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31.发明授权公开(公告)号：US06353012B1
公开(公告)日：2002-03-05
申请号：US09694713
申请日：2000-10-23
IPC分类号： A61K3141
摘要： HETE derivatives and methods of their use for treating dry eye are disclosed.
摘要翻译： 公开了HETE衍生物及其用于治疗干眼症的方法
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公开(公告)号：US06172109B2
公开(公告)日：2001-01-09
申请号：US09077507
申请日：1998-06-03
申请人： Paul W. Zinke , Mark R. Hellberg
发明人： Paul W. Zinke , Mark R. Hellberg
IPC分类号： A61K315575
CPC分类号： C07C405/0033
摘要： 13-thia prostaglandins are useful in the treatment of glaucoma and ocular hypertension. Also disclosed are ophthalmic, pharmaceutical compositions comprising said prostaglandins.
摘要翻译： 13-thia前列腺素可用于治疗青光眼和高眼压症。 还公开了包含所述前列腺素的眼科药物组合物。
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33.发明授权公开(公告)号：US06169111A
公开(公告)日：2001-01-02
申请号：US09308052
申请日：1999-05-12
IPC分类号： A61K31557
CPC分类号： C07C405/0016 , A61K31/557 , A61K31/5575 , C07C405/00
摘要： Conformationally rigid aryl prostaglandins are useful in the treatment of glaucoma and ocular hypertension. Also disclosed are ophthalmic pharmaceutical compositions comprising said prostaglandins.
摘要翻译： 构形刚性的前列腺素可用于治疗青光眼和高眼压症。 还公开了包含所述前列腺素的眼用药物组合物。
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![3,6-substituted imidazol[1,2-b]pyridazine analogs for treating allergic and inflammatory diseases](/abs-image/US/2011/03/15/US07906512B2/abs.jpg.150x150.jpg)
34.发明授权3,6-substituted imidazol[1,2-b]pyridazine analogs for treating allergic and inflammatory diseases 有权3,6-取代咪唑并[1,2-b]哒嗪类似物用于治疗过敏性和炎性疾病公开(公告)号：US07906512B2
公开(公告)日：2011-03-15
申请号：US12720808
申请日：2010-03-10
IPC分类号： A01N43/58 , A01N43/60 , A01N43/52 , A61K31/50 , A61K31/495 , A61K31/501 , A61K31/415 , C07D487/00 , C07D401/00 , C07D403/00 , C07D405/00 , C07D409/00 , C07D235/02 , C07D403/02
CPC分类号： A61K31/5025 , C07D473/04 , C07D487/04 , Y02A50/411
摘要： Methods for treating an allergic or inflammatory disease or other Syk-mediated disease or Syk-mediated condition characterized by administering a composition which contains a therapeutically effective amount of a 3,6-substituted imidazol[1,2-b]pyridazine compound.
摘要翻译： 用于治疗过敏性或炎性疾病或其它Syk介导的疾病或Syk介导的病症的方法，其特征在于施用含有治疗有效量的3,6-取代的咪唑并[1,2-b]哒嗪化合物的组合物。
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![6-aminoimidazo[1,2-b]pyridazine analogs as rho kinase inhibitors for the treatment of rho kinase-mediated diseases and conditions](/abs-image/US/2010/10/26/US07820670B2/abs.jpg.150x150.jpg)
35.发明授权6-aminoimidazo[1,2-b]pyridazine analogs as rho kinase inhibitors for the treatment of rho kinase-mediated diseases and conditions 有权6-氨基咪唑并[1,2-b]哒嗪类似物作为rho激酶抑制剂，用于治疗rho激酶介导的疾病和病症公开(公告)号：US07820670B2
公开(公告)日：2010-10-26
申请号：US11960476
申请日：2007-12-19
申请人： Hwang-Hsing Chen , Andrew Rusinko , Mark R. Hellberg , Bryon S. Severns , Alan J. Henderson , Cheng Guo , Mark Hadden
发明人： Hwang-Hsing Chen , Andrew Rusinko , Mark R. Hellberg , Bryon S. Severns , Alan J. Henderson , Cheng Guo , Mark Hadden
IPC分类号： A61K31/501
CPC分类号： A61K31/5025 , A61K9/0048
摘要： Methods for using 6-aminoimidazo[1,2-b]pyridazine analogs are disclosed herein to treat rho kinase-mediated diseases or rho kinase-mediated conditions, including controlling intraocular pressure and treating glaucoma, are disclosed. Ophthalmic pharmaceutical compositions useful in the treatment of eye diseases such as glaucoma, and additionally useful for controlling intraocular pressure, the compositions comprising an effective amount of 6-aminoimidazo[1,2-b]pyridazine analogs, are disclosed herein.
摘要翻译： 本文公开了使用6-氨基咪唑并[1,2-b]哒嗪类似物的方法，用于治疗rho激酶介导的疾病或rho激酶介导的病症，包括控制眼内压和治疗青光眼。 用于治疗眼睛疾病如青光眼的眼用药物组合物，另外可用于控制眼内压，本文公开了包含有效量的6-氨基咪唑并[1,2-b]哒嗪类似物的组合物。
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36.发明授权5-substituted 2-aminopyridine analogs for treating allergic and inflammatory diseases 有权用于治疗过敏性和炎性疾病的5-取代的2-氨基吡啶类似物公开(公告)号：US07799778B1
公开(公告)日：2010-09-21
申请号：US11330629
申请日：2006-01-12
IPC分类号： A61K31/535 , A61K31/50 , A61K31/497 , A61K31/44 , A01N43/58 , A01N43/42 , C07D221/18 , C07D221/22 , C07D401/00 , C07D421/00 , C07D405/00
CPC分类号： C07D213/74 , A61K31/44 , A61K31/497 , A61K31/50 , A61K31/535 , C07D405/04 , Y02A50/411
摘要： Methods for treating an allergic or inflammatory disease or other Syk-mediated disease or Syk-mediated condition characterized by administering a composition which contains a therapeutically effective amount of a 5-substituted 2-aminopyridine compound.
摘要翻译： 用于治疗过敏性或炎性疾病或其它Syk介导的疾病或Syk介导的病症的方法，其特征在于施用含有治疗有效量的5-取代的2-氨基吡啶化合物的组合物。
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37.发明申请COMPOUNDS WITH 5-HT1A ACTIVITY USEFUL FOR TREATING DISORDERS OF THE OUTER RETINA 审中-公开具有5-HT1A活性的化合物可用于治疗外周疾病公开(公告)号：US20100168121A1
公开(公告)日：2010-07-01
申请号：US12719152
申请日：2010-03-08
IPC分类号： A61K31/506 , A61K31/496 , A61K31/428 , A61K31/4418 , A61K31/438 , A61K31/4433 , A61K31/135 , A61P27/02
CPC分类号： A61K31/519 , A61K31/496 , A61K31/506 , Y10S514/912
摘要： Compositions and methods for treating disorders of the outer retina with compounds with 5-HT1A agonist activity are disclosed.
摘要翻译： 公开了用具有5-HT1A激动剂活性的化合物治疗外部视网膜疾病的组合物和方法。
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38.发明申请INHIBITORS OF GLYCOGEN SYNTHASE KINASE-3 (GSK-3) FOR TREATING GLAUCOMA 审中-公开GLYCOGEN SYNTHASE KINASE-3（GSK-3）用于治疗GLAUCOMA的抑制剂公开(公告)号：US20090312390A1
公开(公告)日：2009-12-17
申请号：US12545611
申请日：2009-08-21
申请人： Mark R. Hellberg , Abbot F. Clark , Iok-Hou Pang , Peggy Elizabeth Hellberg , Loretta Graves McNatt , Wan-Heng Wang
发明人： Mark R. Hellberg , Abbot F. Clark , Iok-Hou Pang , Peggy Elizabeth Hellberg , Loretta Graves McNatt , Wan-Heng Wang
IPC分类号： A61K31/404 , A61K31/4015
CPC分类号： A61K9/0048 , A61K31/4015 , A61K31/404 , A61K31/4196 , A61K31/426 , A61K31/427 , A61K31/4439 , A61K31/55
摘要： The use of inhibitors of GSK-3 useful for treating glaucoma is disclosed.
摘要翻译： 公开了使用可用于治疗青光眼的GSK-3抑制剂。
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公开(公告)号：US07297505B2
公开(公告)日：2007-11-20
申请号：US11114649
申请日：2005-04-25
IPC分类号： G01N33/567
CPC分类号： G01N33/502 , G01N33/5008 , G01N33/5035 , G01N33/5044 , G01N2800/16
摘要： A new method of evaluating the ability of drug molecules to penetrate the cornea is described. The permeation rate of the drug molecules in MDCK cells is utilized to predict the ability of the molecules to penetrate the cornea. The method is useful for in vitro screening of potential new ophthalmic drugs, as well as in the design of new drug molecules for topical ocular administration.
摘要翻译： 描述了评估药物分子穿透角膜的能力的新方法。 MDCK细胞中药物分子的渗透速率用于预测分子穿透角膜的能力。 该方法可用于体外筛选潜在的新眼科药物，以及用于局部眼部给药的新药物分子的设计。
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公开(公告)号：US06509355B1
公开(公告)日：2003-01-21
申请号：US09807805
申请日：2001-04-18
申请人： Robert J. Collier, Jr. , Mark R. Hellberg , Michael A. Kapin , George E. Barnes , Michael L. Chandler
发明人： Robert J. Collier, Jr. , Mark R. Hellberg , Michael A. Kapin , George E. Barnes , Michael L. Chandler
IPC分类号： A61K31445
CPC分类号： A61K31/00 , A61K31/445 , Y10S514/912
摘要： This invention is directed to the use of glutamate antagonists to treat the disorders of outer retina.
摘要翻译： 本发明涉及谷氨酸拮抗剂用于治疗外部视网膜疾病的用途。
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