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31.发明授权Optically active (meth)acrylamides, a process for their preparation, and their use for racemate resolution 失效光学活性（甲基）丙烯酰胺，其制备方法及其用于消旋物分解的用途
公开(公告)号：US4914159A
公开(公告)日：1990-04-03
申请号：US162529
申请日：1988-03-01
申请人： Bruno Bomer , Rolf Grosser , Ulrich Schwartz , Dieter Arlt , Karl-Erwin Piejko
发明人： Bruno Bomer , Rolf Grosser , Ulrich Schwartz , Dieter Arlt , Karl-Erwin Piejko
IPC分类号： B01J20/291 , B01J20/281 , B01J20/32 , C08F2/44 , C08F20/52 , C08F20/54 , C08F20/56 , C08L33/24 , C08L33/26 , G01N30/88
CPC分类号： B01J20/29 , B01J20/286 , B01J20/3204 , B01J20/3217 , B01J20/327 , B01J20/3276 , B01J20/3278 , C08F20/54 , B01J2220/54
摘要： The invention relates to optically active homo- and copolymers made from optically active (meth)acrylamides, the polymers being immobilized on silica gel, a process for their preparation, and their use as adsorbents, in particular as the stationary phase for chromatographic racemate resolution.
摘要翻译： 本发明涉及由光学活性（甲基）丙烯酰胺制成的光学活性均聚物和共聚物，该聚合物固定在硅胶上，其制备方法及其作为吸附剂的用途，特别是作为色谱外消旋体拆分的固定相。
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32.发明授权3-cyano 5-thiazaheteroaryl-dihydropyridine and the use thereof for the treatment of cardiovascular diseases 有权3-氰基-5-硫杂杂环芳基 - 二氢吡啶及其用于治疗心血管疾病的用途公开(公告)号：US08404723B2
公开(公告)日：2013-03-26
申请号：US12442399
申请日：2007-09-08
IPC分类号： A61K31/4436 , C07D417/04
CPC分类号： C07D417/04 , C07D417/14
摘要： The present application relates to novel aryl-substituted 3-cyano-5-thiazolyl- and 3-cyano-5-thiadiazolyl-1,4-dihydropyridines, a process for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for the manufacture of medicaments for the treatment and/or prophylaxis of diseases, especially cardiovascular disorders.
摘要翻译： 本申请涉及新的芳基取代的3-氰基-5-噻唑基 - 和3-氰基-5-噻二唑基-1,4-二氢吡啶，其制备方法，它们用于治疗和/或预防疾病， 以及它们用于制备用于治疗和/或预防疾病，特别是心血管疾病的药物的用途。
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33.发明授权Heterocyclyl-substituted dihydroquinazolines and their use as antiviral agents 有权杂环取代的二氢喹唑啉及其作为抗病毒剂的用途公开(公告)号：US08343981B2
公开(公告)日：2013-01-01
申请号：US10556198
申请日：2004-04-28
申请人： Tobias Wunberg , Judith Baumeister , Mario Jeske , Peter Nell , Susanne Nikolic , Frank Suessmeier , Holger Zimmermann , Rolf Grosser , Kerstin Henninger , Guy Hewlett , Joerg Keldenich , Dieter Lang
发明人： Tobias Wunberg , Judith Baumeister , Mario Jeske , Peter Nell , Susanne Nikolic , Frank Suessmeier , Holger Zimmermann , Rolf Grosser , Kerstin Henninger , Guy Hewlett , Joerg Keldenich , Dieter Lang
IPC分类号： A01N43/54 , A61K31/517
CPC分类号： C07D487/04
摘要： The invention relates to heterocyclyl-substituted dihydroquinazolines of formula (I), to processes for their preparation, to medicaments containing them, and to methods for the treatment and/or prophylaxis of diseases, in particular, for use as anti-viral agents, in particular, against cytomegaloviruses.
摘要翻译： 本发明涉及式（I）的杂环基取代的二氢喹唑啉，其制备方法，含有它们的药物，以及用于治疗和/或预防疾病，特别是用作抗病毒剂的方法 特别是针对巨细胞病毒。
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公开(公告)号：US08314113B2
公开(公告)日：2012-11-20
申请号：US10579253
申请日：2004-10-28
申请人： Tobias Wunberg , Judith Baumeister , Mario Jeske , Peter Nell , Susanne Nikolic , Frank Suessmeier , Holger Zimmermann , Rolf Grosser , Guy Hewlett , Jorg Keldenich , Dieter Lang , Kerstin Henninger
发明人： Tobias Wunberg , Judith Baumeister , Mario Jeske , Peter Nell , Susanne Nikolic , Frank Suessmeier , Holger Zimmermann , Rolf Grosser , Guy Hewlett , Jorg Keldenich , Dieter Lang , Kerstin Henninger
IPC分类号： A01N43/54 , A61K31/517
CPC分类号： C07D401/04
摘要： The invention relates to substituted dihydroquinazolines and to a method for the production thereof, the use thereof for treating and/or preventing diseases and for producing drugs for treating and/or preventing diseases, in particular for the use of the inventive dihydroquinazolines in the form of antiviral agents, in particular against cytomegaloviruses.
摘要翻译： 本发明涉及取代的二氢喹唑啉及其制备方法，其用于治疗和/或预防疾病和用于生产用于治疗和/或预防疾病的药物的用途，特别是用于本发明的二氢喹唑啉 抗病毒剂，特别是针对巨细胞病毒。
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35.发明申请3-Cyano-5-thiazaheteroaryl-dihydropyridine and the use thereof for the treatment of cardiovascular diseases 有权3-氰基-5-硫杂杂环芳基 - 二氢吡啶及其用于治疗心血管疾病的用途公开(公告)号：US20100240620A1
公开(公告)日：2010-09-23
申请号：US12442399
申请日：2007-09-08
IPC分类号： A61K31/60 , C07D417/04 , A61K31/4439 , A61P5/42 , A61P9/12 , A61P9/04 , A61P9/10 , A61P13/12 , A61P1/16 , C07D417/14 , A61K31/444 , A61K31/4709
CPC分类号： C07D417/04 , C07D417/14
摘要： The present application relates to novel aryl-substituted 3-cyano-5-thiazolyl- and 3-cyano-5-thiadiazolyl-1,4-dihydropyridines, a process for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for the manufacture of medicaments for the treatment and/or prophylaxis of diseases, especially cardiovascular disorders.
摘要翻译： 本申请涉及新的芳基取代的3-氰基-5-噻唑基 - 和3-氰基-5-噻二唑基-1,4-二氢吡啶，其制备方法，它们用于治疗和/或预防疾病， 以及它们用于制备用于治疗和/或预防疾病，特别是心血管疾病的药物的用途。
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36.发明申请SUBSTITUTED 7-SULFANYLMETHYL-, 7-SULFINYLMETHYL- AND 7-SULFONYLMETHYLINDOLES AND THE USE THEREOF 失效取代的7-磺基甲基 - ，7-磺酰基甲基和7-磺酰基甲基和其用途公开(公告)号：US20100105744A1
公开(公告)日：2010-04-29
申请号：US12490333
申请日：2009-06-24
申请人： Peter Kolkhof , Astrid Brüns , Kai Thede , Karl-Heinz Schlemmer , Alexander Hillisch , Dieter Lang , Michael Gerisch , Andreas Göller , Rolf Grosser , Carsten Schmeck , Elisabeth Woltering , Olaf Prien , Holger Paulsen , Armin Kern
发明人： Peter Kolkhof , Astrid Brüns , Kai Thede , Karl-Heinz Schlemmer , Alexander Hillisch , Dieter Lang , Michael Gerisch , Andreas Göller , Rolf Grosser , Carsten Schmeck , Elisabeth Woltering , Olaf Prien , Holger Paulsen , Armin Kern
IPC分类号： A61K31/404 , C07D209/04 , C07D277/22 , A61K31/427 , A61P5/42
CPC分类号： C07D209/10 , C07D209/12 , C07D209/18 , C07D405/06 , C07D409/06
摘要： The present application relates to novel 7-sulfanylmethyl-, 7-sulfinylmethyl- and 7-sulfonylmethylindole derivatives, processes for the preparation thereof, the use thereof alone or in combinations for the treatment and/or prevention of diseases, and the use thereof for the manufacture of medicaments for the treatment and/or prevention of diseases, especially for the treatment and/or prevention of cardiovascular disorders.
摘要翻译： 本申请涉及新的7-硫基甲基 - ，7-亚磺酰基甲基 - 和7-磺酰基甲基吲哚衍生物，其制备方法，其单独使用或组合用于治疗和/或预防疾病的用途，以及其用于 制造用于治疗和/或预防疾病的药物，特别是用于治疗和/或预防心血管疾病。
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37.发明申请5-ARYL-SUBSTITUTED DIHYDROPYRIDOPYRIMIDINES AND DIHYDROPYRIDAZINES AND USE THEREOF AS MINERAL CORTICOID ANTAGONISTS 有权5-ARYL取代的二氢吡啶并嘧啶和二羟基吡啶并将其用作矿物质抗坏血酸公开(公告)号：US20100035902A1
公开(公告)日：2010-02-11
申请号：US12303369
申请日：2007-05-25
申请人： Santiago Figueroa Perez , Peter Kolkhof , Lars Bärfacker , Ingo Flamme , Karl-Heinz Schlemmer , Alexander Kuhl , Rolf Grosser , Klaus Münter , Andreas Knorr
发明人： Santiago Figueroa Perez , Peter Kolkhof , Lars Bärfacker , Ingo Flamme , Karl-Heinz Schlemmer , Alexander Kuhl , Rolf Grosser , Klaus Münter , Andreas Knorr
IPC分类号： A61K31/519 , C07D471/04 , A61P9/10 , A61P9/12
CPC分类号： C07D471/04
摘要： The present application relates to novel aryl-substituted heterobicyclic compounds, a process for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for the manufacture of medicaments for the treatment and/or prophylaxis of diseases, especially cardiovascular disorders.
摘要翻译： 本申请涉及新的芳基取代的杂双环化合物，其制备方法，其用于治疗和/或预防疾病的用途及其用于制备用于治疗和/或预防疾病尤其是心血管疾病的药物的用途 疾病
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38.发明申请Optically active 2,5-bisaryl-delta¹ -pyrrolines and their use as pest control agents 审中-公开光活性2,5-二芳基-δ-吡咯啉及其作为害虫防治剂的用途公开(公告)号：US20090012144A1
公开(公告)日：2009-01-08
申请号：US12220723
申请日：2008-07-28
申请人： Andrew Plant , Thomas Geller , Bernd Gallenkamp , Rolf Grosser , Albrecht Marhold , Christoph Erdelen , Andreas Turberg , Olaf Hansen
发明人： Andrew Plant , Thomas Geller , Bernd Gallenkamp , Rolf Grosser , Albrecht Marhold , Christoph Erdelen , Andreas Turberg , Olaf Hansen
IPC分类号： A01N37/52 , C07D207/18 , C07C269/00 , C07D207/00
CPC分类号： C07D207/27 , A01N43/36 , A01N47/02 , A01N47/16 , A01N55/00 , C07B2200/07 , C07C271/18 , C07C309/65 , C07D207/20 , C07D207/26 , C07F5/025 , C07F7/1804
摘要： Novel optically active Δ1-pyrrolines of the formula (I) in which R1, R2, R3, R4, and m are each as defined in the description, a plurality of the processes for preparing these substances and their use for controlling pests.
摘要翻译： 其中R1，R2，R3，R4和m各自如说明书中所定义的式（I）的新型光学活性Delta1-吡咯啉，多种制备这些物质的方法及其用于防治害虫的方法。
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![(-)-Enantiomer of the 2-[2-(1-chloro-cyclopropyl)-3-(2-chlorophenyl)-2-hydroxypropyl]-2,4-dihydro-[1,2,4]-triazole-3-thione](/abs-image/US/2008/05/15/US20080113864A1/abs.jpg.150x150.jpg)
39.发明申请(-)-Enantiomer of the 2-[2-(1-chloro-cyclopropyl)-3-(2-chlorophenyl)-2-hydroxypropyl]-2,4-dihydro-[1,2,4]-triazole-3-thione 有权（ - ） - 2- [2-（1-氯 - 环丙基）-3-（2-氯苯基）-2-羟丙基] -2,4-二氢 - [1,2,4] - 三唑-3 - 硫酮公开(公告)号：US20080113864A1
公开(公告)日：2008-05-15
申请号：US11981050
申请日：2007-10-31
申请人： Rolf Grosser , Manfred Jautelat , Astrid Mauler-Machnik , Stefan Dutzmann , Gerd Hanssler , Klaus Stenzel
发明人： Rolf Grosser , Manfred Jautelat , Astrid Mauler-Machnik , Stefan Dutzmann , Gerd Hanssler , Klaus Stenzel
IPC分类号： A01N43/653 , C07D249/12 , A01P3/00 , A01P13/00 , A01P1/00
CPC分类号： C07D249/12 , A01N43/653
摘要： A novel (−)-enantiomer of 2-[2-(1-chloro-cyclopropyl)-3-(2-chloro-phenyl)-2-hydroxypropyl]-2,4-dihydro-[1,2,4]-triazole-3-thione of the formula a process for preparing this novel active compound and its use as microbicide in crop protection and in the protection of materials.
摘要翻译： 2- [2-（1-氯 - 环丙基）-3-（2-氯 - 苯基）-2-羟丙基] -2,4-二氢 - [1,2,4] - 三唑-3-硫酮的制备方法，该方法用于制备该新型活性化合物及其作为杀菌剂在作物保护和材料保护中的用途。
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公开(公告)号：US20070281953A1
公开(公告)日：2007-12-06
申请号：US10579253
申请日：2004-10-28
申请人： Tobias Wunberg , Judith Baumeister , Mario Jeske , Peter Nell , Susanne Nikolic , Frank Sussmeier , Holger Zimmermann , Rolf Grosser , Guy Hewlett , Jorg Keldenich , Dieter Lang , Kerstin Henninger
发明人： Tobias Wunberg , Judith Baumeister , Mario Jeske , Peter Nell , Susanne Nikolic , Frank Sussmeier , Holger Zimmermann , Rolf Grosser , Guy Hewlett , Jorg Keldenich , Dieter Lang , Kerstin Henninger
IPC分类号： A61K31/517 , A61P31/12 , C07D239/72 , C07D401/04
CPC分类号： C07D401/04
摘要： The invention relates to substituted dihydroquinazolines and to a method for the production thereof, the use thereof for treating and/or preventing diseases and for producing drugs for treating and/or preventing diseases, in particular for the use of the inventive dihydroquinazolines in the form of antiviral agents, in particular against cytomegaloviruses.
摘要翻译： 本发明涉及取代的二氢喹唑啉及其制备方法，其用于治疗和/或预防疾病和用于生产用于治疗和/或预防疾病的药物的用途，特别是用于本发明的二氢喹唑啉 抗病毒剂，特别是针对巨细胞病毒。
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