公开(公告)号：US08995577B2

公开(公告)日：2015-03-31

申请号：US12989009

申请日：2009-04-14

申请人： Andreas Ullrich ,  Martin Pfennigbauer ,  Walter Schubert ,  Wolfgang Zierlinger ,  Andreas Hofbauer ,  Gerhard Ederer

发明人： Andreas Ullrich ,  Martin Pfennigbauer ,  Walter Schubert ,  Wolfgang Zierlinger ,  Andreas Hofbauer ,  Gerhard Ederer

IPC分类号： H04L27/06 ,  G01S7/497 ,  G01S7/40 ,  G01S7/52

CPC分类号： G01S7/497 ,  G01S7/40 ,  G01S7/4052 ,  G01S7/52004 ,  G01S2007/4082

摘要： Apparatus for measurement of the reception time of a pulse in a receiving system, which contains at least one receiving channel with a non-linear transmission response, which receiving channel produces at its output a received signal, having a memory, in which the received signals of reference pulses with a predetermined different amplitude are available as reference signals with respect to a time scale, and having an evaluation device, which is connected to the receiving system and to the memory and compares a received signal with each reference signal with a variant time offset in order to determine that reference signal and that time offset for which the comparison discrepancy is a minimum, and outputs this time offset as the reception time with respect to the time scale.

摘要翻译： 用于测量接收系统中的脉冲的接收时间的装置，其包含至少一个具有非线性传输响应的接收信道，该接收信道在其输出端产生具有存储器的接收信号，其中接收信号 具有预定不同振幅的参考脉冲可用作相对于时标的参考信号，并且具有连接到接收系统和存储器的评估装置，并将接收信号与每个参考信号与变量时间进行比较 偏移以便确定参考信号和比较差异最小的时间偏移量，并输出该时间偏移量作为相对于时间标度的接收时间。

公开(公告)号：US20110311443A1

公开(公告)日：2011-12-22

申请号：US13254103

申请日：2010-03-01

申请人： Walter Schubert

发明人： Walter Schubert

IPC分类号： A61K51/10 ,  A61K38/17 ,  A61P35/00 ,  C12Q1/02 ,  C07K16/18 ,  G01N33/567 ,  A61K39/395 ,  A61K38/45

CPC分类号： G01N33/57434 ,  C07K16/2842 ,  C07K16/2896 ,  G01N33/57492 ,  G01N33/6893 ,  G01N2333/7055 ,  G01N2333/70596 ,  G01N2500/10

摘要： The invention relates to a method for treating a cancerous and/or an inflammatory disease in a patient, comprising internally administering to the patient an effective amount of a pharmaceutical preparation blocking the biological activity of at least one protein cluster (CMP) or group of CMPs containing at least CD26 and/or CD29. The invention also relates to a pharmaceutical composition for the treatment of a cancerous and/or an inflammatory disease in a patient, a method for identifying a cancerous and/or an inflammatory disease in a patient, a method of identifying at least one candidate for development of anti-cancerous or anti-inflammatory agents, a use of an antibody for preparing a pharmaceutical preparation or medicament for the treatment of prostate cancer, a composition or kit comprising at least one antibody and/or at least one ligand, and a biochip.

摘要翻译： 本发明涉及一种用于治疗患者的癌性和/或炎性疾病的方法，其包括向患者内部施用有效量的阻断至少一种蛋白质簇（CMP）或一组CMP的生物学活性的药物制剂 至少含有CD26和/或CD29。 本发明还涉及用于治疗患者中的癌性和/或炎性疾病的药物组合物，用于鉴定患者中的癌性和/或炎性疾病的方法，鉴定至少一种发育候选物的方法 抗癌剂或抗炎剂，抗体用于制备用于治疗前列腺癌的药物制剂或药物，包含至少一种抗体和/或至少一种配体的组合物或试剂盒以及生物芯片。

公开(公告)号：US20110038442A1

公开(公告)日：2011-02-17

申请号：US12989009

申请日：2009-04-14

申请人： Andreas Ullrich ,  Martin Pfennigbauer ,  Walter Schubert ,  Wolfgang Zierlinger ,  Andreas Hofbauer ,  Gerhard Ederer

发明人： Andreas Ullrich ,  Martin Pfennigbauer ,  Walter Schubert ,  Wolfgang Zierlinger ,  Andreas Hofbauer ,  Gerhard Ederer

IPC分类号： H04L27/06

CPC分类号： G01S7/497 ,  G01S7/40 ,  G01S7/4052 ,  G01S7/52004 ,  G01S2007/4082

摘要： Apparatus for measurement of the reception time of a pulse in a receiving system, which contains at least one receiving channel with a non-linear transmission response, which receiving channel produces at its output a received signal, having a memory, in which the received signals of reference pulses with a predetermined different amplitude are available as reference signals with respect to a time scale, and having an evaluation device, which is connected to the receiving system and to the memory and compares a received signal with each reference signal with a variant time offset in order to determine that reference signal and that time offset for which the comparison discrepancy is a minimum, and outputs this time offset as the reception time with respect to the time scale.

摘要翻译： 用于测量接收系统中的脉冲的接收时间的装置，其包含至少一个具有非线性传输响应的接收信道，该接收信道在其输出端产生具有存储器的接收信号，其中接收信号 具有预定不同振幅的参考脉冲可用作相对于时标的参考信号，并且具有连接到接收系统和存储器的评估装置，并将接收信号与每个参考信号与变量时间进行比较 偏移以便确定参考信号和比较差异最小的时间偏移量，并输出该时间偏移量作为相对于时间标度的接收时间。

公开(公告)号：US06974675B2

公开(公告)日：2005-12-13

申请号：US09808225

申请日：2001-03-14

申请人： Walter Schubert

发明人： Walter Schubert

IPC分类号： C12N5/06 ,  C12Q1/02 ,  C12R1/91 ,  G01N1/30 ,  G01N33/569 ,  G01N33/68 ,  G01N33/567 ,  G01N33/53 ,  G01N35/00

CPC分类号： G01N33/6845 ,  G01N1/30 ,  G01N33/56966 ,  G01N33/68 ,  G01N33/6842

摘要： This invention relates to a process for identifying and enriching cell-specific target structures, in particular for the identification of cell-specific protein combination patterns on the surface of cells and for enriching such cells. The process comprises depositing a heterogeneous cell mixture one or plural surfaces with predefined structures causing cells with corresponding target structures to become bound to such surface(s), removing any non-binding cells of said cell mixture from said surface, identifying the cell-specific target structures responsible for the binding of the cells to said surface(s), selecting and enriching cells with identical cell-specific target structures on said surface(s), and biochemically characterizing the target structures.

摘要翻译： 本发明涉及用于鉴定和富集细胞特异性靶结构的方法，特别是用于鉴定细胞表面上的细胞特异性蛋白质组合图案并富集这种细胞。 该方法包括用预定义的结构沉积一个或多个表面的异质细胞混合物，使得具有相应靶结构的细胞结合到这样的表面，从所述表面去除所述细胞混合物的任何非结合细胞，鉴定细胞特异性 负责细胞与所述表面结合的靶结构，在所述表面上选择和富集具有相同细胞特异性靶结构的细胞，以及生物化学表征靶结构。

公开(公告)号：US06649165B2

公开(公告)日：2003-11-18

申请号：US09802305

申请日：2001-03-08

申请人： Walter Schubert

发明人： Walter Schubert

IPC分类号： A61K3817

CPC分类号： A61K38/164 ,  Y10S424/81 ,  Y10S514/885 ,  Y10S530/82 ,  Y10S530/825 ,  Y10S530/868

摘要： The present invention is directed to a method of blocking the cytotoxic activity of Fc&ggr;RIII receptor-positive immune cells in a patient with amyotrophic lateral sclerosis using an effective amount of soluble Fc&ggr;RIII receptors. The soluble Fc&ggr;RIII receptors of the invention are specific for immunoglobulin G of under-class 1 (IgG1) and/or 3 (IgG3).

摘要翻译： 本发明涉及使用有效量的可溶性FcγRIII受体来阻断肌萎缩性侧索硬化患者中FcγAM受体阳性免疫细胞的细胞毒活性的方法。 本发明的可溶性FcγRIII受体对于低于1级（IgG1）和/或3（IgG3）的免疫球蛋白G是特异性的。

公开(公告)号：US06638515B2

公开(公告)日：2003-10-28

申请号：US09801414

申请日：2001-03-08

申请人： Walter Schubert

发明人： Walter Schubert

IPC分类号： A61K3574

CPC分类号： A61K38/164 ,  Y10S424/81 ,  Y10S514/885 ,  Y10S530/82 ,  Y10S530/825 ,  Y10S530/868

摘要： The present invention is directed to a method of blocking the cytotoxic activity of Fc&ggr;RIII receptor-positive immune cells in a patient with amyotrophic lateral sclerosis using protein V specific for IgG1 and/or IgG3. In one aspect of the invention, protein V blocks the binding of IgG1 and/or IgG3 to the Fc&ggr;RIII receptor, which inactivates the receptor, and destroys cellular forms containing the receptor.

摘要翻译： 本发明涉及使用对IgG1和/或IgG3特异的蛋白质V来阻断肌萎缩性侧索硬化患者中FcγAM受体阳性免疫细胞的细胞毒性活性的方法。 在本发明的一个方面，蛋白质V阻断IgG1和/或IgG3与FcγRIII受体的结合，其使受体失活，并破坏含有受体的细胞形式。

公开(公告)号：US6037404A

公开(公告)日：2000-03-14

申请号：US089754

申请日：1998-06-02

申请人： Ralf Dahm ,  Carmen Flosbach ,  Hermann Kerber ,  Sandra Kirchgassler ,  Dieter Lerch ,  Frank Schnodewind ,  Walter Schubert

发明人： Ralf Dahm ,  Carmen Flosbach ,  Hermann Kerber ,  Sandra Kirchgassler ,  Dieter Lerch ,  Frank Schnodewind ,  Walter Schubert

IPC分类号： C09K3/00 ,  C08G18/40 ,  C08G18/42 ,  C08G18/62 ,  C08G18/63 ,  C08G18/80 ,  C09D5/04 ,  C09D7/12 ,  C08J3/00 ,  C08F8/30 ,  C08G18/08 ,  C08K3/20 ,  C08L75/00

CPC分类号： C08G18/631 ,  C08G18/4072 ,  C08G18/8074 ,  C09D5/04

摘要： This invention relates to a composition, and to the preparation and use of thereof said composition being suitable as a rheology influencer for coating media and comprising the reaction product formed by reaction of a mixture of components A, B and C with components D, E and F. Components A, B and C form a mixture wherein component A is one or more (meth)acrylic copolymers and/or one or more polyesters which contain hydroxyl groups. Component B is a copolymer of ethylhexyl (meth)acrylate and one or more hydroxyalkyl (meth)acrylates, as well as .alpha.,.beta.-unsaturated monomers which are different therefrom. Component C is a hydroxy--functional microdispersion which is produced by polymerizing hydroxylalkyl (meth)acrylates in combination with unsaturated monomers in a mixture of polyesters or polyacrylates containing carboxyl and/or hydroxyl groups. Component D is one or more aliphatic polyisocyantes and component E is .epsilon.-caprolactam. The caprolactam partially blocks the polyisocyanate. The component F is one or more primary amines. These ingredients are combined in certain specified amounts. The invention also relates to coating media and to the production of these coating media, which contain said composition as a rheology influencer.

摘要翻译： 本发明涉及一种组合物及其制备和用途，所述组合物适合用作涂料介质的流变学影响剂，并且包含通过组分A，B和C的混合物与组分D，E反应形成的反应产物和 F.组分A，B和C形成混合物，其中组分A是一种或多种（甲基）丙烯酸共聚物和/或一种或多种含有羟基的聚酯。 组分B是（甲基）丙烯酸乙基己酯和一种或多种（甲基）丙烯酸羟烷基酯以及与其不同的α，β-不饱和单体的共聚物。 组分C是通过在含有羧基和/或羟基的聚酯或聚丙烯酸酯的混合物中聚合（甲基）丙烯酸羟烷基酯与不饱和单体组合制备的羟基官能微分散体。 组分D是一种或多种脂肪族聚异氰酸酯，组分E是ε-己内酰胺。 己内酰胺部分阻断多异氰酸酯。 组分F是一种或多种伯胺。 这些成分以特定的量组合。 本发明还涉及涂料介质和这些包含所述组合物作为流变学影响剂的涂料介质的生产。

公开(公告)号：US5430107A

公开(公告)日：1995-07-04

申请号：US235269

申请日：1994-04-29

申请人： Klaus Bederke ,  Hermann Kerber ,  Walter Schubert ,  Thomas Brock ,  Helmut Loffler

发明人： Klaus Bederke ,  Hermann Kerber ,  Walter Schubert ,  Thomas Brock ,  Helmut Loffler

IPC分类号： C08G18/42 ,  B05D7/26 ,  C08F8/32 ,  C08F265/04 ,  C08F283/02 ,  C08F283/06 ,  C08G18/48 ,  C08G18/52 ,  C08G18/63 ,  C08G63/46 ,  C08K5/00 ,  C08L67/06 ,  C09D151/00 ,  C09D167/00 ,  C09D167/06 ,  C09D175/00 ,  C09D175/04 ,  C09D179/02

CPC分类号： C09D179/02 ,  C08F265/04 ,  C08F283/02 ,  C08F283/06 ,  C09D151/00 ,  C09D167/00

摘要： A binding-agent composition for coating agents which can be cured at low temperature contains:A. 4-72% by weight of an acidic CH-compound, obtained by transesterification of an aliphatic .beta.-ketocarboxylic acid ester with one or several monomers and/or polymers containing hydroxyl groups and which contain at least two hydroxyl groups in the molecule,B. 4-72% by weight of an .alpha.,.beta.-unsaturated compound with at least two groups of the general formulaR.sub.1 R.sub.2 C.dbd.CR.sub.3 --CO--attached via the residue of a divalent or polyvalent alcohol, a diamine or polyamine or amino alcohol to at least one additional R.sub.1 R.sub.2 C.dbd.CR.sub.3 --CO--group, where R.sub.1, R.sub.2 and R.sub.3 independently of each other are a hydrogen atom or a straight or branched alkyl residue with 1 to 10 carbon atoms,C. 10-80% by weight of one or several polyamines with, by way of curing agents, at least two amine functions, which can be primary and/or secondary and can be blocked, in the molecule, andD. 0.01-5% by weight, relative to the sum of the weights of components A), B) and C), of a catalyst in the form of a Lewis or Bronstedt base, whereby the conjugated acids of the latter have a pKA-value of at least 10.

摘要翻译： 用于在低温下固化的涂布剂的粘合剂组合物包含：A. 4-72重量％的酸性CH-化合物，其通过脂族β-酮羧酸酯与一种或几种单体的酯交换和/ 或含有羟基并且在分子中含有至少两个羟基的聚合物，B 4-72重量％的α，β-不饱和化合物，其具有至少两个通式R 1 R 2 C = CR 3 -CO-连接通过的基团 二价或多价醇，二胺或多胺或氨基醇的残基至少一个另外的R 1 R 2 C = CR 3 -CO-基团，其中R 1，R 2和R 3彼此独立地是氢原子或直链或支链烷基 具有1至10个碳原子，C 10-80重量％的一种或多种多胺，通过固化剂，在分子中可以是伯和/或仲和可以被阻断的至少两种胺官能团 ，和D 0.01-5重量％，相对于 组分A），B）和C）的重量，其为路易斯或布朗斯台德形式的催化剂，由此后者的共轭酸的pKA值至少为10。

公开(公告)号：US5426156A

公开(公告)日：1995-06-20

申请号：US341450

申请日：1994-11-16

申请人： Klaus Bederke ,  Hermann Kerber ,  Walter Schubert ,  Gerhard Bremer ,  Thomas Brock ,  Fritz Sadowski

发明人： Klaus Bederke ,  Hermann Kerber ,  Walter Schubert ,  Gerhard Bremer ,  Thomas Brock ,  Fritz Sadowski

IPC分类号： C09D4/00 ,  C08F8/32 ,  C08F290/12 ,  C08F299/00 ,  C09D4/06 ,  C09D133/04 ,  C09D161/20 ,  C08L79/02

CPC分类号： C08F299/00 ,  C08F290/126 ,  C08F8/32 ,  C09D4/06 ,  C08F2800/20

摘要： Previous two-component coatings with enamine components cured very slowly at low temperatures and led to yellowed products. A binder composition is prepared which cures rapidly at low temperatures and leads to non-yellowing products. It contains as CH-acid component a polymer with at least two enamine functions in the molecule, obtained byA) transesterification of a .beta.-keto-ester with hydroxyl-group-containing compounds or polymers which contain at least two hydroxyl groups in the molecule, with an OH value of at least 50 and a number-average molecular weight of 500 to 10,000, followed by reaction with ammonia or primary and/or secondary amines, andB) as .alpha.,.beta.-unsaturated component a compound with at least two groups of the general formula R.sub.1 R.sub.2 C.dbd.CR.sub.3 --X; in which X signifies --CO-- which is bonded via the residue of a di- or polyhydric alcohol, a di- or polyamine or an aminoalcohol to a further R.sub.1 R.sub.2 C.dbd.CR.sub.3 --X group, where R.sub.1, R.sub.2 and R.sub.3 signify hydrogen or an alkyl group, components A) and B) are present in the ratio 2:1 to 1:1.5 relative to their equivalent weights, the composition exists as a two-component system, and component A) contains a Lewis or Bronsted base as catalyst.

摘要翻译： 以前的双组分涂料，烯胺组分在低温下非常缓慢地固化并导致黄色产品。 制备粘合剂组合物，其在低温下快速固化并导致非黄变产物。 它包含作为CH酸组分的分子中具有至少两个烯胺功能的聚合物，其通过以下方式获得：A）β-酮酯与含有羟基的化合物或在分子中含有至少两个羟基的聚合物的酯交换 OH值至少为50，数均分子量为500至10,000，随后与氨或伯胺和/或仲胺反应，B）作为α，β-不饱和组分，具有至少两个 通式为R1R2C = CR3-X的基团; 其中X表示-CO-，其通过二元或多元醇，二胺或多胺或氨基醇的残基与另外的R 1 R 2 C = CR 3 -X基团结合，其中R 1，R 2和R 3表示氢或烷基 组分A）和B）相对于其当量的比例为2:1至1:1.5，组合物以双组分体系存在，组分A）含有路易斯或布朗斯台德碱作为催化剂。

公开(公告)号：US5426138A

公开(公告)日：1995-06-20

申请号：US235206

申请日：1994-04-29

申请人： Klaus Bederke ,  Hermann Kerber ,  Walter Schubert ,  Thomas Brock ,  Fritz Sadowski ,  Helmut Loffler

发明人： Klaus Bederke ,  Hermann Kerber ,  Walter Schubert ,  Thomas Brock ,  Fritz Sadowski ,  Helmut Loffler

IPC分类号： B05D1/36 ,  B05D7/24 ,  C08G18/32 ,  C08G18/42 ,  C08G18/48 ,  C08G18/62 ,  C08G18/76 ,  C08L33/14 ,  C08L63/10 ,  C08L67/02 ,  C09D133/14 ,  C09D163/00 ,  C09D163/10 ,  C09D175/00 ,  C09D175/04 ,  C08K3/20 ,  C08L63/02

CPC分类号： C09D163/00 ,  C09D133/14 ,  C08L2205/02 ,  C08L33/14 ,  C08L63/10 ,  C08L67/02

摘要： A binding-agent composition for solvent-based or aqueous coating agents can be cured at low temperature to produce coatings which are non-yellowing and resistant to solvents. The binding-agent composition contains binding-agent components based on polyethers, polyesters, polyether polyesters and/or (meth)acrylic copolymers with, in each case, at least one acryloyl group and at least one epoxide group in the molecule, whereby the acryloyl groups and epoxide groups are present in the ratio 2:8 to 8:2. Also included are several polyamines as curing agents in a proportion of equivalent weights ranging from 2:0.5 to 1:1.5. The binding agents are used in pigmented and pigment-free lacquers, for use particularly in multi-layer lacquering.

摘要翻译： 用于溶剂型或水性涂布剂的粘合剂组合物可以在低温下固化，以产生不变黄并且耐溶剂的涂层。 粘合剂组合物包含基于聚醚，聚酯，聚醚聚酯和/或（甲基）丙烯酸共聚物的粘合剂组分，在每种情况下，分子中至少有一个丙烯酰基和至少一个环氧基，由此将丙烯酰基 基团和环氧基以2：8至8：2的比例存在。 还包括几种多胺作为固化剂，其当量重量范围为2：0.5至1：1.5。 粘合剂用于着色和无颜料的漆中，特别用于多层涂漆。