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31.发明申请Compositions containing fast-leaching plasticizers for improved performance of medical devices 有权含有快速浸出增塑剂的组合物可改善医疗器械的性能公开(公告)号：US20060058868A1
公开(公告)日：2006-03-16
申请号：US10937975
申请日：2004-09-10
Applicant: David Gale , Klaus Kleine , Anthony Abbate , Svava Atladottir , Stephen Pacetti
Inventor： David Gale , Klaus Kleine , Anthony Abbate , Svava Atladottir , Stephen Pacetti
CPC classification number: A61L31/141
Abstract: Medical implants containing a temporary plasticizer, methods of producing such implants, and methods of using the implants in treating a disease, or ameliorating one or more symptoms thereof, in a subject are provided.
Abstract translation: 提供了包含临时增塑剂的医疗植入物，生产这种植入物的方法，以及使用植入物治疗疾病或改善其一种或多种症状的方法。
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公开(公告)号：US20050271700A1
公开(公告)日：2005-12-08
申请号：US10750139
申请日：2004-06-03
Applicant: Jessica DesNoyer , Syed Hossainy , Stephen Pacetti , Yiwen Tang
Inventor： Jessica DesNoyer , Syed Hossainy , Stephen Pacetti , Yiwen Tang
IPC: A61F2/00 , A61L2/00 , A61L31/10 , A61L31/16 , C09D177/12 , C09D187/00
CPC classification number: A61L31/16 , A61L31/10 , A61L2300/602 , C08L77/12
Abstract: A poly(ester amide) (PEA) coating with enhanced mechanical and/or release rate for coating an implantable device, such as a drug-eluting stent, is disclosed. A method of forming the PEA coating onto a device and a method of treating a disorder, such as restenosis, are also disclosed.
Abstract translation: 公开了用于涂覆可植入装置（例如药物洗脱支架）的具有增强的机械和/或释放速率的聚（酯酰胺）（PEA）涂层。 还公开了将PEA涂层形成在器件上的方法和治疗诸如再狭窄的病症的方法。
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33.发明申请Barriers for polymer-coated implantable medical devices and methods for making the same 有权聚合物涂覆的可植入医疗器械的障碍物及其制造方法公开(公告)号：US20050208098A1
公开(公告)日：2005-09-22
申请号：US11132048
申请日：2005-05-17
Applicant: Daniel Castro , Stephen Pacetti
Inventor： Daniel Castro , Stephen Pacetti
IPC: A61F2/02 , A61F2/82 , A61F2/86 , A61L27/30 , A61L27/34 , A61L27/56 , A61L31/08 , A61L31/10 , A61L31/16 , A61F2/06
CPC classification number: A61F2/82 , A61F2/86 , A61F2250/0067 , A61F2310/0097 , A61L27/306 , A61L27/34 , A61L27/56 , A61L31/088 , A61L31/10 , A61L31/16 , A61L2300/416 , A61L2300/602 , A61L2300/606 , A61L2420/08 , C08L31/04 , C08L33/10
Abstract: A drug eluting medical device is disclosed. The device includes a barrier layer for reducing the rate of release of a drug.
Abstract translation: 公开了药物洗脱医疗装置。 该装置包括用于降低药物释放速率的阻挡层。
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公开(公告)号：US20050143808A1
公开(公告)日：2005-06-30
申请号：US11067375
申请日：2005-02-25
Applicant: Syed Hossainy , Yiwen Tang , Andrew Tung , Stephen Pacetti
Inventor： Syed Hossainy , Yiwen Tang , Andrew Tung , Stephen Pacetti
CPC classification number: A61F2/06 , A61F2/0077 , A61F2250/0067 , Y10T428/13 , Y10T428/24942 , Y10T428/3154 , Y10T428/31786 , Y10T428/31855 , Y10T428/31935
Abstract: An implantable medical device, such as a stent, is disclosed having a coating. The coating includes a poly(butylene terephthalate-co-ethylene glycol) polymer. The coating can also include a drug.
Abstract translation: 公开了一种具有涂层的可植入医疗装置，例如支架。 涂层包括聚（对苯二甲酸丁二醇酯 - 共 - 乙二醇）聚合物。 涂层还可以包括药物。
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35.发明申请Coatings for implantable devices including biologically erodable polyesters and methods for fabricating the same 有权用于可植入装置的涂层，包括生物可侵蚀的聚酯及其制造方法公开(公告)号：US20050112171A1
公开(公告)日：2005-05-26
申请号：US10719516
申请日：2003-11-21
Applicant: Yiwen Tang , Stephen Pacetti
Inventor： Yiwen Tang , Stephen Pacetti
CPC classification number: A61L31/16 , A61F2/86 , A61L31/10 , A61L31/148 , A61L2300/606 , A61L2420/08 , C08L67/04
Abstract: A medical article comprising an implantable substrate having a coating is disclosed, the coating comprising a biologically erodable polymer having the glass transition temperature below about −50° C. The biologically erodable polymer can be blended with a polymeric additive which either has the glass transition temperature of about −50° C. or higher, or a degree of crystallinity greater than that of the first polymer.
Abstract translation: 公开了包含具有涂层的可植入基材的医疗制品，所述涂层包含玻璃化转变温度低于约-50℃的生物侵蚀性聚合物。可生物侵蚀的聚合物可与聚合物添加剂共混，所述聚合物添加剂具有玻璃化转变温度 约-50℃或更高，或结晶度大于第一聚合物的结晶度。
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Patent Agency Ranking
36.发明申请Coatings for implantable devices comprising polymers of lactic acid and methods for fabricating the same 审中-公开用于包含乳酸聚合物的可植入装置的涂层及其制造方法公开(公告)号：US20050112170A1
公开(公告)日：2005-05-26
申请号：US10718976
申请日：2003-11-20
Applicant: Syed Hossainy , Yiwen Tang , Eugene Michal , Thierry Glauser , Stephen Pacetti , Jessica DesNoyer
Inventor： Syed Hossainy , Yiwen Tang , Eugene Michal , Thierry Glauser , Stephen Pacetti , Jessica DesNoyer
IPC: A61F2/00 , A61F2/86 , A61L29/08 , A61L29/16 , A61L31/10 , A61L31/14 , A61L31/16 , A61L33/06 , A61M29/02
CPC classification number: A61L31/10 , A61F2/86 , A61F2250/0067 , A61L31/148 , A61L31/16 , A61L2300/416 , A61L2300/606 , C08L67/04
Abstract: Coatings for an implantable medical device and a method of fabricating thereof are disclosed, the coatings comprising polymers of lactic acid.
Abstract translation: 公开了用于可植入医疗装置的涂层及其制造方法，所述涂层包含乳酸聚合物。
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37.发明授权公开(公告)号：US08870847B2
公开(公告)日：2014-10-28
申请号：US13079239
申请日：2011-04-04
Applicant: Dariush Davalian , Stephen Pacetti , Florian Niklas Ludwig , Syed Faiyaz Ahmed Hossainy , Irina Astafieva , Kimchi Tran
Inventor： Dariush Davalian , Stephen Pacetti , Florian Niklas Ludwig , Syed Faiyaz Ahmed Hossainy , Irina Astafieva , Kimchi Tran
CPC classification number: A61K9/0019 , A61F2/95 , A61L29/16 , A61L31/16 , A61L2300/416 , A61L2300/62 , A61M25/0084 , A61M25/104 , A61M2025/105
Abstract: This invention is directed to a method of treating a vascular disease involving administration to a patient by means of an angioplasty balloon a composition comprising a permeability-enhancing substance and a therapeutic agent.
Abstract translation: 本发明涉及一种治疗血管疾病的方法，所述血管疾病涉及通过血管成形术球囊向患者施用包含渗透性增强物质和治疗剂的组合物。
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38.发明申请IMPLANTABLE PROSTHESIS WITH HOLLOW STRUTS AND PASSIVATING COATING, AND METHOD OF MAKING SAME 审中-公开具有中空砂浆和钝化涂料的可植入物及其制备方法公开(公告)号：US20130345793A1
公开(公告)日：2013-12-26
申请号：US13533738
申请日：2012-06-26
Applicant: Stephen Pacetti
Inventor： Stephen Pacetti
CPC classification number: A61L31/022 , A61F2/86 , A61F2250/0068 , A61L31/088 , A61L31/10 , A61L31/14 , A61L31/16 , A61L31/18 , B05D5/08
Abstract: An implantable prosthesis can comprise a passivating coating within a lumen of a strut and on an interior surface of a metal layer surrounding the lumen. A therapeutic agent is disposed in the lumen. A method for making an implantable prosthesis can comprise applying a passivating coating onto an interior surface of a metal layer surrounding a lumen of a strut, and followed by introducing a therapeutic agent into the lumen.
Abstract translation: 可植入假体可以包括在支柱的内腔内和在围绕内腔的金属层的内表面上的钝化涂层。 治疗剂设置在内腔中。 用于制造可植入假体的方法可以包括将钝化涂层施加到围绕支柱内腔的金属层的内表面上，随后将治疗剂引入内腔。
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公开(公告)号：US20130345792A1
公开(公告)日：2013-12-26
申请号：US13533589
申请日：2012-06-26
Applicant: Stephen Pacetti
Inventor： Stephen Pacetti
CPC classification number: A61F2/86 , A61B90/39 , A61B2090/3966 , A61F2/90 , A61F2/915 , A61F2002/91541 , A61F2002/91558 , A61F2002/91575 , A61F2250/0068 , A61F2250/0098 , B22F5/00 , B22F7/04
Abstract: An implantable prosthesis can comprise a strut having a lumen, and radiopaque particles within the lumen. The radiopaque particles placed within the lumen can improve visualization of the prosthesis during an implantation procedure. The radiopaque particles can be bonded to each other to prevent the radiopaque particles from escaping out of the strut.
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40.发明授权Amino acid mimetic copolymers and medical devices coated with the copolymers 失效用共聚物涂覆的氨基酸模拟共聚物和医疗器械公开(公告)号：US08569435B2
公开(公告)日：2013-10-29
申请号：US13045467
申请日：2011-03-10
Applicant: Stephen Pacetti
Inventor： Stephen Pacetti
IPC: C08F120/58
CPC classification number: A61L27/54 , A61L27/34 , A61L29/085 , A61L29/16 , A61L31/10 , A61L31/16 , A61L2300/00 , C08L27/18
Abstract: Biocompatible polymers are manufactured to include an amino acid mimetic monomer and one or more hydrophobic acrylate monomers. The amino acid mimetic monomers are selected to mimic the side chain of the amino acids asparagine or glutamine. The amino acid mimetic monomer can be a methacryloyl or acryloyl derivative of 2-hydroxyacetamide, 3-hydroxypropionamide, alaninamide, lactamide, or glycinamide. These amide functional groups offer the advantage of moderate hydrophilicity with little chemical reactivity. The amino acid mimetic monomer can be copolymerized with one or more hydrophobic acrylate monomers to obtain desired coating properties.
Abstract translation: 制造生物相容性聚合物以包括氨基酸模拟单体和一种或多种疏水丙烯酸酯单体。 选择氨基酸模拟单体以模拟氨基酸天冬酰胺或谷氨酰胺的侧链。 氨基酸模拟单体可以是2-羟基乙酰胺，3-羟基丙酰胺，丙烯酰胺，乳酰胺或甘氨酰胺的甲基丙烯酰基或丙烯酰基衍生物。 这些酰胺官能团具有中等的亲水性，几乎没有化学反应性的优点。 氨基酸模拟单体可以与一种或多种疏水丙烯酸酯单体共聚以获得所需的涂料性质。
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