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公开(公告)号：US10253193B2
公开(公告)日：2019-04-09
申请号：US15994206
申请日：2018-05-31
Applicant: Surmodics, Inc.
Inventor： Aleksey V. Kurdyumov , Dale G. Swan
IPC: C07F9/145 , C09D7/63 , A61L17/14 , A61L27/34 , A61L29/08 , A61L31/10 , C07F7/10 , C07F9/12 , C07F9/40 , C08F2/48 , C07F7/18 , C07F9/06 , C08K5/51 , C08K5/5419 , C08K5/544
Abstract: Described herein is a degradable linking agent of formula Photo1-LG-Photo2, wherein Photo1 and Photo2 independently represent at least one photoreactive group and LG represents a linking group comprising one or more silicon atoms or one or more phosphorous atoms. The degradable linking agent includes a covalent linkage between at least one photoreactive group and the linking group, wherein the covalent linkage between at least one photoreactive group and the linking group is interrupted by at least one heteroatom. A method for coating a support surface with the degradable linking agent, coated support surfaces and medical devices are also described.
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公开(公告)号：US09994721B2
公开(公告)日：2018-06-12
申请号：US15283818
申请日：2016-10-03
Applicant: Surmodics, Inc.
Inventor： Aleksey V. Kurdyumov , Dale G. Swan
IPC: C07F7/10 , C09D7/12 , A61L17/14 , A61L27/34 , A61L29/08 , A61L31/10 , C07F7/18 , C07F9/12 , C07F9/145 , C07F9/40 , C08F2/48 , C07F9/06 , C08K5/51 , C08K5/5419 , C08K5/544
CPC classification number: C09D7/63 , A61L17/145 , A61L27/34 , A61L29/085 , A61L31/10 , A61L2400/18 , A61L2420/02 , C07F7/10 , C07F7/1804 , C07F7/184 , C07F9/06 , C07F9/12 , C07F9/145 , C07F9/4025 , C07F9/4084 , C08F2/48 , C08K5/51 , C08K5/5419 , C08K5/544 , C09D7/1233
Abstract: Described herein is a degradable linking agent of formula Photo1-LG-Photo2, wherein Photo1 and Photo2 independently represent at least one photoreactive group and LG represents a linking group comprising one or more silicon atoms or one or more phosphorous atoms. The degradable linking agent includes a covalent linkage between at least one photoreactive group and the linking group, wherein the covalent linkage between at least one photoreactive group and the linking group is interrupted by at least one heteroatom. A method for coating a support surface with the degradable linking agent, coated support surfaces and medical devices are also described.
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公开(公告)号：US20170022375A1
公开(公告)日：2017-01-26
申请号：US15283818
申请日：2016-10-03
Applicant: Surmodics, Inc.
Inventor： Aleksey V. Kurdyumov , Dale G. Swan
CPC classification number: C09D7/63 , A61L17/145 , A61L27/34 , A61L29/085 , A61L31/10 , A61L2400/18 , A61L2420/02 , C07F7/10 , C07F7/1804 , C07F7/184 , C07F9/06 , C07F9/12 , C07F9/145 , C07F9/4025 , C07F9/4084 , C08F2/48 , C08K5/51 , C08K5/5419 , C08K5/544 , C09D7/1233
Abstract: Described herein is a degradable linking agent of formula Photo1-LG-Photo2, wherein Photo1 and Photo2 independently represent at least one photoreactive group and LG represents a linking group comprising one or more silicon atoms or one or more phosphorous atoms. The degradable linking agent includes a covalent linkage between at least one photoreactive group and the linking group, wherein the covalent linkage between at least one photoreactive group and the linking group is interrupted by at least one heteroatom. A method for coating a support surface with the degradable linking agent, coated support surfaces and medical devices are also described.
Abstract translation: 本文描述了分子式为Photo1-LG-Photo2的可降解连接剂，其中Photo1和Photo2独立地表示至少一个光反应性基团，LG代表包含一个或多个硅原子或一个或多个磷原子的连接基团。 可降解交联剂包括至少一个光反应基团和连接基团之间的共价键，其中至少一个光反应基团和连接基团之间的共价键被至少一个杂原子中断。 还描述了用可降解的连接剂，涂覆的支撑表面和医疗装置涂覆支撑表面的方法。
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公开(公告)号：US20150166801A1
公开(公告)日：2015-06-18
申请号：US14541768
申请日：2014-11-14
Applicant: SurModics, Inc.
Inventor： Aleksey V. Kurdyumov , Dale G. Swan
CPC classification number: C09D7/63 , A61L17/145 , A61L27/34 , A61L29/085 , A61L31/10 , A61L2400/18 , A61L2420/02 , C07F7/10 , C07F7/1804 , C07F7/184 , C07F9/06 , C07F9/12 , C07F9/145 , C07F9/4025 , C07F9/4084 , C08F2/48 , C08K5/51 , C08K5/5419 , C08K5/544 , C09D7/1233
Abstract: Described herein is a degradable linking agent of formula Photo1-LG-Photo2, wherein Photo1 and Photo2 independently represent at least one photoreactive group and LG represents a linking group comprising one or more silicon atoms or one or more phosphorous atoms. The degradable linking agent includes a covalent linkage between at least one photoreactive group and the linking group, wherein the covalent linkage between at least one photoreactive group and the linking group is interrupted by at least one heteroatom. A method for coating a support surface with the degradable linking agent, coated support surfaces and medical devices are also described.
Abstract translation: 本文描述了分子式为Photo1-LG-Photo2的可降解连接剂，其中Photo1和Photo2独立地表示至少一个光反应性基团，LG代表包含一个或多个硅原子或一个或多个磷原子的连接基团。 可降解交联剂包括至少一个光反应基团和连接基团之间的共价键，其中至少一个光反应基团和连接基团之间的共价键被至少一个杂原子中断。 还描述了用可降解的连接剂，涂覆的支撑表面和医疗装置涂覆支撑表面的方法。
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公开(公告)号：US09487663B2
公开(公告)日：2016-11-08
申请号：US14541768
申请日：2014-11-14
Applicant: SurModics, Inc.
Inventor： Aleksey V. Kurdyumov , Dale G. Swan
IPC: C07F9/145 , C09D7/12 , A61L17/14 , A61L27/34 , A61L29/08 , A61L31/10 , C07F7/10 , C07F7/18 , C07F9/12 , C07F9/40 , C08F2/48 , C07F9/06 , C08K5/51 , C08K5/5419 , C08K5/544
CPC classification number: C09D7/63 , A61L17/145 , A61L27/34 , A61L29/085 , A61L31/10 , A61L2400/18 , A61L2420/02 , C07F7/10 , C07F7/1804 , C07F7/184 , C07F9/06 , C07F9/12 , C07F9/145 , C07F9/4025 , C07F9/4084 , C08F2/48 , C08K5/51 , C08K5/5419 , C08K5/544 , C09D7/1233
Abstract: Described herein is a degradable linking agent of formula Photo1-LG-Photo2, wherein Photo1 and Photo2 independently represent at least one photoreactive group and LG represents a linking group comprising one or more silicon atoms or one or more phosphorous atoms. The degradable linking agent includes a covalent linkage between at least one photoreactive group and the linking group, wherein the covalent linkage between at least one photoreactive group and the linking group is interrupted by at least one heteroatom. A method for coating a support surface with the degradable linking agent, coated support surfaces and medical devices are also described.
Abstract translation: 本文描述了分子式为Photo1-LG-Photo2的可降解连接剂，其中Photo1和Photo2独立地表示至少一个光反应性基团，LG代表包含一个或多个硅原子或一个或多个磷原子的连接基团。 可降解交联剂包括至少一个光反应基团和连接基团之间的共价键，其中至少一个光反应基团和连接基团之间的共价键被至少一个杂原子中断。 还描述了用可降解的连接剂，涂覆的支撑表面和医疗装置涂覆支撑表面的方法。
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Patent Agency Ranking
公开(公告)号：US10745573B2
公开(公告)日：2020-08-18
申请号：US16378222
申请日：2019-04-08
Applicant: Surmodics, Inc.
Inventor： Aleksey V. Kurdyumov , Dale G. Swan
IPC: C07F7/18 , C09D7/63 , A61L17/14 , A61L27/34 , A61L29/08 , A61L31/10 , C07F7/10 , C07F9/12 , C07F9/145 , C07F9/40 , C08F2/48 , C07F9/06 , C08K5/51 , C08K5/5419 , C08K5/544
Abstract: Described herein is a degradable linking agent of formula Photo1-LG-Photo2, wherein Photo1 and Photo2 independently represent at least one photoreactive group and LG represents a linking group comprising one or more silicon atoms or one or more phosphorous atoms. The degradable linking agent includes a covalent linkage between at least one photoreactive group and the linking group, wherein the covalent linkage between at least one photoreactive group and the linking group is interrupted by at least one heteroatom. A method for coating a support surface with the degradable linking agent, coated support surfaces and medical devices are also described.
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公开(公告)号：US20140336571A1
公开(公告)日：2014-11-13
申请号：US14280170
申请日：2014-05-16
Applicant: SurModics, Inc.
Inventor： Joram Slager , Dale G. Swan , Darin DuMez , Joseph Ventura , Shannon Wadman , Joseph Schmidt McGonigle , Robert W. Hergenrother
IPC: A61K47/32 , A61K31/436 , A61L29/04 , A61M25/10 , A61L29/08 , A61L29/16 , A61K31/337 , A61K9/14
CPC classification number: A61L29/041 , A61K9/0019 , A61K31/337 , A61K31/436 , A61K47/34 , A61L29/085 , A61L29/16 , A61L2300/416 , A61L2300/62 , A61L2300/63 , A61L2400/06 , A61L2420/06 , A61L2420/08 , A61M25/10 , A61M2025/105 , C08L79/02
Abstract: Disclosed herein is a delivery composition for administering a hydrophobic active agent. In one embodiment, a delivery composition for local administration of a hydrophobic active agent to a tissue or organ of a patient is disclosed. In one embodiment, the delivery composition includes a cationic delivery agent, a therapeutically effective amount of a hydrophobic active agent and a pharmaceutically acceptable aqueous carrier. In one embodiment, the cationic delivery agent includes polyethyleneimine (PEI). In an embodiment, the invention includes a drug delivery device including a substrate; and coated therapeutic agent particles disposed on the substrate, the coated therapeutic agent particles comprising a particulate hydrophobic therapeutic agent; and a vinyl amine polymer. Methods of making the delivery composition, as well as kits and methods of use are also included herein.
Abstract translation: 本文公开了用于施用疏水性活性剂的递送组合物。 在一个实施方案中，公开了用于向患者的组织或器官局部施用疏水性活性剂的递送组合物。 在一个实施方案中，递送组合物包括阳离子递送剂，治疗有效量的疏水活性剂和药学上可接受的水性载体。 在一个实施方案中，阳离子递送剂包括聚乙烯亚胺（PEI）。 在一个实施方案中，本发明包括药物递送装置，其包括基底; 以及设置在基材上的被覆治疗剂颗粒，所述涂敷的治疗剂颗粒包含颗粒状疏水性治疗剂; 和乙烯基胺聚合物。 制备递送组合物的方法以及试剂盒和使用方法也包括在本文中。
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8.发明申请STILBENE-BASED REACTIVE COMPOUNDS, POLYMERIC MATRICES FORMED THEREFROM, AND ARTICLES VISUALIZABLE BY FLUORESCENCE 有权基于STILBENE的反应性化合物，其形成的聚合物和可透过荧光的物质公开(公告)号：US20140162083A1
公开(公告)日：2014-06-12
申请号：US14104208
申请日：2013-12-12
Applicant: SurModics, Inc.
Inventor： Aleksey V. Kurdyumov , Dale G. Swan , Nathan A. Lockwood , Bruce M. Jelle
IPC: A61L31/14 , C07C233/81 , A61L31/10 , C07D251/68
CPC classification number: A61L31/14 , A61B1/00135 , A61B1/005 , A61L31/10 , C07C235/84 , C07C309/46 , C07D251/54 , C07D251/68 , Y10T428/31942
Abstract: The invention is directed to latent reactive and polymerizable derivatives of fluorescent stilbene-based compounds. The compounds can be used to provide articles with a fluorescence property, such as medical devices (e.g., catheters). The fluorescent compounds can be used in association with polymers, or can be incorporated into polymers, and the polymers used in a coating composition on the article surface. The compounds allow for visual or machine inspection of coating properties such as uniformity of coverage.
Abstract translation: 本发明涉及荧光芪类化合物的潜在反应性和可聚合衍生物。 这些化合物可用于提供具有荧光性质的制品，例如医疗装置（例如导管）。 荧光化合物可以与聚合物结合使用，或者可以并入聚合物中，以及用于制品表面上的涂料组合物中的聚合物。 这些化合物允许对涂层性能进行视觉或机器检查，例如覆盖的均匀性。
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公开(公告)号：US20190367748A1
公开(公告)日：2019-12-05
申请号：US16378222
申请日：2019-04-08
Applicant: Surmodics, Inc.
Inventor： Aleksey V. Kurdyumov , Dale G. Swan
IPC: C09D7/63 , C08K5/544 , C08K5/5419 , C08K5/51 , C07F9/06 , C07F7/18 , C07F9/40 , C08F2/48 , C07F9/145 , C07F9/12 , C07F7/10 , A61L31/10 , A61L29/08 , A61L27/34 , A61L17/14
Abstract: Described herein is a degradable linking agent of formula Photo1-LG-Photo2, wherein Photo1 and Photo2 independently represent at least one photoreactive group and LG represents a linking group comprising one or more silicon atoms or one or more phosphorous atoms. The degradable linking agent includes a covalent linkage between at least one photoreactive group and the linking group, wherein the covalent linkage between at least one photoreactive group and the linking group is interrupted by at least one heteroatom. A method for coating a support surface with the degradable linking agent, coated support surfaces and medical devices are also described.
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公开(公告)号：US11246963B2
公开(公告)日：2022-02-15
申请号：US14280170
申请日：2014-05-16
Applicant: SurModics, Inc.
Inventor： Joram Slager , Dale G. Swan , Darin DuMez , Joseph Ventura , Shannon Wadman , Joseph Schmidt McGonigle , Robert W. Hergenrother
IPC: A61K47/32 , A61L29/04 , A61L29/08 , A61K31/337 , A61K31/436 , A61M25/10 , A61L29/16 , A61K47/34 , A61K9/00
Abstract: Disclosed herein is a delivery composition for administering a hydrophobic active agent. In one embodiment, a delivery composition for local administration of a hydrophobic active agent to a tissue or organ of a patient is disclosed. In one embodiment, the delivery composition includes a cationic delivery agent, a therapeutically effective amount of a hydrophobic active agent and a pharmaceutically acceptable aqueous carrier. In one embodiment, the cationic delivery agent includes polyethyleneimine (PEI). In an embodiment, the invention includes a drug delivery device including a substrate; and coated therapeutic agent particles disposed on the substrate, the coated therapeutic agent particles comprising a particulate hydrophobic therapeutic agent; and a vinyl amine polymer. Methods of making the delivery composition, as well as kits and methods of use are also included herein.
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