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公开(公告)号：US11982474B2
公开(公告)日：2024-05-14
申请号：US16837260
申请日：2020-04-01
申请人： Michael R. Jackson , Christopher Seith , Nathan Barrett , Kara O'donnell , Neal B. Almeida , Wen Lu , James E. Usowicz , Maruth Sok , Kurt D. Joudrey , Joshua A. Shreve
发明人： Michael R. Jackson , Christopher Seith , Nathan Barrett , Kara O'donnell , Neal B. Almeida , Wen Lu , James E. Usowicz , Maruth Sok , Kurt D. Joudrey , Joshua A. Shreve
CPC分类号： F25B25/005 , B01D15/18 , B01D15/40 , G01N30/30 , F04B2205/09
摘要： The present disclosure relates to methodologies, systems and apparatus for cooling pump heads and providing balanced cooling and heat transfer between multiple pump heads. Multi-pump systems that are used to pump fluids that vary greatly in density with minor changes in temperature, such as the mobile phase of a C02-based chromatography system, require highly stable temperature conditions. In order to achieve a substantially equal average heat transfer between multiple pump heads and a coolant fluid, coolant fluid may be flowed through coolant passageways within the pump heads in a recursive and/or parallel coolant flow patterns. Such recursive and/or parallel coolant fluid flow patterns provide increased stability in temperature, compressibility, and density of the fluids passing through a multi-pump system.
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公开(公告)号：US20200224938A1
公开(公告)日：2020-07-16
申请号：US16837260
申请日：2020-04-01
申请人： Michael R. Jackson , Christopher Seith , Nathan Barrett , Kara O'Donnell , Neal B. Almeida , Wen Lu , James E. Usowicz , Maruth Sok , Kurt D. Joudrey , Joshua A. Shreve
发明人： Michael R. Jackson , Christopher Seith , Nathan Barrett , Kara O'Donnell , Neal B. Almeida , Wen Lu , James E. Usowicz , Maruth Sok , Kurt D. Joudrey , Joshua A. Shreve
摘要： The present disclosure relates to methodologies, systems and apparatus for cooling pump heads and providing balanced cooling and heat transfer between multiple pump heads. Multi-pump systems that are used to pump fluids that vary greatly in density with minor changes in temperature, such as the mobile phase of a C02-based chromatography system, require highly stable temperature conditions. In order to achieve a substantially equal average heat transfer between multiple pump heads and a coolant fluid, coolant fluid may be flowed through coolant passageways within the pump heads in a recursive and/or parallel coolant flow patterns. Such recursive and/or parallel coolant fluid flow patterns provide increased stability in temperature, compressibility, and density of the fluids passing through a multi-pump system.
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3.发明申请APPARATUS FOR REDUCING VARIATION IN SAMPLE TEMPERATURES IN A LIQUID CHROMATOGRAPHY SYSTEM 有权用于降低液相色谱系统中样品温度变化的设备公开(公告)号：US20130019695A1
公开(公告)日：2013-01-24
申请号：US13520189
申请日：2011-01-11
IPC分类号： G01N1/10
CPC分类号： B01L7/02 , B01L2300/0829 , B01L2300/1838 , G01N30/7233 , G01N35/028 , G01N2035/00356 , G01N2035/00386
摘要： Described is an apparatus for reducing a temperature variation of a liquid chromatography sample. A tray drive using at least one of linear or rotational motion moves a sample tray along a path inside a sample compartment of the liquid chromatography system. A control module coordinates the movement of the sample tray by the tray drive and the movement of a sample needle by a needle drive so that any sample in the sample tray can be injected into the mobile phase of the system during a sample load operation. The tray drive is also used to move the sample tray along the path during a temperature averaging period when no loading occurs. Differences in sample temperatures due to variations in the air temperature at different locations inside the sample compartment are reduced, leading to more accurate and repeatable chromatographic measurement results.
摘要翻译： 描述了一种用于降低液相色谱样品的温度变化的装置。 使用线性或旋转运动中的至少一种的托盘驱动器沿着液相色谱系统的样品室内的路径移动样品盘。 控制模块通过托盘驱动器来协调样品托盘的移动和通过针驱动器移动样品针，使得样品托盘中的任何样品可以在样品加载操作期间被注入到系统的流动相中。 托盘驱动器也可用于在温度平均期间沿着路径移动样品托盘，而不会发生加载。 由于样品室内不同位置的空气温度变化导致的样品温度差异减小，从而导致更精确和可重复的色谱测量结果。
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公开(公告)号：US20130004388A1
公开(公告)日：2013-01-03
申请号：US13519706
申请日：2011-01-11
IPC分类号： B01L9/00
CPC分类号： G01N30/04 , G01N30/54 , G01N2030/3084
摘要： Described is a self-sealing thermal enclosure. In various embodiments, the self-sealing thermal enclosure includes an enclosure having a wall with an opening. The enclosure is configured to surround a temperature-controlled environment. The self-sealing thermal enclosure also includes a porous seal disposed adjacent to the wall at the opening. The porous seal is compressible and is fabricated from an open cell foam material. When the porous seal has absorbed a fluid such as a condensate, the temperature-controlled environment is sealed from an ambient environment such that the flow of air into or out of the enclosure is substantially reduced or eliminated.
摘要翻译： 描述了一种自密封热封装。 在各种实施例中，自密封热封套包括具有开口的壁的外壳。 外壳配置为围绕温度控制的环境。 自密封热封壳还包括邻近开口处的壁布置的多孔密封件。 多孔密封是可压缩的，并由开孔泡沫材料制成。 当多孔密封件已经吸收了诸如冷凝物的流体时，温度受控的环境与环境环境密封，使得进入或离开外壳的空气流大幅减少或消除。
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5.发明授权Apparatus for reducing variation in sample temperatures in a liquid chromatography system 有权用于降低液相色谱系统中样品温度变化的装置公开(公告)号：US09289768B2
公开(公告)日：2016-03-22
申请号：US13520189
申请日：2011-01-11
CPC分类号： B01L7/02 , B01L2300/0829 , B01L2300/1838 , G01N30/7233 , G01N35/028 , G01N2035/00356 , G01N2035/00386
摘要： Described is an apparatus for reducing a temperature variation of a liquid chromatography sample. A tray drive using at least one of linear or rotational motion moves a sample tray along a path inside a sample compartment of the liquid chromatography system. A control module coordinates the movement of the sample tray by the tray drive and the movement of a sample needle by a needle drive so that any sample in the sample tray can be injected into the mobile phase of the system during a sample load operation. The tray drive is also used to move the sample tray along the path during a temperature averaging period when no loading occurs. Differences in sample temperatures due to variations in the air temperature at different locations inside the sample compartment are reduced, leading to more accurate and repeatable chromatographic measurement results.
摘要翻译： 描述了一种用于降低液相色谱样品的温度变化的装置。 使用线性或旋转运动中的至少一种的托盘驱动器沿着液相色谱系统的样品室内的路径移动样品盘。 控制模块通过托盘驱动器来协调样品托盘的移动和通过针驱动器移动样品针，使得样品托盘中的任何样品可以在样品加载操作期间被注入到系统的流动相中。 托盘驱动器也可用于在温度平均期间沿着路径移动样品托盘，而不会发生加载。 由于样品室内不同位置的空气温度变化导致的样品温度差异减小，从而导致更精确和可重复的色谱测量结果。
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公开(公告)号：US08945487B2
公开(公告)日：2015-02-03
申请号：US13519706
申请日：2011-01-11
CPC分类号： G01N30/04 , G01N30/54 , G01N2030/3084
摘要： Described is a self-sealing thermal enclosure. In various embodiments, the self-sealing thermal enclosure includes an enclosure having a wall with an opening. The enclosure is configured to surround a temperature-controlled environment. The self-sealing thermal enclosure also includes a porous seal disposed adjacent to the wall at the opening. The porous seal is compressible and is fabricated from an open cell foam material. When the porous seal has absorbed a fluid such as a condensate, the temperature-controlled environment is sealed from an ambient environment such that the flow of air into or out of the enclosure is substantially reduced or eliminated.
摘要翻译： 描述了一种自密封热封装。 在各种实施例中，自密封热封套包括具有开口的壁的外壳。 外壳配置为围绕温度控制的环境。 自密封热封壳还包括邻近开口处的壁布置的多孔密封件。 多孔密封是可压缩的，并由开孔泡沫材料制成。 当多孔密封件已经吸收了诸如冷凝物的流体时，温度受控的环境与环境环境密封，使得进入或离开外壳的空气流大幅减少或消除。
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公开(公告)号：US09028780B2
公开(公告)日：2015-05-12
申请号：US13519687
申请日：2011-01-11
申请人： John Auclair , James E. Usowicz , Tony A. Lin , Marc Lemelin , Robert A. Jencks , Kenneth R. Plant
发明人： John Auclair , James E. Usowicz , Tony A. Lin , Marc Lemelin , Robert A. Jencks , Kenneth R. Plant
CPC分类号： G01N30/18 , B01L3/561 , B01L3/563 , B01L2200/026 , G01N1/10 , G01N30/24 , G01N30/36 , G01N30/6039
摘要： Described is a compound sample needle for a liquid chromatography system. In one embodiment, the compound sample needle includes a rigid needle having a coupling end with a face and a counterbore. The compound sample needle also includes a flexible tubing having an outer surface and a coupling end disposed in the counterbore of the rigid needle. The coupling end of the flexible tubing has a face adjacent to a base of the counterbore. The coupling ends of the rigid needle and flexible tubing are secured to each other by a weld formed along a circumference of the outer surface and the face of the rigid needle. A rigid sleeve protects the welded joint. The compound sample needle is suitable for injection into the high pressure mobile phase of ultra performance liquid chromatography systems.
摘要翻译： 描述了用于液相色谱系统的复合样品针。 在一个实施例中，复合样品针包括刚性针，其具有带有面和联轴器的连接端。 复合样品针还包括柔性管，其具有设置在刚性针的沉孔中的外表面和联接端。 柔性管的联接端具有邻近沉孔的底部的面。 刚性针和柔性管的联接端通过沿着外表面的圆周和刚性针的表面形成的焊接彼此固定。 刚性套筒保护焊接接头。 复合样品针适用于高效液相色谱系统的高压流动相。
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公开(公告)号：US08881582B2
公开(公告)日：2014-11-11
申请号：US13227078
申请日：2011-09-07
CPC分类号： F16K11/0853 , G01N30/20 , G01N2030/201 , G01N2030/202 , G01N2030/207 , Y10T137/0396 , Y10T137/86871
摘要： The present invention provides a method and apparatus for substantially eliminating destructive transients of pressure or flow rate which can degrade the efficiency and useful lifetime of chromatography columns. The present invention enables a substantially constant flow of mobile phase liquid to be maintained through the chromatography system by eliminating the flow blockage interval associated with the actuation of sample injection valves. The present invention further provides a method to reduce the pressure and flow rate transients associated with pressurization of the sample loop contents when the sample loop is introduced to chromatography system delivery pressure.
摘要翻译： 本发明提供了用于基本上消除压力或流速的破坏性瞬变的方法和装置，其可能降低色谱柱的效率和使用寿命。 通过消除与致动样品注射阀相关联的流动阻塞间隔，本发明能够通过色谱系统保持流动相液体的基本上恒定的流动。 本发明还提供了一种方法，当将样品环引入色谱系统输送压力时，减少与样品环含量的加压相关的压力和流速瞬变。
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公开(公告)号：US20140079606A1
公开(公告)日：2014-03-20
申请号：US13519785
申请日：2011-01-11
CPC分类号： G01N30/24 , G01N30/16 , G01N30/20 , G01N2035/00287 , G01N2035/00346 , G01N2035/0498
摘要： A sample manager of a liquid chromatography system uses a sample tray having a base with side walls separated by a cross wall that divides the base into two compartments. The side walls and cross wall bound each compartment on three sides. A fourth side of each compartment is open. Each compartment is sized to closely receive a sample-vial carrier. Each compartment has a magnet affixed to a bottom surface at an edge of the open fourth side. Each of two drawers slides into the open fourth side of one compartment. Each drawer has a support surface with a magnet affixed at an edge of its bottom side, which aligns with the magnet affixed to the bottom surface of the compartment. The magnet of the drawer and the magnet of the compartment bias the drawer into its compartment when the magnets are brought into proximity of each other.
摘要翻译： 液相色谱系统的样品管理器使用具有底部的样品盘，其侧壁由跨壁分隔，所述横壁将基部分成两个隔室。 侧墙和十字墙三面分隔每个隔间。 每个隔间的第四面是敞开的。 每个隔室的大小可以紧密接收样品瓶载体。 每个隔室具有固定到开放的第四侧边缘处的底表面的磁体。 两个抽屉中的每一个都滑入一个隔间的敞开的第四侧。 每个抽屉具有一个支撑表面，一个磁体固定在其底部的边缘，该磁体与固定在隔室底部表面上的磁体对准。 当磁体彼此靠近时，抽屉的磁体和室的磁体将抽屉偏置到其隔间中。
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公开(公告)号：US20130008237A1
公开(公告)日：2013-01-10
申请号：US13520605
申请日：2011-01-10
申请人： James E. Usowicz , Tony A. Lin , Joshua A. Burnett , Marc Lemelin
发明人： James E. Usowicz , Tony A. Lin , Joshua A. Burnett , Marc Lemelin
IPC分类号： G01N30/00
CPC分类号： G01N30/16 , G01L1/00 , G01L5/0038 , G01N30/24 , G01N35/1011 , G01N2030/185
摘要： Described are techniques for force sensing. A computing device is configured to have a desired force setting. A first vertical position of a needle is determined using the computer device. A control signal is sent from the computing device to a positioning device. In response to the control signal, the needle is positioned at the first vertical position. When in the first vertical position, surfaces of a tip of the needle are in contact with surfaces of an opening of a sealing member and positioning the needle causes application of a force at surfaces of the opening in contact with surfaces of the tip of the needle. In response to application of the force, a spring is compressed a distance that is proportional to the force. The force is measured using a force sensor.
摘要翻译： 描述了用于力感测的技术。 计算设备被配置为具有期望的力设置。 使用计算机设备确定针的第一垂直位置。 控制信号从计算设备发送到定位设备。 响应于控制信号，针位于第一垂直位置。 当在第一垂直位置时，针的尖端的表面与密封构件的开口的表面接触，并且定位针使得在开口的表面处施加力以与针的尖端的表面接触 。 响应于施加力，弹簧被压缩与力成比例的距离。 使用力传感器测量力。
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