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公开(公告)号：US20060271170A1
公开(公告)日：2006-11-30
申请号：US11141834
申请日：2005-05-31
申请人： David Gale , Klaus Kleine , Anthony Abbate , Svava Atladottir , Stephen Pacetti
发明人： David Gale , Klaus Kleine , Anthony Abbate , Svava Atladottir , Stephen Pacetti
IPC分类号： A61F2/06
CPC分类号： A61F2/91 , A61F2/915 , A61F2002/91533 , A61F2002/91575 , A61F2250/0029
摘要： A stent for treating a bodily lumen with a flexible section in a high strain region is disclosed. A flexible section may be selectively positioned to reduce an amount of strain in the high strain region when subjected to the applied stress during use to inhibit or prevent fracturing in the high strain region.
摘要翻译： 公开了一种用于在高应变区域中用柔性部分处理身体管腔的支架。 柔性部分可以选择性地定位成在使用过程中受到施加的应力时，在高应变区域中减小应变量，以抑制或防止高应变区域中的断裂。
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2.发明申请Compositions containing fast-leaching plasticizers for improved performance of medical devices 有权含有快速浸出增塑剂的组合物可改善医疗器械的性能公开(公告)号：US20060058868A1
公开(公告)日：2006-03-16
申请号：US10937975
申请日：2004-09-10
申请人： David Gale , Klaus Kleine , Anthony Abbate , Svava Atladottir , Stephen Pacetti
发明人： David Gale , Klaus Kleine , Anthony Abbate , Svava Atladottir , Stephen Pacetti
CPC分类号： A61L31/141
摘要： Medical implants containing a temporary plasticizer, methods of producing such implants, and methods of using the implants in treating a disease, or ameliorating one or more symptoms thereof, in a subject are provided.
摘要翻译： 提供了包含临时增塑剂的医疗植入物，生产这种植入物的方法，以及使用植入物治疗疾病或改善其一种或多种症状的方法。
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3.发明申请Compositions containing fast-leaching plasticizers for improved performance of medical devices 失效含有快速浸出增塑剂的组合物可改善医疗器械的性能公开(公告)号：US20070203568A1
公开(公告)日：2007-08-30
申请号：US11796454
申请日：2007-04-27
申请人： David Gale , Klaus Kleine , Anthony Abbate , Svava Atladottir , Stephen Pacetti
发明人： David Gale , Klaus Kleine , Anthony Abbate , Svava Atladottir , Stephen Pacetti
CPC分类号： A61L31/141
摘要： Medical implants containing a temporary plasticizer, methods of producing such implants, and methods of using the implants in treating a disease, or ameliorating one or more symptoms thereof, in a subject are provided.
摘要翻译： 提供了包含临时增塑剂的医疗植入物，生产这种植入物的方法，以及使用植入物治疗疾病或改善其一种或多种症状的方法。
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公开(公告)号：US20050119720A1
公开(公告)日：2005-06-02
申请号：US10957022
申请日：2004-10-01
申请人： David Gale , Bin Huang , Anthony Abbate , Stephen Pacetti
发明人： David Gale , Bin Huang , Anthony Abbate , Stephen Pacetti
CPC分类号： A61F2/958 , A61F2002/9522 , A61L31/10 , A61L31/14 , B29B13/024 , B29C65/56 , B29C65/76 , B29C66/9121 , B29C66/91431 , B29C66/91641 , B29C66/919 , B29C66/91921 , B29C66/91941 , B29C66/91945 , B29C2035/0822 , B29C2071/022 , B29K2001/00 , B29K2001/12 , B29K2023/00 , B29K2023/083 , B29K2023/086 , B29K2027/06 , B29K2027/08 , B29K2027/16 , B29K2029/00 , B29K2031/00 , B29K2033/08 , B29K2033/20 , B29K2055/02 , B29K2063/00 , B29K2075/00 , B29K2077/00 , B29K2083/00 , B29L2031/7542 , Y10T29/49865 , Y10T428/24942 , Y10T428/3154 , Y10T428/31544 , Y10T428/31855
摘要： This disclosure describes a method for crimping a polymeric stent onto a catheter for percutaneous transluminal coronary angioplasty or other intraluminal interventions. The method comprises crimping the stent onto a catheter when the polymer is at a target temperature other than ambient temperature. The polymer can optionally comprise drug(s).
摘要翻译： 本公开描述了一种用于将聚合物支架卷曲到用于经皮冠状动脉腔内冠状动脉成形术或其他管腔内干预的导管上的方法。 该方法包括当聚合物处于不同于环境温度的目标温度时将支架卷曲到导管上。 聚合物可任选地包含药物。
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公开(公告)号：US20090036972A1
公开(公告)日：2009-02-05
申请号：US12247164
申请日：2008-10-07
CPC分类号： A61F2/91 , A61F2/915 , A61F2002/91533 , A61F2002/91575 , A61F2250/0029
摘要： A stent for treating a bodily lumen with a flexible section in a high strain region is disclosed. A flexible section may be selectively positioned to reduce an amount of strain in the high strain region when subjected to the applied stress during use to inhibit or prevent fracturing in the high strain region.
摘要翻译： 公开了一种用于在高应变区域中用柔性部分处理身体管腔的支架。 柔性部分可以选择性地定位成在使用过程中受到施加的应力时，在高应变区域中减小应变量，以抑制或防止高应变区域中的断裂。
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公开(公告)号：US08894900B2
公开(公告)日：2014-11-25
申请号：US12247164
申请日：2008-10-07
IPC分类号： B29C70/74
CPC分类号： A61F2/91 , A61F2/915 , A61F2002/91533 , A61F2002/91575 , A61F2250/0029
摘要： A stent for treating a bodily lumen with a flexible section in a high strain region is disclosed. A flexible section may be selectively positioned to reduce an amount of strain in the high strain region when subjected to the applied stress during use to inhibit or prevent fracturing in the high strain region.
摘要翻译： 公开了一种用于在高应变区域中用柔性部分处理身体管腔的支架。 柔性部分可以选择性地定位成在使用过程中受到施加的应力时，在高应变区域中减小应变量，以抑制或防止高应变区域中的断裂。
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公开(公告)号：US20060246108A1
公开(公告)日：2006-11-02
申请号：US11117813
申请日：2005-04-29
申请人： Stephen Pacetti , Syed Hossainy , David Gale
发明人： Stephen Pacetti , Syed Hossainy , David Gale
CPC分类号： A61L31/10 , A61L31/06 , A61L31/148 , A61L31/16 , C08L101/00 , C09D167/04 , C08L67/04 , C08L2666/02
摘要： Implantable devices formed of or coated with a material that includes an amorphous poly(D,L-lactide) formed of a starting material such as meso-D,L-lactide are provided. The implantable device can be used for the treatment, mitigation, prevention, or inhibition of a disorder such as atherosclerosis, thrombosis, restenosis, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, patent foramen ovale, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, or combinations thereof.
摘要翻译： 提供由包含由诸如内消旋-D，L-丙交酯的原料形成的无定形聚（D，L-丙交酯）的材料形成或涂覆的可植入装置。 可植入装置可用于治疗，缓解，预防或抑制动脉粥样硬化，血栓形成，再狭窄，出血，血管解剖或穿孔，血管动脉瘤，易损斑块，慢性完全闭塞，卵圆孔未闭，跛行， 静脉和人造移植物的吻合增殖，胆管阻塞，输尿管阻塞，肿瘤阻塞或其组合。
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8.发明申请Implantable devices comprising biologically absorbable polymers having constant rate of degradation and methods for fabricating the same 审中-公开可植入装置包括具有恒定降解速率的生物可吸收聚合物及其制造方法公开(公告)号：US20060041102A1
公开(公告)日：2006-02-23
申请号：US10925257
申请日：2004-08-23
申请人： Syed Hossainy , Stephen Pacetti , David Gale
发明人： Syed Hossainy , Stephen Pacetti , David Gale
IPC分类号： C08G63/08
CPC分类号： A61L31/16 , A61L31/06 , A61L31/10 , A61L31/14 , A61L2300/606 , C08G63/06 , C08G63/08 , C08G64/0208 , C08G64/0241 , C09D167/04 , C09D169/00 , C08L67/04
摘要： Polymers that can form the substrate of an implantable medical device and form coatings for implantable medical devices and methods for their fabrication are disclosed, the coatings comprising polymers that are hydrolyzed at a substantially constant rate or that have been prepared so that they degrade at a rate closer to constant.
摘要翻译： 公开了可以形成可植入医疗装置的基底并形成用于可植入医疗装置的涂层的聚合物及其制造方法，所述涂层包含以基本上恒定的速率水解或已被制备以使其以一定速率降解的聚合物 更接近常数。
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9.发明申请Implantable devices comprising biologically absorbable polymers having constant rate of degradation and methods for fabricating the same 审中-公开可植入装置包括具有恒定降解速率的生物可吸收聚合物及其制造方法公开(公告)号：US20080004400A1
公开(公告)日：2008-01-03
申请号：US11820314
申请日：2007-06-18
申请人： Syed Hossainy , Stephen Pacetti , David Gale
发明人： Syed Hossainy , Stephen Pacetti , David Gale
IPC分类号： C08L53/00
CPC分类号： A61L31/16 , A61L31/06 , A61L31/10 , A61L31/14 , A61L2300/606 , C08G63/06 , C08G63/08 , C08G64/0208 , C08G64/0241 , C09D167/04 , C09D169/00 , C08L67/04
摘要： Polymers that can form the substrate of an implantable medical device and form coatings for implantable medical devices and methods for their fabrication are disclosed, the coatings comprising polymers that are hydrolyzed at a substantially constant rate or that have been prepared so that they degrade at a rate closer to constant.
摘要翻译： 公开了可以形成可植入医疗装置的基底并形成用于可植入医疗装置的涂层的聚合物及其制造方法，所述涂层包含以基本上恒定的速率水解或已被制备以使其以一定速率降解的聚合物 更接近常数。
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公开(公告)号：US09242005B1
公开(公告)日：2016-01-26
申请号：US11507860
申请日：2006-08-21
申请人： Syed Hossainy , Florian Niklas Ludwig , Stephen Pacetti , Paul Consigny , Fozan El-Nounou , Thierry Glauser , Jessica DesNoyer
发明人： Syed Hossainy , Florian Niklas Ludwig , Stephen Pacetti , Paul Consigny , Fozan El-Nounou , Thierry Glauser , Jessica DesNoyer
CPC分类号： A61K47/42 , A61K9/0019 , A61K9/1075 , A61K9/127 , A61K9/1273 , A61M5/178 , A61M25/104 , A61M31/00 , A61M2025/0087 , A61M2025/105 , A61M2025/1052
摘要： Pro-healing agent formulation compositions, methods and treatments for enhancing vascular healing are disclosed herein. In some embodiments, a pro-healing agent is encapsulated, suspended, disposed within or loaded into a biodegradable carrier for sustained-release delivery to a denuded or damaged endothelium treatment area in a blood vessel. In some applications, the pro-healing agent can accelerate re-endothelialization of a denuded vascular region. In some applications, the pro-healing agent can assist in the regaining of endothelium functionality. The formulation can be delivered by a delivery assembly such as an infusion catheter, a porous balloon catheter, a needle injection catheter, a double balloon catheter or the like.
摘要翻译： 本文公开了用于增强血管愈合的预愈合剂制剂组合物，方法和治疗。 在一些实施方案中，将前修复剂包封，悬浮，置于生物降解载体内或装载到可生物降解的载体中，以缓释递送至血管内的裸露或损伤的内皮治疗区域。 在一些应用中，预愈合剂可以加速裸露的血管区域的再内皮化。 在一些应用中，前修复剂可以帮助恢复内皮功能。 制剂可以通过输送组件例如输注导管，多孔气囊导管，针注射导管，双气囊导管等来递送。
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