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31.发明申请公开(公告)号：US20080268027A1
公开(公告)日：2008-10-30
申请号：US12171692
申请日：2008-07-11
CPC分类号： A61K9/7007 , A61K9/0056 , A61K9/006 , A61K9/1635 , A61K9/1652 , A61K9/7015 , A61K31/192 , A61K31/422 , A61K31/435 , A61K31/4525 , A61K31/4545 , A61K31/80 , A61K47/02 , A61K47/10 , A61K47/22 , A61K47/32 , A61K47/38 , A61K47/44 , A61K47/46 , C08J5/18
摘要： The invention relates to the film products and methods of their preparation that demonstrate a non-self-aggregating uniform heterogeneity. Desirably the films disintegrate in water and may be formed by a controlled drying process, or other process that maintains the required uniformity of the film.
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32.发明授权
公开(公告)号：US6083430A
公开(公告)日：2000-07-04
申请号：US642026
申请日：1996-04-29
申请人： Richard C. Fuisz , Garry L. Myers , Robert K. Yang , Mark R. Herman , Whitney S. Cavanagh , John R. Sisak , Andrea S. Brothers
发明人： Richard C. Fuisz , Garry L. Myers , Robert K. Yang , Mark R. Herman , Whitney S. Cavanagh , John R. Sisak , Andrea S. Brothers
IPC分类号： A61J3/02 , A61J1/00 , A61J7/00 , A61K9/00 , A61K9/16 , A61K9/20 , A61K9/50 , B01J2/00 , B01J2/02 , A61K9/14
CPC分类号： A61J1/00 , A61J7/0015 , A61K9/1688 , A61K9/1694 , A61K9/2081 , A61K9/2095 , A61K9/5026 , B01J2/00 , B01J2/02
摘要： The present invention is a process and apparatus for making a dosage unit by direct tableting of shearlite particles. The present invention also includes the dosage unit itself. Shearlite particles, which are prepared by subjecting a feedstock material to liquiflash processing, can be directly fed from a shearlite device to a tableting apparatus without the necessity of any intermediate steps or additional ingredients to facilitate flowability or tablet formation.
摘要翻译： 本发明是通过直接压片剪切碎片制造剂量单位的方法和装置。 本发明还包括剂量单位本身。 通过使原料进行液化处理制备的剪切剂颗粒可以从剪切装置直接进给到压片装置，而不需要任何中间步骤或附加成分来促进流动性或形成片剂。
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公开(公告)号：US6020002A
公开(公告)日：2000-02-01
申请号：US967248
申请日：1997-11-05
CPC分类号： A23G3/10 , A23G3/346 , A23G2220/20 , A61K9/0056 , Y10S514/965
摘要： The present invention is a method and a dosage unit for delivery of a controlled-release system. The dosage unit is a quick dissolve unit which can be prepared by mixing uncured shearform matrix and a controlled-release system, either molding or compacting a unit dosage form and curing the shearform matrix. The controlled-release systems used in the present invention include instantaneous release components, delayed release components, sustained release components, and combinations thereof.
摘要翻译： 本发明是用于递送受控释放系统的方法和剂量单元。 剂量单位是快速溶解单元，其可以通过混合未固化的剪切形式基质和控制释放系统来制备，模制或压实单位剂型并固化剪切矩阵。 用于本发明的控制释放系统包括瞬时释放组分，延迟释放组分，缓释组分及其组合。
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34.发明授权
公开(公告)号：US5895664A
公开(公告)日：1999-04-20
申请号：US259258
申请日：1994-06-14
IPC分类号： A23G3/00 , A23G3/10 , A23G3/34 , A23G3/36 , A61K9/00 , A61K9/20 , A61K9/70 , B30B11/02 , C13B30/02 , C13B50/00
CPC分类号： A23G3/368 , A23G3/10 , A23G3/346 , A61K9/0056 , A61K9/2018 , A61K9/2095 , A61K9/70 , B30B11/027 , C13B30/021 , C13B50/00 , A23G2200/06
摘要： The present invention is a method of preparing a comestible unit which disperses quickly in the mouth. The present invention also includes the product resulting from the method. The method includes initiating crystallization of shearform matrix and combining with an additive, either before or after initiating crystallization, to form flowable, compactible micro-particulates. The combination is then subjected to compacting to form a comestible unit having high structural integrity, good appearance, and excellent release characteristics.
摘要翻译： 本发明是一种制备可快速分散在口中的食物单元的方法。 本发明还包括由该方法得到的产品。 该方法包括在开始结晶之前或之后引发剪切形式基质的结晶和与添加剂的结合，以形成可流动的，可压实的微粒子。 然后将组合物进行压实以形成具有高结构完整性，良好外观和优异的脱模特性的食品单元。
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公开(公告)号：US5827563A
公开(公告)日：1998-10-27
申请号：US782446
申请日：1997-01-13
IPC分类号： A21D15/08 , A23G3/00 , A23G3/10 , A23G3/34 , A23G3/36 , A61K9/00 , A61K9/20 , A61K9/70 , C13B30/02 , C13B50/00 , C13K1/10 , C13K13/00 , A23L1/09
CPC分类号： A23G3/368 , A23G3/10 , A23G3/346 , A61K9/2018 , A61K9/2095 , A61K9/70 , C13B30/021 , C13B50/00 , A23G2200/06 , A61K9/0056
摘要： The present invention is a new fondant product including spheroidal polycrystallite structures or monodispersed sugar crystallites released from the polycrystallite structures.
摘要翻译： 本发明是一种新型的软糖产品，其包括从多晶结构中释放的球形多晶结构或单分散糖微晶。
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公开(公告)号：US5653926A
公开(公告)日：1997-08-05
申请号：US437300
申请日：1995-05-09
IPC分类号： A61J3/10 , A23G3/00 , A23G3/10 , A23G3/34 , A23G3/36 , A61K9/00 , A61K9/20 , A61K9/70 , B30B11/02 , B30B11/08 , B30B11/10 , B30B11/14 , B30B15/30 , C13B30/02 , C13B50/00 , B29C43/04
CPC分类号： B30B15/302 , A23G3/10 , A23G3/346 , A23G3/368 , A61J3/10 , A61K9/0056 , A61K9/2018 , A61K9/2095 , A61K9/70 , B30B11/027 , B30B11/10 , B30B11/14 , C13B30/021 , C13B50/00 , A23G2200/06
摘要： A method and apparatus provides for the formation of compression dosage units from tableting feedstock. A feedstock dossiter is provided including an open ended chamber for insertion into a reservoir containing the tableting feedstock. The dossiter includes a movable die punch which is movable within the chamber between at least two positions. A first position away from the open end of the chamber provides for the collection of a preselected volume of tableting feedstock from the reservoir. The die punch is movable to a second position which effects formation of the tablet within the accumulation chamber. The dossiter shown herein may be used in combination with a fixed die punch to form the tablet.
摘要翻译： 一种方法和装置提供从压片原料形成压缩剂量单位。 提供了一种原料分布器，包括用于插入到含有压片原料的储存器中的开口端室。 该装置包括一个活动模具冲头，它可在室内至少在两个位置之间移动。 离开室的开口端的第一位置提供从储存器收集预选量的压片原料。 模具冲头可移动到第二位置，其实现在积聚室内形成片剂。 本文所示的装置可以与固定模具冲头组合使用以形成片剂。
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37.发明授权Method and apparatus for retaining a formed compression dosage unit within a die cavity 失效用于将形成的压缩剂量单元保持在模腔内的方法和装置
公开(公告)号：US5648033A
公开(公告)日：1997-07-15
申请号：US438165
申请日：1995-05-09
IPC分类号： A61J3/10 , A23G3/00 , A23G3/10 , A23G3/34 , A23G3/36 , A61K9/00 , A61K9/20 , A61K9/70 , B30B11/02 , B30B11/08 , B30B11/10 , B30B11/14 , C13B30/02 , C13B50/00 , B29C43/08
CPC分类号： A23G3/10 , A23G3/346 , A23G3/368 , A61J3/10 , A61K9/0056 , A61K9/2018 , A61K9/2095 , A61K9/70 , B30B11/027 , B30B11/10 , B30B11/14 , C13B30/021 , C13B50/00 , A23G2200/06
摘要： A method and apparatus is provided for the formation of a tablet from tableting feedstock. An elongate die is provided which has a cavity defined by an inner wall. A pair of die punches are insertably positioned within the cavity. The die punches include opposed facing surfaces for supporting therebetween tableting feedstock. The die punches are relatively movable within the cavity to a tablet forming position to compress the feedstock into a tablet. The tablet forming positions defined by the facing die punch surfaces are spaced apart sufficient distance so as to maintain the formed tablet in contact with the inner wall of the cavity so as to retain the tablet within the cavity upon removal of the die punches.
摘要翻译： 提供了一种从压片原料形成片剂的方法和装置。 提供具有由内壁限定的空腔的细长模具。 一对模冲头可插入腔内。 冲模包括相对的相对的表面，用于在其间支撑压片原料。 冲模在空腔内相对移动到片剂形成位置，以将原料压缩成片剂。 由面对的模具冲头表面限定的片剂形成位置间隔开足够的距离，以便保持形成的片剂与空腔的内壁接触，以便在去除模具冲头时将片剂保持在空腔内。
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公开(公告)号：US5593502A
公开(公告)日：1997-01-14
申请号：US468383
申请日：1995-06-06
IPC分类号： A23G3/00 , A23G3/10 , A23G3/34 , A23G3/36 , A23L27/00 , A61K9/00 , A61K9/20 , A61K9/70 , A61K47/26 , C07H1/00 , C13B30/02 , C13B50/00 , C13F3/00 , C13F1/02
CPC分类号： A23G3/368 , A23G3/10 , A61K9/2018 , A61K9/2095 , A61K9/70 , C13B30/021 , A61K9/0056
摘要： The present invention is a new crystalline sugar product and method of making same which includes forming a bi-dimensionally stabilized sugar crystalline frame from an outer portion of an amorphous shearform sugar mass, and, subsequently, converting the remaining portion of the mass to a substantially completely crystalline structure which retains the cross-sectional dimension of the sugar crystalline frame. The present invention also includes co-crystallizing an additive, especially a bio-affecting additive, during the process to provide a co-crystallized product. The structure of the crystallized product can also be loaded with a non-solvent liquid by force of capillary action in the space created within the structure during the conversion from amorphous mass to crystalline structure.
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公开(公告)号：US5587172A
公开(公告)日：1996-12-24
申请号：US452666
申请日：1995-05-26
IPC分类号： A23G3/00 , A23G3/10 , A23G3/34 , A23G3/36 , A61K9/00 , A61K9/20 , A61K9/70 , B30B11/02 , C13B30/02 , C13B50/00
CPC分类号： A23G3/368 , A23G3/10 , A23G3/346 , A61K9/0056 , A61K9/2018 , A61K9/2095 , A61K9/70 , B30B11/027 , C13B30/021 , C13B50/00 , A23G2200/06
摘要： The present invention is a method of preparing a comestible unit which disperses quickly in the mouth. The present invention also includes the product resulting from the method. The method includes initiating crystallization of shearform matrix and combining with an additive, either before or after initiating crystallization, to form flowable, compactible micro-particulates. The combination is then subjected to compacting to form a comestible unit having high structural integrity, good appearance, and excellent release characteristics.
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公开(公告)号：US5567439A
公开(公告)日：1996-10-22
申请号：US334729
申请日：1994-11-04
IPC分类号： A61K9/16 , A23G3/00 , A23G3/10 , A23G3/36 , A61J3/10 , A61K9/00 , A61K9/20 , A61K9/22 , A61K9/46 , A61K9/70 , B30B11/02
CPC分类号： A23G3/368 , A23G3/10 , A61J3/10 , A61K9/0056 , A61K9/2018 , A61K9/2095 , A61K9/70 , B30B11/027
摘要： The present invention is a method and a dosage unit for delivery of a controlled-release system. The dosage unit is a quick dissolve unit which can be prepared by mixing uncured shearform matrix and a controlled-release system, either molding or compacting a unit dosage form and curing the shearform matrix. The controlled-release systems used in the present invention include instantaneous release components, delayed release components, sustained release components, and combinations thereof.
摘要翻译： 本发明是用于递送受控释放系统的方法和剂量单元。 剂量单位是快速溶解单元，其可以通过混合未固化的剪切形式基质和控制释放系统来制备，模制或压实单位剂型并固化剪切矩阵。 用于本发明的控制释放系统包括瞬时释放组分，延迟释放组分，缓释组分及其组合。
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