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公开(公告)号：US07844323B2
公开(公告)日：2010-11-30
申请号：US11812827
申请日：2007-06-22
申请人： David R. Fischell , Tim A. Fischell , Jonathan Harwood , Robert E. Fischell , Steven R. Johnson
发明人： David R. Fischell , Tim A. Fischell , Jonathan Harwood , Robert E. Fischell , Steven R. Johnson
IPC分类号： A61B5/00
CPC分类号： A61B5/0452 , A61B5/0006 , A61B5/0031 , A61B5/0456 , A61B5/046 , A61B5/0464 , A61B5/7465 , A61B2560/0209 , A61N1/3627 , A61N1/3702
摘要： Disclosed is a system for the detection of cardiac events that includes an implanted device called a cardiosaver, a physician's programmer and an external alarm system. The system is designed to provide early detection of cardiac events such as acute myocardial infarction or exercise induced myocardial ischemia caused by an increased heart rate or exertion. The system can also alert the patient with a less urgent alarm if a heart arrhythmia is detected. Using different algorithms, the cardiosaver can detect a change in the patient's electrogram that is indicative of a cardiac event within five minutes after it occurs and then automatically warn the patient that the event is occurring. To provide this warning, the system includes an internal alarm sub-system (internal alarm means) within the cardiosaver and/or an external alarm system (external alarm means) which are activated after the ST segment of the electrogram exceeds a preset threshold.
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公开(公告)号：US06936065B2
公开(公告)日：2005-08-30
申请号：US10158714
申请日：2002-05-30
CPC分类号： A61F2/95 , A61F2/958 , A61M2025/0186 , A61M2025/1004
摘要： The present invention is a stent delivery system that uses short section of guidewire fixedly attached to the distal section of a balloon angioplasty catheter onto which a stent is co-axially mounted. By not having a guidewire that slides through the balloon of the balloon angioplasty catheter, the deflated balloon on which the stent is mounted can have a reduced diameter. Therefore, the outer diameter of the pre-deployed stent mounted onto that balloon is also minimized. This provides a smaller profile, i.e., a smaller outer diameter, for the stent. The time to perform a stent delivery procedure is reduced; a separate guidewire does not have to be placed prior to using the stent delivery system to place the stent at the site of a stenosis. Another embodiment of the present invention has a core wire that extends for nearly the entire length of the stent delivery system, the guidewire having different levels of stiffness for different portions of the core wire's length.
摘要翻译： 本发明是一种支架输送系统，其使用固定连接到气囊血管成形术导管的远侧部分的导线短段，支架同轴安装在该支架上。 通过不具有穿过球囊血管成形术导管的球囊的导丝，其上安装支架的放气球可具有减小的直径。 因此，安装在该球囊上的预先展开的支架的外径也被最小化。 这为支架提供了更小的外形，即较小的外径。 执行支架递送程序的时间减少; 在使用支架输送系统将支架置于狭窄部位之前，不必放置单独的导丝。 本发明的另一个实施例具有延伸到支架输送系统的整个长度的芯线，该导丝对于芯线长度的不同部分具有不同的刚度水平。
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33.发明授权System and method for controlling epileptic seizures with spatially separated detection and stimulation electrodes 有权用空间分离的检测和刺激电极控制癫痫发作的系统和方法公开(公告)号：US06597954B1
公开(公告)日：2003-07-22
申请号：US09724805
申请日：2000-11-28
IPC分类号： A61N136
CPC分类号： A61N1/0529 , A61B5/0002 , A61B5/0476 , A61B5/4094 , A61B5/7217 , A61M5/14276 , A61N1/0534 , A61N1/36064 , A61N1/36082 , G06F19/00
摘要： A system and method for controlling epilepsy and other neurological disorders by providing electrical stimulation to a patient's brain in response to detected neurological conditions. An implantable device includes a stimulation subsystem coupled to a stimulation electrode to provide responsive electrical brain stimulation in response to an event detected via an on-board processor's analysis of data received from a detection subsystem coupled to a detection electrode located in a different portion of the patient's brain.
摘要翻译： 一种通过响应于检测到的神经病症向患者的大脑提供电刺激来控制癫痫和其他神经障碍的系统和方法。 可植入装置包括耦合到刺激电极的刺激子系统，以响应于经由车载处理器对从耦合到位于所述第二部分的不同部分的检测电极的检测子系统接收的数据的分析而检测的事件来响应电脑刺激 病人的大脑
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34.发明授权Implantable responsive system for sensing and treating acute myocardial infarction and for treating stroke 有权用于感染和治疗急性心肌梗死和治疗中风的植入式反应系统公开(公告)号：US06468263B1
公开(公告)日：2002-10-22
申请号：US09860693
申请日：2001-05-21
IPC分类号： A61K922
CPC分类号： A61B5/0452 , A61B5/0031 , A61N1/362
摘要： Disclosed is a completely implantable system that can detect the occurrence of a myocardial infarction, i.e., a heart attack, and automatically inject a thrombolytic and/or anti-thrombogenic agent into the bloodstream to promptly dissolve the thrombus that caused the myocardial infarction and prevent the formation of additional thrombi. It is well known that a myocardial infarction can be detected from a patient's electrocardiogram by noting an ST segment voltage deviation. Upon detection of a myocardial infarction, an ST segment deviation electronic detection circuit within the implanted device can produce an output signal that can cause a thrombolytic and/or anti-thrombogenic agent contained within an implanted, pressurized reservoir to immediately and automatically release medications into the patient's bloodstream. A patient warning system is also provided by an audio alarm or an electrical tickle within the human body indicating that a myocardial infarction has been detected. An externally located part of the system, in the form of a patient operated initiator, can be used to trigger the release of medication as soon as a first sign of a stroke has been detected in order to prevent damage to brain tissue that would be caused by that stroke. Thus the system can be used to prevent trissue damage from either a myocardial infarction or a stroke. The implanted system can also send a radio message to an externally located receiver that automatically dials an emergency rescue team to take the patient to a hospital for continuing treatment of a myocardial infarction or a stroke.
摘要翻译： 公开了一种完全可植入的系统，其可以检测心肌梗死的发生，即心脏病发作，并自动将血栓溶解和/或抗血栓形成剂注射到血流中，以迅速溶解引起心肌梗死的血栓，并防止 形成额外的血栓。 众所周知，通过注意到ST段电压偏差，可以从患者的心电图中检测出心肌梗死。 在检测到心肌梗塞时，植入装置内的ST段偏移电子检测电路可以产生输出信号，其可以引起包含在植入的加压贮存器内的血栓溶解和/或抗血栓形成剂立即并自动将药物释放到 病人的血液。 患者预警系统还由人体内的音频警报器或电子痒痒声提供，表明已经检测到心肌梗死。 只要已经检测出中风的第一个迹象，为了防止会导致的脑组织的损伤，可以使用以病人操作的引发剂的形式的系统的外部定位部分，以触发药物的释放 中风。 因此，该系统可用于防止心肌梗塞或中风的三体损伤。 植入的系统还可以向外部定位的接收器发送无线电消息，自动拨打紧急救援队以将病人带到医院继续治疗心肌梗死或中风。
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公开(公告)号：US06459936B2
公开(公告)日：2002-10-01
申请号：US09932175
申请日：2001-08-17
IPC分类号： A61N118
CPC分类号： A61N1/36135 , A61N1/36017 , A61N1/36025 , A61N1/36064 , A61N1/36067 , A61N1/36075 , A61N1/37252
摘要： Disclosed is a multiple electrode, closed-loop, responsive system for the treatment of certain neurological diseases such as epilepsy, migraine headaches and Parkinson's disease. Brain electrodes would be placed in close proximity to the brain or deep within brain tissue. When a neurological event such as the onset of an epileptic seizure occurs, EEG signals from the electrodes are processed by signal conditioning means in a control module that can be placed beneath the patient's scalp, within the patient's chest, or situated externally on the patient. Neurological event detection means in the control module will then cause a response to be generated for stopping the neurological event. The response could be an electrical signal to brain electrodes or to electrodes located remotely in the patient's body. The response could also be the release of medication or the application of a sensory input such as sound, light or mechanical vibration or electrical stimulation of the skin. The response to the neurological event can originate from devices either internal or external to the patient. The system also has the capability for multi-channel recording of EEG related signals that occur both before and after the detection of a neurological event. Programmability of many different operating parameters of the system by means of external equipment provides adaptability for treating patients who manifest different symptoms and who respond differently to the response generated by the system.
摘要翻译： 公开了一种用于治疗某些神经系统疾病如癫痫，偏头痛和帕金森病的多重电极闭环应答系统。 脑电极将放置在靠近脑部或脑组织深处。 当出现诸如癫痫发作的神经系统事件时，来自电极的EEG信号由控制模块中的信号调节装置处理，该控制模块可以放置在患者的头皮之下，患者的胸部内，或者位于病人的外部。 然后，控制模块中的神经事件检测装置将产生用于停止神经系统事件的响应。 响应可以是对脑电极或位于病人身体远端的电极的电信号。 该反应也可以是药物的释放或者诸如声音，光或机械振动或电刺激皮肤的感觉输入的应用。 对神经系统事件的反应可以来自患者内部或外部的装置。 该系统还具有在检测神经系统事件之前和之后发生的EEG相关信号的多通道记录的能力。 通过外部设备对系统的许多不同操作参数的可编程性提供了适应性，用于治疗表现不同症状的患者，并且对系统产生的反应有不同的反应。
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公开(公告)号：US06360122B1
公开(公告)日：2002-03-19
申请号：US09628977
申请日：2000-08-02
IPC分类号： A61B504
CPC分类号： A61B5/0476 , A61B5/4094 , A61B5/6814 , A61N1/36025 , A61N1/3605 , A61N1/36082 , A61N1/37211 , G06F19/00
摘要： Disclosed is a multiple electrode, closed-loop, responsive system for the treatment of certain neurological diseases such as epilepsy, migraine headaches and Parkinson's disease. Brain electrodes would be placed in close proximity to the brain or deep within brain tissue. When a neurological event such as the onset of an epileptic seizure occurs, EEG signals from the electrodes are processed by signal conditioning in a control module that can be placed beneath the patient's scalp, within the patient's chest, or situated externally on the patient. Neurological event detection means in the control module will then cause a response to be generated for stopping the neurological event. The response could be an electrical signal to brain electrodes or to electrodes located remotely in the patient's body. The response could also be the release of medication or the application of a sensory input such as sound, light or mechanical vibration or electrical stimulation of the skin. The response to the neurological event can originate from devices either internal or external to the patient. The system also has the capability for multi-channel recording of EEG related signals that occur both before and after the detection of a neurological event. Programmability of many different operating parameters of the system by means of external equipment provides adaptability for treating patients who manifest different symptoms and who respond differently to the response generated by the system.
摘要翻译： 公开了一种用于治疗某些神经系统疾病如癫痫，偏头痛和帕金森病的多重电极闭环应答系统。 脑电极将放置在靠近脑部或脑组织深处。 当出现诸如发作癫痫发作的神经系统事件时，来自电极的EEG信号通过控制模块中的信号调节进行处理，所述控制模块可以放置在患者的头皮之下，患者的胸部内，或位于患者的外部。 然后，控制模块中的神经事件检测装置将产生用于停止神经系统事件的响应。 响应可以是对脑电极或位于病人身体远端的电极的电信号。 该反应也可以是药物的释放或者诸如声音，光或机械振动或电刺激皮肤的感觉输入的应用。 对神经系统事件的反应可以来自患者内部或外部的装置。 该系统还具有在检测神经系统事件之前和之后发生的EEG相关信号的多通道记录的能力。 通过外部设备对系统的许多不同操作参数的可编程性提供了适应性，用于治疗表现不同症状的患者，并且对系统产生的反应有不同的反应。
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公开(公告)号：US06354299B1
公开(公告)日：2002-03-12
申请号：US09609086
申请日：2000-06-30
IPC分类号： A61B1900
CPC分类号： A61N1/37217 , A61N1/36025 , A61N1/36082 , A61N1/36135
摘要： An implantable device incorporating an acoustic transducer allows information and alerts to be communicated from the device to a patient. Sounds, including but not limited to buzzes, tones, sequences of tones, combinations of tones, complex sounds, and segments of reproduced or simulated human speech, are transmitted from an intracranially implanted portion of the device via bone conduction to the patient's ears, particularly the inner ears. In the disclosed embodiment, the acoustic transducer is used in cooperation with an implantable closed-loop system for the treatment of certain neurological disorders such as epilepsy, migraine headaches and Parkinson's disease, to warn the patient of an imminent seizure or other episode, to provide information to the patient on the state of the implantable apparatus, and to provide reminders and other information to the patient.
摘要翻译： 结合声学换能器的可植入装置允许将信息和警报从装置传送到患者。 特别是通过骨传导从设备的颅内植入部分发送声音，包括但不限于嗡嗡声，音调，音调序列，音调的组合，复合声音和再现或模拟人类语言的段 内耳。 在所公开的实施例中，声换能器与用于治疗某些神经障碍如癫痫，偏头痛和帕金森病的可植入闭环系统配合使用，以警告患者即将发作或其他发作，以提供 向患者提供关于植入式装置的状态的信息，并向患者提供提醒和其他信息。
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公开(公告)号：US06350226B1
公开(公告)日：2002-02-26
申请号：US09637999
申请日：2000-08-15
IPC分类号： A61N500
CPC分类号： A61N5/1029
摘要： Disclosed is a novel wound dressing which applies ionizing radiation to the surface of the wound as soon after the wound is created as is possible. Optimally, the radiation has a range which extends to the bottom surface of the skin but not significantly beyond that depth. An example of a radioactive source that can apply this type of radiation dosing is a beta particle emitting radioisotope such as phosphorous-32 which has a range of approximately 3.5 mm for 90% of the electrons that it emits. Even very small amounts of phosphorous-32 can provide a sufficiently high level of irradiation to significantly diminish scar tissue formation. The radioactive bandage would typically be an elongated flexible structure which can be applied along a wound or surgical incision. Typically, the radioactive bandage would extend for approximately 1 to 5 mm beyond the cut in all directions. The radioactive bandage would include a shield structure which surrounds the thin, elongated radioactive portion thus disallowing stray radiation outward from the patient's skin. A radiation dose applied to the top of the incision of between 500 and 2000 cGy can substantially reduce scar tissue formation for most patients.
摘要翻译： 公开了一种新颖的伤口敷料，其可以在伤口创建之后尽可能快地向伤口的表面施加电离辐射。 最佳地，辐射具有延伸到皮肤底部表面但不超过该深度的范围。 可以应用这种辐射剂量的放射源的一个例子是发射放射性同位素的β粒子，例如磷32，其发射的电子的90％具有大约3.5mm的范围。 甚至非常少量的磷32可以提供足够高的照射水平以显着减少瘢痕组织形成。 放射性绷带通常是可以沿着伤口或手术切口施用的细长柔性结构。 通常，放射性绷带将在所有方向上延伸超过切口约1至5毫米。 放射性绷带将包括围绕细长的放射性部分的屏蔽结构，从而不允许从患者皮肤向外的杂散辐射。 施加到切口顶部的辐射剂量在500和2000cGy之间可以大大减少大多数患者的瘢痕组织形成。
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39.发明授权Implantable electronic system with acute myocardial infarction detection and patient warning capabilities 有权具有急性心肌梗死检测和患者警戒能力的植入式电子系统公开(公告)号：US06272379B1
公开(公告)日：2001-08-07
申请号：US09271219
申请日：1999-03-17
IPC分类号： A61N139
CPC分类号： A61B5/0031 , A61B5/0006 , A61N1/3925
摘要： Disclosed is a system for detecting a myocardial infarction (i.e., a heart attack) at the earliest possible time and promptly warning the patient that he should immediately seek medical care. Specifically, a first embodiment of the present invention has an implantable electronic system that can sense a change in the patient's electrogram that is indicative of a myocardial infarction. If a myocardial infarction is sensed, the device would then cause an implantable or externally located alarm means such as an audio sound to be actuated to warn the patient of his condition. The patient could then promptly seek medical care, for example, at a hospital emergency room. Having been trained to recognize such an alarm, most patient would neither fail to recognize such an indication of a myocardial infarction nor would they ignore such an alarm signal if it were to occur. Since an implantable heart pacemaker or defibrillator already has within its structure many of the elements required for the device to recognize a myocardial infarction, it would be expeditious to add a capability to these existing devices to detect a myocardial infarction and provide an implantable or external alarm means to inform the patient to take appropriate action.
摘要翻译： 公开了一种用于早期检测心肌梗死（即心脏病发作）的系统，并且及时警告患者应立即求医。 具体地，本发明的第一实施例具有可以感测指示心肌梗塞的患者电描记图变化的可植入电子系统。 如果感测到心肌梗塞，则该装置然后将引起可植入或外部定位的报警装置，例如音频声音被致动以警告患者他的状况。 患者可以立即就医，例如在医院急诊室就医。 经过训练以识别这样的警报，大多数患者既不会认识到这种心肌梗塞的指示，也不会忽视这种报警信号，如果发生。 由于植入式心脏起搏器或除颤器在其结构内已经具有设备识别心肌梗塞所需要的许多元件，因此将快速地向这些现有装置添加能力以检测心肌梗死并提供可植入或外部警报 意味着通知患者采取适当的行动。
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40.发明授权Integrated system for EEG monitoring and electrical stimulation with a multiplicity of electrodes 有权用于EEG监测和电刺激与多个电极的集成系统公开(公告)号：US06230049B1
公开(公告)日：2001-05-08
申请号：US09373676
申请日：1999-08-13
IPC分类号： A61B0500
CPC分类号： A61B5/4094 , A61B5/0002 , A61B5/0476 , A61N1/36017 , A61N1/36025 , A61N1/36082
摘要： The disclosed invention is an integrated system for EEG monitoring and electrical stimulation from a multiplicity of scalp or intracranial implanted electrodes. The system integrates EEG monitoring and brain stimulation, supports remote electrode selection for stimulation and provides a wireless connection between the patient's brain electrodes and the EEG analysis workstation used to collect EEG data, analyze EEG signals and control system functionality.
摘要翻译： 所公开的发明是用于从多个头皮或颅内植入电极进行脑电监测和电刺激的集成系统。 该系统集成了EEG监测和脑刺激，支持远程电极选择进行刺激，并提供患者脑电极与用于收集EEG数据的EEG分析工作站之间的无线连接，分析脑电信号和控制系统功能。
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