公开(公告)号：US20110210726A1

公开(公告)日：2011-09-01

申请号：US12672596

申请日：2008-02-26

申请人： Gang Cui ,  Keun Ki Kim ,  Dong Hoon Han ,  Moon Hwan Kim ,  Hakhyun Nam ,  Geun Sig Cha

发明人： Gang Cui ,  Keun Ki Kim ,  Dong Hoon Han ,  Moon Hwan Kim ,  Hakhyun Nam ,  Geun Sig Cha

IPC分类号： G01R33/02

CPC分类号： G01N33/48771 ,  A61B5/14532 ,  A61B5/1486 ,  C12Q1/004

摘要： Disclosed are an electrochemical biosensor which comprises a production lot information identification portion, on which information is recorded in a magnetization mark, and a measuring device which can automatically identify the production lot information of the biosensor with the insertion of the electrochemical biosensor into the measuring device. The electrochemical biosensor and the measuring device thereof can record production lot information in the form of magnetization marks on an electrochemical biosensor strip and read the information as digital signals through a magnetoresistance sensor device, which can be mounted on the surface of a circuit board using Surface Mounted Technology (SMT). Without the need for a high-priced filter or a complicated calculation system, the magnetic detector system has a simple construction and realizes economic efficiency in the construction of the measuring device. Also, the measuring device automatically identifies the production lot information recorded on the biosensor, so that inconvenience and the frequency of errors, which occur when a user personally inputs the production lot information, can be reduced, with the result that the measured values can be conveniently and accurately acquired.

摘要翻译： 公开了一种电化学生物传感器，其包括将信息记录在磁化标记中的生产批次信息识别部分和能够通过将电化学生物传感器插入到测量装置中来自动识别生物传感器的生产批次信息的测量装置 。 电化学生物传感器及其测量装置可以在电化学生物传感器条上以磁化标记的形式记录生产批量信息，并通过磁阻传感器装置读取作为数字信号的信息，该磁阻传感器装置可以使用表面安装在电路板的表面上 安装技术（SMT）。 不需要高价格的过滤器或复杂的计算系统，磁检测系统结构简单，实现了测量装置结构的经济效益。 此外，测量装置自动识别记录在生物传感器上的生产批次信息，从而可以减少当用户亲自输入生产批次信息时出现的不便和错误频率，结果是测量值可以是 方便准确地获取。

公开(公告)号：US20110147457A1

公开(公告)日：2011-06-23

申请号：US13060049

申请日：2008-11-11

申请人： Geun Sig Cha ,  Hakhyun Nam ,  Gang Cui ,  Keun-Ki Kim ,  Shim-Ho Lee

发明人： Geun Sig Cha ,  Hakhyun Nam ,  Gang Cui ,  Keun-Ki Kim ,  Shim-Ho Lee

IPC分类号： G06K7/10

CPC分类号： G01N33/48771 ,  A61B5/14532 ,  A61B2560/0276 ,  G01N2035/00772

摘要： A biosensor can be measured by a method that includes: determining malfunction of a production lot information sensing unit; alerting malfunction when the production lot information sensing unit malfunctions; encoding the production lot information through the production lot information sensing unit when the production lot information sensing unit does not malfunction; and detecting a component of a sample through a biosensor strip by using the encoded production lot information.

摘要翻译： 可以通过以下方法测量生物传感器：包括：确定生产批次信息感测单元的故障; 当生产批量信息传感单元发生故障时发出警报故障; 当生产批次信息感测单元不发生故障时，通过生产批次信息感测单元对生产批次信息进行编码; 以及通过使用编码的生产批次信息通过生物传感器条检测样品的成分。

公开(公告)号：US20090308744A1

公开(公告)日：2009-12-17

申请号：US12375635

申请日：2006-07-29

申请人： Hakhyun Nam ,  Fenghua Zhang ,  Soon Hye Yang ,  Bo Kyeong Kang ,  Gang Cui ,  Moon Hee Choi ,  Joung Su Lee ,  Geun Sig Cha

发明人： Hakhyun Nam ,  Fenghua Zhang ,  Soon Hye Yang ,  Bo Kyeong Kang ,  Gang Cui ,  Moon Hee Choi ,  Joung Su Lee ,  Geun Sig Cha

IPC分类号： G01N33/68 ,  G01N33/50 ,  G01N1/14

CPC分类号： G01N33/723 ,  G01N33/5308 ,  G01N33/5438

摘要： Disclosed relates to an electrochemical determination system of glycated proteins, the system comprising: a filtering means for filtering labeled compounds bound to glycated proteins and non-glycated proteins after adding labeling compounds, capable of selectively binding to the glycated proteins to a solution, in which glycated/non-glycated proteins coexist, to be bound all to the glycated proteins; and a quantifying means for quantifying the filtered labeling compounds, not bound to the glycated proteins. The system of the present invention filters the residual labeled compounds left after binding to glycated proteins to quantify, instead of directly quantifying glycated proteins via the known glycated protein determination methods, thus simplifying the configuration of the system that can provide exact determinations with a low cost. Moreover, the electrochemical determination system of glycated proteins of the present invention minimizes the interference that the proteins are absorbed to an analysis device and a sensor in the system, not using immune antibodies that are expensive and have limited lives and, furthermore, not modifying the electrodes of the electrode sensor with antibodies or enzymes, thus facilitating mass production, quality control and circulation of the products.

摘要翻译： 本发明涉及一种糖化蛋白质的电化学测定系统，该系统包括：过滤装置，用于在加入能够选择性结合糖基化蛋白质至溶液的标记化合物之后过滤与糖化蛋白质和非糖基化蛋白质结合的标记化合物，其中 糖化/非糖化蛋白共存，与糖基化蛋白结合; 以及用于定量未与糖基化蛋白结合的经过滤的标记化合物的定量方法。 本发明的系统对结合糖化蛋白质后残留的残留标记化合物进行过滤以定量，而不是通过已知的糖化蛋白质测定方法直接定量糖化蛋白质，从而简化可以以低成本提供精确测定的系统的配置 。 此外，本发明的糖化蛋白质的电化学测定系统使得蛋白质被吸收到系统中的分析装置和传感器的干扰最小化，而不是使用昂贵的且具有有限寿命的免疫抗体，此外，不改变 电极传感器的电极与抗体或酶，从而促进产品的大量生产，质量控制和循环。

公开(公告)号：US20080237062A1

公开(公告)日：2008-10-02

申请号：US11747945

申请日：2007-05-14

申请人： Keun Ki Kim ,  Jae Hyun Yoo ,  Gang Cui ,  Moon Hwan Kim ,  Hakhyun Nam ,  Geun Sig Cha

发明人： Keun Ki Kim ,  Jae Hyun Yoo ,  Gang Cui ,  Moon Hwan Kim ,  Hakhyun Nam ,  Geun Sig Cha

IPC分类号： C12Q1/00

CPC分类号： B01L3/545 ,  B01L3/5027 ,  B01L2300/0645 ,  B01L2300/0825 ,  B01L2300/0887 ,  B01L2400/0406 ,  G01N27/3272 ,  G01N35/00732 ,  G01N2035/00772 ,  G01N2035/00851

摘要： An electrochemical biosensor and a biosensor measuring device. The electrochemical biosensor includes a plurality of electrodes, capillary sample cell portions, reaction reagent layers, electrode connection portions, and a production lot information identification portion. The production lot information identification portion is configured such that the production lot information is recorded thereon has one or more infrared absorption/reflection marks, which indicate information about differences between production lots through the printing and/or attachment of colored or colorless materials, having differences in absorbency or reflectivity of infrared rays, in conformity of a predetermined pattern or through the attachment of transparent films. The electrochemical biosensor measuring device includes a plurality of integrated photo-reflector sensing devices that emit and receive infrared rays to identify the production lot information recorded on the production lot information identification portion of the biosensor.

摘要翻译： 电化学生物传感器和生物传感器测量装置。 电化学生物传感器包括多个电极，毛细管样品池部分，反应试剂层，电极连接部分和生产批次信息识别部分。 生产批次信息识别部被配置为使得生产批次信息被记录在其上，具有一个或多个红外吸收/反射标记，其表示通过有色或无色材料的印刷和/或附着的生产批次之间的差异的信息，其具有差异 红外线的吸收性或反射率，符合预定图案或通过透明膜的附着。 电化学生物传感器测量装置包括发射和接收红外线的多个集成光反射器感测装置，以识别记录在生物传感器的生产批次信息识别部分上的生产批次信息。

公开(公告)号：US20050000808A1

公开(公告)日：2005-01-06

申请号：US10778685

申请日：2004-02-12

申请人： Gang Cui ,  Jae-Hyun Yoo ,  Moon-Hwan Kim ,  Ju-Yong Kim ,  Jung-Hee Uhm ,  Hakhyun Nam ,  Geun-Sig Cha

发明人： Gang Cui ,  Jae-Hyun Yoo ,  Moon-Hwan Kim ,  Ju-Yong Kim ,  Jung-Hee Uhm ,  Hakhyun Nam ,  Geun-Sig Cha

IPC分类号： G01N27/327 ,  C12Q1/00 ,  C12Q1/25 ,  G01N27/416 ,  G01N1/00 ,  C12M1/00 ,  C12M1/42

CPC分类号： C12Q1/004 ,  C12Q1/001

摘要： There is provided the reagent layer composition that can substantially reduce the measurement bias arising from hematocrits. The addition of fatty acid (4-20 carbons) and quaternary ammonium salt to a commonly used reagent layer composition composed of an enzyme, an electron transfer mediator, and several water soluble polymers not only reduce the hematocrit level-dependent bias but also provide very stable performance for an extended period of time. Disclosed are also various types of sub microliter sample volume electrochemical biosensors that are suitable to use with the reagent layer composition of present invention.

摘要翻译： 提供了可以显着降低由血细胞比容引起的测量偏差的试剂层组合物。 向酶，电子传递介质和几种水溶性聚合物组成的常用试剂​​层组合物中加入脂肪酸（4-20碳）和季铵盐不仅可降低血细胞比容水平依赖性偏倚， 稳定的性能在较长的一段时间。 还公开了适用于本发明的试剂层组合物的各种类型的微微升样品体积电化学生物传感器。

公开(公告)号：US06663756B2

公开(公告)日：2003-12-16

申请号：US09982490

申请日：2001-10-18

申请人： Dong Kwon Lee ,  Tae Young Kang ,  Sung Hyuk Choi ,  Jae Seon Lee ,  Hakhyun Nam ,  Geun Sig Cha

发明人： Dong Kwon Lee ,  Tae Young Kang ,  Sung Hyuk Choi ,  Jae Seon Lee ,  Hakhyun Nam ,  Geun Sig Cha

IPC分类号： G01N2731

CPC分类号： G01N27/4035

摘要： Disclosed is a microchip-based differential-type potentiometric oxygen gas sensor, which comprises a working electrode and a reference electrode. The working electrode is composed of a cobalt-plated electrode, a buffered hydrogel, and an ion sensitive gas permeable membrane while the reference electrode is composed of an oxygen non-sensitive silver chloride electrode and the same ion-selective gas-permeable membrane of working electrode. By taking advantage of the corrosion potential, the microchip-based oxygen gas sensor can accurately and quickly detect the content of dissolved oxygen in a sample solution. With this structure, the oxygen gas sensor is applied to a microchip-based all potentiometric multi-sensor capable of detecting two or more ions and gas species on a single chip.

公开(公告)号：US20130274781A1

公开(公告)日：2013-10-17

申请号：US13993059

申请日：2011-09-20

申请人： Geun Sig Cha ,  Hakhyun Nam ,  Eun-Jong Cha ,  Kyung-Ah Kim

发明人： Geun Sig Cha ,  Hakhyun Nam ,  Eun-Jong Cha ,  Kyung-Ah Kim

IPC分类号： A61B5/151

CPC分类号： A61B5/15126 ,  A61B5/1411 ,  A61B5/150022 ,  A61B5/150068 ,  A61B5/150114 ,  A61B5/150183 ,  A61B5/150412 ,  A61B5/150519 ,  A61B5/150664 ,  A61B5/15113 ,  A61B5/15117 ,  A61B5/15128 ,  A61B5/1513 ,  A61B5/1519 ,  A61B5/15194

摘要： A releasing structure for a lancing device according to an exemplary embodiment of the present invention may include: a lancet body with a lancet at the front; a lancet holder mounted with the lancet body with the lancet at the front; a stem disposed behind the lancet holder and moving the lancet holder forward/backward; a rotary housing pushing/pulling the stem while turning forward at a predetermined angle about a rotational axis defined in the movement direction of the lancet; a torsion spring storing torque for turning the rotary housing forward at a predetermined angle; and a loading handle transmitting torque to the torsion spring while turning forward at a predetermined angle.

摘要翻译： 根据本发明的示例性实施例的用于采血装置的释放结构可以包括：在前部具有刺血针的柳叶刀体; 一个刺血针架，带有柳叶刀身体，前面有刺血针; 设置在刺血针保持器后方的杆，向前/向后移动刺血针保持器; 旋转壳​​体，其以围绕在柳叶刀的移动方向上限定的旋转轴线以预定角度向前转动的方式推动/拉动所述杆; 扭转弹簧存储用于以预定角度向前转动旋转壳体的扭矩; 以及在以预定角度向前转动的同时向扭转弹簧传递扭矩的加载手柄。

公开(公告)号：US20130267979A1

公开(公告)日：2013-10-10

申请号：US13995149

申请日：2011-09-20

申请人： Geun Sig Cha ,  Hakhyun Nam ,  Eun-Jong Cha ,  Kyung-Ah Kim

发明人： Geun Sig Cha ,  Hakhyun Nam ,  Eun-Jong Cha ,  Kyung-Ah Kim

IPC分类号： A61B5/151

CPC分类号： A61B5/15126 ,  A61B5/150022 ,  A61B5/150114 ,  A61B5/150183 ,  A61B5/150412 ,  A61B5/150503 ,  A61B5/150664 ,  A61B5/150809 ,  A61B5/15113 ,  A61B5/15117 ,  A61B5/1519 ,  A61B5/15194

摘要： A lancet device with an adjustable hypodermic penetration depth according to an exemplary embodiment of the present invention includes: a lancet holder having a lancet seat to mount a lancet at one end; an operating mechanism disposed at the other end of the lancet holder and loading and releasing the lancet holder along a predetermined path; a depth adjusting member receiving the lancet holder and having at least two grooves formed at a predetermined angle on the circumferential surface of one end to form inclined passages clockwise or counterclockwise; and a housing receiving the lancet holder and the operating mechanism and having a protrusion that is formed on the inner side of an end and fitted step by step in the grooves when the depth adjusting member turns at a predetermined angle.

摘要翻译： 根据本发明的示例性实施例的具有可调节皮下注射深度的刺血针装置包括：具有刺血针座的柳叶刀保持器，用于在一端安装刺血针; 操作机构，其设置在所述柳叶刀套的另一端，并沿着规定的路径装卸所述柳叶刀套; 深度调节构件，其接收所述柳叶刀套，并且在一端的周面上具有以规定角度形成的至少两个槽，以顺时针或逆时针方向形成倾斜通道; 以及容纳所述柳叶刀套和所述操作机构的壳体，具有形成在所述端部的内侧的突起，并且当所述深度调节构件以规定的角度转动时，所述突起部逐渐地嵌入所述槽。

公开(公告)号：US08277635B2

公开(公告)日：2012-10-02

申请号：US12530128

申请日：2008-02-26

申请人： Moon Hwan Kim ,  Keun Ki Kim ,  Gang Cui ,  Hakhyun Nam ,  Geun Sig Cha

发明人： Moon Hwan Kim ,  Keun Ki Kim ,  Gang Cui ,  Hakhyun Nam ,  Geun Sig Cha

IPC分类号： G01N27/327 ,  G01N27/403 ,  G01N27/26 ,  G01N33/53

CPC分类号： G01N33/48771 ,  A61B5/14532 ,  A61B5/1486 ,  A61B2562/08 ,  B01L3/545 ,  B01L2200/148 ,  B01L2300/0645 ,  B01L2300/0825 ,  G01N2035/00752 ,  G01N2035/00811

摘要： Disclosed herein is an electrochemical biosensor measuring device which comprises at least two photodiodes for emitting light beams at regular time intervals in a sequential manner, with the insertion of an electrochemical biosensor thereto, and a detector for sensing the emitted light beams, thereby identifying the production lot information recorded on a production lot information identification portion on the electrochemical biosensor. Thus, the device enjoys economic advantages of not requiring a high-priced optical filter in detecting the light absorbed through or reflected from the production identification information recorded in biosensor and a complicated software algorithm to recover the production lot information. Also, the measuring device automatically identifies the production lot information recorded on the biosensor, so that the frequency of inconvenience and error that occur when a user personally inputs the production lot information of the biosensor can be reduced, with the result that the measured values can be conveniently and accurately acquired.

摘要翻译： 本文公开了一种电化学生物传感器测量装置，其包括至少两个光电二极管，用于以顺序方式以规则的时间间隔发射光束，同时插入电化学生物传感器，以及用于感测发射的光束的检测器，从而识别生产 记录在电化学生物传感器上的生产批次信息识别部分上的批次信息。 因此，该设备具有经济上的优点，即不需要高价格的光学滤波器来检测由生物传感器中记录的生产识别信息吸收或反射的光，以及复杂的软件算法来恢复生产批次信息。 此外，测量装置自动识别记录在生物传感器上的生产批次信息，从而可以减少当用户亲自输入生物传感器的生产批次信息时发生的不便和错误的频率，结果是测量值可以 方便，准确地获得。

公开(公告)号：US08226004B2

公开(公告)日：2012-07-24

申请号：US13060049

申请日：2008-11-11

申请人： Geun Sig Cha ,  Hakhyun Nam ,  Gang Cui ,  Keun-Ki Kim ,  Shim-Ho Lee

发明人： Geun Sig Cha ,  Hakhyun Nam ,  Gang Cui ,  Keun-Ki Kim ,  Shim-Ho Lee

IPC分类号： G06K7/10

CPC分类号： G01N33/48771 ,  A61B5/14532 ,  A61B2560/0276 ,  G01N2035/00772

摘要： A biosensor can be measured by a method that includes: determining malfunction of a production lot information sensing unit; alerting malfunction when the production lot information sensing unit malfunctions; encoding the production lot information through the production lot information sensing unit when the production lot information sensing unit does not malfunction; and detecting a component of a sample through a biosensor strip by using the encoded production lot information.

摘要翻译： 可以通过以下方法测量生物传感器：包括：确定生产批次信息感测单元的故障; 当生产批量信息传感单元发生故障时发出警报故障; 当生产批次信息感测单元不发生故障时，通过生产批次信息感测单元对生产批次信息进行编码; 以及通过使用编码的生产批次信息通过生物传感器条检测样品的成分。