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    Adsorbent for oral administration
    31.
    发明授权
    Adsorbent for oral administration 有权
    用于口服的吸附剂

    公开(公告)号：US08309130B2

    公开(公告)日：2012-11-13

    申请号：US12630581

    申请日：2009-12-03

    申请人： Naohiro Sonobe ,  Susumu Morimoto ,  Hideyuki Yoshihara ,  Hiroyuki Hanatsuka ,  Makoto Arakawa

    发明人： Naohiro Sonobe ,  Susumu Morimoto ,  Hideyuki Yoshihara ,  Hiroyuki Hanatsuka ,  Makoto Arakawa

    IPC分类号： A61K9/18 ,  A61K33/44 ,  A61P1/16 ,  A61P31/12

    CPC分类号： A61K33/44

    摘要： An adsorbent for oral administration, characterized by comprising a spherical activated carbon, wherein a diameter is 0.01 to 1 mm, a specific surface area determined by Langmuir's adsorption equation is 1000 m2/g or more, and a diffraction intensity ratio, an R value, determined by an equation (1): R=(I15−I35)/(I24−I35)  (1) wherein I15 is a diffraction intensity when a diffraction angle (2θ) of an X-ray diffractometry is 15°, I35 is a diffraction intensity when a diffraction angle (2θ) of an X-ray diffractometry is 35°, and I24 is a diffraction intensity when a diffraction angle (2θ) of an X-ray diffractometry is 24°, is 1.4 or more; and an adsorbent for an oral administration, characterized by comprising a surface-modified spherical activated carbon, wherein a diameter is 0.01 to 1 mm, a specific surface area determined by Langmuir's adsorption equation is 1000 m2/g or more, a total amount of acidic groups is 0.40 to 1.00 meq/g, a total amount of basic groups is 0.40 to 1.10 meq/g, and a diffraction intensity ratio, an R value, determined by equation (1) is 1.4 or more. The adsorbents for oral administration exhibit a useful selective adsorbability, that is, a less adsorbability of useful substances in a body, and a greater adsorbability of toxic substances.

    摘要翻译： 一种用于口服给药的吸附剂，其特征在于包含球形活性炭，其直径为0.01至1mm，由Langmuir吸附方程确定的比表面积为1000m 2 / g以上，衍射强度比R值， 由式（1）确定：R =（I15-I35）/（I24-I35）（1）其中I15是当X射线衍射的衍射角（2θ）为15°时的衍射强度，I35为 X射线衍射的衍射角（2θ）为35°时的衍射强度，I24为X射线衍射的衍射角（2θ）为24°时的衍射强度为1.4以上。 和口服给药用吸附剂，其特征在于，包含直径为0.01〜1mm的表面改性球形活性炭，朗缪尔吸附方程式测定的比表面积为1000m 2 / g以上，酸性总量 基团为0.40〜1.00meq / g，碱性基团的总量为0.40〜1.10meq / g，衍生强度比（R值）为1.4以上。 用于口服给药的吸附剂表现出有用的选择性吸附性，即有用物质在体内的吸附性较差，并且有毒物质的吸附性更高。

    Support member for high-temperature heat-treated metal molding object and process for production thereof
    32.
    发明授权
    Support member for high-temperature heat-treated metal molding object and process for production thereof 失效
    高温热处理金属成型体的支撑构件及其制造方法

    公开(公告)号：US07989066B2

    公开(公告)日：2011-08-02

    申请号：US10869832

    申请日：2004-06-18

    申请人： Naohiro Sonobe ,  Hiroshi Ohta ,  Hideaki Sato ,  Yo Otani

    发明人： Naohiro Sonobe ,  Hiroshi Ohta ,  Hideaki Sato ,  Yo Otani

    IPC分类号： B32B9/00

    CPC分类号： C04B35/532 ,  B22F2003/1042 ,  C04B2235/3217 ,  C04B2235/48 ,  C04B2235/528 ,  C04B2235/5427 ,  C04B2235/604 ,  C04B2235/6581 ,  C04B2235/77 ,  C04B2235/94 ,  C04B2235/9623 ,  Y10T428/30

    摘要： A carbonaceous support member for a high-temperature heat-treated metal molding object, particularly a setter for heat-treatment in powder metallurgy, is formed as a carbon-ceramic composite shaped product having a bulk density of 1.2-1.6 g/ml and including a carbonaceous matrix and 3-20 wt. % of ceramic particles which are uniformly dispersed in the carbonaceous matrix and partly exposed to the surface of the composite. The support member can effectively prevent carburization of a metal molding object supported thereby during the heat-treatment without causing a problem of peeling of coating layer as encountered in a ceramic-coated support member. The support member may be prepared by compression molding of a powdery mixture of a fine carbon precursor and ceramic particles, followed by heating at 1000-2000° C. to carbonize the fine carbon precursor.

    摘要翻译： 形成用于高温热处理的金属成型体的碳质支撑构件，特别是粉末冶金用热处理装置，其为堆积密度为1.2〜1.6g / ml的碳陶瓷复合成形体， 碳质基质和3-20重量％ ％的陶瓷颗粒均匀地分散在碳质基质中并且部分地暴露于复合材料的表面。 支撑构件可以有效地防止在热处理期间由其支撑的金属模制物体的渗碳，而不会引起如陶瓷涂覆的支撑构件中遇到的涂层剥落的问题。 支撑构件可以通过压缩成型细碳前体和陶瓷颗粒的粉末混合物，然后在1000-2000℃加热以使细碳前体碳化来制备。

    Process for producing spherical carbon material
    33.
    发明授权
    Process for producing spherical carbon material 失效
    球形碳材料的制造方法

    公开(公告)号：US07651817B2

    公开(公告)日：2010-01-26

    申请号：US11547364

    申请日：2005-03-25

    申请人： Naohiro Sonobe ,  Hiroshi Ohta

    发明人： Naohiro Sonobe ,  Hiroshi Ohta

    IPC分类号： H01M4/58 ,  C01D3/00

    CPC分类号： H01M10/0525 ,  C01B32/05 ,  H01M4/133 ,  H01M4/587 ,  Y02T10/7011

    摘要： A process for producing a spherical carbon material, comprising: subjecting a spherical vinyl resin to an oxidation treatment in an oxidizing gas atmosphere to obtain a spherical carbon precursor, and carbonizing the spherical carbon precursor at 1000-2000° C. in a non-oxidizing gas atmosphere. The thus-obtained spherical carbon material exhibits excellent performances, including high output performance and durability, when used, e.g., as a negative electrode material for non-aqueous electrolyte secondary batteries.

    摘要翻译： 一种球形碳材料的制造方法，其特征在于，包括：使球状乙烯基树脂在氧化性气体气氛中进行氧化处理，得到球形碳前体，并将所述球形碳前体在1000-2000℃下以非氧化性 气体气氛。 由此获得的球形碳材料在用作非水电解质二次电池的负极材料时表现出优异的性能，包括高输出性能和耐久性。

    Method for producing pitch-based carbon fiber sliver and spun yarn
    34.
    发明申请
    Method for producing pitch-based carbon fiber sliver and spun yarn 失效
    沥青基碳纤维纱条和细纱生产方法

    公开(公告)号：US20070145620A1

    公开(公告)日：2007-06-28

    申请号：US10582866

    申请日：2004-12-14

    申请人： Tatsuo Kobayashi ,  Naohiro Sonobe

    发明人： Tatsuo Kobayashi ,  Naohiro Sonobe

    IPC分类号： D01F9/12

    CPC分类号： D01G15/68

    摘要： A pitch-based carbon fiber sliver providing a high-strength carbon fiber spun yarn is efficiently produced by providing a pitch-based carbon fiber mat comprising a mass of piled-up pitch-based carbon fibers of which fiber extension directions are aligned preferentially in one direction; and directly subjecting the carbon fiber mat to drawing and carding by means of a carding machine while moving the mat in said one preferential alignment direction. The thus-obtained carbon fiber sliver is drawn and twisted to produce a pitch-based carbon fiber spun yarn containing at least 3 wt. % of fibers having a fiber length of at least 150 mm, a number of primary twist of 50-400 turns/m and a tensile strength of at least 0.10 N/tex.

    摘要翻译： 提供高强度碳纤维短纤纱的沥青基碳纤维条通过提供一种基于沥青的碳纤维垫而有效地制成，所述沥青基碳纤维垫包括一堆堆积的沥青类碳纤维，其纤维延伸方向优先于一个 方向; 并且通过梳理机直接对碳纤维毡进行拉伸和梳理，同时沿所述一个优先排列方向移动垫子。 将如此获得的碳纤维纱线拉伸和扭曲，以生产含有至少3重量％ 纤维长度至少为150mm，初捻为50-400匝/ m，拉伸强度为至少0.10N / tex的纤维的％。

    Adsorbent for oral administration, and agent for treating or preventing renal or liver disease
    35.
    发明申请
    Adsorbent for oral administration, and agent for treating or preventing renal or liver disease 审中-公开
    用于口服的吸附剂和用于治疗或预防肾或肝脏疾病的药剂

    公开(公告)号：US20050079167A1

    公开(公告)日：2005-04-14

    申请号：US10948334

    申请日：2004-09-24

    申请人： Naohiro Sonobe ,  Susumu Morimoto ,  Hideyuki Yoshihara ,  Hiroyuki Hanatsuka ,  Makoto Arakawa

    发明人： Naohiro Sonobe ,  Susumu Morimoto ,  Hideyuki Yoshihara ,  Hiroyuki Hanatsuka ,  Makoto Arakawa

    IPC分类号： A61K33/44 ,  A61P1/16 ,  A61P13/12 ,  A61P39/02

    CPC分类号： A61K33/44

    摘要： An adsorbent for oral administration, characterized by comprising a spherical activated carbon prepared from a thermosetting resin as a carbon source, wherein a diameter is 0.01 to 1 mm, and a specific surface area determined by Langmuir's adsorption equation is 1000 m2/g or more; and an adsorbent for oral administration, characterized by comprising a surface-modified spherical activated carbon prepared from a thermosetting resin as a carbon source, wherein a diameter is 0.01 to 1 mm, a specific surface area determined by Langmuir's adsorption equation is 1000 m2/g or more, a total amount of acidic groups is 0.40 to 1.00 meq/g, and a total amount of basic groups is 0.40 to 1.10 meq/g. The adsorbents for oral administration exhibit a useful selective adsorbability, that is, a less adsorbability of useful substances in a body, and a greater adsorbability of toxic substances.

    摘要翻译： 一种用于口服给药的吸附剂，其特征在于包含由作为碳源的热固性树脂制备的球形活性炭，其直径为0.01至1mm，并且由Langmuir吸附方程确定的比表面积为1000m 2 / g 或者更多; 和用于口服的吸附剂，其特征在于包含由作为碳源的热固性树脂制备的表面改性的球形活性炭，其直径为0.01至1mm，由Langmuir吸附方程确定的比表面积为1000m 2 > g以上，酸性基团的总量为0.40〜1.00meq / g，碱性基团的总量为0.40〜1.10meq / g。 用于口服给药的吸附剂表现出有用的选择性吸附性，即有用物质在体内的吸附性较差，并且有毒物质的吸附性更高。

    Adsorbent for an oral administration, and agent for treating or preventing renal or liver disease
    38.
    发明授权
    Adsorbent for an oral administration, and agent for treating or preventing renal or liver disease 有权
    用于口服给药的吸附剂和用于治疗或预防肾或肝脏疾病的药剂

    公开(公告)号：US08357366B2

    公开(公告)日：2013-01-22

    申请号：US11547043

    申请日：2005-04-04

    申请人： Naohiro Sonobe ,  Takashi Wakahoi ,  Mieko Kuwahara

    发明人： Naohiro Sonobe ,  Takashi Wakahoi ,  Mieko Kuwahara

    IPC分类号： A61K33/44 ,  A61K9/14

    CPC分类号： A61K33/44 ,  Y10T428/2991

    摘要： An adsorbent for an oral administration, comprising a surface-modified spherical activated carbon wherein an average particle diameter is 50 to 200 μm, a specific surface area determined by a BET method is 700 m2/g or more, a bulk density is less than 0.54 g/mL, a total amount of acidic groups is 0.30 to 1.20 meq/g, and a total amount of basic groups is 0.20 to 0.9 meq/g is disclosed. The adsorbent for an oral administration has a high adsorbability, and is capable of adsorbing a large amount of toxins during a retention period in an intestine, and of remarkably reducing an amount of urinary proteins excretion.

    摘要翻译： 用于口服给药的吸附剂，其包含平均粒径为50〜200μm的表面改性的球形活性炭，BET法测定的比表面积为700m 2 / g以上，堆积密度小于0.54 g / mL，酸性基团的总量为0.30〜1.20meq / g，碱性基团的总量为0.20〜0.9meq / g。 用于口服的吸附剂具有高的吸附性，并且能够在保留期间在肠中吸附大量的毒素，并且显着减少尿蛋白排泄量。

    Process for producing spherical activated carbon
    40.
    发明授权
    Process for producing spherical activated carbon 有权
    球形活性炭的制备方法

    公开(公告)号：US07781370B2

    公开(公告)日：2010-08-24

    申请号：US10948302

    申请日：2004-09-24

    申请人： Naohiro Sonobe ,  Ikuo Seo

    发明人： Naohiro Sonobe ,  Ikuo Seo

    IPC分类号： C01B31/10

    CPC分类号： C10C3/04 ,  C01B32/382

    摘要： A spherical activated carbon is produced from a starting pitch obtainable from a heavy hydrocarbon oil, such as petroleum tar, coal tar or ethylene, through a moderate process. The starting pitch has a softening point of at least 150° C., a toluene-insoluble content of at least 40% and a property of retaining optical isotropy even after being heated at 430° C. for 1 hour. The starting pitch is converted into a porous spherical pitch, which is then infusibilized, carbonized and activated to provide a spherical activated carbon.

    摘要翻译： 球形活性炭通过中等程度从可得自重质烃油如石油焦油，煤焦油或乙烯的起始沥青产生。 起始沥青的软化点至少为150℃，甲苯不溶物含量至少为40％，即使在430℃加热1小时后也保持光学各向同性。 起始沥青转化为多孔球形沥青，然后将其熔融，碳化并活化以提供球形活性炭。