公开(公告)号：US06635690B2

公开(公告)日：2003-10-21

申请号：US09884173

申请日：2001-06-19

申请人： Steven M. Heilmann ,  Babu N. Gaddam ,  Ahmed S. Abuelyaman ,  Duane D. Fansler ,  Todd D. Jones ,  Maureen A. Kavanagh ,  Kevin M. Lewandowski ,  Michael S. Wendland

发明人： Steven M. Heilmann ,  Babu N. Gaddam ,  Ahmed S. Abuelyaman ,  Duane D. Fansler ,  Todd D. Jones ,  Maureen A. Kavanagh ,  Kevin M. Lewandowski ,  Michael S. Wendland

IPC分类号： C08L8700

CPC分类号： C09D201/005 ,  C09D201/08

摘要： The present invention provides novel compositions prepared from a first oligomer containing reactive functional groups capable of reaction at effective rates (at normal processing temperatures) with a co-reactive second component possessing functionality that is complementary to that of the first oligomer. The compositions may be used as coatings, including hard surface coatings, clear coatings, powder coatings and pattern coatings; as adhesives, including pressure sensitive adhesives and hot melt adhesives; as sealants; as optical coatings; as blown microfibers (BMF); as high refractive index optical materials; as barrier films; in microreplication; as low adhesion backsizes, (LABs) and as release coatings.

公开(公告)号：US5292840A

公开(公告)日：1994-03-08

申请号：US335835

申请日：1989-04-10

申请人： Steven M. Heilmann ,  Jerald K. Rasmussen ,  Larry R. Krepski ,  Dean S. Milbrath ,  Patrick L. Coleman ,  Margaret M. Walker

发明人： Steven M. Heilmann ,  Jerald K. Rasmussen ,  Larry R. Krepski ,  Dean S. Milbrath ,  Patrick L. Coleman ,  Margaret M. Walker

IPC分类号： B01J20/281 ,  A61K39/395 ,  B01J20/26 ,  C07K17/08 ,  C08F8/00 ,  C08F8/48 ,  C08F20/58 ,  C08F26/00 ,  C08F26/06 ,  C08J5/18 ,  C12N11/08 ,  G01N30/88 ,  C08F22/38

CPC分类号： A61K39/39525 ,  B01J20/26 ,  C07K17/08 ,  C08F20/58 ,  C08F8/00 ,  C08F8/12 ,  C08F8/16 ,  C08F8/32 ,  C08F8/48 ,  C12N11/08 ,  C08F2800/10 ,  C08F2800/20 ,  C08F2810/20

摘要： Azlactone-functional polymer supports are useful reactive supports for the attachment of functional materials to provide novel adduct beads. The adduct beads are useful as complexing agents, catalysts, polymeric reagents, chromatographic supports, and as enzyme- or other biologically active supports. Novel carboxylate-functional polymer beads, are intermediates in the preparation of the azlactone-functional beads.Azlactone-functional supports have units of the formula: ##STR1## wherein R.sup.1 is H or CH.sub.3,R.sup.2 and R.sup.3 independently can be an alkyl group having 1 to 14 carbon atoms, a cycloalkyl group having 3 to 14 carbon atoms, an aryl group having 5 to 12 ring atoms, an arenyl group having 6 to 26 carbon and 0 to 3 S, N, and nonperoxidic O heteroatoms, or R.sup.2 and R.sup.3 taken together with the carbon to which they are joined can form a carbocyclic ring containing 4 to 12 ring atoms, andn is an integer 0 or 1,the azlactone functional supports having 0.1 to 99 molar parts of crosslinking monomer incorporated therein.

摘要翻译： 吖内酯官能聚合物载体是用于附着功能材料以提供新型加合珠的有用的反应性载体。 加合珠可用作络合剂，催化剂，聚合物试剂，色谱载体，以及酶或其它生物活性载体。 新型羧酸盐官能化聚合物珠粒是制备吖内酯官能团珠粒的中间体。 吖内酯官能载体具有下式的单元：（*化学结构*）V其中R 1为H或CH 3，R 2和R 3可独立地为具有1至14个碳原子的烷基，具有3至14个碳原子的环烷基， 具有5至12个环原子的芳基，具有6至26个碳和0至3个S，N和非过氧O的杂原子的芳基，或与其连接的碳一起的R 2和R 3可以形成碳环 含有4〜12个环原子，n为0或1的整数，所述吖内酯官能团的载体中含有0.1〜99摩尔份的交联单体。

公开(公告)号：US5292514A

公开(公告)日：1994-03-08

申请号：US903367

申请日：1992-06-24

申请人： John T. Capecchi ,  Steven M. Heilmann ,  Larry R. Krepski ,  Oh-Seung Kwon ,  David B. Olson

发明人： John T. Capecchi ,  Steven M. Heilmann ,  Larry R. Krepski ,  Oh-Seung Kwon ,  David B. Olson

IPC分类号： A61L27/00 ,  A61L27/28 ,  A61L27/34 ,  A61L27/50 ,  C07C45/71 ,  C07C49/84 ,  C08F8/30 ,  A61F2/14 ,  C08K5/15

CPC分类号： C08F8/30 ,  A61F2/14 ,  A61L27/28 ,  A61L27/34 ,  A61L27/50 ,  C07C45/71 ,  C07C49/84 ,  C08K5/15

摘要： Azlactone-functional substrates, (especially hydrogels), mammalian body implants, and methods of making and using them are disclosed. The azlactone-functional substrates are the reaction product of substrates having azlactone-reactive nucleophilic surfaces and a multi-functional azlactone composition having at least two azlactone moieties, where at least one moiety covalently couples to the azlactone-reactive nucleophilic surface and at least one moiety remains available for further nucleophilic reaction, such as with a biologically active material. A preferred use of azlactone-functional hydrogel is as the optical element of a corneal prosthesis which enhances epithethial cell growth.

摘要翻译： 公开了吖内酯功能底物（特别是水凝胶），哺乳动物体植入物及其制备和使用方法。 吖内酯功能底物是具有吖内酯反应性亲核表面的底物和具有至少两个吖内酯部分的多功能吖内酯组合物的反应产物，其中至少一个部分共价连接到吖内酯反应性亲核表面和至少一个部分 仍然可用于进一步的亲核反应，例如用生物活性物质。 吖内酯功能水凝胶的优选用途是作为增强上皮细胞生长的角膜假体的光学元件。

公开(公告)号：US5210248A

公开(公告)日：1993-05-11

申请号：US749926

申请日：1991-08-26

申请人： Stefan A. Babirad ,  Dean M. Moren ,  Steven M. Heilmann ,  Larry R. Krepski ,  Jerald K. Rasmussen

发明人： Stefan A. Babirad ,  Dean M. Moren ,  Steven M. Heilmann ,  Larry R. Krepski ,  Jerald K. Rasmussen

IPC分类号： C07F7/10 ,  C07F7/18 ,  C08F30/08 ,  C08F130/08 ,  C08F230/08

CPC分类号： C08F30/08 ,  C07F7/1836

摘要： The present invention provides novel fluorinated acrylamide silane monomers which are useful as adhesion promoting agents in optical fiber cladding compositions. Polymerization of the novel monomers, optionally in the presence compatible ethylenically-unsaturated monomers, provides homopolymers and copolymers which are useful as non-wetting agents.

公开(公告)号：US4931582A

公开(公告)日：1990-06-05

申请号：US267186

申请日：1988-11-04

申请人： Steven M. Heilmann ,  Larry R. Krepski ,  Dean M. Moren ,  Jerald K. Rasmussen ,  Howell K. Smith, II

发明人： Steven M. Heilmann ,  Larry R. Krepski ,  Dean M. Moren ,  Jerald K. Rasmussen ,  Howell K. Smith, II

IPC分类号： B01J31/02 ,  C07B61/00 ,  C07C231/10 ,  C07C233/49 ,  C07C311/03 ,  C08F20/00 ,  C08F20/58

CPC分类号： C07C311/03 ,  C07C233/49 ,  C08F20/58 ,  C07C2101/14

摘要： Novel fluorinated, acrylamide monomers are prepared from 2-alkenyl azlactones reacted with fluorinated alcohols. The novel monomers have the formula ##STR1## wherein R.sup.1 and R.sup.6 are independently hydrogen or methyl;R.sup.2 and R.sup.3 independently can be an alkyl, cycloalkyl, or aryl group, or R.sup.2 and R.sup.3 taken together with the carbon to which they are joined can form a carbocyclic ring containing 4 to 12 ring atoms;R.sup.4 and R.sup.5 are independently hydrogen or lower alkyl;a is 0 or 1;b is 1 or 2;X is a single bond, CH.sub.2, CH.sub.2 OCH.sub.2, and CH.sub.2 CH.sub.2 OCH.sub.2 ; andR.sub.F is a substantially perfluorinated alkyl, cycloalkyl, or aryl group when b is 1 and perfluorinated alkylene when b is 2.Novel polymers and copolymers can be prepared from the monomers of the invention.

公开(公告)号：US4918231A

公开(公告)日：1990-04-17

申请号：US284595

申请日：1988-12-15

申请人： Larry R. Krepski ,  Steven M. Heilmann ,  Jerald K. Rasmussen

发明人： Larry R. Krepski ,  Steven M. Heilmann ,  Jerald K. Rasmussen

IPC分类号： C07F7/18

CPC分类号： C07F7/1852

摘要： A process for the production of 1,2-amino alcohols, in improved yields, comprising the steps of:(1) reacting a silylated cyanohydrin compound with a Grignard reagent;(2) treating the reaction product of Step 1 with either a reducing agent, or an organolithium compound;(3) hydrolyzing the reaction product of Step 2;(4) isolating the resulting 1,2-amino alcohol.The 1,2-amino alcohols thus formed are useful as pharmaceuticals or precursors therefor.

摘要翻译： 一种以提高的产率生产1,2-氨基醇的方法，包括以下步骤：（1）使甲硅烷基化的氰醇化合物与格氏试剂反应; （2）用还原剂或有机锂化合物处理步骤1的反应产物; （3）水解步骤2的反应产物; （4）分离得到的1,2-氨基醇。 这样形成的1,2-氨基醇可用作药物或其前体。

公开(公告)号：US4914223A

公开(公告)日：1990-04-03

申请号：US233218

申请日：1988-08-17

申请人： Jerald K. Rasmussen ,  Steven M. Heilmann ,  Frederick J. Palensky

发明人： Jerald K. Rasmussen ,  Steven M. Heilmann ,  Frederick J. Palensky

IPC分类号： C08F299/02 ,  C09D4/00 ,  C09J4/00 ,  C07C121/413 ,  C07C121/66

CPC分类号： C09D4/00 ,  C08F299/024 ,  C09J4/00

摘要： A composition of matter comprising an acrylamido-acyl or methacrylamido-acyl oligomer derived from at least one nucleophilic oligomer having at least one amino-, hydroxyl-, or thio-substituted polyoxyalkylene, polyalkyleneimine, polyester, polyolefin, polyacrylate, or polysiloxane oligomer, said nucleophilic oligomer having a molecular weight in the range of 200 to 20,000 is disclosed. Also disclosed are free radically polymerizable monomer-containing compositions containing said oligomers as well as acrylamido- and methacrylamido-acylated polymers which are the thermal or photocured products of said oligomers. In addition, a process is disclosed for providing said acrylamido- and methacrylamido-acylated oligomers which are useful, for example, in coatings, films, printing inks, adhesives, and saturants.

摘要翻译： 包含衍生自至少一种具有至少一个氨基，羟基或硫代取代的聚氧化烯，聚亚烷基亚胺，聚酯，聚烯烃，聚丙烯酸酯或聚硅氧烷低聚物的亲核低聚物的丙烯酰氨基 - 酰基或甲基丙烯酰氨基 - 酰基低聚物的组合物， 公开了分子量在200至20,000范围内的亲核低聚物。 还公开了含有所述低聚物以及作为所述低聚物的热或光固化产物的丙烯酰氨基和甲基丙烯酰氨基酰化聚合物的可自由基聚合的含单体的组合物。 此外，公开了一种用于提供所述丙烯酰氨基和甲基丙烯酰氨基酰化的低聚物的方法，其可用于例如涂料，膜，印刷油墨，粘合剂和饱和物。

公开(公告)号：US4906792A

公开(公告)日：1990-03-06

申请号：US267035

申请日：1988-11-04

申请人： Steven M. Heilmann ,  Larry R. Krepski ,  Dean M. Moren ,  Jerald K. Rasmussen

发明人： Steven M. Heilmann ,  Larry R. Krepski ,  Dean M. Moren ,  Jerald K. Rasmussen

IPC分类号： B01J27/08 ,  B01J27/232 ,  B01J31/04 ,  C07B61/00 ,  C07C41/16 ,  C07C43/13 ,  C07C43/178

CPC分类号： C07C41/16

摘要： Mono O-hydroxyalkylated derivatives of 1,1-dihydroperfluorinated alcohols are prepared by reaction the alcohols with alkylene carbonates. The O-hydroxyalkylated derivatives are useful non-ionic surfactants and emulsifiable compounds for fire extinguishing systems.

公开(公告)号：US4874822A

公开(公告)日：1989-10-17

申请号：US178507

申请日：1988-04-07

申请人： Jerald K. Rasmussen ,  Steven M. Heilmann ,  Larry R. Krepski ,  Dean M. Moren

发明人： Jerald K. Rasmussen ,  Steven M. Heilmann ,  Larry R. Krepski ,  Dean M. Moren

IPC分类号： C08J3/24 ,  C07C231/14 ,  C07C233/49 ,  C08F8/00 ,  C08F8/30 ,  C08F20/00 ,  C08F20/52 ,  C08F20/58 ,  C08F290/00 ,  C08F299/02 ,  C08G63/08 ,  C08G63/68 ,  C08G65/32

CPC分类号： C07C231/14 ,  C08F8/30

摘要： The present invention provides a dramatically improved process for the preparation of acrylamide and methacrylamide functional monomers, oligomers, and polymers that avoids the use of acidic catalysts which can cause undesired side reactions. The present invention process involves reacting an alkenyl azlactone with a hydroxy functional compound in the presence of a catalytic amount of either a bicyclic amidine or a trivalent phosphorus compound. These efficient basic catalysts provide unexpectedly increased reaction rates under mild conditions.

公开(公告)号：US4785070A

公开(公告)日：1988-11-15

申请号：US014875

申请日：1987-02-17

申请人： Jerald K. Rasmussen ,  Alan R. Katritzky ,  Larry R. Krepski ,  Howell K. Smith, II ,  Steven M. Heilmann ,  Kumars Sakizadeh

发明人： Jerald K. Rasmussen ,  Alan R. Katritzky ,  Larry R. Krepski ,  Howell K. Smith, II ,  Steven M. Heilmann ,  Kumars Sakizadeh

IPC分类号： C08G73/00 ,  C08G73/06 ,  C08G83/00

CPC分类号： C08G73/0616

摘要： A novel class of heterocyclic polymers and copolymers containing the 2-imidazolin-5-one ring structure is described. These polymers are prepared by reaction of bisazlactones and diamines, with or without suitable condensation monomers; the resultant polyamides are then thermally cyclodehydrated in the presence of a catalyst to produce the imidazolinone-containing polymers. Many of the poly(imidazolinones) are water soluble and therefore find utility in various aspects of water treatment, or in paper or fabric sizing.

摘要翻译： 描述了一类含有2-咪唑啉-5-酮环结构的杂环聚合物和共聚物。 这些聚合物通过双偶氮内酯和二胺的反应制备，具有或不具有合适的缩合单体; 然后将所得的聚酰胺在催化剂的存在下进行热环化脱水以制备含咪唑啉酮的聚合物。 许多聚（咪唑啉酮）是水溶性的，因此可用于水处理的各个方面，或在纸或织物施胶中。