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31.发明申请Device, method and computer programmme product for carrying out integrity tests on filter elements 有权用于对过滤元件进行完整性测试的设备，方法和计算机程序产品公开(公告)号：US20050027484A1
公开(公告)日：2005-02-03
申请号：US10492263
申请日：2002-10-14
CPC分类号： G01N15/0826 , B01D46/0086 , B01D2201/56 , B01D2273/18
摘要： The invention relates to a device for carrying out integrity tests on filter elements by means of test gases, comprising a device housing (3), with an electronic controller (4), arranged therein for regulation and control of the progress of a test programme for filter elements, a filter housing (6), for housing a filter element (2) under test, a pneumatic unit (5), connected to the controller (4) and the filter housing (6), in particular for the generation and measurement of gas pressures, an electronic memory unit (10), which may be connected to the filter element (2) under test and a communication unit (13′), connected to the controller (4), for the exchange of data between the controller (4) and the electronic memory element (10). The communication unit (13′) is preferably embodied as an antenna (14′) and the electronic memory element (10) as a transponder (11). In addition to the device a method for carrying out integrity tests and a computer programme product are also disclosed.
摘要翻译： 本发明涉及一种用于通过测试气体对过滤元件执行完整性测试的装置，包括设置有用于调节和控制测试程序进度的装置壳体（3），其中安装有电子控制器（4） 过滤器元件，用于容纳被测试的过滤元件（2）的过滤器壳体（6），连接到控制器（4）和过滤器壳体（6）的气动单元（5），特别是用于产生和测量 的气体压力的电子存储器单元（10），可连接到被测试的过滤元件（2）的电子存储器单元（10）和连接到控制器（4）的通信单元（13'），用于在控制器 （4）和电子存储元件（10）。 通信单元（13'）优选地被实施为天线（14'）和作为应答器（11）的电子存储元件（10）。 此外，还公开了用于执行完整性测试的方法和计算机程序产品。
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32.发明授权Apparatus for removing samples from systems having flexible walls and for introducing fluids into the same 有权用于从具有柔性壁的系统中去除样品并将流体引入其中的装置公开(公告)号：US08408078B2
公开(公告)日：2013-04-02
申请号：US11713978
申请日：2007-03-05
CPC分类号： G01N35/1079 , A61J1/12 , A61J1/20 , C12M33/00 , C12M37/04 , G01N2001/1056
摘要： The invention discloses an apparatus for removing samples or introducing fluids from/into system(s) having flexible walls. A sampler/fluid dispenser (3) is fixed on the outside with a connecting area (4) of its base (5) on a sample removal region/fluid dispensing region (6) of the flexible wall (2) and, in its interior, has a severing element (8). At least the severing element (8) can be pushed forward in the direction of the sample removal region/fluid dispensing region (6) in order to remove the samples and in order to introduce fluids, in such a way that the wall (2) can be perforated within the sample removal region/fluid dispensing region (6). The system (1) comprises containers, bags or tubes for filling, mixing, transporting, storage of media, such as biological liquids, sera, buffers, ultra-pure water and can be used as biological reactors or cell culture vessels in the pharmaceutical and biotechnical industry.
摘要翻译： 本发明公开了一种用于从具有柔性壁的系统中移出样品或将流体从/进入系统的装置。 取样器/流体分配器（3）在其外部固定有其基部（5）的连接区域（4）在柔性壁（2）的样品移除区域/流体分配区域（6）上，并且在其内部 ，具有切断要素（8）。 至少切断元件（8）可以沿样品移除区域/流体分配区域（6）的方向向前推动，以便去除样品并且以这样的方式引入流体，使得壁（2） 可以在样品去除区域/流体分配区域（6）内穿孔。 系统（1）包括用于填充，混合，运输，储存诸如生物液体，血清，缓冲液，超纯水的介质的容器，袋或管，并可用作药物和/或制剂中的生物反应器或细胞培养容器 生物工业。
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公开(公告)号：US20110148597A1
公开(公告)日：2011-06-23
申请号：US13059362
申请日：2009-11-05
申请人： Oscar-Werner Reif , Reinhard Baurnfalk , Dieter Schmidt , Christian Oldendorf , Swen Weitemeier
发明人： Oscar-Werner Reif , Reinhard Baurnfalk , Dieter Schmidt , Christian Oldendorf , Swen Weitemeier
IPC分类号： G06K7/01
CPC分类号： B01F13/1055 , B01F15/0445
摘要： A dosing system and a method for dosing a medium, having a dosing control unit (4), at least one exchangeable container (2) containing a medium to be dosed, and a dosing valve (3, 3′) that can be connected to the container (2), wherein at least one part of the dosing valve (3, 3′) that comes into contact with the medium is designed as an exchangeable system component (7, 10) and has a machine-readable code for identification purposes, wherein at least one container (2), as an exchangeable system component (2), has a machine-readable code for identification purposes, wherein the exchangeable parts (2, 7, 10, 19) that come into contact with the medium are designed as disposable parts, and wherein the dosing control unit (4) is connected with a communication unit (5) to read the codes, and wherein the communication unit (5) has a unique read connection (22) to each exchangeable system component (2, 7, 10, 19) or its code.
摘要翻译： 一种定量给料系统和一种用于计量介质的方法，所述计量系统和方法具有计量控制单元（4），包含待计量介质的至少一个可替换容器（2）和可连接到 所述容器（2），其中与所述介质接触的所述计量阀（3,3'）的至少一部分被设计为可更换系统部件（7,10），并且具有用于识别目的的机器可读代码 ，其中作为可交换系统组件（2）的至少一个容器（2）具有用于识别目的的机器可读代码，其中与介质接触的可更换部件（2,7,10,19）是 设计为一次性部件，并且其中所述计量控制单元（4）与通信单元（5）连接以读取代码，并且其中所述通信单元（5）具有到每个可更换系统组件的唯一读取连接（22） 2，7，10，19）或其代码。
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34.发明申请Apparatus for removing samples from systems having flexible walls and for introducing fluids into the same 有权用于从具有柔性壁的系统中去除样品并将流体引入其中的装置公开(公告)号：US20070227270A1
公开(公告)日：2007-10-04
申请号：US11713978
申请日：2007-03-05
IPC分类号： G01N1/14
CPC分类号： G01N35/1079 , A61J1/12 , A61J1/20 , C12M33/00 , C12M37/04 , G01N2001/1056
摘要： The invention discloses an apparatus for removing samples or introducing fluids from/into system(s) having flexible walls. A sampler/fluid dispenser (3) is fixed on the outside with a connecting area (4) of its base (5) on a sample removal region/fluid dispensing region (6) of the flexible wall (2) and, in its interior, has a severing element (8). At least the severing element (8) can be pushed forward in the direction of the sample removal region/fluid dispensing region (6) in order to remove the samples and in order to introduce fluids, in such a way that the wall (2) can be perforated within the sample removal region/fluid dispensing region (6). The system (1) comprises containers, bags or tubes for filling, mixing, transporting, storage of media, such as biological liquids, sera, buffers, ultra-pure water and can be used as biological reactors or cell culture vessels in the pharmaceutical and biotechnical industry.
摘要翻译： 本发明公开了一种用于从具有柔性壁的系统中去除样品或将流体从/进入系统的装置。 取样器/流体分配器（3）在其外部固定有其基部（5）的连接区域（4）在柔性壁（2）的样品移除区域/流体分配区域（6）上，并且在其内部 ，具有切断要素（8）。 至少切断元件（8）可以沿着样品移除区域/流体分配区域（6）的方向向前推动，以便去除样品并且以这样的方式引入流体：壁（2） 可以在样品去除区域/流体分配区域（6）内穿孔。 系统（1）包括用于填充，混合，运输，储存诸如生物液体，血清，缓冲液，超纯水的介质的容器，袋或管，并可用作药物和/或制剂中的生物反应器或细胞培养容器 生物工业。
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公开(公告)号：US08342737B2
公开(公告)日：2013-01-01
申请号：US12226297
申请日：2007-04-24
申请人： Gerhard Greller , Oscar-Werner Reif
发明人： Gerhard Greller , Oscar-Werner Reif
CPC分类号： B01F11/0082 , B01F3/04262 , B01F11/0091 , B01F15/00071 , B01F15/0085 , B01F2215/0073 , C12M23/28 , C12M27/16 , C12M27/22
摘要： A vibrational mixer (1), in particular a single-path mixer for use in single-path bioreactors (4) with flexible walls, consisting of a mixer shaft (2) that can be set into longitudinal motions by a drive (8), with at least one mixing element (3), wherein at least one channel (13) is arranged in the mixer shaft with an opening to an interior reactor space (6).
摘要翻译： 振动混合器（1），特别是用于具有柔性壁的单路生物反应器（4）的单路混合器，由混合器轴（2）组成，该混合器轴可由驱动器（8）设置成纵向运动， 至少一个混合元件（3），其中至少一个通道（13）布置在混合器轴中，开口通向内部反应器空间（6）。
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公开(公告)号：US20110229963A1
公开(公告)日：2011-09-22
申请号：US13129700
申请日：2009-10-19
CPC分类号： B01F7/00058 , B01F15/00707 , B01F15/00831 , B01F15/0085 , C12M27/02
摘要： A stirrer for a bioreactor has first and second opposed mountings fastened to the inner surfaces of opposite walls of the bioreactor and disposed along a common rotational axis. A first arm has an end connected to the first mounting for rotation about the rotational axis and for pivoting about a first pivot axis that is transverse to the rotational axis. A second arm has an end connected to the second mounting for rotation about the rotational axis and for pivoting about a second pivot axis that is transverse to the rotational axis. Ends of the arms are coupled for pivoting about at least one additional pivot axis that is transverse to the rotational axis.
摘要翻译： 用于生物反应器的搅拌器具有固定到生物反应器的相对壁的内表面并沿着公共旋转轴线设置的第一和第二相对的安装件。 第一臂具有连接到第一安装件的端部，用于围绕旋转轴线旋转并围绕横向于旋转轴线的第一枢转轴线枢转。 第二臂具有连接到第二安装件的端部，用于围绕旋转轴线旋转并且围绕横向于旋转轴线的第二枢转轴线枢转。 臂的端部被联接以围绕横向于旋转轴线的至少一个附加枢转轴线枢转。
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公开(公告)号：US20110058448A1
公开(公告)日：2011-03-10
申请号：US12991466
申请日：2009-05-07
申请人： Oscar-Werner Reif , Gerhard Greller , Juergen Van Den Boogaard , Karl-Heinz Kompart , Marco Lohrengel
发明人： Oscar-Werner Reif , Gerhard Greller , Juergen Van Den Boogaard , Karl-Heinz Kompart , Marco Lohrengel
IPC分类号： B01F7/16
CPC分类号： B01F7/16 , B01F11/0082 , B01F13/045 , B01F15/00071 , B01F15/00831 , B01F15/0085
摘要： A mixing system has a single-use container (1) with flexible walls and a mixing device. The mixing device has at least one encapsulated drive (5) and a mixer shaft (3). The drive (5) can be disposed of after use together with the mixer shaft (3) and the single-use container (1). The mixing system can be used in biotechnology and the pharmaceutical industry for mixing liquids, dissolving solids or cultivating cells and microorganisms.
摘要翻译： 混合系统具有具有柔性壁的一次性容器（1）和混合装置。 混合装置具有至少一个封装的驱动器（5）和混合器轴（3）。 驱动器（5）可以与混合器轴（3）和一次性容器（1）一起使用后被处理。 混合系统可用于生物技术和制药工业用于混合液体，溶解固体或培养细胞和微生物。
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38.发明申请Device, method and computer program product for carrying out a process for the filtration of fluids 有权用于进行流体过滤的装置，方法和计算机程序产品公开(公告)号：US20090188871A1
公开(公告)日：2009-07-30
申请号：US12380732
申请日：2009-03-03
IPC分类号： B01D37/04
CPC分类号： B01D35/143 , B01D2201/4046 , B01D2201/52 , B01D2201/54 , B01D2201/56 , G06Q10/20
摘要： The invention relates to a filtration system and method for carrying out a process for the filtration of fluids, comprising at least one filtration device with at least one filtration element comprising readable data and a check and/or test apparatus to which the filtration device may be connected, by means of data and testing means lines. The check and/or testing device is connected to a process controller, by data exchange means, for regulation and control of the filtration process and the process controller is connected to a filtration databank, by means of data exchange means, which comprises data sets for at least one filter element and/or for each filtration device and/or for the filtration process. The invention further relates to a computer programme product for carrying out a filtration process on fluids whereby programme components may be called up from a programme memory which support the carrying out of the filtration process.
摘要翻译： 本发明涉及一种用于进行流体过滤的过程的过滤系统和方法，该过滤系统和方法包括至少一个具有至少一个过滤元件的过滤装置，该过滤元件包括可读取的数据，以及检查和/或测试装置，过滤装置可以 通过数据和测试手段连线。 支票和/或测试装置通过数据交换装置连接到过程控制器，用于调节和控制过滤过程，并且过程控制器通过数据交换装置连接到过滤数据库，数据交换装置包括用于 至少一个过滤元件和/或每个过滤装置和/或用于过滤过程。 本发明还涉及一种用于对流体进行过滤处理的计算机程序产品，其中可以从支持进行过滤处理的程序存储器调用程序组件。
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公开(公告)号：US20060252298A1
公开(公告)日：2006-11-09
申请号：US11410185
申请日：2006-04-24
IPC分类号： H01R11/20
CPC分类号： A61M39/16 , A61M39/18 , A61M2039/1027 , F16L37/26 , F16L2201/44
摘要： A connector system (10) for producing a sterile connection includes a fluid conduit (32), an engagement device (14, 22) designed to engage with a complementary engagement device (16, 24) of a complementary connector (12), a displacement device (26) with a substantially plane displacement surface (30) and a fluid conduit aperture (60) which extends through the displacement surface (30) and is connected to the fluid conduit (32), with the displacement device (26) being designed to displace the connector (12) and the complementary connector (12) relative to one another in a displacement direction (40) after the engagement device (14, 22) has engaged with the complementary engagement device (16, 24), and with the displacement direction (40) being substantially parallel to the displacement surface (30), and a sterile cover device (20, 74) designed to cover at least the fluid conduit aperture (60) in a sterile manner. The invention also relates to a method of use of the connector system (10) and of the complementary connector (12) for sterile connection of a fluid inlet of the connector (10) to a fluid outlet of the complementary connector.
摘要翻译： 用于产生无菌连接的连接器系统（10）包括流体导管（32），设计成与互补连接器（12）的互补接合装置（16,24）接合的接合装置（14,22） 具有基本平面位移表面（30）的装置（26）和延伸穿过位移表面（30）并且连接到流体导管（32）的流体导管孔（60），位移装置（26）被设计 在所述接合装置（14,22）已经与所述互补接合装置（16,24）接合之后，使所述连接器（12）和所述互补连接器（12）相对于彼此在位移方向（40）上移位，并且 位移方向（40）基本上平行于位移表面（30），以及设计成以无菌方式至少覆盖流体导管孔（60）的无菌盖装置（20,74）。 本发明还涉及使用连接器系统（10）和互补连接器（12）的方法，用于将连接器（10）的流体入口与互补连接器的流体出口无菌连接。
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公开(公告)号：US10267304B2
公开(公告)日：2019-04-23
申请号：US12828450
申请日：2010-07-01
申请人： Oscar-Werner Reif , Paul Priebe
发明人： Oscar-Werner Reif , Paul Priebe
IPC分类号： F04B43/12
摘要： A hose system has a pump hose with a hose portion insertable into a pump head of a hose pump. The hose portion has at least a first stop element fixing the hose portion in the feed direction. The first stop element can subsequently be connected immovably to the pump hose at a predefinable position of the pump hose. Thus, the pump hose can be used more universally and can be adapted to different pump heads.
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