公开(公告)号：US06663756B2

公开(公告)日：2003-12-16

申请号：US09982490

申请日：2001-10-18

申请人： Dong Kwon Lee ,  Tae Young Kang ,  Sung Hyuk Choi ,  Jae Seon Lee ,  Hakhyun Nam ,  Geun Sig Cha

发明人： Dong Kwon Lee ,  Tae Young Kang ,  Sung Hyuk Choi ,  Jae Seon Lee ,  Hakhyun Nam ,  Geun Sig Cha

IPC分类号： G01N2731

CPC分类号： G01N27/4035

摘要： Disclosed is a microchip-based differential-type potentiometric oxygen gas sensor, which comprises a working electrode and a reference electrode. The working electrode is composed of a cobalt-plated electrode, a buffered hydrogel, and an ion sensitive gas permeable membrane while the reference electrode is composed of an oxygen non-sensitive silver chloride electrode and the same ion-selective gas-permeable membrane of working electrode. By taking advantage of the corrosion potential, the microchip-based oxygen gas sensor can accurately and quickly detect the content of dissolved oxygen in a sample solution. With this structure, the oxygen gas sensor is applied to a microchip-based all potentiometric multi-sensor capable of detecting two or more ions and gas species on a single chip.

公开(公告)号：US20110195490A1

公开(公告)日：2011-08-11

申请号：US12739686

申请日：2008-10-30

申请人： Tae Young Kang ,  Heejun Lee ,  Jeonghan Ha ,  Jungwon Shin ,  Hakhyun Nam ,  Geun Sig Cha

发明人： Tae Young Kang ,  Heejun Lee ,  Jeonghan Ha ,  Jungwon Shin ,  Hakhyun Nam ,  Geun Sig Cha

IPC分类号： C12M1/34 ,  G01N33/48

CPC分类号： G01N33/492 ,  G01N2035/00089 ,  G01N2035/00148

摘要： The present invention provides a cartridge for an apparatus for analyzing blood chemistry that is used for medical treatment, and automatically analyzes and records data needed for medical service, such as the concentrations of electrolytes, the partial pressures of gases, and the concentrations of metabolites, or the volume ratio of red blood cells contained in blood. The apparatus for analyzing blood chemistry of present invention includes: an apparatus frame having a compartment; a cartridge that is inserted into the compartment of the apparatus frame and includes a sensor card, a solution valve unit, and a blood introducing unit; a controller that receives a signal generated from the sensor card and processes the signal; a lever for the blood introducing unit is connected to the apparatus frame; a power transmitting unit that is provide to the apparatus frame and transmits power of the lever for the blood introducing unit to open/close the blood introducing unit of the cartridge; a solution transporting unit that is provided to the apparatus frame and transports the solutions in the cartridge; and driving units that actuates the solution valve unit of the cartridge by the controller and opens or close the tubing flowing of the solutions.

摘要翻译： 本发明提供一种用于分析用于医疗的血液化学物质的装置的盒，并且自动分析和记录医疗服务所需的数据，例如电解质的浓度，气体的分压和代谢物的浓度， 或血液中含有的红细胞的体积比。 本发明的血液化学分析装置包括：具有隔室的装置框架; 插入到装置框架的隔室中的盒，包括传感器卡，溶液阀单元和血液引入单元; 控制器，其接收从所述传感器卡生成的信号并处理所述信号; 用于血液引入单元的杆连接到装置框架; 动力传递单元，其向所述装置框架提供并且传送所述用于所述血液导入单元的所述杆的动力以打开/关闭所述盒的血液引入单元; 溶液输送单元，其被提供到所述装置框架并将所述溶液输送到所述盒中; 以及通过控制器致动药筒的溶液阀单元并打开或关闭溶液流动的管道的驱动单元。

公开(公告)号：US06746583B2

公开(公告)日：2004-06-08

申请号：US09877857

申请日：2001-06-08

申请人： Jae Seon Lee ,  Jae Ho Shin ,  Min Hyung Lee ,  Hakhyun Nam ,  Geun Sig Cha

发明人： Jae Seon Lee ,  Jae Ho Shin ,  Min Hyung Lee ,  Hakhyun Nam ,  Geun Sig Cha

IPC分类号： G01N27327

CPC分类号： G01N27/333 ,  G01N27/4162 ,  G01N33/004

摘要： There is provided a microchip-based differential-type carbon dioxide gas sensor for detecting dissolved carbon dioxide levels. It functions with at least one working electrode composed of an unbuffered hydrogel membrane containing a certain amount of sodium bicarbonate and a pH-sensitive gas-permeable membrane; and a reference electrode composed of a buffered hydrogel membrane and a pH-sensitive gas-permeable membrane. The unbuffered hydrogel membrane contains carbonic anhydrase, which reduces the time period for the hydration of carbon dioxide, thereby allowing the quick measurement of the level of carbon dioxide. In addition to being significantly improved in stabilization, sensing, and recovering time periods, the differential-type carbon dioxide gas sensor can be fabricated in small sizes and quickly measure levels of carbon dioxide dissolved in sample solution.

摘要翻译： 提供了一种用于检测溶解二氧化碳水平的基于微芯片的差分式二氧化碳气体传感器。 它与至少一个由含有一定量碳酸氢钠和pH敏感性透气膜的无缓冲水凝胶膜组成的工作电极起作用; 以及由缓冲水凝胶膜和pH敏感性透气膜构成的参比电极。 无缓冲水凝胶膜含有碳酸酐酶，减少了二氧化碳水化的时间，从而可以快速测定二氧化碳的含量。 除了稳定化，感测和恢复时间段的显着改进之外，差分型二氧化碳气体传感器可以制造成小尺寸并且快速测量溶解在样品溶液中的二氧化碳的水平。

公开(公告)号：US08940233B2

公开(公告)日：2015-01-27

申请号：US12739686

申请日：2008-10-30

申请人： Tae Young Kang ,  Heejun Lee ,  Jeonghan Ha ,  Jungwon Shin ,  Hakhyun Nam ,  Geun Sig Cha

发明人： Tae Young Kang ,  Heejun Lee ,  Jeonghan Ha ,  Jungwon Shin ,  Hakhyun Nam ,  Geun Sig Cha

IPC分类号： C12Q1/68 ,  G01N21/00 ,  G01N15/06 ,  G01N33/00 ,  G01N33/49 ,  G01N35/00

CPC分类号： G01N33/492 ,  G01N2035/00089 ,  G01N2035/00148

摘要： A cartridge for an apparatus for analyzing blood chemistry includes an apparatus frame having a compartment; a cartridge that is inserted into the compartment of the apparatus frame and includes a sensor card, a solution valve unit, and a blood introducing unit; a controller that receives a signal generated from the sensor card and processes the signal; a lever for the blood introducing unit connected to the apparatus frame; a power transmitting unit that is provided to the apparatus frame and transmits power of the lever for the blood introducing unit to open/close the blood introducing unit of the cartridge; a solution transporting unit that is provided to the apparatus frame and transports the solutions; and a driving unit that actuates the solution valve unit of the cartridge by the controller and opens or closes the tubing flowing of the solutions.

摘要翻译： 用于分析血液化学物质的装置的药筒包括具有隔室的装置框架; 插入到装置框架的隔室中的盒，包括传感器卡，溶液阀单元和血液引入单元; 控制器，其接收从所述传感器卡生成的信号并处理所述信号; 用于连接到装置框架的血液引入单元的杆; 动力传递单元，其设置在所述装置框架上，并且传递用于所述血液导入单元的所述杆的动力以打开/关闭所述药筒的所述血液导入单元; 溶液输送单元，其设置在所述装置框架上并输送溶液; 以及驱动单元，其通过控制器致动盒的溶液阀单元并打开或关闭溶液流动的管道。

公开(公告)号：US08475744B2

公开(公告)日：2013-07-02

申请号：US12739696

申请日：2008-10-30

申请人： Jeonghan Ha ,  Heejun Lee ,  Tae Young Kang ,  Jungwon Shin ,  Hakhyun Nam ,  Geun Sig Cha

发明人： Jeonghan Ha ,  Heejun Lee ,  Tae Young Kang ,  Jungwon Shin ,  Hakhyun Nam ,  Geun Sig Cha

IPC分类号： A61J1/10

CPC分类号： B01L3/505 ,  B01L3/567 ,  B01L2200/026 ,  B01L2200/141 ,  B01L2200/148 ,  B01L2400/065 ,  F16K3/24 ,  F16K3/246 ,  G01N35/1002 ,  Y10T436/2575

摘要： The present invention provides a solution bag that is used for medical treatment and stores solution used for an apparatus for analyzing blood chemistry that measures and analyzes the concentrations of electrolytes, the partial pressures of gases, and the concentrations of metabolites or the volume ratio of red blood cells contained in blood. The solution bag for an apparatus for analyzing blood chemistry of the present invention includes: a receptacle that contains a solution; a valve body that is attached to the receptacle and has a through-hole longitudinally formed therein; a valve spool that is disposed in the through-hole of the valve body; and a solution leakage preventing unit that is disposed in the valve spool, in which the valve body has a flow channel and a solution discharging pipe spaced at a predetermined distance from each other.

摘要翻译： 本发明提供了一种溶液袋，其用于医疗处理，并且存储用于分析血液化学物质的装置的溶液，其用于测量和分析电解质的浓度，气体的分压以及代谢物的浓度或红色的体积比 血液中含有血细胞。 用于本发明血液化学分析装置的溶液袋包括：容纳溶液的容器; 阀体，其附接到所述容器并且具有纵向地形成在其中的通孔; 阀芯，其设置在所述阀体的通孔中; 以及溶液泄漏防止单元，其设置在所述阀芯中，所述阀体具有流路和彼此隔开预定距离的溶液排出管。

公开(公告)号：US20100273248A1

公开(公告)日：2010-10-28

申请号：US12739696

申请日：2008-10-30

申请人： Jeonghan Ha ,  Heejun Lee ,  Tae Young Kang ,  Jungwon Shin ,  Hakhyun Nam ,  Geun Sig Cha

发明人： Jeonghan Ha ,  Heejun Lee ,  Tae Young Kang ,  Jungwon Shin ,  Hakhyun Nam ,  Geun Sig Cha

IPC分类号： C12M1/34

CPC分类号： B01L3/505 ,  B01L3/567 ,  B01L2200/026 ,  B01L2200/141 ,  B01L2200/148 ,  B01L2400/065 ,  F16K3/24 ,  F16K3/246 ,  G01N35/1002 ,  Y10T436/2575

摘要： The present invention provides a solution bag that is used for medical treatment and stores solution used for an apparatus for analyzing blood chemistry that measures and analyzes the concentrations of electrolytes, the partial pressures of gases, and the concentrations of metabolites or the volume ratio of red blood cells contained in blood. The solution bag for an apparatus for analyzing blood chemistry of the present invention includes: a receptacle that contains a solution; a valve body that is attached to the receptacle and has a through-hole longitudinally formed therein; a valve spool that is disposed in the thorough-hole of the valve body; and a solution leakage preventing unit that is disposed in the valve spool, in which the valve body has a flow channel and a solution discharging pipe spaced at a predetermined distance from each other, and the solution leakage preventing unit of the valve spool includes a first blocking member that prevents the solution from leaking outside and a second blocking member that is spaced apart from the first blocking member and stops or allows the solution flow from the flow channel to the solution discharging pipe.

摘要翻译： 本发明提供了一种溶液袋，其用于医疗处理，并且存储用于分析血液化学物质的装置的溶液，其用于测量和分析电解质的浓度，气体的分压以及代谢物的浓度或红色的体积比 血液中含有血细胞。 用于本发明血液化学分析装置的溶液袋包括：容纳溶液的容器; 阀体，其附接到所述容器并且具有纵向地形成在其中的通孔; 阀芯，其设置在阀体的通孔中; 以及溶液泄漏防止单元，其设置在所述阀芯中，所述阀体具有流路和彼此隔开预定距离的溶液排出管，所述阀芯的溶液泄漏防止单元包括第一 防止溶液泄漏到外部的阻挡构件和与第一阻挡构件间隔开的第二阻挡构件，并且停止或允许溶液从流动通道流向溶液排出管。

公开(公告)号：US09512458B2

公开(公告)日：2016-12-06

申请号：US12740016

申请日：2008-10-24

申请人： Gang Cui ,  Jae Hyun Yoo ,  Ju Yong Kim ,  Keun Ki Kim ,  Moon Hwan Kim ,  Hakhyun Nam ,  Geun Sig Cha

发明人： Gang Cui ,  Jae Hyun Yoo ,  Ju Yong Kim ,  Keun Ki Kim ,  Moon Hwan Kim ,  Hakhyun Nam ,  Geun Sig Cha

IPC分类号： C12Q1/00 ,  G01N27/327 ,  B01L3/00

CPC分类号： C12Q1/006 ,  B01L3/5027 ,  B01L2300/0645 ,  B01L2300/0825 ,  B01L2300/0887 ,  B01L2400/0406 ,  G01N27/3272

摘要： Disclosed is an electrochemical biosensor having a sample introduction channel in which an insulator is employed to introduce a small amount of a sample uniformly and accurately and to adjust an area of a working electrode, thereby guaranteeing the accurate quantitative analysis of a sample. Provided with a sample collection barrier at a sample entrance, the biosensor allows a sample to be introduced at higher accuracy and to be analyzed with higher reproducibility and reliability.

摘要翻译： 公开了一种具有样品导入通道的电化学生物传感器，其中采用绝缘体均匀且准确地引入少量样品并调节工作电极的面积，从而保证了样品的准确定量分析。 在样品入口处提供样品收集屏障，生物传感器允许以更高的精度引入样品并以更高的再现性和可靠性进行分析。

公开(公告)号：US09192331B2

公开(公告)日：2015-11-24

申请号：US13993059

申请日：2011-09-20

申请人： Geun Sig Cha ,  Hakhyun Nam ,  Eun-Jong Cha ,  Kyung-Ah Kim

发明人： Geun Sig Cha ,  Hakhyun Nam ,  Eun-Jong Cha ,  Kyung-Ah Kim

IPC分类号： A61B5/151 ,  A61B5/15

CPC分类号： A61B5/15126 ,  A61B5/1411 ,  A61B5/150022 ,  A61B5/150068 ,  A61B5/150114 ,  A61B5/150183 ,  A61B5/150412 ,  A61B5/150519 ,  A61B5/150664 ,  A61B5/15113 ,  A61B5/15117 ,  A61B5/15128 ,  A61B5/1513 ,  A61B5/1519 ,  A61B5/15194

摘要： A releasing structure for a lancing device according to an exemplary embodiment of the present invention may include: a lancet body with a lancet at the front; a lancet holder mounted with the lancet body with the lancet at the front; a stem disposed behind the lancet holder and moving the lancet holder forward/backward; a rotary housing pushing/pulling the stem while turning forward at a predetermined angle about a rotational axis defined in the movement direction of the lancet; a torsion spring storing torque for turning the rotary housing forward at a predetermined angle; and a loading handle transmitting torque to the torsion spring while turning forward at a predetermined angle.

摘要翻译： 根据本发明的示例性实施例的用于采血装置的释放结构可以包括：在前部具有刺血针的柳叶刀体; 一个刺血针架，带有柳叶刀身体，前面有刺血针; 设置在刺血针保持器后方的杆，向前/向后移动刺血针保持器; 旋转壳​​体，其以围绕在柳叶刀的移动方向上限定的旋转轴线以预定角度向前转动的方式推动/拉动所述杆; 扭转弹簧存储用于以预定角度向前转动旋转壳体的扭矩; 以及在以预定角度向前转动的同时向扭转弹簧传递扭矩的加载手柄。

公开(公告)号：US20140014512A1

公开(公告)日：2014-01-16

申请号：US13264382

申请日：2011-04-14

申请人： Sung A Hong ,  Da Yeon Sung ,  Jun Hee Han ,  Jea Hun Song ,  Hakhyun Nam ,  Geun Sig Cha ,  Jae Ho Shin

发明人： Sung A Hong ,  Da Yeon Sung ,  Jun Hee Han ,  Jea Hun Song ,  Hakhyun Nam ,  Geun Sig Cha ,  Jae Ho Shin

IPC分类号： G01N27/30

CPC分类号： G01N27/30 ,  G01N27/3271

摘要： Provided are an amperometric sensor and device for electrochemically quantifying nitrosothiol (RSNO), which is associated with storage and delivery of nitric oxide (NO) in the human body. The amperometric sensor for measuring a concentration of RSNO includes an electrode configured to measure an electric current generated by an oxidation reaction of NO, and a means configured to start and stop photo-induced decomposition of RSNO. Here, the electric current is measured by the oxidation reaction of NO before and after the photo-induced decomposition of RSNO. The amperometric sensor may measure separate signals of RSNO and NO, which are present in the sample at the same time, using one electrode, thereby preventing an inhibition action caused by NO during the measurement of RSNO. Also, the amperometric sensor is simple in structure and easy to manufacture and may be applied to manufacture of a small electrode, and thus may be developed as a sensor for in vivo measurements.

摘要翻译： 提供了用于电化学量化亚硝基硫醇（RSNO）的电流传感器和装置，其与人体中一氧化氮（NO）的储存和递送相关。 用于测量RSNO浓度的电流传感器包括配置为测量由NO的氧化反应产生的电流的电极和被配置为启动和停止光诱导的RSNO分解的装置。 这里，通过在RSNO的光诱导分解之前和之后的NO的氧化反应来测量电流。 电流传感器可以使用一个电极同时测量样品中存在的RSNO和NO的单独信号，从而防止在RSNO测量期间由NO引起的抑制作用。 此外，电流传感器的结构简单，易于制造，并且可以应用于小电极的制造，因此可以被开发为用于体内测量的传感器。

公开(公告)号：US20130267977A1

公开(公告)日：2013-10-10

申请号：US13995153

申请日：2011-09-20

申请人： Geun Sig Cha ,  Hakhyun Nam ,  Eun-Jong Cha ,  Kyung-Ah Kim

发明人： Geun Sig Cha ,  Hakhyun Nam ,  Eun-Jong Cha ,  Kyung-Ah Kim

IPC分类号： A61B5/151

CPC分类号： A61B5/15101 ,  A61B5/1411 ,  A61B5/150022 ,  A61B5/150412 ,  A61B5/150519 ,  A61B5/150664 ,  A61B5/150732 ,  A61B5/15113 ,  A61B5/15117 ,  A61B5/1513 ,  A61B5/1519 ,  A61B5/15194

摘要： The present invention provides a lancet holder that can smoothly and accurately hold all of lancets with different cross-sections and diameters and can keep them vertical, and a lancet device including the lancet holder.To this end, a lancet holder according to an exemplary embodiment of the present invention includes a holder body having a lancet seat at one end to mount a lancet and receiving the lancet and elastic fixing portions arranged in pairs to face each other on the inner side of the holder body so that the lancet received in the holder body is vertically held, and elastically fixing the lancet.According to this configuration, the lancet holder can accurately keep all of lancets vertical, even if the lancets are different in cross-section and diameter, such that the lancet can be mounted on the lancet holder and protrude at a predetermined length in releasing and the lancet needle can vertically protrude through the through-hole of the cover and damage only a predetermined target portion of a subject.

摘要翻译： 本发明提供一种柳叶刀套，其能够平滑且准确地保持具有不同截面和直径的所有刺血针，并且可以使其保持垂直，并且包括刺血针保持器的刺血针装置。 为此，根据本发明的一个示例性实施方式的柳叶刀套件包括：保持器主体，其在一端具有刺血针座，用于安装柳叶刀并且接收柳叶刀和成对地布置成在内侧彼此面对的弹性固定部 使得容纳在保持器主体中的刺血针被竖直地保持，并且弹性地固定刺血针。 根据该结构，即使柳叶刀的横截面积和直径不同，柳叶刀套也能够将所有的刺血针保持在垂直方向，使得可以将柳叶刀安装在柳叶刀套上并以预定的长度突出而释放， 柳叶刀针可以垂直突出穿过盖的通孔，并且仅损坏被检体的预定目标部分。