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1.发明申请BIS-AMINO ACID HYDROXYETHYLAMINO SULFONAMIDE RETROVIRAL PROTEASE INHIBITORS 审中-公开BIS-氨基酸羟基乙酰氨基磺酰胺逆转录酶抑制剂公开(公告)号：US20080118969A1
公开(公告)日：2008-05-22
申请号：US12021735
申请日：2008-01-29
申请人： Daniel Getman , Gary DeCrescenzo , John Freskos , Michael Vazquez , James Sikorski , Balekudru Devadas , Srinivasan Nagarajan , David Brown , Joseph McDonald
发明人： Daniel Getman , Gary DeCrescenzo , John Freskos , Michael Vazquez , James Sikorski , Balekudru Devadas , Srinivasan Nagarajan , David Brown , Joseph McDonald
IPC分类号： C12N7/06
CPC分类号： C07K5/06026 , A61K31/16 , A61K31/165 , A61K31/357 , A61K31/36 , A61K31/4184 , A61K31/423 , A61K31/428 , A61K38/00 , C07K5/06078 , C07K5/06139 , C07K5/06191
摘要： Selected bis-amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. The present invention relates to such retroviral protease inhibitors and, more particularly, relates to selected novel compounds, compositions, and methods for inhibiting retroviral proteases, such as human immunodeficiency virus (HIV) protease, prophylactically preventing retroviral infection or the spread of a retrovirus, and treatment of a retroviral infection.
摘要翻译： 选择的双氨基酸羟乙基氨基磺酰胺化合物作为逆转录病毒蛋白酶抑制剂是有效的，特别是作为HIV蛋白酶的抑制剂。 本发明涉及这样的逆转录病毒蛋白酶抑制剂，更具体地涉及用于抑制逆转录病毒蛋白酶（例如人免疫缺陷病毒（HIV）蛋白酶），预防性逆转录病毒感染或逆转录病毒扩散的选择的新化合物，组合物和方法， 并治疗逆转录病毒感染。
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2.发明申请Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors 失效双氨基酸羟乙基氨基磺酰胺逆转录病毒蛋白酶抑制剂公开(公告)号：US20070037754A1
公开(公告)日：2007-02-15
申请号：US11501926
申请日：2006-08-10
申请人： Daniel Getman , Gary DeCrescenzo , John Freskos , Michael Vazquez , James Sikorski , Balekudru Devadas , Srinivasan Nagarajan , David Brown , Joseph McDonald
发明人： Daniel Getman , Gary DeCrescenzo , John Freskos , Michael Vazquez , James Sikorski , Balekudru Devadas , Srinivasan Nagarajan , David Brown , Joseph McDonald
CPC分类号： C07K5/06026 , A61K31/16 , A61K31/165 , A61K31/357 , A61K31/36 , A61K31/4184 , A61K31/423 , A61K31/428 , A61K38/00 , C07K5/06078 , C07K5/06139 , C07K5/06191
摘要： Selected bis-amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. The present invention relates to such retroviral protease inhibitors and, more particularly, relates to selected novel compounds, compositions, and methods for inhibiting retroviral proteases, such as human inmmunodeficiency virus (HIV) protease, prophylactically preventing retroviral infection or the spread of a retrovirus, and treatment of a retroviral infection.
摘要翻译： 选择的双氨基酸羟乙基氨基磺酰胺化合物作为逆转录病毒蛋白酶抑制剂是有效的，特别是作为HIV蛋白酶的抑制剂。 本发明涉及这样的逆转录病毒蛋白酶抑制剂，更具体地涉及用于抑制逆转录病毒蛋白酶（例如人类免疫缺陷病毒（HIV）蛋白酶），预防性逆转录病毒感染或逆转录病毒扩散的选择的新化合物，组合物和方法， 并治疗逆转录病毒感染。
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3.发明申请Heterocyclecarbonyl amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors 审中-公开杂环羰基氨基酸羟乙基氨基磺酰胺逆转录病毒蛋白酶抑制剂公开(公告)号：US20070004646A1
公开(公告)日：2007-01-04
申请号：US11450959
申请日：2006-06-12
申请人： Daniel Getman , Gary DeCrescenzo , John Freskos , Michael Vazquez , James Sikorski , Balekudru Devadas , Srinivasan Nagarajan , David Brown , Joseph McDonald
发明人： Daniel Getman , Gary DeCrescenzo , John Freskos , Michael Vazquez , James Sikorski , Balekudru Devadas , Srinivasan Nagarajan , David Brown , Joseph McDonald
IPC分类号： A61K38/04 , C07K5/04 , C07D403/02
CPC分类号： C07K5/021 , A61K38/00 , C07K5/06139 , C07K5/06165
摘要： Selected heterocyclecarbonyl amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. The present invention relates to such retroviral protease inhibitors and, more particularly, relates to selected novel compounds, compositions, and methods for inhibiting retroviral proteases, such as human immunodeficiency virus (HIV) protease, prophylactically preventing retroviral infection or the spread of a retrovirus, and treatment of a retroviral infection.
摘要翻译： 选择的杂环羰基氨基酸羟乙基氨基磺酰胺化合物作为逆转录病毒蛋白酶抑制剂是有效的，特别是作为HIV蛋白酶的抑制剂。 本发明涉及这样的逆转录病毒蛋白酶抑制剂，更具体地涉及用于抑制逆转录病毒蛋白酶（例如人免疫缺陷病毒（HIV）蛋白酶），预防性逆转录病毒感染或逆转录病毒扩散的选择的新化合物，组合物和方法， 并治疗逆转录病毒感染。
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公开(公告)号：US20060189611A1
公开(公告)日：2006-08-24
申请号：US11337836
申请日：2006-01-24
申请人： Daniel Getman , Gary DeCrescenzo , John Freskos , Michael Vazquez , James Sikorski , Balekudru Devadas , Srinivasan Nagarajan , David Brown , Joseph McDonald
发明人： Daniel Getman , Gary DeCrescenzo , John Freskos , Michael Vazquez , James Sikorski , Balekudru Devadas , Srinivasan Nagarajan , David Brown , Joseph McDonald
IPC分类号： A61K31/5377 , A61K31/4025 , A61K31/40 , C07D413/02 , C07D405/02
CPC分类号： C07D307/79 , A61K38/00 , C07D235/30 , C07D277/62 , C07D295/15 , C07D311/58 , C07D317/62 , C07D319/18 , C07D339/06 , C07D405/12 , C07D405/14 , C07K5/06026 , C07K5/06034 , C07K5/0606 , C07K5/06069
摘要： Selected amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. The present invention relates to such retroviral protease inhibitors and, more particularly, relates to selected novel compounds, composition and method for inhibiting retroviral proteases, such as human immunodeficiency virus (HIV) protease, prophylactically preventing retroviral infection or the spread of a retrovirus, and treatment of a retroviral infection.
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公开(公告)号：US20050227926A1
公开(公告)日：2005-10-13
申请号：US11036606
申请日：2005-01-18
申请人： Daniel Getman , Gary DeCrescenzo , John Freskos , Michael Vazquez , James Sikorski , Balekudru Devadas , Srinivasan Nagarajan , David Brown , Joseph McDonald
发明人： Daniel Getman , Gary DeCrescenzo , John Freskos , Michael Vazquez , James Sikorski , Balekudru Devadas , Srinivasan Nagarajan , David Brown , Joseph McDonald
CPC分类号： C07K5/06026 , A61K38/00
摘要： Selected bis-amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. The present invention relates to such retroviral protease inhibitors and, more particularly, relates to selected novel compounds, composition and method for inhibiting retroviral proteases, such as human immunodeficiency virus (HIV) protease, prophylactically preventing retroviral infection or the spread of a retrovirus, and treatment of a retroviral infection.
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公开(公告)号：US20060264483A1
公开(公告)日：2006-11-23
申请号：US11397055
申请日：2006-04-04
申请人： Daniel Getman , Gary DeCrescenzo , John Freskos , Michael Vazquez , James Sikorski , Balekudru Devadas , Srinivasan Nagarajan , Joseph McDonald
发明人： Daniel Getman , Gary DeCrescenzo , John Freskos , Michael Vazquez , James Sikorski , Balekudru Devadas , Srinivasan Nagarajan , Joseph McDonald
IPC分类号： A61K31/428 , A61K31/423 , A61K31/4184 , A61K31/343 , C07D417/02 , C07D277/62 , C07D263/60 , C07D235/04
CPC分类号： C07D263/56 , C07C317/44 , C07D215/36 , C07D217/02 , C07D217/04 , C07D235/30 , C07D235/32 , C07D249/20 , C07D277/62 , C07D277/82 , C07D307/79 , C07D307/82 , C07D311/58 , C07D317/62 , C07D319/18
摘要： Selected sulfonylalkanoylamino hydroxyethylamine sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. The present invention relates to such retroviral protease inhibitors and, more particularly, relates to selected novel compounds, composition and method for inhibiting retroviral proteases, such as human immunodeficiency virus (HIV) protease, prophylactically preventing retroviral infection or the spread of a retrovirus, and treatment of a retroviral infection.
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公开(公告)号：US20050049252A1
公开(公告)日：2005-03-03
申请号：US10922036
申请日：2004-08-19
申请人： Jeffery Carter , Mark Obukowicz , Balekudru Devadas , John Talley , David Brown , Matthew Graneto , Stephen Bertenshaw , Donald Rogier , Srinivasan Nagarajan , Cathleen Hanau , Susan Hartmann , Cindy Ludwig , Suzanne Metz , Donald Korte
发明人： Jeffery Carter , Mark Obukowicz , Balekudru Devadas , John Talley , David Brown , Matthew Graneto , Stephen Bertenshaw , Donald Rogier , Srinivasan Nagarajan , Cathleen Hanau , Susan Hartmann , Cindy Ludwig , Suzanne Metz , Donald Korte
IPC分类号： A61K31/35 , A61K31/352 , A61K31/36 , A61K31/382 , A61K31/4184 , A61K31/436 , A61K31/4375 , A61K31/47 , A61P29/00 , A61P43/00 , C07D215/54 , C07D311/22 , C07D311/58 , C07D311/92 , C07D335/06 , C07D401/12 , C07D405/04 , C07D407/04 , C07D407/12 , C07D409/04 , C07D471/04 , C07D491/04 , C07D491/052 , C07D493/04 , C07D471/02 , A61K31/519 , C07D491/02 , C07D498/02
CPC分类号： C07D335/06 , C07D215/54 , C07D311/22 , C07D311/58 , C07D311/92 , C07D401/12 , C07D405/04 , C07D407/04 , C07D407/12 , C07D409/04 , C07D471/04 , C07D491/04 , C07D493/04
摘要： A class of benzopyran, derivatives is described for use in treating cyclooxygenase-2 mediated disorders. Compounds of particular interest are defined by Formula I′ wherein X, A1, A2, A3, A4, R, R″, R1 and R2 are as described in the specification.
摘要翻译： 描述了一类苯并吡喃衍生物用于治疗环氧合酶-2介导的病症。 特别感兴趣的化合物由式I'定义，其中X，A 1，A 2，A 3，A 4，R，R“，R 1和R 2如 在说明书中描述。
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8.发明授权公开(公告)号：US06673822B2
公开(公告)日：2004-01-06
申请号：US10120791
申请日：2002-04-12
申请人： Daniel P Getman , Gary A DeCrescenzo , John N Freskos , Michael L Vazquez , James A Sikorski , Balekudru Devadas , Srinivasan Nagarajan , David L Brown , Joseph J McDonald
发明人： Daniel P Getman , Gary A DeCrescenzo , John N Freskos , Michael L Vazquez , James A Sikorski , Balekudru Devadas , Srinivasan Nagarajan , David L Brown , Joseph J McDonald
IPC分类号： A61K31428
CPC分类号： C07K5/021 , A61K38/00 , C07K5/06139 , C07K5/06165
摘要： Selected heterocyclecarbonyl amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. The present invention relates to such retroviral protease inhibitors and, more particularly, relates to selected novel compounds, composition and method for inhibiting retroviral proteases, such as human immunodeficiency virus (HIV) protease, prophylactically preventing retroviral infection or the spread of a retrovirus, and treatment of a retroviral infection.
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9.发明授权公开(公告)号：US06458785B1
公开(公告)日：2002-10-01
申请号：US09836443
申请日：2001-04-18
申请人： Daniel P Getman , Gary A. DeCrescenzo , John N. Freskos , Michael L. Vazquez , James A. Sikorski , Balekudru Devadas , Srinivasan Nagarajan , David L. Brown , Joseph J. McDonald
发明人： Daniel P Getman , Gary A. DeCrescenzo , John N. Freskos , Michael L. Vazquez , James A. Sikorski , Balekudru Devadas , Srinivasan Nagarajan , David L. Brown , Joseph J. McDonald
IPC分类号： A61K3154
CPC分类号： C07D307/79 , A61K38/00 , C07D235/30 , C07D277/62 , C07D295/15 , C07D311/58 , C07D317/62 , C07D319/18 , C07D339/06 , C07D405/12 , C07D405/14 , C07K5/06026 , C07K5/06034 , C07K5/0606 , C07K5/06069
摘要： Selected amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. The present invention relates to retroviral protease inhibitors and, more particularly, relates to selected novel compounds, composition and method for inhibiting retroviral proteases, such as human immunodeficiency virus (HIV) protease, prophylactically preventing retroviral infection or the spread of a retrovirus, and treatment of a retroviral infection.
摘要翻译： 选择的氨基酸羟乙基氨基磺酰胺化合物作为逆转录病毒蛋白酶抑制剂是有效的，特别是作为HIV蛋白酶的抑制剂。 本发明涉及逆转录病毒蛋白酶抑制剂，更具体地涉及选择的新化合物，用于抑制逆转录病毒蛋白酶如人免疫缺陷病毒（HIV）蛋白酶的组合物和方法，预防性地预防逆转录病毒感染或逆转录病毒的扩散，以及治疗 的逆转录病毒感染。
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公开(公告)号：US6100423A
公开(公告)日：2000-08-08
申请号：US261822
申请日：1999-03-03
申请人： Joe T. Collins , Balekudru Devadas , Hwang-fun Lu , James W. Malecha , Julie Marion Miyashiro , Srinivasan Nagarajan , Joseph Gerace Rico , Thomas E. Rogers
发明人： Joe T. Collins , Balekudru Devadas , Hwang-fun Lu , James W. Malecha , Julie Marion Miyashiro , Srinivasan Nagarajan , Joseph Gerace Rico , Thomas E. Rogers
IPC分类号： C07D239/14 , C07C229/00
CPC分类号： C07D239/14
摘要： The present invention is directed to compounds of the formula ##STR1## where R.sup.1 is BOC or H, R is H or lower alkyl; X and Y are the same or different halo atoms selected from the group consisting of Cl, Br or I and pharmaceutically acceptable salts and isomers thereof.
摘要翻译： 本发明涉及下式的化合物，其中R 1是BOC或H，R是H或低级烷基; X和Y是选自Cl，Br或I的相同或不同的卤原子及其药学上可接受的盐和异构体。
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