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31.发明授权Macrolide particulates, methods for preparation, and medical devices associated therewith 有权大环内酯颗粒，制备方法和与其相关的医疗装置公开(公告)号：US09439892B2
公开(公告)日：2016-09-13
申请号：US14280054
申请日：2014-05-16
Applicant: SurModics, Inc.
Inventor： Joram Slager
CPC classification number: A61K31/436 , A61K9/0019 , A61K9/1075 , A61K9/145 , A61K9/1688 , A61K9/19 , A61K9/5123 , A61K9/5138 , A61K9/5146 , A61L29/085 , A61L29/16 , Y02A50/402 , Y02A50/478 , Y10T428/2982
Abstract: The disclosure provides macrolide particulates including a macrolide therapeutic agent such as rapamycin at high concentration in the particulate. In one method the particulates are made by adding a composition containing an polyoxyethylene sorbitan n-acyl ester, poly(ethyleneimine), or alkylated quaternary ammonium salt to a composition including macrolide dissolved in an alcohol such as ethanol. In another method the particulates are made by adding a non-solvent composition to a composition including macrolide and an alkyl-substituted chromanol dissolved in an alcohol such as ethanol. The formed macrolide particulates have one or more desirable properties including sizes in the range of 0.1 μm to 10 μm, spherical or near spherical shapes, low polydispersity, and/or stability. The macrolide particulates can be used for therapeutic compositions, or in association with an implantable or insertable medical device, such as associated with a polymeric coating on a device.
Abstract translation: 本公开提供了大环内酯颗粒，其包括大环内酯治疗剂，例如高浓度颗粒物中的雷帕霉素。 在一种方法中，颗粒通过将包含聚氧乙烯失水山梨糖醇n-酰基酯，聚（乙烯亚胺）或烷基化季铵盐的组合物加入到溶解在醇如乙醇中的大环内酯的组合物中来制备。 在另一种方法中，通过将非溶剂组合物加入到包含大环内酯和溶解在醇如乙醇中的烷基取代的苯并二氢苯并三氢吡喃的组合物中来制备颗粒。 形成的大环内酯颗粒具有一种或多种所需性质，包括0.1μm至10μm范围内的尺寸，球形或近球形，低分散性和/或稳定性。 大环内酯颗粒可用于治疗组合物，或与可植入或可插入的医疗装置相关联，例如与装置上的聚合物涂层相关联。
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32.发明申请MACROLIDE PARTICULATES, METHODS FOR PREPARATION, AND MEDICAL DEVICES ASSOCIATED THEREWITH 有权麦芽糖苷颗粒，制备方法和与之相关的医疗器械公开(公告)号：US20140343491A1
公开(公告)日：2014-11-20
申请号：US14280054
申请日：2014-05-16
Applicant: SurModics, Inc.
Inventor： Joram Slager
IPC: A61K31/436 , A61M25/10 , A61K9/16
CPC classification number: A61K31/436 , A61K9/0019 , A61K9/1075 , A61K9/145 , A61K9/1688 , A61K9/19 , A61K9/5123 , A61K9/5138 , A61K9/5146 , A61L29/085 , A61L29/16 , Y02A50/402 , Y02A50/478 , Y10T428/2982
Abstract: The disclosure provides macrolide particulates including a macrolide therapeutic agent such as rapamycin at high concentration in the particulate. In one method the particulates are made by adding a composition containing an polyoxyethylene sorbitan n-acyl ester, poly(ethyleneimine), or alkylated quaternary ammonium salt to a composition including macrolide dissolved in an alcohol such as ethanol. In another method the particulates are made by adding a non-solvent composition to a composition including macrolide and an alkyl-substituted chromanol dissolved in an alcohol such as ethanol. The formed macrolide particulates have one or more desirable properties including sizes in the range of 0.1 μm to 10 μm, spherical or near spherical shapes, low polydispersity, and/or stability. The macrolide particulates can be used for therapeutic compositions, or in association with an implantable or insertable medical device, such as associated with a polymeric coating on a device.
Abstract translation: 本公开提供了大环内酯颗粒，其包括大环内酯治疗剂，例如高浓度颗粒物中的雷帕霉素。 在一种方法中，颗粒通过将包含聚氧乙烯失水山梨糖醇n-酰基酯，聚（乙烯亚胺）或烷基化季铵盐的组合物加入到溶解在醇如乙醇中的大环内酯的组合物中来制备。 在另一种方法中，通过将非溶剂组合物加入到包含大环内酯和溶解在醇如乙醇中的烷基取代的苯并二氢苯并三氢吡喃的组合物中来制备颗粒。 形成的大环内酯颗粒具有一种或多种所需性质，包括0.1μm至10μm范围内的尺寸，球形或近球形，低分散性和/或稳定性。 大环内酯颗粒可用于治疗组合物，或与可植入或可插入的医疗装置相关联，例如与装置上的聚合物涂层相关联。
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公开(公告)号：US20140180229A1
公开(公告)日：2014-06-26
申请号：US14055654
申请日：2013-10-16
Applicant: SurModics, Inc.
Inventor： Shawn Fuller , Bryan A. Claseman , Joram Slager , Jeffrey J. Missling , Gary Maharaj , Gary W. Opperman , Nathan Lockwood , Robert W. Hergenrother , Charles Olson
IPC: A61F13/84
CPC classification number: A61F13/00068 , A61F13/00021 , A61F13/00029 , A61F13/8405 , A61F2013/00153 , A61F2013/00327 , A61F2013/00331 , A61F2013/00357 , A61F2013/00557 , A61L15/22 , A61L15/44 , A61L15/60 , A61L2300/102 , A61L2300/208
Abstract: Embodiments of the invention include wound packing devices and methods of making and using the same. In an embodiment, the invention includes a wound packing device including a plurality of spacing elements capable of absorbing exudate, wherein the surface of the spacing elements resist colonization by microorganisms. The wound packing device can also include a connector connecting the plurality of spacing elements to one another. Other embodiments are also included herein.
Abstract translation: 本发明的实施例包括伤口包装装置及其制造和使用方法。 在一个实施方案中，本发明包括包含能够吸收渗出物的多个间隔元件的伤口包装装置，其中间隔元件的表面抵抗微生物的定居。 卷绕包装装置还可以包括将多个间隔元件彼此连接的连接器。 本文还包括其它实施例。
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公开(公告)号：US11576774B2
公开(公告)日：2023-02-14
申请号：US16914950
申请日：2020-06-29
Applicant: Surmodics, Inc.
Inventor： Bruce M. Jelle , Joram Slager , Joseph S. McGonigle , Rick Murphy , Andrew G. Bach , Teryl L. Woodwick Sides , Ambereen Angamuthu , Sean Lundquist , Gary Opperman , Nathan A. Lockwood
Abstract: The disclosure provides insertion tools and articles that facilitate entry of a medical device, such as a balloon catheter, into the body. In embodiments the insertion tools have an elongate hollow body (50) that is able to protect a portion of a medical device, such as a balloon of a balloon catheter, during an insertion procedure. In one embodiment the insertion tool has an elongate hollow body (131), a tapered distal end (135), and a locking mechanism (133) at the proximal end which can secure a portion of a balloon catheter. An opening at the distal end can allow passage of the balloon in a folded uninflated state.
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公开(公告)号：US11298451B2
公开(公告)日：2022-04-12
申请号：US16685642
申请日：2019-11-15
Applicant: Surmodics, Inc.
Inventor： Joram Slager , Joe McGonigle , Anh Tri La , David E. Babcock , Bruce Jelle , Aleksey Kurdyumov , Timothy M. Kloke , Charlie Olson , Gary Maharaj , Nathan Lockwood
Abstract: A hemodialysis vascular access device includes a proximal end sized and shaped to sealably couple to a hemodialysis catheter, a movable structure coupled to the proximal end, a fixation structure coupled to the movable region and sized and shaped for fixation on a patient, an elongated sleeve coupled to the fixation structure and sized and shaped for insertion into a patient's vasculature, and a valve at a distal end of the internal lumen. When a hemodialysis catheter is inserted into the device and coupled to the proximal end, distal movement of the proximal end relative to the fixation structure biases a distal end of the hemodialysis catheter from a position inside the elongated sleeve through a valve out of the device and into the patient's blood.
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Patent Agency Ranking
公开(公告)号：US11246963B2
公开(公告)日：2022-02-15
申请号：US14280170
申请日：2014-05-16
Applicant: SurModics, Inc.
Inventor： Joram Slager , Dale G. Swan , Darin DuMez , Joseph Ventura , Shannon Wadman , Joseph Schmidt McGonigle , Robert W. Hergenrother
IPC: A61K47/32 , A61L29/04 , A61L29/08 , A61K31/337 , A61K31/436 , A61M25/10 , A61L29/16 , A61K47/34 , A61K9/00
Abstract: Disclosed herein is a delivery composition for administering a hydrophobic active agent. In one embodiment, a delivery composition for local administration of a hydrophobic active agent to a tissue or organ of a patient is disclosed. In one embodiment, the delivery composition includes a cationic delivery agent, a therapeutically effective amount of a hydrophobic active agent and a pharmaceutically acceptable aqueous carrier. In one embodiment, the cationic delivery agent includes polyethyleneimine (PEI). In an embodiment, the invention includes a drug delivery device including a substrate; and coated therapeutic agent particles disposed on the substrate, the coated therapeutic agent particles comprising a particulate hydrophobic therapeutic agent; and a vinyl amine polymer. Methods of making the delivery composition, as well as kits and methods of use are also included herein.
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公开(公告)号：US20210093753A1
公开(公告)日：2021-04-01
申请号：US17038171
申请日：2020-09-30
Applicant: Surmodics, Inc.
Inventor： Joram Slager
Abstract: Embodiments herein relate to active agent depots formed in situ and related methods. In various embodiments, a method of forming an active agent depot in situ is included. The method can include contacting a composition with a vessel wall, wherein the composition includes an active agent and a fibrin promoting vessel wall transfer agent wherein the ratio of active agent to fibrin promoting vessel wall transfer agent (wt./wt.) is at least 5:1. The method also includes transferring the composition from a device surface to the vessel wall surface. The method also includes forming a fibrin matrix around the composition. Other embodiments are also included herein.
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公开(公告)号：US20210015613A1
公开(公告)日：2021-01-21
申请号：US16914950
申请日：2020-06-29
Applicant: Surmodics, Inc.
Inventor： Bruce M. Jelle , Joram Slager , Joseph S. McGonigle , Rick Murphy , Andrew G. Bach , Teryl L. Woodwick Sides , Ambereen Angamuthu , Sean Lundquist , Gary Opperman , Nathan A. Lockwood
Abstract: The disclosure provides insertion tools and articles that facilitate entry of a medical device, such as a balloon catheter, into the body. In embodiments the insertion tools have an elongate hollow body (50) that is able to protect a portion of a medical device, such as a balloon of a balloon catheter, during an insertion procedure. In one embodiment the insertion tool has an elongate hollow body (131), a tapered distal end (135), and a locking mechanism (133) at the proximal end which can secure a portion of a balloon catheter. An opening at the distal end can allow passage of the balloon in a folded uninflated state.
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公开(公告)号：US10478546B2
公开(公告)日：2019-11-19
申请号：US15257252
申请日：2016-09-06
Applicant: Surmodics, Inc.
Inventor： Joram Slager , Joe McGonigle , Anh Tri La , David E. Babcock , Bruce Jelle , Aleksey Kurdyumov , Timothy M. Kloke , Charlie Olson , Gary Maharaj , Nathan Lockwood
Abstract: A hemodialysis vascular access device includes a proximal end sized and shaped to sealably couple to a hemodialysis catheter, a movable structure coupled to the proximal end, a fixation structure coupled to the movable region and sized and shaped for fixation on a patient, an elongated sleeve coupled to the fixation structure and sized and shaped for insertion into a patient's vasculature, and a valve at a distal end of the internal lumen. When a hemodialysis catheter is inserted into the device and coupled to the proximal end, distal movement of the proximal end relative to the fixation structure biases a distal end of the hemodialysis catheter from a position inside the elongated sleeve through a valve out of the device and into the patient's blood.
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公开(公告)号：US20190330551A1
公开(公告)日：2019-10-31
申请号：US16505145
申请日：2019-07-08
Applicant: Surmodics, Inc.
Inventor： David E. Babcock , Joram Slager , Robert W. Hergenrother
IPC: C10M107/26 , C10M107/46 , C10M107/42 , A61L27/34 , A61M25/10
Abstract: Embodiments herein include coated medical devices and coatings with salt groups. In an embodiment, a coated medical device is included, the coated medical device including a substrate and a polymeric layer disposed over the substrate. The polymeric layer includes a polymer and has an exterior surface. The coated medical device further includes a plurality of salt groups bonded to the polymer of the polymeric layer and disposed on the exterior surface of the polymeric layer. The salt groups can be the reaction product of a reactive group with an acid or base. In an embodiment, a method of making a medical device is included. Other embodiments are also included herein.
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