公开(公告)号：US06830753B2

公开(公告)日：2004-12-14

申请号：US10267795

申请日：2002-10-10

申请人： Naohiro Sonobe ,  Michihito Ise ,  Susumu Morimoto ,  Hideyuki Yamato ,  Satoshi Mitsuhashi ,  Haruhisa Hayashi

发明人： Naohiro Sonobe ,  Michihito Ise ,  Susumu Morimoto ,  Hideyuki Yamato ,  Satoshi Mitsuhashi ,  Haruhisa Hayashi

IPC分类号： A61K900

CPC分类号： A61K33/44 ,  A61K9/143

摘要： An adsorbent for an oral administration, comprising a porous spherical carbonaceous substance wherein a diameter is 0.01 to 1 mm, a specific surface area determined by a BET method is 700 m2/g or more, a volume of pores having a pore diameter of 20 to 15000 nm is from not less than 0.04 mL/g to less than 0.10 mL/g, a total amount of acidic groups is 0.30 to 1.20 meq/g, and a total amount of basic groups is 0.20 to 1.00 meq/g, is disclosed.

摘要翻译： 一种用于口服给药的吸附剂，其包含直径为0.01至1mm的多孔球形碳质物质，通过BET法测定的比表面积为700m 2 / g以上，具有孔径的孔的体积 20至15000nm的范围为不小于0.04mL / g至小于0.10mL / g，酸性基团的总量为0.30至1.20meq / g，碱性基团的总量为0.20至1.00meq / g ，被披露。

公开(公告)号：US08530203B2

公开(公告)日：2013-09-10

申请号：US13061551

申请日：2009-08-26

申请人： Masato Ikeda ,  Seiki Takeno ,  Yuta Mizuno ,  Satoshi Mitsuhashi

发明人： Masato Ikeda ,  Seiki Takeno ,  Yuta Mizuno ,  Satoshi Mitsuhashi

IPC分类号： C12P13/04

CPC分类号： C12P13/04 ,  C07K14/34 ,  C12P13/08 ,  C12R1/15

摘要： The present invention provides a process for efficiently producing a useful substance; and a microorganism which belongs to coryneform bacteria and which can be used in the process. The present invention provides a process for producing a useful substance by using a microorganism belonging to coryneform bacteria, the microorganism having an ability to take a sugar, which is taken into a cell via a phosphotransferase system (PTS), into a cell via a system other than the PTS, and having an ability to produce a useful substance.

摘要翻译： 本发明提供一种有效生产有用物质的方法; 和属于棒状细菌的微生物，可用于该过程。 本发明提供了一种通过使用属于棒状细菌的微生物来生产有用物质的方法，所述微生物具有将通过磷酸转移酶系统（PTS）摄入细胞的糖的能力通过系统进入细胞 而不是PTS，并且具有产生有用物质的能力。

公开(公告)号：US5751358A

公开(公告)日：1998-05-12

申请号：US534857

申请日：1995-09-27

申请人： Kazuhiro Suzuki ,  Satoshi Mitsuhashi ,  Yuji Ando

发明人： Kazuhiro Suzuki ,  Satoshi Mitsuhashi ,  Yuji Ando

IPC分类号： G06T9/00 ,  H03M7/30 ,  H04N19/107 ,  H04N19/126 ,  H04N19/136 ,  H04N19/137 ,  H04N19/14 ,  H04N19/142 ,  H04N19/147 ,  H04N19/172 ,  H04N19/176 ,  H04N19/177 ,  H04N19/196 ,  H04N19/423 ,  H04N19/503 ,  H04N19/51 ,  H04N19/567 ,  H04N19/577 ,  H04N19/60 ,  H04N19/61 ,  H04N19/625 ,  H04N19/85 ,  H04N19/87 ,  H04N19/91 ,  H04N7/32

CPC分类号： H04N19/87 ,  H04N19/107 ,  H04N19/114 ,  H04N19/124 ,  H04N19/14 ,  H04N19/142 ,  H04N19/149 ,  H04N19/15 ,  H04N19/172 ,  H04N19/176 ,  H04N19/177 ,  H04N19/179 ,  H04N19/60 ,  H04N19/61 ,  H04N19/146

摘要： A method and apparatus for encoding a picture with improved prediction accuracy in predicting the basic quantization step. The apparatus for encoding a picture includes a picture data storage unit, a picture information evaluating unit, an inter-picture correlation detection unit, an orthogonal transform unit for orthogonally transforming the picture data for generating orthogonal transform coefficients, a quantization unit for quantizing the orthogonal transform coefficients produced by the orthogonal transform unit at a pre-set quantization step, an adaptive compression method selection unit and a quantization step control unit. The information quantity is evaluated from stored picture data of plural pictures, and the inter-picture correlation is detected. A picture data compression method is adaptively selected based upon the evaluated value of the information quantity and the inter-picture correlation information. The basic quantization step is predicted from the evaluated value and a pre-set compressed data quantity obtained on compressing one-picture picture data by the selected compression method and the evaluated value.

摘要翻译： 一种用于在预测基本量化步骤中以改进的预测精度编码图像的方法和装置。 用于编码图像的装置包括图像数据存储单元，图像信息评估单元，图像间相关检测单元，用于正交变换用于产生正交变换系数的图像数据的正交变换单元，用于量化正交变换系数的量化单元 由预定量化步骤由正交变换单元产生的变换系数，自适应压缩方法选择单元和量化步长控制单元。 从多张图像的存储图像数据评估信息量，并检测画面间相关性。 基于信息量和图像间相关信息的评估值自适应地选择图像数据压缩方法。 从评估值和通过所选择的压缩方法压缩单画面图像数据获得的预设压缩数据量和评估值来预测基本量化步长。

公开(公告)号：US07989191B2

公开(公告)日：2011-08-02

申请号：US12430592

申请日：2009-04-27

申请人： Masato Ikeda ,  Junko Ohnishi ,  Satoshi Mitsuhashi ,  Keiko Ochiai

发明人： Masato Ikeda ,  Junko Ohnishi ,  Satoshi Mitsuhashi ,  Keiko Ochiai

IPC分类号： C12N9/04 ,  C12N1/20 ,  C12N15/00 ,  C12P13/04 ,  C12P21/04 ,  C12Q1/00 ,  C12Q1/68 ,  C07H21/04

CPC分类号： C12N9/0006 ,  C12P13/04 ,  C12P13/06 ,  C12P13/08 ,  C12P13/10 ,  C12P13/227

摘要： The present invention relates to a polypeptide having a modified amino acid sequence of 6-phosphogluconate dehydrogenase (hereinafter abbreviated as GND) derived from a microorganism belonging to the genus Corynebacterium, said modification being substitution of the amino acid residue(s) at the position(s) corresponding to the 158th and/or the 361st amino acid(s) of the amino acid sequence shown in SEQ ID NO: 1, and having GND activity; DNA encoding the polypeptide; a recombinant DNA comprising the DNA; a transformant carrying the recombinant DNA; a microorganism carrying the DNA on the chromosome; and a process for producing a useful substance which comprises culturing the transformant or the microorganism in a medium.

摘要翻译： 本发明涉及一种多肽，其具有衍生自属于棒杆菌属的微生物的6-磷酸葡糖酸脱氢酶（以下简写为GND）的修饰氨基酸序列，所述修饰是将位点（ s）对应于SEQ ID NO：1所示氨基酸序列的第158位和/或第361位氨基酸，并具有GND活性; 编码多肽的DNA; 包含DNA的重组DNA; 携带重组DNA的转化体; 在染色体上携带DNA的微生物; 以及生产有用物质的方法，包括在培养基中培养转化体或微生物。

公开(公告)号：US07445915B2

公开(公告)日：2008-11-04

申请号：US10508313

申请日：2003-03-19

申请人： Masato Ikeda ,  Mikiro Hayashi ,  Junko Ohnishi ,  Satoshi Mitsuhashi ,  Hiroshi Mizoguchi ,  Satoshi Nakagawa

发明人： Masato Ikeda ,  Mikiro Hayashi ,  Junko Ohnishi ,  Satoshi Mitsuhashi ,  Hiroshi Mizoguchi ,  Satoshi Nakagawa

IPC分类号： C12N13/04 ,  C12P13/08 ,  C12P13/10 ,  C12P13/14 ,  C12P13/22 ,  C12P13/24 ,  C07H21/04

CPC分类号： C12P13/04 ,  C12N9/88 ,  C12P13/08 ,  C12P13/10 ,  C12P13/14 ,  C12P13/227 ,  C12P13/24

摘要： The present invention provides a polypeptide comprising an amino acid sequence in which at least one amino acid is deleted, substituted or added in an amino acid sequence of isopropylmalate isomerase derived from a microorganism belonging to coryneform bacteria, wherein a coryneform bacterium which produces the polypeptide comprising the amino acid sequence as the sole isopropylmalate isomerase exhibits a partial leucine requirement in a minimal medium; a DNA encoding the polypeptide, a recombinant DNA comprising the DNA, a microorganism transformed with the recombinant DNA, and a process for producing an L-amino acid using the microorganism.

摘要翻译： 本发明提供一种多肽，其包含氨基酸序列，其中至少一个氨基酸被缺失，取代或添加在衍生自属于棒状细菌的微生物的异丙基丙酸异丙酯的氨基酸序列中，其中产生多肽的棒状杆菌型细菌包含 作为唯一的异丙基苹果酸异构酶的氨基酸序列在基本培养基中表现出部分亮氨酸要求; 编码该多肽的DNA，包含DNA的重组DNA，用该重组DNA转化的微生物和使用该微生物产生L-氨基酸的方法。

公开(公告)号：US06580830B1

公开(公告)日：2003-06-17

申请号：US09358032

申请日：1999-07-21

申请人： Kazushi Sato ,  Kenji Komori ,  Tetsuo Kaneko ,  Satoshi Mitsuhashi ,  Masami Goseki ,  Naofumi Yanagihara

发明人： Kazushi Sato ,  Kenji Komori ,  Tetsuo Kaneko ,  Satoshi Mitsuhashi ,  Masami Goseki ,  Naofumi Yanagihara

IPC分类号： G06K936

CPC分类号： H04N7/014 ,  G06F17/147 ,  H04N7/0125 ,  H04N19/122 ,  H04N19/132 ,  H04N19/157 ,  H04N19/176 ,  H04N19/523 ,  H04N19/59 ,  H04N19/61 ,  H04N19/80 ,  H04N19/90

摘要： An MPEG downdecoder is to be provided which eliminates dephasing of pixels of moving picture data without losing properties inherent in a picture obtained on interlaced scanning. In the case of a field DCT mode, 4×4 decimating IDCT is executed for phase correction for a ¼ pixel for pixels in the vertical direction of a top field and for phase correction for ¾ pixel for pixels in the vertical direction of a bottom field. In the case of a frame DCT mode, the totality of coefficients of a DCT block are IDCTed and separated into two pixel blocks associated with interlaced scanning. The low-frequency components of these two pixel blocks are IDCTed to synthesize the two pixel blocks. The pixels in the vertical direction of the top field are phase-corrected by a ¼ pixel, while those in the vertical direction of the bottom field are phase-corrected by a ¾ pixel.

摘要翻译： 将提供一种MPEG降解编码器，其消除了运动图像数据的像素的去相位，而不会损失在隔行扫描中获得的图像中固有的特性。 在场DCT模式的情况下，对顶场的垂直方向上的像素的1/4像素执行4×4抽取IDCT，并且对于底场的垂直方向上的像素的¾像素进行相位校正。 在帧DCT模式的情况下，DCT块的系数的总和被IDCT化并分离成与隔行扫描相关联的两个像素块。 这两个像素块的低频分量被IDCTed以合成两个像素块。 顶场的垂直方向上的像素被1/4像素相位校正，而底场的垂直方向上的像素被¾像素相位校正。

公开(公告)号：US07524667B2

公开(公告)日：2009-04-28

申请号：US10497502

申请日：2002-12-03

申请人： Masato Ikeda ,  Junko Ohnishi ,  Satoshi Mitsuhashi ,  Keiko Ochiai

发明人： Masato Ikeda ,  Junko Ohnishi ,  Satoshi Mitsuhashi ,  Keiko Ochiai

IPC分类号： C12N9/04 ,  C12N1/20 ,  C12N15/00 ,  C12Q1/00 ,  C12Q1/68 ,  C12P21/04 ,  C07H21/04

CPC分类号： C12N9/0006 ,  C12P13/04 ,  C12P13/06 ,  C12P13/08 ,  C12P13/10 ,  C12P13/227

摘要： The present invention relates to a polypeptide having a modified amino acid sequence of 6-phosphogluconate dehydrogenase (hereinafter abbreviated as GND) derived from a microorganism belonging to the genus Corynebacterium, said modification being substitution of the amino acid residue(s) at the position(s) corresponding to the 158th and/or the 361st amino acid(s) of the amino acid sequence shown in SEQ ID NO: 1, and having GND activity; DNA encoding the polypeptide; a recombinant DNA comprising the DNA; a transformant carrying the recombinant DNA; a microorganism carrying the DNA on the chromosome; and a process for producing a useful substance which comprises culturing the transformant or the microorganism in a medium.

摘要翻译： 本发明涉及一种多肽，其具有衍生自属于棒杆菌属的微生物的6-磷酸葡糖酸脱氢酶（以下简写为GND）的修饰氨基酸序列，所述修饰是将位点（ s）对应于SEQ ID NO：1所示氨基酸序列的第158位和/或第361位氨基酸，并具有GND活性; 编码多肽的DNA; 包含DNA的重组DNA; 携带重组DNA的转化体; 在染色体上携带DNA的微生物; 以及生产有用物质的方法，包括在培养基中培养转化体或微生物。

公开(公告)号：US07158570B2

公开(公告)日：2007-01-02

申请号：US10312555

申请日：2002-05-09

申请人： Takefumi Nagumo ,  Hiroyuki Yasuda ,  Satoshi Mitsuhashi ,  Yuji Ando ,  Takashi Kojima ,  Yiwen Zhu

发明人： Takefumi Nagumo ,  Hiroyuki Yasuda ,  Satoshi Mitsuhashi ,  Yuji Ando ,  Takashi Kojima ,  Yiwen Zhu

IPC分类号： H04B1/66

CPC分类号： H04N19/587 ,  H04N19/105 ,  H04N19/115 ,  H04N19/132 ,  H04N19/139 ,  H04N19/152 ,  H04N19/17 ,  H04N19/172 ,  H04N19/51 ,  H04N19/61

摘要： Motion picture data is compression-encoded by a compression encoder with the frame rate changing according to the amount of accumulated data of the buffer, which can adequately change the number of pieces of frame image data to be compression-encoded per unit time, according to the change in the picture of the motion picture. In addition, tracing is done to trace extract image data in the frame image data by using a simple motion vector detected for the frame image data of the motion picture data, a higher layer motion vector detector detects a motion vector of the frame image data by using the simple motion vector in common, and a compression encoder extracts the extract image data based on the results of tracing and compression-encodes it by using the motion vector.

摘要翻译： 运动图像数据由压缩编码器进行压缩编码，帧速率根据缓冲器的累积数据量而改变，这可以根据单位时间适当地改变要被压缩编码的帧图像数据的数量 电影图片的变化。 此外，通过使用针对运动图像数据的帧图像数据检测的简单运动矢量来跟踪提取帧图像数据中的图像数据，较高层运动矢量检测器通过以下方式检测帧图像数据的运动矢量 使用简单的运动矢量，压缩编码器基于跟踪结果提取提取图像数据，并通过使用运动矢量对其进行压缩编码。

公开(公告)号：US06549670B1

公开(公告)日：2003-04-15

申请号：US09359360

申请日：1999-07-21

申请人： Kazushi Sato ,  Kenji Komori ,  Tetsuo Kaneko ,  Satoshi Mitsuhashi ,  Masami Goseki ,  Takao Terao ,  Naofumi Yanagihara

发明人： Kazushi Sato ,  Kenji Komori ,  Tetsuo Kaneko ,  Satoshi Mitsuhashi ,  Masami Goseki ,  Takao Terao ,  Naofumi Yanagihara

IPC分类号： G06K936

CPC分类号： G06F17/147 ,  H04N19/117 ,  H04N19/122 ,  H04N19/132 ,  H04N19/154 ,  H04N19/156 ,  H04N19/159 ,  H04N19/16 ,  H04N19/176 ,  H04N19/184 ,  H04N19/186 ,  H04N19/523 ,  H04N19/59 ,  H04N19/61 ,  H04N19/80 ,  H04N19/90

摘要： An MPEG downdecoder is to be provided which eliminates pixel dephasing with the field DCT mode and the frame DCT mode without detracting from picture characteristics proper to interlaced pictures. To this end, a decimating IDCT unit 14 effectuates 4×4 decimating IDCT if the DCT mode is the field mode. If the DCT mode is a frame mode, a decimating IDCT unit 15 effectuates IDCT on the totality of coefficients of a DCT block to separate the coefficients into two pixel blocks associated with interlaced scanning. The decimating IDCT unit 15 executes DCT on the separated two pixel blocks. The low-frequency components of the two pixel blocks are processed with IDCT and the two pixel blocks are synthesized.

摘要翻译： 将提供一种使用场DCT模式和帧DCT模式消除像素去相位而不降低隔行扫描图片的图像特性的MPEG下变频器。 为此，如果DCT模式是场模式，则抽取的IDCT单元14实现4×4抽取IDCT。 如果DCT模式是帧模式，则抽取IDCT单元15对DCT块的系数的总和进行IDCT，以将系数分离成与隔行扫描相关联的两个像素块。 抽取的IDCT单元15在分离的两个像素块上执行DCT。 用IDCT处理两个像素块的低频分量，并合成两个像素块。

公开(公告)号：US5578589A

公开(公告)日：1996-11-26

申请号：US440838

申请日：1995-05-15

申请人： Fumio Tamura ,  Tsuyoshi Saito ,  Satoshi Mitsuhashi ,  Tadahiro Matsudaira ,  Kiro Asano

发明人： Fumio Tamura ,  Tsuyoshi Saito ,  Satoshi Mitsuhashi ,  Tadahiro Matsudaira ,  Kiro Asano

IPC分类号： A61K31/575 ,  A61P35/00 ,  A61P37/06 ,  C07J1/00 ,  C07J41/00 ,  A61K31/56

CPC分类号： C07J1/0074 ,  C07J1/007 ,  C07J41/0072

摘要： The invention is drawn to a method for suppressing an immunoresponse in animals by administering an estradiol derivative-chlorambucil conjugate of the formula (I): ##STR1## wherein R.sup.1 is alkyl or alkoxyl of 1 to 4 carbon atoms; R.sup.2 is acyl, dansyl, or alkyl; R.sup.3, R.sup.4, and R.sup.5 independently are H, oxo, OH, or acyloxy; m is an integer of 1 to 3; and n is an integer of 0 to 3; provided that when n is 0, all of R.sup.3, R.sup.4, and R.sup.5 are not H at the same time, and at least one of R.sup.3, R.sup.4, and R.sup.5 is a group other than H and OH; and further, when n is 2 or 3, the groups R.sup.1 are the same or different.

摘要翻译： 本发明涉及一种通过给予式（I）的雌二醇衍生物 - 苯丁酸氮芥配偶体来抑制动物免疫反应的方法：其中R1是1-4个碳原子的烷基或烷氧基; R2是酰基，丹磺酰基或烷基; R3，R4和R5独立地是H，氧代，OH或酰氧基; m为1〜3的整数。 n为0〜3的整数。 条件是当n为0时，R3，R4和R5全部同时不为H，R3，R4和R5中的至少一个为除H和OH以外的基团; 此外，当n为2或3时，基团R 1相同或不同。