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31.发明申请Postpartum cells derived from placental tissue, and methods of making, culturing, and using the same 审中-公开来自胎盘组织的产后细胞，以及制造，培养和使用胎盘组织的方法公开(公告)号：US20060166361A1
公开(公告)日：2006-07-27
申请号：US11297778
申请日：2005-12-08
申请人： Agnieszka Seyda , Anna Gosiewska
发明人： Agnieszka Seyda , Anna Gosiewska
IPC分类号： C12N5/08
CPC分类号： C12N5/0605 , C12N5/0607 , C12N2502/02 , C12N2506/02 , C12N2506/03 , C12N2533/30 , C12N2533/40 , C12N2539/10
摘要： Cells derived from postpartum placenta and methods for their isolation are provided by the invention. The invention further provides cultures and compositions of the placenta-derived cells. The placenta-derived cells of the invention have a plethora of uses, including but not limited to research, diagnostic, and therapeutic applications.
摘要翻译： 由产后胎盘衍生的细胞及其分离方法由本发明提供。 本发明还提供了胎盘衍生细胞的培养物和组合物。 本发明的胎盘衍生细胞具有许多用途，包括但不限于研究，诊断和治疗应用。
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公开(公告)号：US20100158880A1
公开(公告)日：2010-06-24
申请号：US12642773
申请日：2009-12-19
申请人： Agnieszka Seyda , Anna Gosiewska
发明人： Agnieszka Seyda , Anna Gosiewska
CPC分类号： C12N5/0605 , A61K35/12 , C12N5/0668
摘要： Methods, pharmaceutical compositions and kits for regenerating or repairing neural tissue, decreasing apoptosis and improving neurological function following injury are disclosed.
摘要翻译： 公开了用于再生或修复神经组织的药物组合物和试剂盒，减少细胞凋亡并改善损伤后的神经功能。
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33.发明申请Human Umbilical Tissue-Derived Cell Compositions for the Treatment of Incontinence 审中-公开用于治疗失禁的人脐带组织衍生的细胞组合物公开(公告)号：US20080311087A1
公开(公告)日：2008-12-18
申请号：US12133792
申请日：2008-06-05
CPC分类号： A61K35/44 , A61K9/0019 , A61K47/34
摘要： Compositions for the treatment of incontinence are disclosed. More particularly, compositions of human umbilical tissue-derived cells and a carrier are disclosed. The compositions are useful in the treatment urinary and fecal incontinence.
摘要翻译： 公开了治疗失禁的组合物。 更具体地，公开了人脐带组织衍生细胞和载体的组合物。 该组合物可用于治疗尿失禁和大便失禁。
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34.发明申请公开(公告)号：US20060153815A1
公开(公告)日：2006-07-13
申请号：US11304091
申请日：2005-12-15
申请人： Agnieszka Seyda , David Colter , Charito Buensuceso , Sridevi Dhanaraj , Anna Gosiewska , Jeffrey Geesin , Angelo Scopelianos
发明人： Agnieszka Seyda , David Colter , Charito Buensuceso , Sridevi Dhanaraj , Anna Gosiewska , Jeffrey Geesin , Angelo Scopelianos
CPC分类号： C12N5/0068 , A61L27/3604 , A61L27/38 , C12N2533/40
摘要： Tissue engineering devices for use in the repair or regeneration of tissue made of support scaffolds and cell sheets.
摘要翻译： 用于修复或再生由支撑支架和细胞片组成的组织的组织工程装置。
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公开(公告)号：US20080311219A1
公开(公告)日：2008-12-18
申请号：US12133770
申请日：2008-06-05
CPC分类号： A61K35/34 , A61L27/3604 , A61L27/367 , A61L27/3679
摘要： Compositions for the treatment of incontinence are disclosed. More particularly, compositions of viable muscle tissue fragments and a carrier are disclosed. The compositions are useful in the treatment urinary and fecal incontinence.
摘要翻译： 公开了治疗失禁的组合物。 更具体地，公开了活肌组织碎片和载体的组合物。 该组合物可用于治疗尿失禁和大便失禁。
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36.发明申请KIDNEY-DERIVED CELLS AND METHODS OF USE IN TISSUE REPAIR AND REGENERATION 审中-公开KIDNEY衍生细胞和组织修复和再生中的使用方法公开(公告)号：US20080112939A1
公开(公告)日：2008-05-15
申请号：US11871045
申请日：2007-10-11
CPC分类号： A61K35/22 , A61K35/12 , C12N5/0686 , C12N5/0687 , C12N2533/40
摘要： Isolated or purified mammalian kidney-derived cell populations from mammalian kidney tissue are provided. Methods are provided for the isolation and purification of the mammalian kidney-derived cell population. Methods for treating kidney disease are provided by administration of the isolated or purified mammalian kidney-derived cell population to a mammalian subject.
摘要翻译： 提供来自哺乳动物肾组织的分离或纯化的哺乳动物肾源细胞群。 提供了用于分离和纯化哺乳动物肾源细胞群体的方法。 通过向哺乳动物受试者施用分离或纯化的哺乳动物肾来源的细胞群来提供治疗肾脏疾病的方法。
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37.发明申请Postpartum cells derived from umbilical cord tissue, and methods of making, culturing, and using the same 审中-公开来自脐带组织的产后细胞，以及制造，培养和使用它们的方法公开(公告)号：US20060171930A1
公开(公告)日：2006-08-03
申请号：US11297156
申请日：2005-12-08
申请人： Agnieszka Seyda , Anna Gosiewska
发明人： Agnieszka Seyda , Anna Gosiewska
CPC分类号： A61L27/3641 , A61L27/18 , A61L27/3604 , A61L27/3839 , C12N5/0068 , C12N5/0654 , C12N5/0655 , C12N5/0691 , C12N2533/40 , C12N2533/50 , C08L67/04
摘要： Cells derived from human umbilical cords are disclosed along with methods for their therapeutic use. Isolation techniques, culture methods and detailed characterization of the cells with respect to their cell surface markers, gene expression, and their secretion of trophic factors are described.
摘要翻译： 公开了源自人脐带的细胞及其治疗用途的方法。 描述了相对于其细胞表面标志物的细胞的分离技术，培养方法和详细表征，基因表达及其营养因子的分泌。
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38.发明申请Postpartum cells derived from umbilical cord tissue, and methods of making and using the same 审中-公开来自脐带组织的产后细胞，以及制造和使用它们的方法公开(公告)号：US20060223177A1
公开(公告)日：2006-10-05
申请号：US11315897
申请日：2005-12-22
申请人： Ian Harris , Darin Messina , Anthony Kihm , Agnieszka Seyda , David Colter
发明人： Ian Harris , Darin Messina , Anthony Kihm , Agnieszka Seyda , David Colter
CPC分类号： C12N5/0607 , C12N5/0619 , C12N2500/32 , C12N2500/90 , C12N2501/11 , C12N2501/115 , C12N2501/119 , C12N2501/135 , C12N2506/03
摘要： Cells derived from human umbilical cords are disclosed along with methods for their therapeutic use. Isolation techniques, culture methods and detailed characterization of the cells with respect to their cell surface markers, gene expression, and their secretion of trophic factors are described.
摘要翻译： 公开了源自人脐带的细胞及其治疗用途的方法。 描述了相对于其细胞表面标志物的细胞的分离技术，培养方法和详细表征，基因表达及其营养因子的分泌。
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公开(公告)号：US11179422B2
公开(公告)日：2021-11-23
申请号：US11315969
申请日：2005-12-22
申请人： Laura Brown , Sridevi Dhanaraj , Agnieszka Seyda
发明人： Laura Brown , Sridevi Dhanaraj , Agnieszka Seyda
IPC分类号： A61K48/00 , A61K35/51 , C12N5/074 , C12N5/073 , A61K38/18 , A61K38/19 , A61K38/20 , A61K38/27 , C12N5/0735 , A61K35/50 , A61K35/12
摘要： Cells derived from postpartum tissue and methods for their isolation and induction to differentiate to cells of a chondrogenic or osteogenic phenotype are provided by the invention. The invention further provides cultures and compositions of the postpartum-derived cells and products such as lysates related thereto. The postpartum-derived cells of the invention and products related thereto have a plethora of uses, including but not limited to research, diagnostic, and therapeutic applications, for example, in the treatment of bone and cartilage conditions such as osteoarthritis.
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公开(公告)号：US08734527B2
公开(公告)日：2014-05-27
申请号：US12337413
申请日：2008-12-17
CPC分类号： A61K35/22 , A61K9/0024 , A61K9/1652 , A61K9/48 , A61K35/12 , A61L27/34 , A61L27/3604 , A61L27/365 , A61L27/3683
摘要： Provided are therapeutic implants comprising renal tissue encapsulated within a polymer bead. Also disclosed are methods for treating a disease state in a subject comprising implanting within said subject a therapeutic implant comprising renal tissue encapsulated within a polymer bead. Also provided are methods for making a therapeutic implant comprising: providing renal tissue; mixing the renal tissue with a solution comprising a polymer, thereby forming a tissue-polymer suspension; extruding the tissue-polymer suspension into an bead-forming solution, thereby forming a therapeutic implant comprising beads of said polymer within which the renal tissue is encapsulated.
摘要翻译： 提供包含包封在聚合物珠内的肾组织的治疗性植入物。 还公开了用于治疗受试者的疾病状态的方法，包括在所述受试者内植入包含封装在聚合物珠内的肾组织的治疗性植入物。 还提供了用于制备治疗性植入物的方法，包括：提供肾组织; 将肾组织与包含聚合物的溶液混合，由此形成组织 - 聚合物悬浮液; 将组织 - 聚合物悬浮液挤出成珠形成溶液，从而形成治疗性植入物，其包含所述聚合物的珠粒，肾组织在其中被包封。
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