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公开(公告)号：US5482937A
公开(公告)日：1996-01-09
申请号：US318971
申请日：1994-10-06
申请人： Kazuo Okano , Shuhei Miyazawa , Richard S. J. Clark , Shinya Abe , Tetsuya Kawahara , Naoyuki Shimomura , Osamu Asano , Hiroyuki Yoshimura , Mitsuaki Miyamoto , Yoshimori Sakuma , Kenzo Muramoto , Hiroshi Obaishi , Koukichi Harada , Hajime Tsunoda , Satoshi Katayama , Kouji Yamada , Shigeru Souda , Yoshimasa Machida , Kouichi Katayama , Isao Yamatsu
发明人： Kazuo Okano , Shuhei Miyazawa , Richard S. J. Clark , Shinya Abe , Tetsuya Kawahara , Naoyuki Shimomura , Osamu Asano , Hiroyuki Yoshimura , Mitsuaki Miyamoto , Yoshimori Sakuma , Kenzo Muramoto , Hiroshi Obaishi , Koukichi Harada , Hajime Tsunoda , Satoshi Katayama , Kouji Yamada , Shigeru Souda , Yoshimasa Machida , Kouichi Katayama , Isao Yamatsu
IPC分类号： C07D495/14 , C07D495/22 , C07F9/6561 , A61K31/55
CPC分类号： C07D495/14 , C07F9/6561
摘要： A triazolo-1,4-di-azepine compound of the below given formula and a pharmacologically acceptable salt thereof are useful in the pharmaceutical field, especially in treating allergic diseases. ##STR1## in which R.sup.1 and R.sup.2 are hydrogen or an alkyl, R.sup.3 is hydrogen or a halogen, R.sup.4 is hydrogen or an alkyl, X is --OCO--, and Y is a cycloalkyl, a cycloalkylalkyl, an alkynyl or others.
摘要翻译： 以下给定式的三唑并-1,4-二氮杂化合物及其药理学上可接受的盐可用于制药领域，特别是用于治疗过敏性疾病。 其中R1和R2是氢或烷基，R3是氢或卤素，R4是氢或烷基，X是-OCO-，Y是环烷基，环烷基烷基，炔基等。
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公开(公告)号：US5476864A
公开(公告)日：1995-12-19
申请号：US129302
申请日：1993-11-10
申请人： Kazuo Okano , Osamu Asano , Naoyuki Shimomura , Tetsuya Kawahara , Shinya Abe , Shuhei Miyazawa , Mitsuaki Miyamoto , Hiroyuki Yoshimura , Koukichi Harada , Junsaku Nagaoka , Tsutomu Kawata , Tsutomu Yoshimura , Hiromasa Suzuki , Shigeru Souda , Yoshimasa Machida , Kouichi Katayama , Isao Yamatsu
发明人： Kazuo Okano , Osamu Asano , Naoyuki Shimomura , Tetsuya Kawahara , Shinya Abe , Shuhei Miyazawa , Mitsuaki Miyamoto , Hiroyuki Yoshimura , Koukichi Harada , Junsaku Nagaoka , Tsutomu Kawata , Tsutomu Yoshimura , Hiromasa Suzuki , Shigeru Souda , Yoshimasa Machida , Kouichi Katayama , Isao Yamatsu
IPC分类号： C07D213/40 , C07D401/06 , C07D401/12 , C07D405/12 , A61K31/44 , C07D213/02
CPC分类号： C07D213/40 , C07D401/06 , C07D401/12 , C07D405/12
摘要： A glycerin derivative having the following formula (I) or (I') and a pharmacologically acceptable salt thereof are useful to treat diseases caused by the platelet activating factor. ##STR1##
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公开(公告)号：US5468740A
公开(公告)日：1995-11-21
申请号：US386533
申请日：1995-02-10
申请人： Kazuo Okano , Shuhei Miyazawa , Richard S. J. Clark , Shinya Abe , Tetsuya Kawahara , Naoyuki Shimomura , Osamu Asano , Hiroyuki Yoshimura , Mitsuaki Miyamoto , Yoshimori Sakuma , Kenzo Muramoto , Hiroshi Obaishi , Koukichi Harada , Hajime Tsunoda , Satoshi Katayama , Kouji Yamada , Shigeru Souda , Yoshimasa Machida , Kouichi Katayama , Isao Yamatsu
发明人： Kazuo Okano , Shuhei Miyazawa , Richard S. J. Clark , Shinya Abe , Tetsuya Kawahara , Naoyuki Shimomura , Osamu Asano , Hiroyuki Yoshimura , Mitsuaki Miyamoto , Yoshimori Sakuma , Kenzo Muramoto , Hiroshi Obaishi , Koukichi Harada , Hajime Tsunoda , Satoshi Katayama , Kouji Yamada , Shigeru Souda , Yoshimasa Machida , Kouichi Katayama , Isao Yamatsu
IPC分类号： C07D495/14 , C07D495/22 , C07F9/6561 , A61K31/675 , C07F9/00
CPC分类号： C07D495/14 , C07F9/6561
摘要： A triazolo-1,4-di-azepine compound of the below given formula and a pharmacologically acceptable salt thereof are disclosed and useful in the pharmaceutical field, especially to allergic diseases. ##STR1## in which R.sup.1 and R.sup.2 are hydrogen or an alkyl, R.sup.3 is hydrogen or a halogen, R.sup.4 is hydrogen or an alkyl, X is --OCO--, --NHCO--, --CO-- or others and Y is a cycloalkyl, a cycloalkylalkyl, an alkynyl or others.
摘要翻译： 公开了以下给定式的三唑并-1,4-二氮杂化合物及其药理学上可接受的盐，尤其适用于过敏性疾病。 其中R 1和R 2是氢或烷基，R 3是氢或卤素，R 4是氢或烷基，X是-OCO - ， - NHCO-，-CO-或其它，Y是环烷基， 环烷基烷基，炔基等。
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公开(公告)号：US5319139A
公开(公告)日：1994-06-07
申请号：US40026
申请日：1993-03-30
申请人： Hiroyuki Yoshimura , Shinya Abe , Tetsuya Kawahara , Naoyuki Shimomura , Kazuo Okano , Richard S. J. Clark , Takashi Mori , Shuhei Miyazawa , Ryoichi Hashida , Kenzo Muramoto , Koukichi Harada , Takashi Inoue , Hirsohi Shirota , Kenichi Chiba , Kenichi Kusube , Toru Horie , Takeshi Suzuki , Isao Yamatsu
发明人： Hiroyuki Yoshimura , Shinya Abe , Tetsuya Kawahara , Naoyuki Shimomura , Kazuo Okano , Richard S. J. Clark , Takashi Mori , Shuhei Miyazawa , Ryoichi Hashida , Kenzo Muramoto , Koukichi Harada , Takashi Inoue , Hirsohi Shirota , Kenichi Chiba , Kenichi Kusube , Toru Horie , Takeshi Suzuki , Isao Yamatsu
IPC分类号： A61K31/165 , A61K31/19 , A61K31/192 , A61K31/197 , A61K31/215 , A61K31/22 , A61K31/222 , A61K31/275 , A61P19/02 , A61P25/04 , A61P29/00 , A61P43/00 , C07C39/40 , C07C43/20 , C07C43/23 , C07C43/253 , C07C45/00 , C07C47/575 , C07C59/52 , C07C59/64 , C07C59/72 , C07C59/84 , C07C59/90 , C07C69/157 , C07C69/734 , C07C69/738 , C07C235/34 , C07C251/48 , C07C255/41 , C07C233/00
CPC分类号： C07C255/41 , C07C251/48 , C07C39/40 , C07C43/202 , C07C43/23 , C07C43/253 , C07C45/00 , C07C47/575 , C07C59/52 , C07C59/64 , C07C59/72 , C07C59/90 , C07C69/734 , C07C69/738 , C07C2101/08
摘要： Compounds of the formula: ##STR1## where R.sup.1 is a hydrogen atom or a lower alkyl group;R.sub.2 is a lower alkoxy group;R.sub.3 is a group ##STR2## Z is represented by the formula: ##STR3## where R.sub.2 and R.sub.3 may be the same or different from each other and each stands for a hydrogen atom or a lower alkyl;Y is represented by the formula: --(CH.sub.2).sub.n -- where n is 0 or an integer of 1 to 2 or a group represented by the formula: ##STR4## where R.sup.2 and R.sup.3 may be the same or different from each other and each stands for a lower alkyl group; andR.sup.4 represents a group of the formula: ##STR5## where p is 0 or an integer of 1 to 3 and R.sup.12 is hydrogen, a halogen atom, a lower alkyl or a lower alkoxy group a hydrogen atom, R.sup.2 is a methoxy group, R.sup.3 is a hydroxy group and R.sup.4 is a benzyl group having anti-inflammatory activity.
摘要翻译： 下式的化合物：其中R 1是氢原子或低级烷基; R2是低级烷氧基; R 3是一个基团Z由下式表示：其中R 2和R 3可以相同或不同，各代表氢原子或低级烷基; Y由下式表示： - （CH 2）n - 其中n为0或1至2的整数或由下式表示的基团：其中R 2和R 3可以彼此相同或不同， 代表低级烷基; 并且R 4表示下式的基团：其中p为0或1至3的整数，R 12为氢，卤素原子，低级烷基或低级烷氧基，氢原子，R 2为甲氧基， R3是羟基，R4是具有抗炎活性的苄基。
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公开(公告)号：US5304553A
公开(公告)日：1994-04-19
申请号：US68349
申请日：1993-05-28
申请人： Kazuo Okano , Shuhei Miyazawa , Richar S. J. Clark , Shinya Abe , Tetsuya Kawahara , Naoyuki Shimomura , Osamu Asano , Hiroyuki Yoshimura , Mitsuaki Miyamoto , Yoshimori Sakuma , Kenzo Muramoto , Hiroshi Obaishi , Koukichi Harada , Hajime Tsunoda , Satoshi Katayama , Kouji Yamada , Shigeru Souda , Yoshimasa Machida , Kouichi Katayama , Isao Yamatsu
发明人： Kazuo Okano , Shuhei Miyazawa , Richar S. J. Clark , Shinya Abe , Tetsuya Kawahara , Naoyuki Shimomura , Osamu Asano , Hiroyuki Yoshimura , Mitsuaki Miyamoto , Yoshimori Sakuma , Kenzo Muramoto , Hiroshi Obaishi , Koukichi Harada , Hajime Tsunoda , Satoshi Katayama , Kouji Yamada , Shigeru Souda , Yoshimasa Machida , Kouichi Katayama , Isao Yamatsu
IPC分类号： C07D495/14 , C07D495/22 , C07F9/6561 , A61K31/55
CPC分类号： C07D495/14 , C07F9/6561
摘要： A triazolo-1,4-di-azepine compound of the below given formula and a pharmacologically acceptable salt thereof are disclosed and useful in the pharmaceutical field, especially to allergic diseases, ##STR1## in which R.sup.1 and R.sup.2 are hydrogen or an alkyl, R.sup.3 is hydrogen or a halogen, R.sup.4 is hydrogen or an alkyl, X is --OCO--, --NHCO--, --CO-- or others and Y is a cycloalkyl, a cycloalkylalkyl, an alkynyl or others.
摘要翻译： 公开了以下给定式的三唑并-1,4-二氮杂化合物及其药理学上可接受的盐，其可用于药物领域，特别是过敏性疾病（*化学结构*），其中R 1和R 2为氢或 烷基，R 3是氢或卤素，R 4是氢或烷基，X是-OCO - ， - NHCO-，-CO-或其它，Y是环烷基，环烷基烷基，炔基或其它。
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公开(公告)号：US5237091A
公开(公告)日：1993-08-17
申请号：US890223
申请日：1992-05-29
申请人： Hiroyuki Yoshimura , Shinya Abe , Tetsuya Kawahara , Naoyuki Shimomura , Kazuo Okano , Richard S. J. Clark , Takashi Mori , Shuhei Miyazawa , Ryoichi Hashida , Kenzo Muramoto , Koukichi Harada , Takashi Inoue , Hiroshi Shirota , Kenichi Chiba , Kenichi Kusube , Toru Horie , Takeshi Suzuki , Isao Yamatsu
发明人： Hiroyuki Yoshimura , Shinya Abe , Tetsuya Kawahara , Naoyuki Shimomura , Kazuo Okano , Richard S. J. Clark , Takashi Mori , Shuhei Miyazawa , Ryoichi Hashida , Kenzo Muramoto , Koukichi Harada , Takashi Inoue , Hiroshi Shirota , Kenichi Chiba , Kenichi Kusube , Toru Horie , Takeshi Suzuki , Isao Yamatsu
IPC分类号： C07C39/40 , C07C43/20 , C07C43/23 , C07C43/253 , C07C45/00 , C07C47/575 , C07C59/52 , C07C59/64 , C07C59/72 , C07C59/90 , C07C69/734 , C07C69/738 , C07C251/48 , C07C255/41
CPC分类号： C07C255/41 , C07C251/48 , C07C39/40 , C07C43/202 , C07C43/23 , C07C43/253 , C07C45/00 , C07C47/575 , C07C59/52 , C07C59/64 , C07C59/72 , C07C59/90 , C07C69/734 , C07C69/738 , C07C2101/08
摘要： The present invention relates to a naphthalene derivative. More particularly, it relates to a naphthalene derivative exhibiting an excellent activity as a drug.
摘要翻译： 萘衍生物本发明涉及萘衍生物。 更具体地说，本发明涉及作为药物具有优异活性的萘衍生物。
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公开(公告)号：US5037827A
公开(公告)日：1991-08-06
申请号：US373350
申请日：1989-06-29
申请人： Kazuo Okano , Osamu Asano , Naoyuki Shimomura , Tetsuya Kawahara , Shinya Abe , Shuhei Miyazawa , Mitsuaki Miyamoto , Hiroyuki Yoshimura , Koukichi Harada , Junsaku Nagaoka , Tsutomu Kawata , Tsutomu Yoshimura , Hiromasa Suzuki , Shigeru Souda , Yoshimasa Machida , Kouichi Katayama , Isao Yamatsu
发明人： Kazuo Okano , Osamu Asano , Naoyuki Shimomura , Tetsuya Kawahara , Shinya Abe , Shuhei Miyazawa , Mitsuaki Miyamoto , Hiroyuki Yoshimura , Koukichi Harada , Junsaku Nagaoka , Tsutomu Kawata , Tsutomu Yoshimura , Hiromasa Suzuki , Shigeru Souda , Yoshimasa Machida , Kouichi Katayama , Isao Yamatsu
IPC分类号： C07D211/46 , A61K31/44 , A61K31/4402 , A61K31/4418 , A61K31/4425 , A61K31/4427 , A61K31/443 , A61K31/445 , A61K31/495 , A61P7/00 , A61P29/00 , A61P37/08 , A61P43/00 , C07D213/02 , C07D213/20 , C07D213/40 , C07D401/06 , C07D401/12 , C07D405/12
CPC分类号： C07D213/40 , C07D401/06 , C07D401/12 , C07D405/12 , Y10S514/921
摘要： A glycerin derivative having the following formula (I) or (I') and a pharmacologically acceptable salt thereof are useful to treat diseases caused by the platelet activating factor. ##STR1##
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