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公开(公告)号：US08252818B2
公开(公告)日：2012-08-28
申请号：US12713433
申请日：2010-02-26
IPC分类号： A61K31/44 , C07D213/02
CPC分类号： C07D213/82 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/12 , C07D417/12
摘要： Compounds of formula (I): are inhibitors of p38 kinase and are useful in the treatment of conditions or disease states mediated by p38 kinase activity or mediated by cytokines produced by the activity of p38.
摘要翻译： 式（I）化合物：p38激酶的抑制剂，可用于治疗由p38激酶活性介导的或由p38活性产生的细胞因子介导的病状或疾病状态。
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![PYRROLO[2,3-B]PYRIDIN-4-YL-BENZENESULFONAMIDE COMPOUNDS AS 1KK2 INHIBITORS](/abs-image/US/2010/02/11/US20100035917A1/abs.jpg.150x150.jpg)
32.发明申请PYRROLO[2,3-B]PYRIDIN-4-YL-BENZENESULFONAMIDE COMPOUNDS AS 1KK2 INHIBITORS 审中-公开作为1KK2抑制剂的吡咯并[2,3-B]吡啶-4-基 - 苯甲酰胺化合物公开(公告)号：US20100035917A1
公开(公告)日：2010-02-11
申请号：US12442012
申请日：2007-09-20
申请人： Paul Bamborough , Michael David Barker , Sebastien Andre Campos , Richard Peter Charles Cousins , Paul Faulder , Heather Hobbs , Duncan Stuart Holmes , Michael John Johnston , John Liddle , Jeremy John Payne , John Martin Pritchard , Caroline Whitworth
发明人： Paul Bamborough , Michael David Barker , Sebastien Andre Campos , Richard Peter Charles Cousins , Paul Faulder , Heather Hobbs , Duncan Stuart Holmes , Michael John Johnston , John Liddle , Jeremy John Payne , John Martin Pritchard , Caroline Whitworth
IPC分类号： A61K31/437 , C07D471/04
CPC分类号： C07D471/04
摘要： The invention is directed to certain novel compounds. Specifically, the invention is directed to compounds according to Formula (1) and salts thereof. The compounds of the invention are inhibitors of kinase activity, in particular 1KK2 activity.
摘要翻译： 本发明涉及某些新化合物。 具体地，本发明涉及根据式（1）的化合物及其盐。 本发明的化合物是激酶活性的抑制剂，特别是1KK2的活性。
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公开(公告)号：US07598251B2
公开(公告)日：2009-10-06
申请号：US12262290
申请日：2008-10-31
IPC分类号： A61K31/4965 , C07D401/00 , C07D403/00 , C07D405/00 , C07D409/00 , C07D411/00 , C07D413/00 , C07D417/00 , C07D419/00
CPC分类号： C07D471/04 , C07D403/04 , C07D409/14 , C07D473/00 , C07D487/04
摘要： The present invention relates to aminopyrazine derivatives, compositions and medicaments containing the same, as well as processes for the preparation and use of such compounds, compositions and medicaments. Such aminopyrazine derivatives are useful in the treatment of diseases associated with inappropriate tyrosine and/or serine/threonine kinase activity.
摘要翻译： 本发明涉及氨基吡嗪衍生物，含有它们的组合物和药物，以及制备和使用这些化合物，组合物和药物的方法。 这种氨基吡嗪衍生物可用于治疗与不适当的酪氨酸和/或丝氨酸/苏氨酸激酶活性相关的疾病。
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公开(公告)号：US20090156597A1
公开(公告)日：2009-06-18
申请号：US12132793
申请日：2008-06-04
申请人： James F. Callahan , Jeffrey C. Boehm , Anthony William James Cooper , Stefano Livia , Paul Bamborough , Neysa Nevins , Zehong Wan , Beth A. Norton , Xichen Lin
发明人： James F. Callahan , Jeffrey C. Boehm , Anthony William James Cooper , Stefano Livia , Paul Bamborough , Neysa Nevins , Zehong Wan , Beth A. Norton , Xichen Lin
IPC分类号： A61K31/519 , A61K31/5377 , A61P3/00 , A61P27/00 , A61P11/00 , A61P9/00 , A61P25/00 , C07D471/04
CPC分类号： C07D487/04
摘要： Novel substituted 2,4,8-trisubstituted 8H-pyrido[2,3-d]pyrimidin-7-one containing compounds and compositions, and their use in therapy as CSBP/RK/p38 kinase inhibitors.
摘要翻译： 新型取代的2,4,8-三取代8H-吡啶并[2,3-d]嘧啶-7-酮的化合物和组合物，以及它们在CSBP / RK / p38激酶抑制剂治疗中的用途。
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公开(公告)号：US07514456B2
公开(公告)日：2009-04-07
申请号：US11462858
申请日：2006-08-07
IPC分类号： A61K31/455 , C07D213/46
CPC分类号： C07D213/82 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/12 , C07D417/12
摘要： Compounds of formula (I): are inhibitors of p38 kinase and are useful in the treatment of conditions or disease states mediated by p38 kinase activity or mediated by cytokines produced by the activity of p38.
摘要翻译： 式（I）化合物：p38激酶的抑制剂，可用于治疗由p38激酶活性介导的或由p38活性产生的细胞因子介导的病状或疾病状态。
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36.发明授权公开(公告)号：US07425555B2
公开(公告)日：2008-09-16
申请号：US10513095
申请日：2003-04-29
申请人： Richard Martyn Angell , Paul Bamborough , Ian Robert Baldwin , Anne-Marie Li-Kwai-Cheung , Timothy Longstaff , Suzanne Joy Merrick , Kathryn Jane Smith , Stephen Swanson , Ann Louise Walker
发明人： Richard Martyn Angell , Paul Bamborough , Ian Robert Baldwin , Anne-Marie Li-Kwai-Cheung , Timothy Longstaff , Suzanne Joy Merrick , Kathryn Jane Smith , Stephen Swanson , Ann Louise Walker
IPC分类号： A61K31/5377 , C07D413/12
CPC分类号： C07D207/325 , C07D231/12 , C07D233/64 , C07D249/14 , C07D257/04 , C07D271/06 , C07D271/10 , C07D271/113 , C07D277/40 , C07D413/04 , C07D413/12 , C07D417/12
摘要： Compounds of formula (I): are inhibitors of p38 kinase and are useful in the treatment of conditions or disease states mediated by p38 kinase activity or mediated by cytokines produced by the activity of p38.
摘要翻译： 式（I）化合物：p38激酶的抑制剂，可用于治疗由p38激酶活性介导的或由p38活性产生的细胞因子介导的病状或疾病状态。
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公开(公告)号：US20080146606A1
公开(公告)日：2008-06-19
申请号：US11858143
申请日：2007-09-20
申请人： Paul Bamborough , Michael David Barker , Sebastien Andre Campos , Richard Peter Charles Cousins , Paul Faulder , Heather Hobbs , Duncan Stuart Holmes , Michael John Johnston , John Liddle , Jeremy John Payne , John Martin Pritchard , Caroline Whitworth
发明人： Paul Bamborough , Michael David Barker , Sebastien Andre Campos , Richard Peter Charles Cousins , Paul Faulder , Heather Hobbs , Duncan Stuart Holmes , Michael John Johnston , John Liddle , Jeremy John Payne , John Martin Pritchard , Caroline Whitworth
IPC分类号： A61K31/437 , C07D221/04 , A61P11/06 , A61P19/02 , A61P29/00
CPC分类号： C07D471/04
摘要： The invention is directed to certain novel compounds. Specifically, the invention is directed to compounds according to formula (I): and salts thereof.The compounds of the invention are inhibitors of kinase activity, in particular IKK2 activity.
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公开(公告)号：US07309800B2
公开(公告)日：2007-12-18
申请号：US11556285
申请日：2006-11-03
申请人： Richard Martyn Angell , Nicola Mary Aston , Paul Bamborough , Mark James Bamford , George Stuart Cockerill , Stephen Sean Flack , Dramane Ibrahim Lainé , Ann Louise Walker
发明人： Richard Martyn Angell , Nicola Mary Aston , Paul Bamborough , Mark James Bamford , George Stuart Cockerill , Stephen Sean Flack , Dramane Ibrahim Lainé , Ann Louise Walker
IPC分类号： C07C231/02 , C07D207/04 , C07D271/10 , C07D233/54 , C07D285/04 , C07D401/10 , C07D403/10 , C07D265/30
CPC分类号： C07D213/81 , C07D231/12 , C07D233/56 , C07D249/08 , C07D261/18 , C07D307/46 , C07D307/68 , C07D333/38 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/12
摘要： Compounds of formula (I): or pharmaceutically acceptable salts or solvates thereof, and their use as pharmaceuticals, particularly as p38 kinase inhibitors.
摘要翻译： 式（I）化合物或其药学上可接受的盐或溶剂合物，以及它们作为药物的用途，特别是作为p38激酶抑制剂。
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公开(公告)号：US20060084651A1
公开(公告)日：2006-04-20
申请号：US10549972
申请日：2004-03-18
申请人： Michael Alberti , David Drewry , David Miller , Paul Bamborough
发明人： Michael Alberti , David Drewry , David Miller , Paul Bamborough
IPC分类号： A61K31/52 , A61K31/503 , A61K31/497 , A61K31/498 , C07D487/02 , C07D473/02 , C07D471/02
CPC分类号： C07D471/04 , C07D403/04 , C07D409/14 , C07D473/00 , C07D487/04
摘要： The present invention relates to aminopyrazine derivatives, compositions and medicaments containing the same, as well as processes for the preparation and use of such compounds, compositions and medcicaments. Such aminopyrazine derivatives are useful in the treatment of diseases associated with inappropriate tyrosine and/or serine/threonine kinase activity.
摘要翻译： 本发明涉及氨基吡嗪衍生物，含有它们的组合物和药物，以及这些化合物，组合物和药物的制备和用途的方法。 这种氨基吡嗪衍生物可用于治疗与不适当的酪氨酸和/或丝氨酸/苏氨酸激酶活性相关的疾病。
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公开(公告)号：US08778939B2
公开(公告)日：2014-07-15
申请号：US13498975
申请日：2010-09-27
申请人： Paula Louise Nichols , Andrew John Eatherton , Paul Bamborough , Karamjit Singh Jandu , Oliver James Philps , Daniele Andreotti
发明人： Paula Louise Nichols , Andrew John Eatherton , Paul Bamborough , Karamjit Singh Jandu , Oliver James Philps , Daniele Andreotti
IPC分类号： A61K31/5377 , A61K31/4406 , C07C235/56 , A61K31/167 , C07D237/20 , A61K31/50 , A61K31/4402 , C07D239/42 , A61K31/505
CPC分类号： C07C235/64 , C07D213/75 , C07D231/40 , C07D237/20 , C07D261/14 , C07D263/48 , C07D401/12 , C07D403/12 , C07D413/12
摘要： The present invention relates to novel compounds that inhibit LRRK2 kinase activity, processes for their preparation, to compositions containing them and to their use in the treatment of diseases characterized by LRRK2 kinase activity, particularly Parkinson's disease and Alzheimer's disease.
摘要翻译： 本发明涉及抑制LRRK2激酶活性的新化合物，其制备方法，含有它们的组合物及其用于治疗特征为LRRK2激酶活性，特别是帕金森病和阿尔茨海默病的疾病的用途。
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