational model and estimated material properties of the aortic wall, and patient specific clinical parameters are extracted based on the FSI simulations. Disease progression modeling and risk stratification are performed based on the patient specific clinical parameters.

摘要翻译： 公开了一种用于产生患者特异性解剖心脏模型的方法和系统。 接收患者心脏区域的体积图像数据的序列，例如计算机断层摄影（CT），超声心动图或磁共振（MR）图像数据。 根据体积心脏成像数据序列估计的心脏和主动脉的多组分患者特定4D几何模型。 产生了基于4D几何模型中的个性化几何，材料特性，流体边界条件和流速测量中的一个或多个的患者特定4D计算模型。 使用4D几何模型和4D计算模型估计主动脉壁的患者特异性材料性质。 使用4D计算模型和主动脉壁的估计材料特性进行流体结构相互作用（FSI）模拟，并且基于FSI模拟提取患者特异性临床参数。 疾病进展模型和风险分层是根据患者的具体临床参数进行的。

公开(公告)号：US08527251B2

公开(公告)日：2013-09-03

申请号：US12770850

申请日：2010-04-30

申请人： Razvan Ioan Ionasec ,  Puneet Sharma ,  Bogdan Georgescu ,  Andrey Torzhkov ,  Fabian Moerchen ,  Gayle M. Wittenberg ,  Dmitriy Fradkin ,  Dorin Comaniciu

发明人： Razvan Ioan Ionasec ,  Puneet Sharma ,  Bogdan Georgescu ,  Andrey Torzhkov ,  Fabian Moerchen ,  Gayle M. Wittenberg ,  Dmitriy Fradkin ,  Dorin Comaniciu

IPC分类号： G06G7/58

CPC分类号： A61B5/0263 ,  G01R33/56 ,  G01R33/5608 ,  G06F19/00 ,  G06F19/321 ,  G06T17/00 ,  G16H50/20 ,  G16H50/50

摘要： A method and system for generating a patient specific anatomical heart model is disclosed. Volumetric image data, such as computed tomography (CT), echocardiography, or magnetic resonance (MR) image data of a patient's cardiac region is received. Individual models for multiple heart components, such as the left ventricle (LV) endocardium, LV epicardium, right ventricle (RV), left atrium (LA), right atrium (RA), mitral valve, aortic valve, aorta, and pulmonary trunk, are estimated in said volumetric cardiac image data. A multi-component patient specific anatomical heart model is generated by integrating the individual models for each of the heart components. Fluid Structure Interaction (FSI) simulations are performed on the patient specific anatomical model, and patient specific clinical parameters are extracted based on the patient specific heart model and the FSI simulations. Disease progression modeling and risk stratification are performed based on the patient specific clinical parameters.

摘要翻译： 公开了一种用于生成患者特异性解剖心脏模型的方法和系统。 接收患者心脏区域的体积图像数据，例如计算机断层摄影（CT），超声心动图或磁共振（MR）图像数据。 用于多个心脏组件的单独模型，例如左心室（LV）心内膜，LV心外膜，右心室（RV），左心房（LA），右心房（RA），二尖瓣，主动脉瓣，主动脉和肺动脉干， 在所述体积心脏图像数据中估计。 通过对每个心脏组件的各个模型进行整合，产生多组分患者特异性解剖心脏模型。 对患者特异性解剖模型进行流体结构相互作用（FSI）模拟，并根据患者特异性心脏模型和FSI模拟提取患者特异性临床参数。 疾病进展模型和风险分层是根据患者的具体临床参数进行的。

公开(公告)号：US08224640B2

公开(公告)日：2012-07-17

申请号：US12825905

申请日：2010-06-29

申请人： Puneet Sharma ,  Bogdan Georgescu ,  Razvan Ioan Ionasec ,  Dorin Comaniciu

发明人： Puneet Sharma ,  Bogdan Georgescu ,  Razvan Ioan Ionasec ,  Dorin Comaniciu

IPC分类号： G06F19/00 ,  G06F17/10 ,  G06G7/58 ,  G06K9/00

CPC分类号： G06T17/00 ,  G06F19/00 ,  G06T7/0012 ,  G06T2207/10072 ,  G06T2207/30048 ,  G16H50/20 ,  G16H50/50

摘要： A method and system for generating a patient specific anatomical heart model is disclosed. A sequence of volumetric image data, such as computed tomography (CT), echocardiography, or magnetic resonance (MR) image data of a patient's cardiac region is received. A multi-component patient specific 4D geometric model of the heart and aorta estimated from the sequence of volumetric cardiac imaging data. A patient specific 4D computational model based on one or more of personalized geometry, material properties, fluid boundary conditions, and flow velocity measurements in the 4D geometric model is generated. Patient specific material properties of the aortic wall are estimated using the 4D geometrical model and the 4D computational model. Fluid Structure Interaction (FSI) simulations are performed using the 4D computational model and estimated material properties of the aortic wall, and patient specific clinical parameters are extracted based on the FSI simulations. Disease progression modeling and risk stratification are performed based on the patient specific clinical parameters.

摘要翻译： 公开了一种用于产生患者特异性解剖心脏模型的方法和系统。 接收患者心脏区域的体积图像数据的序列，例如计算机断层摄影（CT），超声心动图或磁共振（MR）图像数据。 根据体积心脏成像数据序列估计的心脏和主动脉的多组分患者特定4D几何模型。 产生了基于4D几何模型中的个性化几何，材料特性，流体边界条件和流速测量中的一个或多个的患者特定4D计算模型。 使用4D几何模型和4D计算模型估计主动脉壁的患者特异性材料性质。 使用4D计算模型和主动脉壁的估计材料特性进行流体结构相互作用（FSI）模拟，并且基于FSI模拟提取患者特异性临床参数。 疾病进展模型和风险分层是根据患者的具体临床参数进行的。

公开(公告)号：US09462952B2

公开(公告)日：2016-10-11

申请号：US14455500

申请日：2014-08-08

申请人： Dorin Comaniciu ,  Bogdan Georgescu ,  Ali Kamen ,  Tommaso Mansi ,  Viorel Mihalef

发明人： Dorin Comaniciu ,  Bogdan Georgescu ,  Ali Kamen ,  Tommaso Mansi ,  Viorel Mihalef

IPC分类号： A61B5/02 ,  A61B5/026 ,  A61B8/04 ,  A61B5/00 ,  A61B8/08 ,  A61B6/03 ,  A61B6/00 ,  A61B5/029 ,  A61B5/021 ,  A61B8/06 ,  G06T7/00 ,  A61B5/055

CPC分类号： A61B5/02007 ,  A61B5/0037 ,  A61B5/0044 ,  A61B5/02125 ,  A61B5/0263 ,  A61B5/029 ,  A61B5/055 ,  A61B6/503 ,  A61B6/5217 ,  A61B8/065 ,  G06T7/0016 ,  G06T7/11 ,  G06T2207/30101 ,  G06T2207/30104

摘要： A method and system for estimating arterial compliance and resistance based on medical image data and pressure measurements is disclosed. An arterial inflow estimate over a plurality of time points is determined based on medical image data of a patient. An arterial pressure measurement of the patient is received. At least one cardiac cycle of the arterial pressure measurement is synchronized with at least one cardiac cycle of the arterial inflow measurement. Arterial compliance and resistance of the patient is estimated based on the arterial inflow estimate and the synchronized arterial pressure measurement.

摘要翻译： 公开了一种基于医学图像数据和压力测量来估计动脉顺应性和阻力的方法和系统。 基于患者的医学图像数据确定多个时间点的动脉流入估计。 接受患者的动脉压测量。 动脉压测量的至少一个心动周期与动脉流入测量的至少一个心动周期同步。 基于动脉血流量估计和同步动脉压测量来估计患者的动脉顺应性和抵抗力。

公开(公告)号：US20150045644A1

公开(公告)日：2015-02-12

申请号：US14455500

申请日：2014-08-08

申请人： Dorin Comaniciu ,  Bogdan Georgescu ,  Ali Kamen ,  Tommaso Mansi ,  Viorel Mihalef

发明人： Dorin Comaniciu ,  Bogdan Georgescu ,  Ali Kamen ,  Tommaso Mansi ,  Viorel Mihalef

IPC分类号： A61B5/02 ,  A61B5/026 ,  A61B8/04 ,  A61B5/00 ,  A61B8/08 ,  A61B6/03 ,  A61B6/00 ,  A61B5/029 ,  A61B5/021 ,  A61B8/06

CPC分类号： A61B5/02007 ,  A61B5/0037 ,  A61B5/0044 ,  A61B5/02125 ,  A61B5/0263 ,  A61B5/029 ,  A61B5/055 ,  A61B6/503 ,  A61B6/5217 ,  A61B8/065 ,  G06T7/0016 ,  G06T7/11 ,  G06T2207/30101 ,  G06T2207/30104

摘要： A method and system for estimating arterial compliance and resistance based on medical image data and pressure measurements is disclosed. An arterial inflow estimate over a plurality of time points is determined based on medical image data of a patient. An arterial pressure measurement of the patient is received. At least one cardiac cycle of the arterial pressure measurement is synchronized with at least one cardiac cycle of the arterial inflow measurement. Arterial compliance and resistance of the patient is estimated based on the arterial inflow estimate and the synchronized arterial pressure measurement.

摘要翻译： 公开了一种基于医学图像数据和压力测量来估计动脉顺应性和阻力的方法和系统。 基于患者的医学图像数据确定多个时间点的动脉流入估计。 接受患者的动脉压测量。 动脉压测量的至少一个心动周期与动脉流入测量的至少一个心动周期同步。 基于动脉血流量估计和同步动脉压测量来估计患者的动脉顺应性和抵抗力。

公开(公告)号：US09846765B2

公开(公告)日：2017-12-19

申请号：US14071688

申请日：2013-11-05

申请人： Chloe Audigier ,  Tommaso Mansi ,  Viorel Mihalef ,  Ali Kamen ,  Dorin Comaniciu ,  Puneet Sharma ,  Saikiran Rapaka ,  Herve Delingette ,  Nicholas Ayache

发明人： Chloe Audigier ,  Tommaso Mansi ,  Viorel Mihalef ,  Ali Kamen ,  Dorin Comaniciu ,  Puneet Sharma ,  Saikiran Rapaka ,  Herve Delingette ,  Nicholas Ayache

IPC分类号： G06F19/00 ,  G06F19/10 ,  G09B23/30

CPC分类号： G16H50/50 ,  G06F19/00 ,  G06F19/3481 ,  G09B23/30

摘要： A method and system for tumor ablation planning and guidance based on a patient-specific model of liver tumor ablation is disclosed. A patient-specific anatomical model of the liver and circulatory system of the liver is estimated from 3D medical image data of a patient. Blood flow in the liver and the circulatory system of the liver is simulated based on the patient-specific anatomical model. Heat diffusion due to ablation is simulated based on a virtual ablation probe position and the simulated blood flow in the liver and the venous system of the liver. Cellular necrosis in the liver is simulated based on the simulated heat diffusion. A visualization of a simulated necrosis region is generated and displayed to the user for decision making and optimal therapy planning and guidance.

公开(公告)号：US20140296842A1

公开(公告)日：2014-10-02

申请号：US13854991

申请日：2013-04-02

申请人： Tommaso Mansi ,  Puneet Sharma ,  Viorel Mihalef ,  Ali Kamen ,  Saikiran Rapaka ,  Dorin Comaniciu

发明人： Tommaso Mansi ,  Puneet Sharma ,  Viorel Mihalef ,  Ali Kamen ,  Saikiran Rapaka ,  Dorin Comaniciu

IPC分类号： A61B19/00 ,  G06F17/50 ,  A61B18/12

CPC分类号： A61B19/50 ,  A61B18/1233 ,  A61B34/10 ,  A61B2018/00577 ,  A61B2034/104 ,  A61B2034/105

摘要： Patient specific temperature distribution in organs, due to an ablative device, is simulated. The effects of ablation are modeled. The modeling is patient specific. The vessel structure for a given patient, segmented from medical images, is accounted for as a heat sink in the model of biological heat transfer. A temperature map is generated to show the effects of ablation in a pre-operative analysis. Temperature maps resulting from different ablation currents and ablation device positions may be used to determine a more optimal location of the ablative device for a given patient. Other models may be included, such as accounting for the tissue damage during the ablation.

摘要翻译： 模拟了器官中由于消融装置而导致的患者特异性温度分布。 模拟消融的效果。 建模是患者特异性的。 从医学图像分割的给定患者的血管结构在生物传热模型中被认为是散热器。 生成温度图以显示术前分析中消融的效果。 可以使用由不同烧蚀电流和消融装置位置产生的温度图来确定给定患者的烧蚀装置的更优选的位置。 可能包括其他模型，例如消融期间的组织损伤。

公开(公告)号：US20140136174A1

公开(公告)日：2014-05-15

申请号：US14071688

申请日：2013-11-05

申请人： Chloe Audigier ,  Tommaso Mansi ,  Viorel Mihalef ,  Ali Kamen ,  Dorin Comaniciu ,  Puneet Sharma ,  Saikiran Rapaka ,  Herve Delingette ,  Nicholas Ayache

发明人： Chloe Audigier ,  Tommaso Mansi ,  Viorel Mihalef ,  Ali Kamen ,  Dorin Comaniciu ,  Puneet Sharma ,  Saikiran Rapaka ,  Herve Delingette ,  Nicholas Ayache

IPC分类号： G06F19/12

CPC分类号： G16H50/50 ,  G06F19/00 ,  G06F19/3481 ,  G09B23/30

摘要： A method and system for tumor ablation planning and guidance based on a patient-specific model of liver tumor ablation is disclosed. A patient-specific anatomical model of the liver and circulatory system of the liver is estimated from 3D medical image data of a patient. Blood flow in the liver and the circulatory system of the liver is simulated based on the patient-specific anatomical model. Heat diffusion due to ablation is simulated based on a virtual ablation probe position and the simulated blood flow in the liver and the venous system of the liver. Cellular necrosis in the liver is simulated based on the simulated heat diffusion. A visualization of a simulated necrosis region is generated and displayed to the user for decision making and optimal therapy planning and guidance.

摘要翻译： 公开了一种基于肝肿瘤消融的患者特异性模型的肿瘤消融计划和指导的方法和系统。 根据患者的3D医学图像数据估计肝脏和肝脏循环系统的患者特异性解剖模型。 根据患者特异性解剖模型模拟肝脏和肝脏循环系统的血流。 基于虚拟消融探针位置和肝脏和肝脏静脉系统中的模拟血流模拟了消融引起的热扩散。 基于模拟热扩散模拟肝脏细胞坏死。 生成模拟坏死区域的可视化，并向用户显示决策和最佳治疗计划和指导。

公开(公告)号：US09259287B2

公开(公告)日：2016-02-16

申请号：US13854991

申请日：2013-04-02

申请人： Tommaso Mansi ,  Puneet Sharma ,  Viorel Mihalef ,  Ali Kamen ,  Saikiran Rapaka ,  Dorin Comaniciu

发明人： Tommaso Mansi ,  Puneet Sharma ,  Viorel Mihalef ,  Ali Kamen ,  Saikiran Rapaka ,  Dorin Comaniciu

IPC分类号： A61B18/12 ,  A61B19/00 ,  A61B18/00

CPC分类号： A61B19/50 ,  A61B18/1233 ,  A61B34/10 ,  A61B2018/00577 ,  A61B2034/104 ,  A61B2034/105

摘要： Patient specific temperature distribution in organs, due to an ablative device, is simulated. The effects of ablation are modeled. The modeling is patient specific. The vessel structure for a given patient, segmented from medical images, is accounted for as a heat sink in the model of biological heat transfer. A temperature map is generated to show the effects of ablation in a pre-operative analysis. Temperature maps resulting from different ablation currents and ablation device positions may be used to determine a more optimal location of the ablative device for a given patient. Other models may be included, such as accounting for the tissue damage during the ablation.

摘要翻译： 模拟了器官中由于消融装置而导致的患者特异性温度分布。 模拟消融的效果。 建模是患者特异性的。 从医学图像分割的给定患者的血管结构在生物传热模型中被认为是散热器。 生成温度图以显示术前分析中消融的效果。 可以使用由不同烧蚀电流和消融装置位置产生的温度图来确定给定患者的烧蚀装置的更优选的位置。 可能包括其他模型，例如消融期间的组织损伤。