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公开(公告)号：US06265583B1
公开(公告)日：2001-07-24
申请号：US09177100
申请日：1998-10-22
申请人： Deborah E. Bertenshaw , Daniel Getman , Robert M. Heintz , John J. Talley , Kathryn L. Reed , Robert Alan Chrusciel , Michael Clare
发明人： Deborah E. Bertenshaw , Daniel Getman , Robert M. Heintz , John J. Talley , Kathryn L. Reed , Robert Alan Chrusciel , Michael Clare
IPC分类号： C07D28506
CPC分类号： C07D333/48 , C07D231/12 , C07D233/56 , C07D249/08 , C07D279/12 , C07D335/02 , C07D409/12
摘要： The present invention relates to cyclic sulfone moiety-containing hydroxyethylamine protease inhibitor compounds and pharmaceutical or method of use therefor, particularly as an inhibitor of HIV protease.
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公开(公告)号：US6022994A
公开(公告)日：2000-02-08
申请号：US41016
申请日：1998-03-12
申请人： Michael L. Vazquez , Richard A. Mueller , John J. Talley , Daniel Getman , Gary A. DeCrescenzo , John N. Freskos
发明人： Michael L. Vazquez , Richard A. Mueller , John J. Talley , Daniel Getman , Gary A. DeCrescenzo , John N. Freskos
IPC分类号： A61K31/145 , A61K38/04 , C07C307/02 , C07C311/06 , C07C311/19 , C07C327/02 , C07D233/54 , C07D233/64 , C07K5/04
CPC分类号： C07C311/05 , C07C311/18 , C07C311/29
摘要： Succinoylamino hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.
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公开(公告)号：US5849784A
公开(公告)日：1998-12-15
申请号：US556883
申请日：1995-11-02
申请人： Deborah E. Bertenshaw , Daniel Getman , Robert M. Heintz , John J. Talley , Kathryn L. Reed , Robert Alan Chrusciel , Michael Clare
发明人： Deborah E. Bertenshaw , Daniel Getman , Robert M. Heintz , John J. Talley , Kathryn L. Reed , Robert Alan Chrusciel , Michael Clare
IPC分类号： A61K31/38 , A61K31/381 , A61K31/382 , A61K31/415 , A61K31/425 , A61K31/4433 , A61K31/445 , A61K31/54 , A61P31/12 , A61P43/00 , C07D279/12 , C07D283/00 , C07D333/48 , C07D335/02 , C07D409/12 , C07D417/12 , C07D521/00
CPC分类号： C07D333/48 , C07D231/12 , C07D233/56 , C07D249/08 , C07D279/12 , C07D335/02 , C07D409/12
摘要： The present invention relates to cyclic sulfone moiety-containing hydroxyethylamine protease inhibitor compounds and pharmaceutical or method of use therefor, particularly as an inhibitor of HIV protease.
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公开(公告)号：US5760076A
公开(公告)日：1998-06-02
申请号：US541747
申请日：1995-10-10
申请人： Michael L. Vazquez , Richard A. Mueller , John J. Talley , Daniel Getman , Gary A. DeCrescenzo , John N. Freskos
发明人： Michael L. Vazquez , Richard A. Mueller , John J. Talley , Daniel Getman , Gary A. DeCrescenzo , John N. Freskos
IPC分类号： A61K31/18 , A61K31/195 , A61K31/197 , A61K31/216 , A61K31/381 , A61K31/4406 , A61K31/4409 , A61K31/215 , A61K31/19
CPC分类号： A61K31/5375 , A61K31/18 , A61K31/195 , A61K31/197 , A61K31/216 , A61K31/381 , A61K31/4406 , A61K31/4409
摘要： Succinoylamino hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.
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公开(公告)号：US5714605A
公开(公告)日：1998-02-03
申请号：US541350
申请日：1995-10-10
申请人： Michael L. Vazquez , Richard A. Mueller , John J. Talley , Daniel Getman , Gary A. DeCrescenzo , John N. Freskos
发明人： Michael L. Vazquez , Richard A. Mueller , John J. Talley , Daniel Getman , Gary A. DeCrescenzo , John N. Freskos
IPC分类号： A61K31/255 , A61K31/18 , A61K31/195 , A61K31/197 , A61K31/381 , A61K31/4406 , A61K31/4409 , A61P31/12 , A61P31/18 , C07C311/05 , C07C311/18 , C07C311/29 , C07C327/38 , C07D265/30 , C07D211/70 , C07D333/20 , C07D333/30
CPC分类号： A61K31/5375 , A61K31/18 , A61K31/195 , A61K31/197 , A61K31/381 , A61K31/4406 , A61K31/4409 , C07C311/05 , C07C311/18 , C07C311/29
摘要： Succinoylamino hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.
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36.发明授权Sulfonylalkanoylamino hydroxyethylamino sulfonamides useful as retroviral protease inhibitors 失效用作逆转录病毒蛋白酶抑制剂的磺酰基烷酰氨基羟乙基氨基磺酰胺
公开(公告)号：US5639769A
公开(公告)日：1997-06-17
申请号：US587688
申请日：1996-01-17
申请人： Michael L. Vazquez , Richard A. Mueller , John J. Talley , Daniel Getman , Gary A. DeCrescenzo , John N. Freskos
发明人： Michael L. Vazquez , Richard A. Mueller , John J. Talley , Daniel Getman , Gary A. DeCrescenzo , John N. Freskos
IPC分类号： A61K31/225 , A61K31/18 , A61K31/63 , A61P31/12 , C07C311/18 , C07C317/44 , C07C327/38 , C07D307/79 , C07D319/16 , A61K31/38 , A61K31/44
CPC分类号： A61K31/63 , A61K31/18 , C07C317/44
摘要： Sulfonamide-containing hydroxyethylamine compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.
摘要翻译： 含磺酰胺的羟乙胺化合物作为逆转录病毒蛋白酶抑制剂是有效的，特别是作为HIV蛋白酶的抑制剂。
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公开(公告)号：US5514801A
公开(公告)日：1996-05-07
申请号：US998187
申请日：1992-12-29
IPC分类号： A61K31/38 , A61K31/381 , A61K31/382 , A61K31/415 , A61K31/425 , A61K31/4433 , A61K31/445 , A61K31/54 , A61P31/12 , A61P43/00 , C07D279/12 , C07D283/00 , C07D333/48 , C07D335/02 , C07D409/12 , C07D417/12 , C07D521/00 , C07D217/22 , C07D217/14
CPC分类号： C07D333/48 , C07D231/12 , C07D233/56 , C07D249/08 , C07D279/12 , C07D335/02 , C07D409/12
摘要： The present invention relates to cyclic sulfone moiety-containing hydroxyethylamine protease inhibitor compounds and pharmaceutical or method of use therefor, particularly as an inhibitor of HIV protease.
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38.发明申请Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors 失效双氨基酸羟乙基氨基磺酰胺逆转录病毒蛋白酶抑制剂公开(公告)号：US20070037754A1
公开(公告)日：2007-02-15
申请号：US11501926
申请日：2006-08-10
申请人： Daniel Getman , Gary DeCrescenzo , John Freskos , Michael Vazquez , James Sikorski , Balekudru Devadas , Srinivasan Nagarajan , David Brown , Joseph McDonald
发明人： Daniel Getman , Gary DeCrescenzo , John Freskos , Michael Vazquez , James Sikorski , Balekudru Devadas , Srinivasan Nagarajan , David Brown , Joseph McDonald
CPC分类号： C07K5/06026 , A61K31/16 , A61K31/165 , A61K31/357 , A61K31/36 , A61K31/4184 , A61K31/423 , A61K31/428 , A61K38/00 , C07K5/06078 , C07K5/06139 , C07K5/06191
摘要： Selected bis-amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. The present invention relates to such retroviral protease inhibitors and, more particularly, relates to selected novel compounds, compositions, and methods for inhibiting retroviral proteases, such as human inmmunodeficiency virus (HIV) protease, prophylactically preventing retroviral infection or the spread of a retrovirus, and treatment of a retroviral infection.
摘要翻译： 选择的双氨基酸羟乙基氨基磺酰胺化合物作为逆转录病毒蛋白酶抑制剂是有效的，特别是作为HIV蛋白酶的抑制剂。 本发明涉及这样的逆转录病毒蛋白酶抑制剂，更具体地涉及用于抑制逆转录病毒蛋白酶（例如人类免疫缺陷病毒（HIV）蛋白酶），预防性逆转录病毒感染或逆转录病毒扩散的选择的新化合物，组合物和方法， 并治疗逆转录病毒感染。
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公开(公告)号：US20070015818A1
公开(公告)日：2007-01-18
申请号：US11480586
申请日：2006-07-05
申请人： Deborah Bertenshaw , Daniel Getman , Robert Heintz , John Talley , Kathryn Reed , Robert Chrusciel , Michael Clare
发明人： Deborah Bertenshaw , Daniel Getman , Robert Heintz , John Talley , Kathryn Reed , Robert Chrusciel , Michael Clare
IPC分类号： A61K31/382 , A61K31/381 , C07D335/02 , C07D333/20
CPC分类号： C07D207/30 , C07C213/10 , C07C215/18 , C07C215/26 , C07C215/28 , C07C271/20 , C07C275/24 , C07D211/06 , C07D211/26
摘要： The present invention relates to cyclic sulfone moiety-containing hydroxyethylamine protease inhibitor compounds and pharmaceutical or method of use therefor, particularly as an inhibitor of HIV protease.
摘要翻译： 本发明涉及含环状砜部分的羟乙基胺蛋白酶抑制剂化合物及其用途的药物或方法，特别是作为HIV蛋白酶的抑制剂。
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40.发明申请Heterocyclecarbonyl amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors 审中-公开杂环羰基氨基酸羟乙基氨基磺酰胺逆转录病毒蛋白酶抑制剂公开(公告)号：US20070004646A1
公开(公告)日：2007-01-04
申请号：US11450959
申请日：2006-06-12
申请人： Daniel Getman , Gary DeCrescenzo , John Freskos , Michael Vazquez , James Sikorski , Balekudru Devadas , Srinivasan Nagarajan , David Brown , Joseph McDonald
发明人： Daniel Getman , Gary DeCrescenzo , John Freskos , Michael Vazquez , James Sikorski , Balekudru Devadas , Srinivasan Nagarajan , David Brown , Joseph McDonald
IPC分类号： A61K38/04 , C07K5/04 , C07D403/02
CPC分类号： C07K5/021 , A61K38/00 , C07K5/06139 , C07K5/06165
摘要： Selected heterocyclecarbonyl amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. The present invention relates to such retroviral protease inhibitors and, more particularly, relates to selected novel compounds, compositions, and methods for inhibiting retroviral proteases, such as human immunodeficiency virus (HIV) protease, prophylactically preventing retroviral infection or the spread of a retrovirus, and treatment of a retroviral infection.
摘要翻译： 选择的杂环羰基氨基酸羟乙基氨基磺酰胺化合物作为逆转录病毒蛋白酶抑制剂是有效的，特别是作为HIV蛋白酶的抑制剂。 本发明涉及这样的逆转录病毒蛋白酶抑制剂，更具体地涉及用于抑制逆转录病毒蛋白酶（例如人免疫缺陷病毒（HIV）蛋白酶），预防性逆转录病毒感染或逆转录病毒扩散的选择的新化合物，组合物和方法， 并治疗逆转录病毒感染。
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