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公开(公告)号：US20100065495A1
公开(公告)日：2010-03-18
申请号：US12555032
申请日：2009-09-08
CPC分类号： B01D15/18 , B01D15/166 , G01N30/34
摘要： A method of liquid chromatography includes providing one or more solvent reservoirs, providing a solvent pump, drawing one or more solvents into the pump in response to a pressure drop that promotes outgassing of the solvents, and dispersing outgassed bubbles into smaller bubbles to promote re-dissolution of the gas. A liquid-chromatography apparatus includes at least two solvent reservoirs, a pump, at least one bubble-dispersing unit that receives a pressurized flow of proportioned solvents from the pump, and a control unit. The control unit includes a processor and a memory that stores instructions; the control unit controls proportioning of solvents to obtain a preselected solvent composition, and pumping at flow rates to support preparative-scale or process-scale liquid chromatography.
摘要翻译： 液相色谱法包括提供一个或多个溶剂储存器，提供溶剂泵，响应于促进溶剂除气的压降而将一种或多种溶剂吸入泵中，以及将脱气气泡分散成较小的气泡， 溶解气体。 液相色谱装置包括至少两个溶剂储存器，泵，至少一个气泡分散单元，其从泵接收加压的成比例溶剂流，以及控制单元。 控制单元包括处理器和存储指令的存储器; 控制单元控制溶剂的比例以获得预选的溶剂组合物，并以流速泵送以支持制备规模或过程规模的液相色谱。
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公开(公告)号：US20120287746A1
公开(公告)日：2012-11-15
申请号：US13519833
申请日：2011-01-11
申请人： John Angelosanto , Charles T. Murphy , Kurt Joudrey , Kara O'Donnell , Paul E. Linderson , Michael LeBeau , Wade P. Leveille , Michael R. Jackson
发明人： John Angelosanto , Charles T. Murphy , Kurt Joudrey , Kara O'Donnell , Paul E. Linderson , Michael LeBeau , Wade P. Leveille , Michael R. Jackson
CPC分类号： G01N30/32 , B01D15/166 , B29B7/007 , B29B7/385 , G01N30/24 , G01N30/34 , G01N2030/201 , G01N2030/326 , G01N2030/347
摘要： Low-pressure mixing of fluids includes a pumping system having a pump and a fluidic inlet port through which fluid is introduced to the pump. A fluid proportioning system is in fluidic communication with the fluidic inlet port of the pumping system to deliver thereto a fluid stream comprised of multiple different fluids. The fluid proportioning system includes a manifold having a plurality of inlet ports, an outlet port connected by tubing to the fluidic inlet port of the pumping system, and an outlet conduit providing an internal fluidic passageway to the outlet port. Each inlet port is fluidically coupled to a fluid source to receive one of the different fluids and to the outlet conduit to deliver thereto the received fluid for delivery out of the manifold through the outlet port to the fluidic inlet port of the pumping system.
摘要翻译： 液体的低压混合包括具有泵和流体入口的泵送系统，流体通过该入口进入泵。 流体配比系统与泵送系统的流体入口端口流体连通，以向其输送由多种不同流体组成的流体流。 流体分配系统包括具有多个入口端口的歧管，通过管道连接到泵送系统的流体入口端口的出口端口以及向出口端口提供内部流体通道的出口管道。 每个入口端口流体耦合到流体源以接收不同流体中的一种和出口管道，以将其接收到的流体输送到歧管通过出口到达泵送系统的流体入口端口。
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公开(公告)号：US20080208344A1
公开(公告)日：2008-08-28
申请号：US12026895
申请日：2008-02-06
申请人： Thomas S. Kilpela , Brian P. Janowski , Jeffrey L. Trudeau , Russell M. Pietila , Michael R. Jackson , John Sullivan
发明人： Thomas S. Kilpela , Brian P. Janowski , Jeffrey L. Trudeau , Russell M. Pietila , Michael R. Jackson , John Sullivan
IPC分类号： A61F2/44
CPC分类号： A61B17/7068 , A61B17/70 , A61B17/7065 , A61B17/7071 , A61B2017/0256 , A61F2/442 , A61F2002/30131 , A61F2002/30166 , A61F2002/30471 , A61F2002/305 , A61F2002/30522 , A61F2002/30563 , A61F2002/30565 , A61F2002/30579 , A61F2002/30604 , A61F2002/30616 , A61F2002/30685 , A61F2002/4435 , A61F2002/444 , A61F2002/4622 , A61F2220/0025 , A61F2220/0091 , A61F2230/0013 , A61F2230/0028
摘要： An implant device is provided that is configured for implantation at multiple locations between adjacent vertebrae. The implant device comprises an implant body, a first portion of the implant body, and a second portion of the implant body adjustably interconnected with the first portion. The implant body has a compact orientation and an extended orientation to allow the implant body to be shifted from one orientation to the other orientation for being positioned in any one of areas between the spinous processes of the adjacent vertebrae, between laminar regions of the adjacent vertebrae, spanning an opening in the annulus between the adjacent vertebrae, and in the intervertebral space between the adjacent vertebrae.
摘要翻译： 提供植入装置，其被配置用于在相邻椎骨之间的多个位置处植入。 植入装置包括植入体，植入物主体的第一部分和植入物本体的可调节地与第一部分互连的第二部分。 植入物本体具有紧凑的取向和延伸的取向，以允许植入物主体从一个取向移动到另一方向，以便定位在相邻椎骨的棘突之间的区域中，相邻椎骨的层间区域 跨越相邻椎骨之间的环形开口，并在相邻椎骨之间的椎间空间中。
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公开(公告)号：US08672976B2
公开(公告)日：2014-03-18
申请号：US12026895
申请日：2008-02-06
申请人： Thomas S. Kilpela , Brian P. Janowski , Jeffrey L. Trudeau , Russell M. Pietila , Michael R. Jackson , John Sullivan
发明人： Thomas S. Kilpela , Brian P. Janowski , Jeffrey L. Trudeau , Russell M. Pietila , Michael R. Jackson , John Sullivan
CPC分类号： A61B17/7068 , A61B17/70 , A61B17/7065 , A61B17/7071 , A61B2017/0256 , A61F2/442 , A61F2002/30131 , A61F2002/30166 , A61F2002/30471 , A61F2002/305 , A61F2002/30522 , A61F2002/30563 , A61F2002/30565 , A61F2002/30579 , A61F2002/30604 , A61F2002/30616 , A61F2002/30685 , A61F2002/4435 , A61F2002/444 , A61F2002/4622 , A61F2220/0025 , A61F2220/0091 , A61F2230/0013 , A61F2230/0028
摘要： An implant device is provided that is configured for implantation at multiple locations between adjacent vertebrae. The implant device comprises an implant body, a first portion of the implant body, and a second portion of the implant body adjustably interconnected with the first portion. The implant body has a compact orientation and an extended orientation to allow the implant body to be shifted from one orientation to the other orientation for being positioned in any one of areas between the spinous processes of the adjacent vertebrae, between laminar regions of the adjacent vertebrae, spanning an opening in the annulus between the adjacent vertebrae, and in the intervertebral space between the adjacent vertebrae.
摘要翻译： 提供植入装置，其被配置用于在相邻椎骨之间的多个位置处植入。 植入装置包括植入体，植入物主体的第一部分和植入物本体的可调节地与第一部分互连的第二部分。 植入物本体具有紧凑的取向和延伸的取向，以允许植入物主体从一个取向移动到另一方向，以便定位在相邻椎骨的棘突之间的区域中，相邻椎骨的层间区域 跨越相邻椎骨之间的环形开口，并在相邻椎骨之间的椎间空间中。
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公开(公告)号：US08603141B2
公开(公告)日：2013-12-10
申请号：US12945785
申请日：2010-11-12
申请人： Stephen H. Hochschuler , Ali Araghi , Thomas S. Kilpela , Jeffrey A. Hoffman , Michael R. Jackson , Russell M. Pietila
发明人： Stephen H. Hochschuler , Ali Araghi , Thomas S. Kilpela , Jeffrey A. Hoffman , Michael R. Jackson , Russell M. Pietila
IPC分类号： A61B17/70
CPC分类号： A61B17/7068 , A61B17/7065
摘要： An implant device includes a pair of hook devices and an elongate guide device. The hook devices are configured to be disposed between and engage adjacent vertebral bodies. The elongate guide device is connected to the hook devices and allows for relative movement of at least one of the hook devices to adjust for the geometries of the vertebral surfaces to be engaged by the hook devices.
摘要翻译： 植入装置包括一对钩装置和细长引导装置。 钩装置构造成设置在相邻的椎体之间并且与其相接合。 细长引导装置连接到钩装置并且允许至少一个钩装置的相对运动，以调整由钩装置接合的脊椎表面的几何形状。
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公开(公告)号：US08246655B2
公开(公告)日：2012-08-21
申请号：US12685618
申请日：2010-01-11
IPC分类号： A61B17/70
CPC分类号： A61B17/7065 , A61B17/7053 , A61B17/7068 , A61B2017/0256
摘要： Implant apparatuses are provided for being inserted between adjacent vertebral bone portions and maintaining mechanical engagement with the vertebral bone portions. The implant apparatuses are generally constructed to be inserted in an insertion orientation and pivoted between the vertebral bone portions to an implanted orientation. The implant apparatuses are further secured in the implanted orientation to maintain engagement with the adjacent vertebral bone portions.
摘要翻译： 提供植入装置用于插入在相邻的椎骨部分之间并保持与椎骨部分的机械接合。 植入装置通常被构造成以插入方向插入并且在椎骨部分之间枢转到植入方向。 植入装置进一步固定在植入方向上以保持与相邻的椎骨部分的接合。
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公开(公告)号：US20110118788A1
公开(公告)日：2011-05-19
申请号：US12945785
申请日：2010-11-12
申请人： Stephen H. Hochschuler , Ali Araghi , Thomas S. Kilpela , Jeffrey A. Hoffman , Michael R. Jackson , Russell M. Pietila
发明人： Stephen H. Hochschuler , Ali Araghi , Thomas S. Kilpela , Jeffrey A. Hoffman , Michael R. Jackson , Russell M. Pietila
CPC分类号： A61B17/7068 , A61B17/7065
摘要： An implant device includes a pair of hook devices and an elongate guide device. The hook devices are configured to be disposed between and engage adjacent vertebral bodies. The elongate guide device is connected to the hook devices and allows for relative movement of at least one of the hook devices to adjust for the geometries of the vertebral surfaces to be engaged by the hook devices.
摘要翻译： 植入装置包括一对钩装置和细长引导装置。 钩装置构造成设置在相邻的椎体之间并且与其相接合。 细长引导装置连接到钩装置并且允许至少一个钩装置的相对运动，以调整由钩装置接合的脊椎表面的几何形状。
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公开(公告)号：US20200224938A1
公开(公告)日：2020-07-16
申请号：US16837260
申请日：2020-04-01
申请人： Michael R. Jackson , Christopher Seith , Nathan Barrett , Kara O'Donnell , Neal B. Almeida , Wen Lu , James E. Usowicz , Maruth Sok , Kurt D. Joudrey , Joshua A. Shreve
发明人： Michael R. Jackson , Christopher Seith , Nathan Barrett , Kara O'Donnell , Neal B. Almeida , Wen Lu , James E. Usowicz , Maruth Sok , Kurt D. Joudrey , Joshua A. Shreve
摘要： The present disclosure relates to methodologies, systems and apparatus for cooling pump heads and providing balanced cooling and heat transfer between multiple pump heads. Multi-pump systems that are used to pump fluids that vary greatly in density with minor changes in temperature, such as the mobile phase of a C02-based chromatography system, require highly stable temperature conditions. In order to achieve a substantially equal average heat transfer between multiple pump heads and a coolant fluid, coolant fluid may be flowed through coolant passageways within the pump heads in a recursive and/or parallel coolant flow patterns. Such recursive and/or parallel coolant fluid flow patterns provide increased stability in temperature, compressibility, and density of the fluids passing through a multi-pump system.
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公开(公告)号：US09645123B2
公开(公告)日：2017-05-09
申请号：US13519833
申请日：2011-01-11
申请人： John Angelosanto , Charles T. Murphy , Kurt Joudrey , Kara O'Donnell , Paul E. Linderson , Michael LeBeau , Wade P. Leveille , Michael R. Jackson
发明人： John Angelosanto , Charles T. Murphy , Kurt Joudrey , Kara O'Donnell , Paul E. Linderson , Michael LeBeau , Wade P. Leveille , Michael R. Jackson
CPC分类号： G01N30/32 , B01D15/166 , B29B7/007 , B29B7/385 , G01N30/24 , G01N30/34 , G01N2030/201 , G01N2030/326 , G01N2030/347
摘要： Low-pressure mixing of fluids includes a pumping system having a pump and a fluidic inlet port through which fluid is introduced to the pump. A fluid proportioning system is in fluidic communication with the fluidic inlet port of the pumping system to deliver thereto a fluid stream comprised of multiple different fluids. The fluid proportioning system includes a manifold having a plurality of inlet ports, an outlet port connected by tubing to the fluidic inlet port of the pumping system, and an outlet conduit providing an internal fluidic passageway to the outlet port. Each inlet port is fluidically coupled to a fluid source to receive one of the different fluids and to the outlet conduit to deliver thereto the received fluid for delivery out of the manifold through the outlet port to the fluidic inlet port of the pumping system.
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公开(公告)号：US20100179595A1
公开(公告)日：2010-07-15
申请号：US12685618
申请日：2010-01-11
CPC分类号： A61B17/7065 , A61B17/7053 , A61B17/7068 , A61B2017/0256
摘要： Implant apparatuses are provided for being inserted between adjacent vertebral bone portions and maintaining mechanical engagement with the vertebral bone portions. The implant apparatuses are generally constructed to be inserted in an insertion orientation and pivoted between the vertebral bone portions to an implanted orientation. The implant apparatuses are further secured in the implanted orientation to maintain engagement with the adjacent vertebral bone portions.
摘要翻译： 提供植入装置用于插入在相邻的椎骨部分之间并保持与椎骨部分的机械接合。 植入装置通常被构造成以插入方向插入并且在椎骨部分之间枢转到植入方向。 植入装置进一步固定在植入方向上以保持与相邻的椎骨部分的接合。
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