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99 条记录 (耗时 0.049 秒)

    Internal image antibodies for optical imaging and therapy
    31.
    发明授权
    Internal image antibodies for optical imaging and therapy 失效
    用于光学成像和治疗的内部图像抗体

    公开(公告)号：US07431925B2

    公开(公告)日：2008-10-07

    申请号：US10761634

    申请日：2004-01-21

    申请人： Raghavan Rajagopalan ,  Joseph E. Bugaj ,  Samuel I. Achilefu ,  Richard B. Dorshow

    发明人： Raghavan Rajagopalan ,  Joseph E. Bugaj ,  Samuel I. Achilefu ,  Richard B. Dorshow

    IPC分类号： A61K39/395 ,  C07K16/42

    CPC分类号： A61K49/0058 ,  A61K41/0071 ,  A61K49/0032 ,  A61K2039/505 ,  C07K16/4208

    摘要： Methods using internal image antibodies for photodiagnosis and/or phototherapy. The internal image antibodies are conjugated with a photoactive molecule such as a dye or photosensitizer, to target specific regions, such as biological receptors. The photoactive molecules are then activated for diagnosis or therapy. Advantageously, the internal image antibody is specific for a biological receptor, but does not require isolation of the receptor to prepare the antibody, and provides the desired specificity and selectivity for targeted diagnosis or therapy.

    摘要翻译： 使用内部图像抗体进行光诊断和/或光疗的方法。 将内部图像抗体与光活性分子例如染料或光敏剂共轭，以靶向特定区域，例如生物受体。 然后激活光活性分子进行诊断或治疗。 有利地，内部图像抗体对于生物受体是特异性的，但不需要分离受体以制备抗体，并且为靶向诊断或治疗提供期望的特异性和选择性。

    Aromatic sulfenates for type 1 phototherapy
    32.
    发明授权
    Aromatic sulfenates for type 1 phototherapy 失效
    用于1型光疗法的芳香族亚磺酸盐

    公开(公告)号：US07427657B1

    公开(公告)日：2008-09-23

    申请号：US11276971

    申请日：2006-03-20

    申请人： Raghavan Rajagopalan ,  Gary L. Cantrell ,  Samuel I. Achilefu ,  Joseph E. Bugaj ,  Richard B. Dorshow

    发明人： Raghavan Rajagopalan ,  Gary L. Cantrell ,  Samuel I. Achilefu ,  Joseph E. Bugaj ,  Richard B. Dorshow

    IPC分类号： A61K38/16

    CPC分类号： A61K41/0057

    摘要： The present invention discloses novel sulfenate derivatives and their bioconjugates for phototherapy of tumors and other lesions. The sulfenates of the present invention are designed to absorb low-energy ultraviolet, visible, or near-infrared (NIR) region of the electromagnetic spectrum. The phototherapeutic effect is caused by direct interaction of free radicals, the reactive intermediate produced upon photofragmentation of the sulfenate moiety, with the tissue of interest.

    摘要翻译： 本发明公开了用于肿瘤和其他病变光疗的新型次氯酸盐衍生物及其生物缀合物。 本发明的次氯酸盐被设计成吸收电磁光谱的低能量紫外线，可见光或近红外（NIR）区域。 光疗效应是由自由基（在次硫酸盐部分的光分解产生的反应性中间体）与感兴趣的组织的直接相互作用引起的。

    Versatile hydrophilic dyes
    34.
    发明授权
    Versatile hydrophilic dyes 失效
    多用途亲水染料

    公开(公告)号：US06939532B2

    公开(公告)日：2005-09-06

    申请号：US09757333

    申请日：2001-01-09

    申请人： Samuel I. Achilefu ,  Raghavan Rajagopalan ,  Richard B. Dorshow ,  Joseph E. Bugaj

    发明人： Samuel I. Achilefu ,  Raghavan Rajagopalan ,  Richard B. Dorshow ,  Joseph E. Bugaj

    IPC分类号： C07H15/26 ,  A61B1/00 ,  A61K38/00 ,  A61K41/00 ,  A61K49/00 ,  A61P35/00 ,  C07D405/14 ,  C07K7/06 ,  C09B23/00 ,  C09K11/06 ,  A61B10/00 ,  A61B5/00 ,  A61B8/00

    CPC分类号： A61K49/0032 ,  A61K41/0033 ,  A61K41/0057 ,  A61K49/0056

    摘要： Dye-peptide conjugates useful for diagnostic imaging and therapy are disclosed. The dye-peptide conjugates include several cyanine dyes with a variety of bis- and tetrakis(carboxylic acid) homologues. The small size of the compounds allows more favorable delivery to tumor cells as compared to larger molecular weight imaging agents. The various dyes are useful over the range of 350-1300 nm, the exact range being dependent upon the particular dye. Use of dimethylsulfoxide helps to maintain the fluorescence of the compounds. The molecules of the invention are useful for diagnostic imaging and therapy, in endoscopic applications for the detection of tumors and other abnormalities and for localized therapy, for photoacoustic tumor imaging, detection and therapy, and for sonofluorescence tumor imaging, detection and therapy.

    摘要翻译： 公开了用于诊断成像和治疗的染料 - 肽缀合物。 染料 - 肽缀合物包括具有多种双和四（羧酸）同系物的几种花青染料。 与较大的分子量成像剂相比，化合物的小尺寸允许更有利于肿瘤细胞的递送。 各种染料在350-1300nm的范围内是有用的，精确的范围取决于特定的染料。 使用二甲基亚砜有助于维持化合物的荧光。 本发明的分子可用于诊断成像和治疗，用于检测肿瘤和其他异常以及用于局部治疗，用于光声肿瘤成像，检测和治疗以及用于声发射肿瘤成像，检测和治疗的内窥镜应用中。

    Tunable indocyanine dyes for biomedical applications
    36.
    发明授权
    Tunable indocyanine dyes for biomedical applications 失效
    可调式吲哚菁染料用于生物医学应用

    公开(公告)号：US06180087B2

    公开(公告)日：2001-01-30

    申请号：US09484320

    申请日：2000-01-18

    申请人： Samuel Achilefu ,  Raghavan Rajagopalan ,  Richard B. Dorshow ,  Joseph E. Bugaj

    发明人： Samuel Achilefu ,  Raghavan Rajagopalan ,  Richard B. Dorshow ,  Joseph E. Bugaj

    IPC分类号： A61B1000

    CPC分类号： A61K41/0033

    摘要： The sensitivity and specificity of the optical modality can be enhanced by the use of highly absorbing dyes as contrast agents. Novel indocyanine dyes that absorb and emit light in the near infrared region of electromagnetic spectrum are disclosed. These dyes are useful for imaging, diagnosis and therapy of various diseased states. Particularly, the molecules of the invention are useful for optical diagnostic imaging and therapy, in endoscopic applications for the detection of tumors and other abnormalities, for localized therapy, for photoacoustic tumor imaging, detection and therapy, and for sonofluorescence tumor imaging, detection and therapy.

    摘要翻译： 通过使用高吸收性染料作为造影剂可以提高光学模态的灵敏度和特异性。 公开了在电磁光谱的近红外区域吸收和发射光的新型吲哚菁染料。 这些染料可用于各种疾病状态的成像，诊断和治疗。 特别地，本发明的分子可用于光学诊断成像和治疗，在用于检测肿瘤和其他异常的内窥镜应用中，用于局部治疗，光声肿瘤成像，检测和治疗以及用于声发射肿瘤成像，检测和治疗 。

    Hydrophilic cyanine dyes
    37.
    发明授权
    Hydrophilic cyanine dyes 失效
    亲水花青染料

    公开(公告)号：US06180086B2

    公开(公告)日：2001-01-30

    申请号：US09484319

    申请日：2000-01-18

    申请人： Samuel Achilefu ,  Raghavan Rajagopalan ,  Richard B. Dorshow ,  Joseph E. Bugaj

    发明人： Samuel Achilefu ,  Raghavan Rajagopalan ,  Richard B. Dorshow ,  Joseph E. Bugaj

    IPC分类号： A61B1000

    CPC分类号： A61K49/0056 ,  A61K41/0033 ,  A61K41/0057 ,  A61K49/0032 ,  C09B23/0016 ,  C09B23/0025 ,  C09B23/0066 ,  C09B23/0075 ,  C09B23/086

    摘要： The sensitivity and specificity of the optical modality can be enhanced by the use of highly absorbing dyes as contrast agents. Novel cyanine dyes that absorb and emit light in the near infrared region of electromagnetic spectrum are disclosed. These dyes are useful for imaging, diagnosis and therapy of various diseased states. Particularly, the molecules of the invention are useful for optical diagnostic imaging and therapy, in endoscopic applications for the detection of tumors and other abnormalities, for localized therapy, for photoacoustic tumor imaging, detection and therapy, and for sonofluorescence tumor imaging, detection and therapy.

    摘要翻译： 通过使用高吸收性染料作为造影剂可以提高光学模态的灵敏度和特异性。 公开了在电磁光谱的近红外区域吸收和发光的新型花青染料。 这些染料可用于各种疾病状态的成像，诊断和治疗。 特别地，本发明的分子可用于光学诊断成像和治疗，用于检测肿瘤和其他异常的内窥镜应用，局部治疗，光声肿瘤成像，检测和治疗以及用于声发射肿瘤成像，检测和治疗 。

    Dyes
    38.
    发明授权
    Dyes 失效
    染料

    公开(公告)号：US06180085B2

    公开(公告)日：2001-01-30

    申请号：US09484318

    申请日：2000-01-18

    申请人： Samuel Achilefu ,  Raghavan Rajagopalan ,  Richard B. Dorshow ,  Joseph E. Bugaj

    发明人： Samuel Achilefu ,  Raghavan Rajagopalan ,  Richard B. Dorshow ,  Joseph E. Bugaj

    IPC分类号： A61B1000

    CPC分类号： A61K49/0032 ,  A61K41/0033 ,  A61K41/0057 ,  A61K49/0056

    摘要： The sensitivity and specificity of the optical modality can be enhanced by the use of highly absorbing dyes as contrast agents. Novel cyanine dyes that absorb and emit light in the near infrared region of electromagnetic spectrum are disclosed. These dyes are useful for imaging, diagnosis and therapy of various diseased states. Particularly, the molecules of the invention are useful for optical diagnostic imaging and therapy, in endoscopic applications for the detection of tumors and other abnormalities, for localized therapy, for photoacoustic tumor imaging, detection and therapy, and for sonofluorescence tumor imaging, detection and therapy.

    摘要翻译： 通过使用高吸收性染料作为造影剂可以提高光学模态的灵敏度和特异性。 公开了在电磁光谱的近红外区域吸收和发光的新型花青染料。 这些染料可用于各种疾病状态的成像，诊断和治疗。 特别地，本发明的分子可用于光学诊断成像和治疗，用于检测肿瘤和其他异常的内窥镜应用，局部治疗，光声肿瘤成像，检测和治疗以及用于声发射肿瘤成像，检测和治疗 。

    Fused Ring Thiophene Dyes for Imaging and Therapy
    40.
    发明申请
    Fused Ring Thiophene Dyes for Imaging and Therapy 审中-公开
    熔融环噻吩染料用于成像和治疗

    公开(公告)号：US20110196231A1

    公开(公告)日：2011-08-11

    申请号：US13121205

    申请日：2009-09-29

    申请人： Raghavan Rajagopalan ,  William L. Neuman ,  Amruta Poreddy ,  John N. Freskos ,  Richard B. Dorshow

    发明人： Raghavan Rajagopalan ,  William L. Neuman ,  Amruta Poreddy ,  John N. Freskos ,  Richard B. Dorshow

    IPC分类号： A61B6/00 ,  C07D495/14 ,  A61M37/00

    CPC分类号： A61K31/381 ,  A61K41/0057 ,  A61K49/0021 ,  A61K49/005 ,  A61K49/0054 ,  A61K49/0056 ,  C07D495/14

    摘要： The invention provides optical agents, including compositions, preparations and formulations, and methods of using and making optical agents. Optical agents of the present invention include oligomer dyes, and derivatives thereof, having a fused ring backbone structure having an oligothiophene core. In some embodiments, oligomer dyes of the present invention are fused ring thiophene dyes having an oligothiophene core comprising a plurality of fused thiophene, thiophene-oxide, and/or thiophene-dioxide rings, optionally functionalized to provide useful optical, biological, pharmacokinetic and/or physical properties. The compounds are dithieno[3,2-b;2′,3′-d]thiophene derivatives.

    摘要翻译： 本发明提供光学剂，包括组合物，制剂和制剂，以及使用和制造光学剂的方法。 本发明的光学剂包括具有低聚噻吩核的稠环骨架结构的低聚物染料及其衍生物。 在一些实施方案中，本发明的低聚物染料是具有包含多个稠合噻吩，噻吩氧化物和/或噻吩二氧化物环的低聚噻吩核心的稠环噻吩染料，其任选被官能化以提供有用的光学，生物学，药代动力学和/ 或物理性质。 化合物是二噻吩并[3,2-b; 2'，3'-d]噻吩衍生物。