-
公开(公告)号：US06534302B1
公开(公告)日：2003-03-18
申请号：US09773426
申请日：2001-01-31
IPC分类号： C12P2104
摘要： The present invention relates to newly identified human sulfatases. In particular, the invention relates to sulfatase polypeptides and polynucleotides, methods of detecting the sulfatase polypeptides and polynucleotides, and methods of diagnosing and treating sulfatase-related disorders. Also provided are vectors, host cells, and recombinant methods for making and using the novel molecules.
摘要翻译： 本发明涉及新鉴定的人类硫酸酯酶。 特别地，本发明涉及硫酸酯酶多肽和多核苷酸，检测硫酸酯酶多肽和多核苷酸的方法，以及诊断和治疗硫酸酯酶相关病症的方法。 还提供了用于制备和使用新分子的载体，宿主细胞和重组方法。
-
公开(公告)号：US07045325B2
公开(公告)日：2006-05-16
申请号：US10664506
申请日：2003-09-17
CPC分类号： C12N9/0004 , C07K2319/00 , C12N9/0006
摘要： The invention provides isolated nucleic acids molecules, designated DHDR nucleic acid molecules, which encode novel DHDR-related dehydrogenase molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing DHDR nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a DHDR gene has been introduced or disrupted. The invention still further provides isolated DHDR proteins, fusion proteins, antigenic peptides and anti-DHDR antibodies. Diagnostic methods utilizing compositions of the invention are also provided.
-
公开(公告)号：US06627423B2
公开(公告)日：2003-09-30
申请号：US09838561
申请日：2001-04-18
IPC分类号： C12N904
CPC分类号： C12N9/0004 , C07K2319/00 , C12N9/0006
摘要： The invention provides isolated nucleic acids molecules, designated DHDR nucleic acid molecules, which encode novel DHDR-related dehydrogenase molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing DHDR nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a DHDR gene has been introduced or disrupted. The invention still further provides isolated DHDR proteins, fusion proteins, antigenic peptides and anti-DHDR antibodies. Diagnostic methods utilizing compositions of the invention are also provided.
摘要翻译： 本发明提供编码新型DHDR相关脱氢酶分子的分离的核酸分子，命名为DHDR核酸分子。 本发明还提供了反义核酸分子，含有DHDR核酸分子的重组表达载体，其中引入了表达载体的宿主细胞，以及DHDR基因导入或破坏的非人类转基因动物。 本发明还进一步提供了分离的DHDR蛋白，融合蛋白，抗原肽和抗DHDR抗体。 还提供了利用本发明组合物的诊断方法。
-
34.发明申请32142,21481,25964,21686, Novel dehydrogenase molecules and uses therefor 审中-公开32142,21481,25964,21686，新型脱氢酶分子及其用途公开(公告)号：US20100092941A1
公开(公告)日：2010-04-15
申请号：US12316383
申请日：2008-12-10
IPC分类号： C12Q1/70 , C07H21/00 , C12N15/63 , C12N5/00 , C12N1/00 , C12P21/00 , C07K7/08 , C07K14/00 , C07K16/00 , G01N33/53 , G01N33/68 , C12Q1/02
CPC分类号： C12N9/0004 , C07K2319/00 , C12N9/0006
摘要： The invention provides isolated nucleic acids molecules, designated DHDR nucleic acid molecules, which encode novel DHDR-related dehydrogenase molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing DHDR nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a DHDR gene has been introduced or disrupted. The invention still further provides isolated DHDR proteins, fusion proteins, antigenic peptides and anti-DHDR antibodies. Diagnostic methods utilizing compositions of the invention are also provided.
摘要翻译： 本发明提供编码新型DHDR相关脱氢酶分子的分离的核酸分子，命名为DHDR核酸分子。 本发明还提供了反义核酸分子，含有DHDR核酸分子的重组表达载体，其中引入了表达载体的宿主细胞，以及DHDR基因导入或破坏的非人类转基因动物。 本发明还进一步提供了分离的DHDR蛋白，融合蛋白，抗原肽和抗DHDR抗体。 还提供了利用本发明组合物的诊断方法。
-
公开(公告)号：US20070172493A1
公开(公告)日：2007-07-26
申请号：US11725949
申请日：2007-03-20
申请人： Rachel Meyers , Martin Hodge , Mark Williamson
发明人： Rachel Meyers , Martin Hodge , Mark Williamson
CPC分类号： C12N9/1205 , A61K38/00 , A61K48/00 , C07K16/40 , C12Q1/6886 , C12Q2600/136
摘要： Novel human kinase-like polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated, full-length kinase-like proteins, the invention further provides isolated kinase-like fusion proteins, antigenic peptides, and anti-kinase-like antibodies. The invention also provides kinase-like nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a kinase-like gene has been introduced or disrupted. Diagnostic, screening, and therapeutic methods utilizing compositions of the invention are also provided.
-
36.发明申请公开(公告)号：US20050203049A1
公开(公告)日：2005-09-15
申请号：US11120749
申请日：2005-05-03
申请人： Rachel Meyers , Mark Williamson
发明人： Rachel Meyers , Mark Williamson
CPC分类号： C12N9/1048 , A61K38/00
摘要： The invention provides isolated nucleic acids molecules, designated 47169 and 33935 nucleic acid molecules, which encode novel glycosyl transferases. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 47169 and 33935 nucleic acid molecules, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a 47169 or 33935 gene has been introduced or disrupted. The invention still further provides isolated 47169 and 33935 proteins, fusion proteins, antigenic peptides and anti-47169 and anti-33935 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.
摘要翻译： 本发明提供编码新的糖基转移酶的分离的核酸分子，命名为47169和33935核酸分子。 本发明还提供了反义核酸分子，含有47169和33935核酸分子的重组表达载体，其中引入了表达载体的宿主细胞，以及引入或破坏了47169或33935基因的非人转基因动物。 本发明还进一步提供分离的47169和33935蛋白，融合蛋白，抗原肽和抗-47169和抗-33935抗体。 还提供了利用本发明组合物的诊断方法。
-
公开(公告)号：US07214374B2
公开(公告)日：2007-05-08
申请号：US10682739
申请日：2003-10-09
申请人： Rachel Meyers , Martin R. Hodge , Mark Williamson
发明人： Rachel Meyers , Martin R. Hodge , Mark Williamson
CPC分类号： C12N9/1205 , A61K38/00 , A61K48/00 , C07K16/40 , C12Q1/6886 , C12Q2600/136
摘要： Novel human kinase-like polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated, full-length kinase-like proteins, the invention further provides isolated kinase-like fusion proteins, antigenic peptides, and anti-kinase-like antibodies. The invention also provides kinase-like nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a kinase-like gene has been introduced or disrupted. Diagnostic, screening, and therapeutic methods utilizing compositions of the invention are also provided.
摘要翻译： 公开了新的人激酶样多肽，蛋白质和核酸分子。 除了分离的全长激酶样蛋白之外，本发明还提供了分离的激酶样融合蛋白，抗原肽和抗激酶样抗体。 本发明还提供激酶样核酸分子，含有本发明的核酸分子的重组表达载体，已经引入了表达载体的宿主细胞和其中已经引入或破坏了类似激酶的基因的非人类转基因动物 。 还提供了利用本发明组合物的诊断，筛选和治疗方法。
-
公开(公告)号：US06656698B1
公开(公告)日：2003-12-02
申请号：US09562480
申请日：2000-05-01
申请人： Rachel Meyers , Martin R. Hodge , Mark Williamson
发明人： Rachel Meyers , Martin R. Hodge , Mark Williamson
IPC分类号： C12Q148
CPC分类号： C12N9/1205 , A61K38/00 , A61K48/00 , C07K16/40 , C12Q1/6886 , C12Q2600/136
摘要： Novel human kinase-like polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated, full-length kinase-like proteins, the invention further provides isolated kinase-like fusion proteins, antigenic peptides, and anti-kinase-like antibodies. The invention also provides kinase-like nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a kinase-like gene has been introduced or disrupted. Diagnostic, screening, and therapeutic methods utilizing compositions of the invention are also provided.
摘要翻译： 公开了新的人激酶样多肽，蛋白质和核酸分子。 除了分离的全长激酶样蛋白之外，本发明还提供了分离的激酶样融合蛋白，抗原肽和抗激酶样抗体。 本发明还提供激酶样核酸分子，含有本发明的核酸分子的重组表达载体，已经引入了表达载体的宿主细胞和其中已经引入或破坏了类似激酶的基因的非人类转基因动物 。 还提供了利用本发明组合物的诊断，筛选和治疗方法。
-
39.发明授权32142, 21481, 25964, 21686, novel human dehydrogenase molecules and uses therefor 有权32142,21481,25964,21686，新型人脱氢酶分子及其用途公开(公告)号：US06613555B2
公开(公告)日：2003-09-02
申请号：US09816760
申请日：2001-03-23
IPC分类号： C12N904
CPC分类号： C12N9/0004 , C07K2319/00
摘要： The invention provides isolated nucleic acids molecules, designated DHDR nucleic acid molecules, which encode novel DHDR-related dehydrogenase molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing DHDR nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a DHDR gene has been introduced or disrupted. The invention still further provides isolated DHDR proteins, fusion proteins, antigenic peptides and anti-DHDR antibodies. Diagnostic methods utilizing compositions of the invention are also provided.
摘要翻译： 本发明提供编码新型DHDR相关脱氢酶分子的分离的核酸分子，命名为DHDR核酸分子。 本发明还提供了反义核酸分子，含有DHDR核酸分子的重组表达载体，其中引入了表达载体的宿主细胞，以及DHDR基因导入或破坏的非人类转基因动物。 本发明还进一步提供了分离的DHDR蛋白，融合蛋白，抗原肽和抗DHDR抗体。 还提供了利用本发明组合物的诊断方法。
-
公开(公告)号：US06500657B1
公开(公告)日：2002-12-31
申请号：US09584568
申请日：2000-05-31
IPC分类号： C12N914
摘要： The invention provides isolated nucleic acids molecules, designated HYDL-1 nucleic acid molecules, which encode novel hydrolase molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing HYDL-1 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which an HYDL-1 gene has been introduced or disrupted. The invention still further provides isolated HYDL-1 proteins, fusion proteins, antigenic peptides and anti-HYDL-1 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.
摘要翻译： 本发明提供编码新的水解酶分子的分离的核酸分子，命名为HYDL-1核酸分子。 本发明还提供了反义核酸分子，含有HYDL-1核酸分子的重组表达载体，其中引入了表达载体的宿主细胞，以及HYDL-1基因被引入或被破坏的非人类转基因动物。 本发明还进一步提供了分离的HYDL-1蛋白，融合蛋白，抗原肽和抗HYDL-1抗体。 还提供了利用本发明组合物的诊断方法。
-
-
-
-
-
-
-
-
-
搜索结果
72 条记录 (耗时 0.055 秒)
