公开(公告)号：US12054506B2

公开(公告)日：2024-08-06

申请号：US17698283

申请日：2022-03-18

Applicant: Singular Genomics Systems, Inc.

Inventor： Ronald Graham ,  Zachary Terranova

IPC: C07F9/6521

CPC classification number: C07F9/6521

Abstract: Disclosed herein, inter alia, are novel reducing agents having the general formula




and methods of use thereof.

公开(公告)号：US11987709B2

公开(公告)日：2024-05-21

申请号：US17882448

申请日：2022-08-05

Applicant: Singular Genomics Systems, Inc.

Inventor： Megha Cila ,  Ronald Graham ,  Rodrigo Rodriguez

IPC: C09B62/36 ,  C09K11/06 ,  G01N33/58

CPC classification number: C09B62/365 ,  C09K11/06 ,  G01N33/582 ,  C09K2211/1018

Abstract: Disclosed herein, inter alia, are silicon containing detectable compounds and methods of use thereof. In an aspect is provided a monovalent nucleotide or monovalent nucleoside covalently bound to a monovalent form of a compound described herein (e.g., wherein the R13 moiety of a compound described herein has reacted with a bioconjugate reactive group to form a bioconjugate linker thereby covalently bonding the monovalent compound to the monovalent nucleotide or monovalent nucleoside).

公开(公告)号：US11946103B2

公开(公告)日：2024-04-02

申请号：US18449601

申请日：2023-08-14

Applicant: Singular Genomics Systems, Inc

Inventor： Ronald Graham ,  Megha Cila

IPC: C12Q1/68 ,  C07H19/10 ,  C07H19/20 ,  C12Q1/6874 ,  C12Q1/6876 ,  C12Q1/6806

CPC classification number: C12Q1/6874 ,  C07H19/10 ,  C07H19/20 ,  C12Q1/6876 ,  C12Q1/6806

Abstract: Disclosed herein, inter alia, are methods and cleavable compounds that minimize byproduct formation following cleavage.

公开(公告)号：US20230257414A1

公开(公告)日：2023-08-17

申请号：US18295770

申请日：2023-04-04

Applicant: Singular Genomics Systems, Inc

Inventor： Ronald Graham ,  Olga Adelfinskaya ,  Megha Cila ,  Rodrigo Rodriguez ,  Abrehet Abdu ,  Eli N. Glezer

IPC: C07H19/14 ,  C12Q1/6869 ,  C07H19/20 ,  C12Q1/6876 ,  C07H19/10

CPC classification number: C07H19/14 ,  C12Q1/6869 ,  C07H19/20 ,  C12Q1/6876 ,  C07H19/10

Abstract: Disclosed herein, interalia, are compounds, compositions, and methods of using the same for the sequencing of a nucleic acid.

公开(公告)号：US20230028359A1

公开(公告)日：2023-01-26

申请号：US17287255

申请日：2019-10-24

Applicant: Singular Genomics Systems, Inc.

Inventor： Ronald Graham ,  Olga Adelfinskaya ,  Megha Cila ,  Rodrigo Rodriguez ,  Abrehet Abdu ,  Eli N. Glezer

IPC: C07H19/14 ,  C07H19/10 ,  C07H19/20 ,  C12Q1/6876

Abstract: Disclosed herein, interalia, are compounds, compositions, and methods of using the same for the sequencing of a nucleic acid.

公开(公告)号：US11535754B2

公开(公告)日：2022-12-27

申请号：US17737899

申请日：2022-05-05

Applicant: Singular Genomics Systems, Inc.

Inventor： Megha Cila ,  Ronald Graham ,  Rodrigo Rodriguez

IPC: C09B62/36 ,  C09K11/06 ,  G01N33/58

Abstract: Disclosed herein, inter alia, are silicon containing detectable compounds and methods of use thereof. In an aspect is provided a monovalent nucleotide or monovalent nucleoside covalently bound to a monovalent form of a compound described herein (e.g., wherein the R13 moiety of a compound described herein has reacted with a bioconjugate reactive group to form a bioconjugate linker thereby covalently bonding the monovalent compound to the monovalent nucleotide or monovalent nucleoside).

公开(公告)号：US20220298201A1

公开(公告)日：2022-09-22

申请号：US16969879

申请日：2019-02-20

Applicant: SINGULAR GENOMICS SYSTEMS, INC.

Inventor： Ronald Graham ,  Andrew Spaventa ,  Eli Glezer

IPC: C07H21/04 ,  C12Q1/6869

Abstract: Disclosed herein, inter alia, are compounds, compositions, and methods of use thereof in the sequencing a nucleic acid.

公开(公告)号：US20220127299A1

公开(公告)日：2022-04-28

申请号：US17417332

申请日：2020-01-07

Applicant: Singular Genomics Systems, Inc.

Inventor： Ronald Graham ,  Olga Adelfinskaya ,  Megha Cila ,  Rodrigo Rodriguez

IPC: C07H19/20 ,  C07H19/14 ,  C07H19/10 ,  C12Q1/6869 ,  C12Q1/6806 ,  C12N9/12

Abstract: Disclosed herein, inter alia, are compounds, compositions, and methods of use thereof for sequencing a nucleic acid.

公开(公告)号：US10822653B1

公开(公告)日：2020-11-03

申请号：US16736493

申请日：2020-01-07

Applicant: Singular Genomics Systems, Inc.

Inventor： Ronald Graham ,  Olga Adelfinskaya ,  Megha Cila ,  Rodrigo Rodriguez

IPC: C07H19/06 ,  C07H19/10 ,  C07H19/14 ,  C07H19/16 ,  C07H19/20 ,  C12Q1/6869 ,  C12Q1/6806 ,  C07F9/655

Abstract: Disclosed herein, inter alia, are compounds, compositions, and methods of use thereof for sequencing a nucleic acid.

公开(公告)号：US20250101512A1

公开(公告)日：2025-03-27

申请号：US18949596

申请日：2024-11-15

Applicant: Singular Genomics Systems, Inc.

Inventor： Ronald Graham ,  Megha Cila

IPC: C12Q1/6874 ,  C07H19/10 ,  C07H19/20 ,  C12Q1/6806 ,  C12Q1/6876

Abstract: Disclosed herein, inter alia, are methods and cleavable compounds that minimize byproduct formation following cleavage in situ.