Abstract:
This invention is directed to a method of treating fibromyalgia in a patient which comprises administering a growth hormone secretagogue, prodrugs thereof or pharmaceutically acceptable salts of said secretagogues or said prodrugs to a patient in need thereof. The present invention provides such a method wherein the growth hormone secretagogue is a compound of Formula I: a prodrug thereof or a pharmaceutically acceptable salt of said secretagogue or said prodrug and wherein the variables HET, R3, R4, X4, R6, R7 and R8 are as defined in the specification.
Abstract translation:本发明涉及一种治疗患者纤维肌痛的方法,该方法包括向有需要的患者施用生长激素促分泌素,其前药或所述促分泌素或所述前药的药学上可接受的盐。 本发明提供了这样的方法,其中生长激素促分泌素是式I的化合物:其前药或所述促分泌素或所述前药的药学上可接受的盐,其中变量HET,R 3,R 4,X R 4,R 6,R 7和R 8如说明书中所定义。
Abstract:
A carbonated beverage container (10, 35, 40) including a hollow insert (1, 20). The insert (1, 20) has one one-way valve (7, 29, 31, 32) and one orifice (6, 28, 33, 34), one of which is arranged to allow gas from a headspace above beverage (11) to enter the insert (1, 20), and the other is arranged to jet gas from inside the insert (1, 20) into the beverage (11) upon opening the container (10, 35, 40). The 20 gas jetting into the beverage (11) causes nucleation of fine bubbles in the beverage (11) which separate out to form a close-knit creamy head.
Abstract:
An insert (10, 12) for use in providing a creamy head on a carbonated beverage dispensed from a beverage container (50) comprises a restricted orifice (20) for providing communication between its inside and outside, and a pressurized gas contained inside. The restricted orifice (20) is separated from the pressurized gas by a closure (22) which is arranged to be permanently and irreversibly opened on being subjected to a temperature above a predetermined threshold, or on being subjected to a pressure difference in which the pressure outside the insert (10, 12) exceeds that within. This enables the insert to be pre-pressurized and completely closed and stable during insertion into the container (50) and during filling. Then the closure (22) is permanently and irreversibly opened during a subsequent pasteurization step to ensure that all of the gas is vented from the insert (10, 12) on opening the container (50).
Abstract:
This invention relates to methods employing IL-1β-ligand/IL-1 receptor disrupting compounds (herein referred to as “IL-1beta Compounds”); such as small molecular compounds disrupting IL-1β ligand-IL-1 receptor interaction, IL-1β antibodies or IL-1 receptor antibodies, e.g. IL-1β binding molecules as described herein, e.g. antibodies disclosed herein, e.g. IL-1β binding compounds or IL-1 receptor binding compounds, and/or RNA compounds decreasing either IL-1β ligands or IL-1 receptor protein levels, in the treatment and/or prevention of auto-inflammatory syndromes, e.g. Juvenile rheumatoid arthritis or adult rheumatoid arthritis syndrome and to methods of treating and/or preventing auto-inflammatory syndromes, e.g. Juvenile rheumatoid arthritis or adult rheumatoid arthritis syndrome, in mammals, particularly humans.
Abstract:
A method for validating payment information for an online transaction is provided. A payment server can receive two representations of the same payment information. The payment information can be validated if it is determined that the two representations match. If there is no match, or the payment information is otherwise invalid, the payment information can be repaired based on a trusted representation of the payment information, such as stored payment information or an image of an associated value token. Payment information can be received via one or more communication channels, and can be provided by one or more consumer devices. A merchant service provider can validate payment information and handle transaction processing on behalf of a merchant.
Abstract:
An optical system includes an outer reflector and at least one inner reflector, wherein the inner reflector is disposed within the outer reflector. The outer reflector has a proximal end, a distal end, and an interior surface extending from the distal end to the proximal end. The inner reflector has a proximal end, a distal end, and an interior surface and exterior surface extending from the distal end to the proximal end. The proximal end of the outer reflector is positioned adjacent a light source, wherein the light source is surrounded by the outer reflector's proximal end. The light source emits narrow angle beams of light through the inner reflector and emits wide angle beams of light between the outer reflector's inner surface and the inner reflector's external surface. The positioning and dimension of the inner reflector prevents the light source from emitting wide angle beams of light directly to an illuminated surface.
Abstract:
The present invention is a method for seaming a polymeric material. The method involves forming an interface between a plurality of separate polymeric sheets of materials. Next, heat and pressure are applied to facilitate the diffusion of the polymer molecules at the interface. A diffusion weld is made when the polymer molecules diffuse across the interface.
Abstract:
This invention relates to methods employing IL-1β-ligand/IL-1 receptor disrupting compounds (herein referred to as “IL-1beta Compounds”); such as small molecular compounds disrupting IL-1β ligand-IL-1 receptor interaction, IL-1β antibodies or IL-1 receptor antibodies, e.g. IL-1β binding molecules as described herein, e.g. antibodies disclosed herein, e.g. IL-1β binding compounds or IL-1 receptor binding compounds, and/or RNA compounds decreasing either IL-1β ligands or IL-1 receptor protein levels, in the treatment and/or prevention of auto-inflammatory syndromes, e.g. Juvenile rheumatoid arthritis or adult rheumatoid arthritis syndrome and to methods of treating and/or preventing auto-inflammatory syndromes, e.g. Juvenile rheumatoid arthritis or adult rheumatoid arthritis syndrome, in mammals, particularly humans.
Abstract:
An optical system includes an outer reflector and at least one inner reflector, wherein the inner reflector is disposed within the outer reflector. The outer reflector has a proximal end, a distal end, and an interior surface extending from the distal end to the proximal end. The inner reflector has a proximal end, a distal end, and an interior surface and exterior surface extending from the distal end to the proximal end. The proximal end of the outer reflector is positioned adjacent a light source, wherein the light source is surrounded by the outer reflector's proximal end. The light source emits narrow angle beams of light through the inner reflector and emits wide angle beams of light between the outer reflector's inner surface and the inner reflector's external surface. The positioning and dimension of the inner reflector prevents the light source from emitting wide angle beams of light directly to an illuminated surface.
Abstract:
A light emitting diode (LED) sign lighter is positioned to illuminate a sign. One or more LED modules on the LED sign lighter are directed toward different portions of the sign. Each LED module is configured with a reflector or over-optic to control the angle of the light emitted toward the sign. Each LED module includes an array of LEDs. The configuration of each LED module within the LED sign lighter helps to reduce the build-up of environmental contaminants on the LED module. The center section of the LED sign lighter includes a compartment for housing electrical components to power the LED modules. Heat sink fins are oriented along the back side of the LED sign lighter to provide thermal efficiency for the LED modules.