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    Fused Ring Thiophene Dyes for Imaging and Therapy
    1.
    发明申请
    Fused Ring Thiophene Dyes for Imaging and Therapy 审中-公开
    熔融环噻吩染料用于成像和治疗

    公开(公告)号：US20110196231A1

    公开(公告)日：2011-08-11

    申请号：US13121205

    申请日：2009-09-29

    申请人： Raghavan Rajagopalan ,  William L. Neuman ,  Amruta Poreddy ,  John N. Freskos ,  Richard B. Dorshow

    发明人： Raghavan Rajagopalan ,  William L. Neuman ,  Amruta Poreddy ,  John N. Freskos ,  Richard B. Dorshow

    IPC分类号： A61B6/00 ,  C07D495/14 ,  A61M37/00

    CPC分类号： A61K31/381 ,  A61K41/0057 ,  A61K49/0021 ,  A61K49/005 ,  A61K49/0054 ,  A61K49/0056 ,  C07D495/14

    摘要： The invention provides optical agents, including compositions, preparations and formulations, and methods of using and making optical agents. Optical agents of the present invention include oligomer dyes, and derivatives thereof, having a fused ring backbone structure having an oligothiophene core. In some embodiments, oligomer dyes of the present invention are fused ring thiophene dyes having an oligothiophene core comprising a plurality of fused thiophene, thiophene-oxide, and/or thiophene-dioxide rings, optionally functionalized to provide useful optical, biological, pharmacokinetic and/or physical properties. The compounds are dithieno[3,2-b;2′,3′-d]thiophene derivatives.

    摘要翻译： 本发明提供光学剂，包括组合物，制剂和制剂，以及使用和制造光学剂的方法。 本发明的光学剂包括具有低聚噻吩核的稠环骨架结构的低聚物染料及其衍生物。 在一些实施方案中，本发明的低聚物染料是具有包含多个稠合噻吩，噻吩氧化物和/或噻吩二氧化物环的低聚噻吩核心的稠环噻吩染料，其任选被官能化以提供有用的光学，生物学，药代动力学和/ 或物理性质。 化合物是二噻吩并[3,2-b; 2'，3'-d]噻吩衍生物。

    Tissue sealant compositions, vascular closure devices, and uses thereof
    4.
    发明授权
    Tissue sealant compositions, vascular closure devices, and uses thereof 有权
    组织密封剂组合物，血管闭合装置及其用途

    公开(公告)号：US09433700B2

    公开(公告)日：2016-09-06

    申请号：US13266161

    申请日：2010-04-27

    申请人： Bob O. Basore ,  William L. Neumann ,  Richard B. Dorshow ,  Raghavan Rajagopalan

    发明人： Bob O. Basore ,  William L. Neumann ,  Richard B. Dorshow ,  Raghavan Rajagopalan

    IPC分类号： A61L24/10 ,  A61L24/00

    CPC分类号： A61L24/102 ,  A61L24/001 ,  A61L24/0015 ,  A61L24/0042 ,  A61L24/046 ,  A61L24/106 ,  A61L24/108 ,  A61L2300/418 ,  A61L2300/442 ,  A61L2300/604 ,  A61L2400/04 ,  A61L2430/20 ,  A61L2430/34

    摘要： The present invention provides tissue sealant compositions and vasculature closure devices useful for the optical detection of tissue seal and/or clot formation. Compositions and devices of the present invention comprise optical dyes which undergo an observable change as the compositions and/or devices are incorporated into a tissue seal and/or clot, for example a change in fluorescence quantum yield and/or a change in visual color including a change in emission and/or absorption wavelength. Tissue sealants and vasculature closure devices of the present invention are useful for visualizing seal and/or clot formation, for example, during or after surgical procedures, after catheter removal, etc. The present invention further provides methods for formation and optical detection of tissue seals or vasculature puncture closures as well as medical kits useful for the formation and optical detection of tissue seals or vasculature puncture closures.

    摘要翻译： 本发明提供组织密封剂组合物和脉管系统闭合装置，其可用于光学检测组织密封和/或凝块形成。 本发明的组合物和装置包括当组合物和/或装置结合到组织密封和/或凝块中时经历可观察到的变化的光学染料，例如荧光量子产率的变化和/或视觉颜色的变化，包括 发射和/或吸收波长的变化。 本发明的组织密封剂和血管闭合装置可用于可视化密封和/或血块形成，例如，在外科手术期间或之后，导管移除之后等。本发明还提供用于组织密封的形成和光学检测的方法 或脉管系统穿刺闭合件以及可用于组织密封或脉管系统穿刺闭合件的形成和光学检测的医疗套件。

    Optical diagnostic and therapeutic agents and compositions
    5.
    发明授权
    Optical diagnostic and therapeutic agents and compositions 有权
    光学诊断和治疗剂及组合物

    公开(公告)号：US07767194B2

    公开(公告)日：2010-08-03

    申请号：US11146377

    申请日：2005-06-06

    申请人： Samuel I. Achilefu ,  Raghavan Rajagopalan ,  Richard B. Dorshow ,  Joseph E. Bugaj ,  Muthunadar P. Periasamy

    发明人： Samuel I. Achilefu ,  Raghavan Rajagopalan ,  Richard B. Dorshow ,  Joseph E. Bugaj ,  Muthunadar P. Periasamy

    IPC分类号： A61K49/00

    CPC分类号： A61K49/0032 ,  A61K41/0033 ,  A61K41/0057 ,  A61K49/0056 ,  C07D209/12 ,  C07D405/14 ,  C09B23/0066 ,  C09B23/0075 ,  C09B23/08 ,  C09B23/086

    摘要： Cyanine and indocyanine dye compounds and bioconjugates are disclosed. The present invention includes several cyanine and indocyanine dyes, including bioconjugates of the same, with a variety of bis- and tetrakis (carboxylic acid) homologues. The compounds of the invention may be conjugated to bioactive peptides, carbohydrates, hormones, drugs, or other bioactive agents. The small size of compounds of the invention allows favorable delivery to tumor cells as compared to larger molecular weight imaging agents. Further, use of a biocompatible organic solvent such as dimethylsulfoxide may be said to assist in maintaining the fluorescence of compounds of the invention. The compounds and bioconjugates herein disclosed are useful in a variety of medical applications including, but not limited to, diagnostic imaging and therapy, endoscopic applications for the detection of tumors and other abnormalities, localized therapy, photoacoustic tumor imaging, detection and therapy, and sonofluorescence tumor imaging, detection and therapy.

    摘要翻译： 公开了花青和靛蓝染料化合物和生物共轭物。 本发明包括几种花青和靛蓝染料，其包括与其各种双和四（羧酸）同系物的生物缀合物。 本发明的化合物可以与生物活性肽，碳水化合物，激素，药物或其他生物活性剂缀合。 与较大的分子量成像剂相比，本发明化合物的小尺寸允许有利地递送到肿瘤细胞。 此外，使用生物相容性有机溶剂如二甲基亚砜可以说有助于维持本发明化合物的荧光。 本文公开的化合物和生物缀合物可用于各种医学应用，包括但不限于诊断成像和治疗，用于检测肿瘤和其他异常的内窥镜应用，局部治疗，光声肿瘤成像，检测和治疗以及声发射 肿瘤成像，检测和治疗。

    RECEPTOR-AVID EXOGENOUS OPTICAL CONTRAST AND THERAPEUTIC AGENTS
    6.
    发明申请
    RECEPTOR-AVID EXOGENOUS OPTICAL CONTRAST AND THERAPEUTIC AGENTS 审中-公开
    受体 - 异常光学对比和治疗药物

    公开(公告)号：US20100022449A1

    公开(公告)日：2010-01-28

    申请号：US12470310

    申请日：2009-05-21

    申请人： Samuel I. Achilefu ,  Raghavan Rajagopalan ,  Richard B. Dorshow ,  Joseph E. Bugaj

    发明人： Samuel I. Achilefu ,  Raghavan Rajagopalan ,  Richard B. Dorshow ,  Joseph E. Bugaj

    IPC分类号： A61K38/08 ,  A61K31/403 ,  A61K38/06 ,  A61P43/00

    CPC分类号： A61K49/0021 ,  A61K49/0032 ,  A61K49/0056 ,  C07D209/12 ,  C07D403/06 ,  C07D403/08 ,  C07D405/14 ,  C09B23/0016 ,  C09B23/0025 ,  C09B23/0066 ,  C09B23/0075 ,  C09B23/086

    摘要： Cyanine and indocyanine dye compounds and bioconjugates are disclosed. The present invention includes several cyanine and indocyanine dyes, including bioconjugates of the same, with a variety of bis- and tetrakis (carboxylic acid) homologues. The compounds of the invention may be conjugated to bioactive peptides, carbohydrates, hormones, drugs, or other bioactive agents. The small size of compounds of the invention allows favorable delivery to tumor cells as compared to larger molecular weight imaging agents. Further, use of a biocompatible organic solvent such as dimethylsulfoxide may be said to assist in maintaining the fluorescence of compounds of the invention. The compounds and bioconjugates herein disclosed are useful in a variety of medical applications including, but not limited to, diagnostic imaging and therapy, endoscopic applications for the detection of tumors and other abnormalities, localized therapy, photoacoustic tumor imaging, detection and therapy, and sonofluorescence tumor imaging, detection and therapy.

    摘要翻译： 公开了花青和靛蓝染料化合物和生物共轭物。 本发明包括几种花青和靛蓝染料，其包括与其各种双和四（羧酸）同系物的生物缀合物。 本发明的化合物可以与生物活性肽，碳水化合物，激素，药物或其他生物活性剂缀合。 与较大的分子量成像剂相比，本发明化合物的小尺寸允许有利地递送到肿瘤细胞。 此外，使用生物相容性有机溶剂如二甲基亚砜可以说有助于维持本发明化合物的荧光。 本文公开的化合物和生物缀合物可用于各种医学应用，包括但不限于诊断成像和治疗，用于检测肿瘤和其他异常的内窥镜应用，局部治疗，光声肿瘤成像，检测和治疗以及声发射 肿瘤成像，检测和治疗。

    Receptor-avid exogenous optical contrast and therapeutic agents
    8.
    发明授权
    Receptor-avid exogenous optical contrast and therapeutic agents 有权
    受体 - 狂热的外源性光学对比和治疗剂

    公开(公告)号：US07504087B2

    公开(公告)日：2009-03-17

    申请号：US11075792

    申请日：2005-03-09

    申请人： Samuel I. Achilefu ,  Raghavan Rajagopalan ,  Richard B. Dorshow ,  Joseph E. Bugaj ,  Muthunadar P. Periasamy

    发明人： Samuel I. Achilefu ,  Raghavan Rajagopalan ,  Richard B. Dorshow ,  Joseph E. Bugaj ,  Muthunadar P. Periasamy

    IPC分类号： A61K51/00 ,  A61M36/14

    CPC分类号： A61K49/0032 ,  A61K41/0033 ,  A61K41/0057 ,  A61K49/0056 ,  C07D209/12 ,  C07D405/14 ,  C09B23/0066 ,  C09B23/0075 ,  C09B23/08 ,  C09B23/086

    摘要： Cyanine and Indocyanine dye compounds and bioconjugates are disclosed. The present invention includes several cyanine and indocyanine dyes, including bioconjugates of the same, with a variety of bis- and tetrakis (carboxylic acid) homologues. The compounds of the invention may be conjugated to bioactive peptides, carbohydrates, hormones, drugs, or other bioactive agents. The small size of compounds of the invention allows favorable delivery to tumor cells as compared to larger molecular weight imaging agents. Further, use of a biocompatible organic solvent such as dimethylsulfoxide may be said to assist in maintaining the fluorescence of compounds of the invention. The compounds and bioconjugates herein disclosed are useful in a variety of medical applications including, but not limited to, diagnostic imaging and therapy, endoscopic applications for the detection of tumors and other abnormalities, localized therapy, photoacoustic tumor imaging, detection and therapy, and sonofluorescence tumor imaging, detection and therapy.

    摘要翻译： 公开了花青和吲哚菁染料化合物和生物共轭物。 本发明包括几种花青和靛蓝染料，其包括与其各种双和四（羧酸）同系物的生物缀合物。 本发明的化合物可以与生物活性肽，碳水化合物，激素，药物或其他生物活性剂缀合。 与较大的分子量成像剂相比，本发明化合物的小尺寸允许有利地递送到肿瘤细胞。 此外，使用生物相容性有机溶剂如二甲基亚砜可以说有助于维持本发明化合物的荧光。 本文公开的化合物和生物缀合物可用于各种医学应用，包括但不限于诊断成像和治疗，用于检测肿瘤和其他异常的内窥镜应用，局部治疗，光声肿瘤成像，检测和治疗以及声发射 肿瘤成像，检测和治疗。

    Fluorescent Pyrazine Derivatives and Methods of Using the Same in Assessing Renal Function
    9.
    发明申请
    Fluorescent Pyrazine Derivatives and Methods of Using the Same in Assessing Renal Function 有权
    荧光吡嗪衍生物及其在肾功能评估中的应用方法

    公开(公告)号：US20090010851A1

    公开(公告)日：2009-01-08

    申请号：US11721186

    申请日：2005-12-22

    申请人： Raghavan Rajagopalan ,  Richard B. Dorshow ,  William L. Neumann ,  Dennis A. Moore

    发明人： Raghavan Rajagopalan ,  Richard B. Dorshow ,  William L. Neumann ,  Dennis A. Moore

    IPC分类号： A61K49/00

    CPC分类号： C07D241/28 ,  A61K31/4965 ,  A61K49/0004 ,  A61K49/0021 ,  A61K49/0052 ,  C07D241/20 ,  C07D241/26

    摘要： The present invention relates to pyrazine derivatives such as those represented by Formulas I and II. X1 to X4 of Formulas I and II may be characterized as electron withdrawing groups, while Y1 to Y4 of Formulas I and II may be characterized as electron donating groups. Pyrazine derivatives of the present invention may be utilized in assessing organ (e.g., kidney) function. In a particular example, an effective amount of a pyrazine derivative that is capable of being renally cleared may be administered into a patient's body. The pyrazine derivative may capable of one or both absorbing and emanating spectral energy of at least about 400 nm (e.g., visible and/or infrared light). At least some of the derivative that is in the body may be exposed to spectral energy and, in turn, spectral energy may emanate from the derivative. This emanating spectral energy may be detected and utilized to determine renal function of the patient.

    摘要翻译： 本发明涉及吡嗪衍生物，例如由式I和II表示的衍生物。 式I和II的X 1至X 4可以表征为吸电子基团，而式I和II的Y1至Y4可以表征为给电子基团。 本发明的吡嗪衍生物可用于评估器官（例如肾）功能。 在具体实例中，有效量的能够被再次清除的吡嗪衍生物可以被施用到患者体内。 吡嗪衍生物可以具有一个或两个吸收和发射至少约400nm的光谱能量（例如可见光和/或红外光）。 身体中的至少一些衍生物可能暴露于光谱能量，反过来，光谱能量可能来自衍生物。 这种发出的光谱能量可以被检测并用于确定患者的肾功能。