公开(公告)号：US20190352639A1

公开(公告)日：2019-11-21

申请号：US16476917

申请日：2018-02-12

Applicant: UNIVERSITY OF WASHINGTON

Inventor： Marc Joseph LAJOIE ,  Elizabeth Erin GRAY ,  Neil P. KING ,  Daniel Brewster STETSON ,  David BAKER ,  Katherine DaPRON

IPC: C12N15/11 ,  C12N9/22 ,  C12N15/85 ,  C07K14/005 ,  C12N7/00

Abstract: The application discloses multimeric assemblies packaging one or more active component and their use to carry out nucleic acid regulation or gene editing.

公开(公告)号：US20190284242A1

公开(公告)日：2019-09-19

申请号：US16427493

申请日：2019-05-31

Applicant: UNIVERSITY OF WASHINGTON

Inventor： David BAKER ,  Jacob B. BALE ,  Neil P. KING ,  William H. SHEFFLER ,  Daniel ELLIS

IPC: C07K14/00

Abstract: Synthetic nanostructures, polypeptides that are useful, for example, in making synthetic nanostructures, and methods for using such synthetic nanostructures are disclosed herein.

公开(公告)号：US20250064903A1

公开(公告)日：2025-02-27

申请号：US18034622

申请日：2021-10-29

Applicant: University of Washington ,  THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Ingrid Swanson PULTZ ,  Clancey WOLF ,  Justin Bloomfield SIEGEL ,  Christine Elaine TINBERG ,  Lance STEWART ,  David BAKER

IPC: A61K38/48 ,  C12N9/52

Abstract: The present disclosure is directed to polypeptides capable of cleaving gluten proteins, e.g., gliadins, nucleic acid molecules encoding the same, pharmaceutical compositions comprising the same, and methods of use thereof for treating celiac sprue disease and/or non-celiac gluten sensitivity (NCGS).

公开(公告)号：US20230416726A1

公开(公告)日：2023-12-28

申请号：US18339519

申请日：2023-06-22

Applicant: University of Washington

Inventor： David BAKER ,  Jue WANG ,  Robert RAGOTTE ,  Lukas MILLES ,  Joseph L. WATSON ,  David JUERGENS ,  Sidney LISANZA ,  Amijai SARAGOVI ,  Wei YANG ,  Derrick HICKS ,  Douglas TISCHER ,  Thomas SCHLICHTHAERLE

IPC: C12N15/10 ,  G16B15/20 ,  G16B15/30 ,  G16B40/20

CPC classification number: C12N15/1037 ,  C12N15/1055 ,  G16B15/20 ,  G16B15/30 ,  G16B40/20

Abstract: De novo designed proteins with binding activity are disclosed, which were designed starting from a desired functional site and jointly filling in the missing sequence and structure needed to complete the protein, and uses of the binding proteins.

公开(公告)号：US20230303626A1

公开(公告)日：2023-09-28

申请号：US18054261

申请日：2022-11-10

Applicant: UNIVERSITY OF WASHINGTON

Inventor： Parisa HOSSEINZADEH ,  David BAKER ,  Gaurav BHARDWAJ ,  Vikram K. MULLIGAN

IPC: C07K7/64

CPC classification number: C07K7/64

Abstract: Disclosed herein are macrocyclic polypeptides having no more than 3 amino acid substitutions compared to the amino acid sequence of any one of SEQ ID NO: 1-2.37 or a mirror image thereof, wherein the polypeptide includes both L and D amino acids, libraries of such polypeptides, and uses thereof.

公开(公告)号：US20230279056A1

公开(公告)日：2023-09-07

申请号：US17999524

申请日：2021-05-25

Applicant: University of Washington

Inventor： Alfredo QUIJANO RUBIO ,  Jooyoung PARK ,  Hsien-Wei YEH ,  David BAKER ,  Longxing CAO ,  Brian COVENTRY ,  Inna GORESHNIK ,  Lisa KOZODOY ,  Lance Joseph STEWART

IPC: C07K14/00 ,  G01N33/542

CPC classification number: C07K14/001 ,  G01N33/542

Abstract: The disclosure provides cage proteins comprising a helical bundle, wherein the cage protein comprises a structural region and a latch region, wherein the latch region comprises one or more target binding polypeptide, wherein the cage protein further comprises a first reporter protein domain, wherein the first reporter protein domain undergoes a detectable change in reporting activity when bound to a second split reporter protein domain, and wherein the structural region interacts with the latch region to prevent solution access to the one or more target binding polypeptide.

公开(公告)号：US20230192773A1

公开(公告)日：2023-06-22

申请号：US17907302

申请日：2021-04-28

Applicant: University of Washington

Inventor： Chunfu XU ,  Peilong LU ,  Tamer GAMAL EL-DIN ,  William A. CATTERALL ,  David BAKER

IPC: C07K14/00 ,  C07K14/705

CPC classification number: C07K14/001 ,  C07K14/705 ,  C07K2319/03 ,  C12Q1/6869

Abstract: Disclosed herein are polypeptide comprising an amino acid sequence at least 50%, 55%, 60%, 65%, 70%, 75%, 80%, 85%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to the amino acid sequence of any one of SEQ ID NOS: 1-4, oligomers thereof, and uses thereof.

公开(公告)号：US20220273711A1

公开(公告)日：2022-09-01

申请号：US17609972

申请日：2020-05-18

Applicant: University of Washington

Inventor： Scott BOYKEN ,  Marc Joseph LAJOIE ,  Robert A. LANGAN ,  David BAKER ,  Jilliane Ruth BRUFFEY

IPC: A61K35/17 ,  C12N15/62 ,  C07K16/18

Abstract: Disclosed am protein switches that can sequester bioactive peptides and/or binding domains, holding them in an inactive (“off”) state, until combined with a second designed polypeptide called die key, which induces a conformational change that activates (“on”) the bioactive peptide or binding domain only when the protein switch components are co-localized when bound to their targets, components of such protein switches, and their use.

公开(公告)号：US20220185853A1

公开(公告)日：2022-06-16

申请号：US17603080

申请日：2020-04-15

Applicant: UNIVERSITY OF WASHINGTON

Inventor： Jooyoung PARK ,  Scott BOYKEN ,  Kathy WEI ,  Gustav OBERDORFER ,  David BAKER

IPC: C07K14/47 ,  C12N15/63

Abstract: Disclosed herein are amantadine binding polypeptides, fusion proteins thereof, and uses of such polypeptides and fusion proteins.

公开(公告)号：US20220177862A1

公开(公告)日：2022-06-09

申请号：US17434832

申请日：2020-03-11

Applicant: UNIVERSITY OF WASHINGTON

Inventor： Shiri LEVY ,  Hannele RUOHOLA-BAKER ,  David BAKER

IPC: C12N9/22 ,  C12N15/11 ,  C12N15/90

Abstract: Disclosed herein are compositions including an embryonic ectoderm development (BED) polypeptide binder (EB) domain and a CRISPR associated protein 9 (CAS9) domain linked to the EB domain, and uses thereof for gene activation in a biological cell.