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57 条记录 (耗时 0.051 秒)

    ANTI-IGA1 ANTIBODY
    36.
    发明申请
    ANTI-IGA1 ANTIBODY 审中-公开
    ANTI-IGA1抗体

    公开(公告)号：US20130059318A1

    公开(公告)日：2013-03-07

    申请号：US13519696

    申请日：2010-12-28

    申请人： Etsuji Kaneko ,  Yuka Sasaki ,  Katsuhiro Mori ,  Yutaka Kanda ,  Mitsuo Satoh

    发明人： Etsuji Kaneko ,  Yuka Sasaki ,  Katsuhiro Mori ,  Yutaka Kanda ,  Mitsuo Satoh

    IPC分类号： C07K16/42 ,  C12N5/12 ,  C12N15/63 ,  G01N33/577 ,  C12N1/19 ,  C12N5/10 ,  C12P21/08 ,  C12N15/13 ,  C12N1/21

    CPC分类号： C07K16/4283 ,  C07K2317/34 ,  C07K2317/92 ,  G01N2800/34

    摘要： An object of the present invention is to provide a monoclonal antibody which is effective for diagnosing IgA nephropathy and specifically recognizes and binds to a hinge region of a polypeptide encoded by a heavy chain gene of immunoglobulin A1 that comprises a serine/threonine-linked sugar chain to which galactose is not bound. According to the present invention, it is possible to provide a monoclonal antibody or an antibody fragment thereof that specifically recognizes and binds to a hinge region of a polypeptide encoded by a heavy chain gene of immunoglobulin A1 that comprises a serine/threonine-linked sugar chain to which galactose is not bound, to provide a diagnostic agent using the antibody or the antibody fragment thereof, and to provide a therapeutic agent comprising the antibody or the antibody fragment thereof as an active ingredient.

    摘要翻译： 本发明的目的是提供一种单克隆抗体，该单克隆抗体对于诊断IgA肾病是有效的，并特异性识别并结合由包含丝氨酸/苏氨酸连接的糖链的免疫球蛋白A1的重链基因编码的多肽的铰链区 半乳糖不结合。 根据本发明，可以提供特异性识别并结合由包含丝氨酸/苏氨酸连接的糖链的免疫球蛋白A1的重链基因编码的多肽的铰链区的单克隆抗体或其抗体片段 使用抗体或其抗体片段提供诊断剂，并提供包含抗体或其抗体片段的治疗剂作为活性成分。

    Camera film stop position adjusting mechanism
    39.
    发明授权
    Camera film stop position adjusting mechanism 失效
    相机胶片停止位置调整机构

    公开(公告)号：US4236800A

    公开(公告)日：1980-12-02

    申请号：US59701

    申请日：1979-07-23

    申请人： Mitsuo Satoh

    发明人： Mitsuo Satoh

    IPC分类号： G03B1/00 ,  G03B1/14 ,  G03B1/62 ,  G03B17/00 ,  G03B17/42

    CPC分类号： G03B1/62 ,  G03B1/14

    摘要： A film stop position adjusting mechanism with a stop lever (3) having a stop pawl (3a) engaged with a ratchet gear (2) and adapted to stop the feeding of a film. A ratchet releasing lever (7) holds the stop lever (3) at a release position, with the ratchet releasing lever having a bent portion (7a) and an extended portion (7b). A locking lever (11) has a step (11a) which engages the bent portion (7a) of the ratchet releasing lever to lock the ratchet releasing lever (7). A detection lever has a protrusion (15a) which is inserted into a perforation of the film to detect a film stop position, and an arm (15b) having a straight edge substantially perpendicular to a film feeding direction. The locking lever (11) is provided with an eccentric pin (10) whose position can be adjusted by rotation. The eccentric pin (10) is engaged with an arm (15b) of the detection lever adapted to detect a film stop position by inserting the protrusion (15a) into a film perforation. The film stop position is adjusted by changing the timing at which the step (11a) is disengaged from the bent portion (7a).

    摘要翻译： 一种具有止动杆（3）的胶片停止位置调节机构，其具有与棘轮（2）接合并适于停止胶片馈送的止动爪（3a）。 棘轮释放杆（7）将止动杆（3）保持在释放位置，棘轮释放杆具有弯曲部分（7a）和延伸部分（7b）。 锁定杆（11）具有与棘轮释放杆的弯曲部分（7a）接合以锁定棘轮释放杆（7）的台阶（11a）。 检测杆具有插入到胶片的穿孔中以检测胶片停止位置的突起（15a）和具有与胶片输送方向基本垂直的直边缘的臂（15b）。 锁定杆（11）设置有偏心销（10），其位置可以通过旋转来调节。 偏心销（10）与检测杆的臂（15b）接合，适于通过将突起（15a）插入薄膜穿孔中来检测胶片停止位置。 通过改变步骤（11a）与弯曲部分（7a）脱离的时间来调整胶片停止位置。

    Anti-CD27 antibody
    40.
    发明授权
    Anti-CD27 antibody 有权
    抗CD27抗体

    公开(公告)号：US09023999B2

    公开(公告)日：2015-05-05

    申请号：US12494827

    申请日：2009-06-30

    申请人： Katsuhiro Mori ,  Naoko Hiura ,  Tsuguo Kubota ,  Akiko Furuya ,  Yutaka Kanda ,  Mitsuo Satoh

    发明人： Katsuhiro Mori ,  Naoko Hiura ,  Tsuguo Kubota ,  Akiko Furuya ,  Yutaka Kanda ,  Mitsuo Satoh

    IPC分类号： C07K16/00 ,  C12P19/00 ,  G01N33/53 ,  G01N33/574 ,  C07K16/28 ,  C12R1/91 ,  G01N33/68

    CPC分类号： G01N33/57484 ,  C07K16/2878 ,  C07K2317/24 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/734 ,  C07K2317/92 ,  C12R1/91 ,  G01N33/6863 ,  G01N2333/70578 ,  G01N2400/02 ,  G01N2800/347

    摘要： The present invention provides a monoclonal antibody which specifically recognizes CD27 containing an O-linked sugar chain to which galactose is not bound and binds to its extracellular region, or a method for using the same.The present invention can provide a monoclonal antibody or an antibody fragment thereof, which specifically recognizes a polypeptide encoded by CD27 gene containing an O-linked sugar chain to which galactose is not bound, and binds to its extracellular region; a hybridoma which produces the antibody; a DNA which encodes the antibody; a vector which comprises the DNA; a transformant obtainable by transforming the vector; a process for producing an antibody or an antibody fragment thereof using the hybridoma or the transformant; and a diagnostic agent or a therapeutic agent comprising the antibody or the antibody fragment thereof as an active ingredient.

    摘要翻译： 本发明提供一种单克隆抗体，其特异性识别含有O-连接的糖链的CD27，其中半乳糖不结合并结合到其胞外区域，或其使用方法。 本发明可以提供一种单克隆抗体或其抗体片段，该单克隆抗体或其抗体片段特异性识别由含有O-连接的糖链的CD27基因编码的多肽，其中半乳糖未结合到其上并结合其胞外区域; 产生抗体的杂交瘤; 编码抗体的DNA; 包含DNA的载体; 通过转化载体可获得的转化体; 使用杂交瘤或转化体生产抗体或其抗体片段的方法; 以及包含该抗体或其抗体片段作为有效成分的诊断剂或治疗剂。