利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

99 条记录 (耗时 0.031 秒)

    Mammals carrying functional single nucleotide polymorphisms in brain-specific tryptophan hydroxylase
    31.
    发明申请
    Mammals carrying functional single nucleotide polymorphisms in brain-specific tryptophan hydroxylase 失效
    在脑特异性色氨酸羟化酶中携带功能性单核苷酸多态性的哺乳动物

    公开(公告)号：US20080010692A1

    公开(公告)日：2008-01-10

    申请号：US11825202

    申请日：2007-07-05

    申请人： Marc Caron ,  Xiaodong Zhang ,  Martin Beaulieu ,  Raul Gainetdinov ,  Tatyana Sotnikova

    发明人： Marc Caron ,  Xiaodong Zhang ,  Martin Beaulieu ,  Raul Gainetdinov ,  Tatyana Sotnikova

    IPC分类号： G01N33/00 ,  A01K67/00 ,  C12N5/00

    CPC分类号： A01K67/0276 ,  A01K2217/075 ,  A01K2227/105 ,  A01K2267/0356 ,  C12N9/0071 ,  C12N15/8509 ,  C12N2800/30

    摘要： Recombinant or transgenic non-human mammals are described having a mutant tryptophan hydroxylase 2 (Tph2) gene resulting in altered synthesis of 5-hydroxytryptophan and serotonin in the brain. In some embodiments the mutant tryptophan hydroxylase 2 gene contains mouse R439H and/or P447R functional mutations, or their corresponding mutations in other species. Congenic non-human mammals having mutant tryptophan hydroxylase 2 genes are also provided. Methods of screening a compound for serotonergic activity or activity in treating a serotonergic neurotransmission dysregulation disorder are provided, which include administering a test compound to a recombinant non-human mammal and then detecting the presence or absence of serotonergic activity, or activity in treating a serotonergic neurotransmission dysregulation disorder, in the mammal. A cell such as a nerve cell (e.g., a central nervous system neuron) isolated from a transgenic or congenic mammal is also disclosed, along with cell cultures containing these cells. Such mammals and cells and cell cultures are useful in vitro for screening the activity of candidate compounds for their effect on serotonergic neurotransmission and for their activity in treating serotonergic neurotransmission dysregulation disorders.

    摘要翻译： 描述了具有突变色氨酸羟化酶2（Tph2）基因的重组或转基因非人哺乳动物，导致脑中5-羟色胺和5-羟色胺的合成改变。 在一些实施方案中，突变色氨酸羟化酶2基因含有小鼠R439H和/或P447R功能性突变或其他物种中相应的突变。 还提供了具有突变色氨酸羟化酶2基因的同种非人哺乳动物。 提供了筛选化合物用于治疗血清素能神经递质调节障碍的5-羟色胺能活性或活性的方法，其包括向重组非人哺乳动物施用测试化合物，然后检测血清素能活性的存在或不存在或治疗血清素能的活性 神经传递异常调节障碍。 还公开了从转基因或同基因哺乳动物分离的细胞例如分离自转基因或同种哺乳动物的神经细胞（例如中枢神经系统神经元）以及含有这些细胞的细胞培养物。 这样的哺乳动物和细胞和细胞培养物在体外可用于筛选候选化合物对5-羟色胺能神经传递的作用及其在治疗5-羟色胺能神经传递失调调节障碍中的活性。

    Method of optimizing amplification in PCR
    32.
    发明申请
    Method of optimizing amplification in PCR 失效
    优化PCR扩增方法

    公开(公告)号：US20060166240A1

    公开(公告)日：2006-07-27

    申请号：US11322764

    申请日：2005-12-29

    申请人： Haikuo Li ,  Jiehuan Huang ,  Junhong Lv ,  Xiaodong Zhang ,  Jun Hu ,  Zhizhou Zhang ,  Chunhai Fan

    发明人： Haikuo Li ,  Jiehuan Huang ,  Junhong Lv ,  Xiaodong Zhang ,  Jun Hu ,  Zhizhou Zhang ,  Chunhai Fan

    IPC分类号： C12Q1/68 ,  C12P19/34

    CPC分类号： C12Q1/6806 ,  C12Q1/6846 ,  C12Q1/6848 ,  C12Q1/686 ,  C12Q2563/137

    摘要： The present invention discloses a method for optimizing PCR amplification by adding elementary substance material into PCR system, wherein the elementary substance material is selected from a group consisting of element titanium, element nickel, element bismuth, element stibium, element selenium, element chromium, and a mixture of the group. This new method is more effective than conventional amplifying method and could be widely employed in many fronts, especially in multiplex PCR, two-round PCR, low-copy PCR, long-term PCR and rapid PCR.

    摘要翻译： 本发明公开了一种通过将基本物质材料添加到PCR系统中来优化PCR扩增的方法，其中基本物质材料选自元素钛，元素镍，元素铋，元素锑，元素硒，元素铬和 该组的混合物。 这种新方法比常规扩增方法更有效，可广泛应用于许多方面，特别是在多重PCR，双向PCR，低拷贝PCR，长期PCR和快速PCR中。

    Daylight transmission system for building
    35.
    发明授权
    Daylight transmission system for building 有权

    公开(公告)号：US10309600B2

    公开(公告)日：2019-06-04

    申请号：US15551719

    申请日：2016-02-16

    申请人： Xiaodong Zhang

    发明人： Xiaodong Zhang

    IPC分类号： F21S11/00

    摘要： A daylight transmission system that can be used in buildings, the system including: dual-axis implementation device, CPU-controller, light position sensor and optical components that include moving and fixed optical components; with the moving optical components including optical light collector and the fixed optical components including first receiver and consecutive receivers. The invented system transmits sunlight in a form of parallel light after it is concentrated and therefore does not rely on expensive medium such as optic fibers, with the entire process being efficient in light transmission and economically viable. With the help of a tracking device, sunlight of any incident angle will be reflected in a fixed direction and to a fixed point where the light is reflected further on to the desired destination inside of a building. The invented system can be installed directly onto the external wall of any building, and be applied within a wide range of buildings.

    Transgenic mice carrying functional single nucleotide polymorphisms in brain-specific tryptophan hydroxylase
    39.
    发明授权
    Transgenic mice carrying functional single nucleotide polymorphisms in brain-specific tryptophan hydroxylase 失效
    在脑特异性色氨酸羟化酶中携带功能单核苷酸多态性的转基因小鼠

    公开(公告)号：US08124831B2

    公开(公告)日：2012-02-28

    申请号：US11825202

    申请日：2007-07-05

    申请人： Marc G. Caron ,  Xiaodong Zhang ,  Martin Beaulieu ,  Raul R. Gainetdinov ,  Tatyana D. Sotnikova

    发明人： Marc G. Caron ,  Xiaodong Zhang ,  Martin Beaulieu ,  Raul R. Gainetdinov ,  Tatyana D. Sotnikova

    IPC分类号： A01K67/027 ,  G01N33/00

    CPC分类号： A01K67/0276 ,  A01K2217/075 ,  A01K2227/105 ,  A01K2267/0356 ,  C12N9/0071 ,  C12N15/8509 ,  C12N2800/30

    摘要： Recombinant or transgenic non-human mammals are described having a mutant tryptophan hydroxylase 2 (Tph2) gene resulting in altered synthesis of 5-hydroxytryptophan and serotonin in the brain. In some embodiments the mutant tryptophan hydroxylase 2 gene contains mouse R439H and/or P447R functional mutations, or their corresponding mutations in other species. Congenic non-human mammals having mutant tryptophan hydroxylase 2 genes are also provided. Methods of screening a compound for serotonergic activity or activity in treating a serotonergic neurotransmission dysregulation disorder are provided, which include administering a test compound to a recombinant non-human mammal and then detecting the presence or absence of serotonergic activity, or activity in treating a serotonergic neurotransmission dysregulation disorder, in the mammal. A cell such as a nerve cell (e.g., a central nervous system neuron) isolated from a transgenic or congenic mammal is also disclosed, along with cell cultures containing these cells.

    摘要翻译： 描述了具有突变色氨酸羟化酶2（Tph2）基因的重组或转基因非人哺乳动物，导致脑中5-羟色胺和5-羟色胺的合成改变。 在一些实施方案中，突变色氨酸羟化酶2基因含有小鼠R439H和/或P447R功能性突变或其他物种中相应的突变。 还提供了具有突变色氨酸羟化酶2基因的同种非人哺乳动物。 提供了筛选化合物用于治疗血清素能神经递质调节障碍的5-羟色胺能活性或活性的方法，其包括向重组非人哺乳动物施用测试化合物，然后检测血清素能活性的存在或不存在或治疗血清素能的活性 神经传递异常调节障碍。 还公开了从转基因或同基因哺乳动物分离的细胞例如分离自转基因或同种哺乳动物的神经细胞（例如中枢神经系统神经元）以及含有这些细胞的细胞培养物。

    PARTICLE BEAM-ASSISTED ULTRA-PRECISION MACHINING METHOD FOR SINGLE-CRYSTAL BRITTLE MATERIALS
    40.
    发明申请
    PARTICLE BEAM-ASSISTED ULTRA-PRECISION MACHINING METHOD FOR SINGLE-CRYSTAL BRITTLE MATERIALS 有权
    用于单晶玻璃材料的粒子束辅助超精密加工方法

    公开(公告)号：US20120012563A1

    公开(公告)日：2012-01-19

    申请号：US13159811

    申请日：2011-06-14

    申请人： Fengzhou Fang ,  Yunhui Chen ,  Zongwei Xu ,  Zhongjun Qiu ,  Xiaodong Zhang ,  Tengfei Dai ,  Xiaotang Hu

    发明人： Fengzhou Fang ,  Yunhui Chen ,  Zongwei Xu ,  Zhongjun Qiu ,  Xiaodong Zhang ,  Tengfei Dai ,  Xiaotang Hu

    IPC分类号： B23K15/08

    CPC分类号： B28D5/00 ,  B24B7/228 ,  B24B37/042 ,  C30B29/06 ,  C30B29/08 ,  C30B33/04

    摘要： The invention relates to a new technology which uses a surface modification method for ultra-precision machining, and in particular relates to a particle beam-assisted ultraprecision machining method for single-crystal brittle materials. The invention, the particle beam-assisted ultra-precision machining method for single-crystal brittle materials, can significantly improve machining accuracy, reduce surface finish and greatly reduce tool wear during ultra-precision machining of brittle materials. The method adopts the technical proposal that the method comprises of the following steps: a) utilizing simulation software to simulate modification parameters according to cutting depth, surface roughness and other machining requirements; b) using particle beams to bombard or irradiate the surface of a single-crystal brittle material to be machined, according to the energy and fluence obtained from the simulation results; c) utilizing ultra-precision cutting (or grinding) technology to perform ultra precise cutting on the single-crystal material which is bombarded or irradiated by the particle beams; and d) measuring and characterizing the surface quality of the machined material and comparing the improvement of the machined surface quality with that of the unmodified machined surface. The method is mainly used for machining the single-crystal brittle materials.

    摘要翻译： 本发明涉及一种使用表面改性方法进行超精密加工的新技术，特别涉及用于单晶脆性材料的粒子束辅助超精密加工方法。 本发明是用于单晶脆性材料的粒子束辅助超精密加工方法，可以显着提高加工精度，降低表面光洁度，大大减少脆性材料超精密加工过程中的刀具磨损。 该方法采用技术方案，该方法包括以下步骤：a）利用模拟软件根据切割深度，表面粗糙度等加工要求模拟修改参数; b）根据从仿真结果得到的能量和能量，使用粒子束轰击或照射要加工的单晶脆性材料的表面; c）利用超精密切割（或研磨）技术对被粒子束轰击或照射的单晶材料进行超精密切割; 以及d）测量和表征加工材料的表面质量，并将加工表面质量的改善与未修饰的加工表面的改进进行比较。 该方法主要用于加工单晶脆性材料。