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公开(公告)号：US06842648B2
公开(公告)日：2005-01-11
申请号：US10054600
申请日：2002-01-22
IPC分类号： A61N1/05
CPC分类号： A61N1/057 , A61N1/0573 , A61N2001/0585
摘要： A lead having a distal end electrode assembly adapted for implantation on or about the heart or within a vein and for connection to a system for monitoring or stimulating cardiac activity. The electrode assembly includes conductive fixation features, such as conductive tines or flexible members, in combination with non-conductive fixation features. The conductive fixation features also include tines coated with a conductive material. The fixation features further include conductive tines which are retractable. A defibrillation coil is optionally disposed at the distal end of the lead in combination with the conductive tines.
摘要翻译： 一种具有远端电极组件的引线，其适于植入在心脏上或周围的静脉内并且用于连接到用于监测或刺激心脏活动的系统。 电极组件包括与非导电固定特征组合的导电固定特征，例如导电尖齿或柔性构件。 导电固定特征还包括涂覆有导电材料的尖齿。 固定特征还包括可伸缩的导电尖齿。 除颤线圈可选地配置在导电尖端的前端，与导电齿结合。
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公开(公告)号：US06477428B1
公开(公告)日：2002-11-05
申请号：US09514811
申请日：2000-02-28
IPC分类号： A61N105
CPC分类号： A61N1/056
摘要： A lead has a flexible lead body which extends from a proximal end to a distal end. The lead body has a conductor coupled with an electrode. At least a portion of the flexible lead body includes a polymer of vinylidene fluoride, or a polymer of vinylidene fluoride and silicone rubber. The polymer of vinylidene fluoride includes, but is not limited to, a homopolymer, a copolymer, or a terpolymer.
摘要翻译： 导线具有从近端延伸到远端的柔性引线体。 引线体具有与电极耦合的导体。 柔性引线体的至少一部分包括偏二氟乙烯的聚合物，或偏二氟乙烯和硅橡胶的聚合物。 偏二氟乙烯的聚合物包括但不限于均聚物，共聚物或三元共聚物。
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33.发明授权Bulk reaction extrusion polymerization process producing aliphatic ester polymer compositions 失效制备脂肪族酯聚合物组合物的本体反应挤出聚合方法
公开(公告)号：US5906783A
公开(公告)日：1999-05-25
申请号：US925528
申请日：1997-09-08
申请人： Ramani Narayan , Mohan Krishnan , Joseph B. Snook , Ajay Gupta , Philippe DuBois
发明人： Ramani Narayan , Mohan Krishnan , Joseph B. Snook , Ajay Gupta , Philippe DuBois
IPC分类号： C08J3/20 , C08G63/08 , C08G63/12 , C08G63/78 , C08G63/82 , C08J5/18 , C08L3/00 , C08L67/00 , C08L67/04 , B29C49/00 , B29C43/22 , B29C55/30
CPC分类号： C08G63/823 , C08G63/08 , C08L67/04
摘要： A bulk extrusion polymerization process to derive an aliphatic polyester from a suitable ester monomer, preferably .epsilon.-caprolactone. Novel reaction formulations containing less than 100 ppm water and having an acid value less than 0.5 mg KOH/g and preferably less than 0.2 mg KOH/g enable the polymerization of bulk monomer in an extruder in a resident time of less than 2 minutes. Different catalyst and initiator systems, processing protocols, and screw configurations lead to the preferred manufacture of poly(.epsilon.-caprolactone) polymer of number average molecular weight, M.sub.n, greater than 100,000. A novel poly(.epsilon.-caprolactone) intermediate optionally grafted to starch, is described which has significantly different processing and use characteristics as compared to a straight-chain polycaprolactone.
摘要翻译： 从合适的酯单体（优选ε-己内酯）衍生脂肪族聚酯的本体挤出聚合方法。 含有小于100ppm水并具有小于0.5mg KOH / g，优选小于0.2mg KOH / g的酸值的新型反应制剂使得在挤出机中以小于2分钟的停留时间聚合本体单体。 不同的催化剂和引发剂体系，加工方案和螺杆构型导致数均分子量Mn大于100,000的聚（ε-己内酯）聚合物的优选制造。 描述了任选接枝到淀粉上的新型聚（ε-己内酯）中间体，其与直链聚己内酯相比具有显着不同的加工和使用特性。
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34.发明授权公开(公告)号：US09205271B2
公开(公告)日：2015-12-08
申请号：US12563733
申请日：2009-09-21
CPC分类号： A61N1/375 , A61N1/05 , C08L53/00 , C08L75/08 , C08L2666/04 , C08L2666/02
摘要： In accordance with various aspects of the invention, copolymers comprising styrene and isobutylene monomers are used in the construction of implantable and insertable medical devices for electrical stimulation, including, for example, electronic signal generating components and electrical leads for such devices.
摘要翻译： 根据本发明的各个方面，包含苯乙烯和异丁烯单体的共聚物用于构建用于电刺激的可植入和可插入的医疗装置，包括例如电子信号产生组件和用于这种装置的电引线。
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35.发明授权Polyisobutylene urethane, urea and urethane/urea copolymers and medical devices containing the same 有权聚异丁烯聚氨酯，尿素和氨基甲酸酯/尿素共聚物以及含有它们的医疗装置公开(公告)号：US08501831B2
公开(公告)日：2013-08-06
申请号：US13618148
申请日：2012-09-14
申请人： Shrojalkumar Desai , Marlene C. Schwarz , Mark Boden , Mohan Krishnan , Michael C. Smith , Frederick H. Strickler , Daniel J. Cooke
发明人： Shrojalkumar Desai , Marlene C. Schwarz , Mark Boden , Mohan Krishnan , Michael C. Smith , Frederick H. Strickler , Daniel J. Cooke
IPC分类号： A61N1/05
CPC分类号： C08G18/6204 , A61L27/18 , A61L31/06 , C08G18/10 , C08G18/12 , C08G18/4063 , C08G18/4854 , C08G18/4858 , C08G18/6511 , C08G18/7657 , C08L75/00 , C08G18/3206
摘要： The present invention pertains to polyisobutylene urethane, urea and urethane/urea copolymers, to methods of making such copolymers and to medical devices that contain such polymers. According to certain aspects of the invention, polyisobutylene urethane, urea and urethane/urea copolymers are provided, which comprise a polyisobutylene segment, an additional polymeric segment that is not a polyisobutylene segment, and a segment comprising a residue of a diisocyanate. According to other aspects of the invention, polyisobutylene urethane, urea and urethane/urea copolymers are provided, which comprise a polyisobutylene segment and end groups that comprise alkyl-, alkenyl- or alkynyl-chain-containing end groups.
摘要翻译： 本发明涉及聚异丁烯氨基甲酸酯，脲和氨基甲酸酯/尿素共聚物，涉及制备这种共聚物的方法和含有这种聚合物的医疗装置。 根据本发明的某些方面，提供聚异丁烯氨基甲酸酯，脲和氨基甲酸酯/脲共聚物，其包含聚异丁烯链段，不是聚异丁烯链段的另外的聚合链段和包含二异氰酸酯残基的链段。 根据本发明的其它方面，提供聚异丁烯氨基甲酸酯，脲和氨基甲酸酯/脲共聚物，其包含聚异丁烯链段和包含含有烷基，链烯基或炔基链的端基的端基。
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36.发明申请公开(公告)号：US20130013040A1
公开(公告)日：2013-01-10
申请号：US13618148
申请日：2012-09-14
申请人： Shrojalkumar Desai , Marlene C. Schwarz , Mark Boden , Mohan Krishnan , Michael C. Smith , Frederick H. Strickler , Daniel J. Cooke
发明人： Shrojalkumar Desai , Marlene C. Schwarz , Mark Boden , Mohan Krishnan , Michael C. Smith , Frederick H. Strickler , Daniel J. Cooke
CPC分类号： C08G18/6204 , A61L27/18 , A61L31/06 , C08G18/10 , C08G18/12 , C08G18/4063 , C08G18/4854 , C08G18/4858 , C08G18/6511 , C08G18/7657 , C08L75/00 , C08G18/3206
摘要： The present invention pertains to polyisobutylene urethane, urea and urethane/urea copolymers, to methods of making such copolymers and to medical devices that contain such polymers. According to certain aspects of the invention, polyisobutylene urethane, urea and urethane/urea copolymers are provided, which comprise a polyisobutylene segment, an additional polymeric segment that is not a polyisobutylene segment, and a segment comprising a residue of a diisocyanate. According to other aspects of the invention, polyisobutylene urethane, urea and urethane/urea copolymers are provided, which comprise a polyisobutylene segment and end groups that comprise alkyl-, alkenyl- or alkynyl-chain-containing end groups.
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公开(公告)号：US20120232607A1
公开(公告)日：2012-09-13
申请号：US13479979
申请日：2012-05-24
IPC分类号： A61N1/365
CPC分类号： A61N1/3627 , A61B5/0031 , A61B5/02028 , A61B5/0215 , A61B5/029 , A61B5/0422 , A61B5/0535 , A61B5/0538 , A61B5/1102 , A61B5/7267 , A61B7/00 , A61N1/3684 , A61N1/3704
摘要： Systolic timing intervals are measured in response to delivering pacing energy to a pacing site of a patient's heart. An estimate of a patient's acute response to cardiac resynchronization therapy (CRT) for the pacing site is determined using the measured systolic timing intervals. The estimate is compared to a threshold. The threshold preferably distinguishes between acute responsiveness and non-responsiveness to CRT for a patient population. An indication of acute responsiveness to CRT for the pacing site may be produced in response to the comparison.
摘要翻译： 响应于将起搏能量递送到患者心脏的起搏部位来测量收缩时间间隔。 使用测量的收缩时间间隔来确定对于起搏部位的患者对心脏再同步治疗（CRT）的急性反应的估计。 将估计值与阈值进行比较。 该阈值优选地区分对于患者群体的急性反应性和对CRT的无反应性。 响应于比较可以产生针对起搏部位对CRT的急性反应性的指示。
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公开(公告)号：US08055355B2
公开(公告)日：2011-11-08
申请号：US11031971
申请日：2005-01-07
IPC分类号： A61N1/05
CPC分类号： A61N1/057 , A61N1/0573 , A61N2001/0585
摘要： A lead having a distal end electrode assembly adapted for implantation on or about the heart or within a vein and for connection to a system for monitoring or stimulating cardiac activity. The electrode assembly includes conductive fixation features, such as conductive tines or flexible members, in combination with non-conductive fixation features. The conductive fixation features also include tines coated with a conductive material. The fixation features further include conductive tines which are retractable. A defibrillation coil is optionally disposed at the distal end of the lead in combination with the conductive tines.
摘要翻译： 一种具有远端电极组件的引线，其适于植入在心脏上或周围的静脉内并且用于连接到用于监测或刺激心脏活动的系统。 电极组件包括与非导电固定特征组合的导电固定特征，例如导电尖齿或柔性构件。 导电固定特征还包括涂覆有导电材料的尖齿。 固定特征还包括可伸缩的导电尖齿。 除颤线圈可选地配置在导电尖端的前端，与导电齿结合。
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公开(公告)号：US07979142B2
公开(公告)日：2011-07-12
申请号：US12794186
申请日：2010-06-04
申请人： Mohan Krishnan
发明人： Mohan Krishnan
IPC分类号： A61N1/00
CPC分类号： A61N1/0563
摘要： An implantable lead includes a distal portion carrying a tissue stimulating electrode, at least a portion of its outer surface being adapted to stimulate cardiac tissue, wherein the electrode is covered by a pliable, electrically conductive sheath. The sheath is made of an electrically conductive material that does not rely on porosity for electrical charge transfer. The sheath is constructed and arranged to minimize or eliminate tissue ingrowth while passing sufficient electrical energy to stimulate the tissue.
摘要翻译： 可植入引线包括携带组织刺激电极的远端部分，其外表面的至少一部分适于刺激心脏组织，其中电极被柔韧的导电护套覆盖。 护套由导电材料制成，不依赖孔隙度进行电荷转移。 鞘被构造和布置成最小化或消除组织向内生长，同时通过足够的电能来刺激组织。
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公开(公告)号：US07904174B2
公开(公告)日：2011-03-08
申请号：US10698843
申请日：2003-10-31
IPC分类号： A61N1/05
CPC分类号： A61N1/056 , A61N1/08 , A61N2001/083
摘要： An implantable lead assembly includes a lead body extending from a proximal end to a distal end having an intermediate portion therebetween, where the lead body includes an insulating layer. A conductor is disposed within the insulating layer and the insulating layer surrounds the conductor. An electrode is coupled to the lead body, and the electrode is in electrical communication with the conductor. At least one conductive sleeve is disposed within the insulating layer. The at least one conductive sleeve surrounds the conductor and is electrically isolated from the electrode. The at least one conductive sleeve has a first impedance value in a first condition.
摘要翻译： 可植入引线组件包括引线本体，该引线体从近端延伸至具有中间部分的远端，其中引线主体包括绝缘层。 导体设置在绝缘层内，绝缘层包围导体。 电极耦合到引线体，并且电极与导体电连通。 至少一个导电套管设置在绝缘层内。 所述至少一个导电套管围绕所述导体并且与所述电极电隔离。 所述至少一个导电套筒在第一状态下具有第一阻抗值。
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