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公开(公告)号：US20100133431A1
公开(公告)日：2010-06-03
申请号：US12593313
申请日：2008-03-19
CPC分类号： G01N30/724 , H01J49/0445 , Y10T29/49718 , Y10T137/85938
摘要： The invention comprises apparatus for use with atmospheric pressure ionization sources in which an aerosol is formed from a solution of a sample. The aerosol is received in a hollow member and discharged outside the chamber of the ionization source in order to reduce contamination of the ionization source itself by involatile material in the solution and by previously analysed samples. The hollow member is easily removable from the ionization source to facilitate cleaning and replacement. Ionization sources, mass spectrometers, and ion mobility spectrometers comprising the apparatus are also described.
摘要翻译： 本发明包括与大气压电离源一起使用的装置，其中气溶胶由样品溶液形成。 气溶胶被容纳在中空构件中并且排出到电离源的室外，以便通过溶液中的非挥发性材料和先前分析的样品来减少电离源本身的污染。 中空构件容易从电离源移除，以便于清洁和更换。 还描述了包括该装置的电离源，质谱仪和离子迁移谱仪。
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公开(公告)号：US09645123B2
公开(公告)日：2017-05-09
申请号：US13519833
申请日：2011-01-11
申请人： John Angelosanto , Charles T. Murphy , Kurt Joudrey , Kara O'Donnell , Paul E. Linderson , Michael LeBeau , Wade P. Leveille , Michael R. Jackson
发明人： John Angelosanto , Charles T. Murphy , Kurt Joudrey , Kara O'Donnell , Paul E. Linderson , Michael LeBeau , Wade P. Leveille , Michael R. Jackson
CPC分类号： G01N30/32 , B01D15/166 , B29B7/007 , B29B7/385 , G01N30/24 , G01N30/34 , G01N2030/201 , G01N2030/326 , G01N2030/347
摘要： Low-pressure mixing of fluids includes a pumping system having a pump and a fluidic inlet port through which fluid is introduced to the pump. A fluid proportioning system is in fluidic communication with the fluidic inlet port of the pumping system to deliver thereto a fluid stream comprised of multiple different fluids. The fluid proportioning system includes a manifold having a plurality of inlet ports, an outlet port connected by tubing to the fluidic inlet port of the pumping system, and an outlet conduit providing an internal fluidic passageway to the outlet port. Each inlet port is fluidically coupled to a fluid source to receive one of the different fluids and to the outlet conduit to deliver thereto the received fluid for delivery out of the manifold through the outlet port to the fluidic inlet port of the pumping system.
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公开(公告)号：US20140166562A1
公开(公告)日：2014-06-19
申请号：US14238278
申请日：2012-08-23
申请人： Joseph D. Michienzi , Keith Fadgen , Wade P. Leveille, Sr. , Raymond P. Fisk , Frank John Marzalkowski, Jr.
发明人： Joseph D. Michienzi , Keith Fadgen , Wade P. Leveille, Sr. , Raymond P. Fisk , Frank John Marzalkowski, Jr.
IPC分类号： B01D15/22
CPC分类号： B05B5/16 , B01D15/10 , B01D15/1871 , B01D15/22 , G01N30/60 , G01N30/6004 , G01N30/6026 , G01N30/603 , G01N30/6039 , G01N30/6052 , G01N30/6095 , G01N30/7266 , Y10T29/49908
摘要： Described is a chromatography column assembly that includes a permanently deformable outer tube, an intermediate tube, an inner tube and a sorbent bed disposed within the inner tube. The sorbent bed may be in the form of packed chromatographic particles or a porous monolithic structure. A radial seal is provided by one or more uniform radial crimps at longitudinal locations on the assembly. The uniform radial crimp compresses the outer tube and underlying intermediate tube onto the inner tube to achieve a high pressure liquid tight seal between the three tubes. The length and depth of each crimp is accurately formed to accommodate the requirements of the particular application. Leakage along the tubing assembly is prevented and void volume is reduced or eliminated. No external ferrule or ferrule swaging mechanism is needed; therefore the chromatography column assembly is easily adapted for use in various chromatographic column configurations.
摘要翻译： 描述了一种色谱柱组件，其包括永久变形的外管，中间管，内管和设置在内管内的吸附剂床。 吸附剂床可以是填充色谱颗粒或多孔整体结构的形式。 在组件的纵向位置处由一个或多个均匀的径向卷曲提供径向密封。 均匀的径向卷曲将外管和下面的中间管压缩到内管上，以实现三管之间的高压液密封。 精确地形成每个卷曲的长度和深度以适应特定应用的要求。 防止管道组件的泄漏，减少或消除空隙体积。 不需要外部套圈或套圈型锻机构; 因此色谱柱组件易于适用于各种色谱柱配置。
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公开(公告)号：US09983178B2
公开(公告)日：2018-05-29
申请号：US14238278
申请日：2012-08-23
申请人： Joseph D. Michienzi , Keith Fadgen , Wade P. Leveille, Sr. , Raymond P. Fisk , Frank John Marzalkowski, Jr.
发明人： Joseph D. Michienzi , Keith Fadgen , Wade P. Leveille, Sr. , Raymond P. Fisk , Frank John Marzalkowski, Jr.
CPC分类号： B05B5/16 , B01D15/10 , B01D15/1871 , B01D15/22 , G01N30/60 , G01N30/6004 , G01N30/6026 , G01N30/603 , G01N30/6039 , G01N30/6052 , G01N30/6095 , G01N30/7266 , Y10T29/49908
摘要： Described is a chromatography column assembly that includes a permanently deformable outer tube, an intermediate tube, an inner tube and a sorbent bed disposed within the inner tube. The sorbent bed may be in the form of packed chromatographic particles or a porous monolithic structure. A radial seal is provided by one or more uniform radial crimps at longitudinal locations on the assembly. The uniform radial crimp compresses the outer tube and underlying intermediate tube onto the inner tube to achieve a high pressure liquid tight seal between the three tubes. The length and depth of each crimp is accurately formed to accommodate the requirements of the particular application. Leakage along the tubing assembly is prevented and void volume is reduced or eliminated. No external ferrule or ferrule swaging mechanism is needed; therefore the chromatography column assembly is easily adapted for use in various chromatographic column configurations.
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公开(公告)号：US20120287746A1
公开(公告)日：2012-11-15
申请号：US13519833
申请日：2011-01-11
申请人： John Angelosanto , Charles T. Murphy , Kurt Joudrey , Kara O'Donnell , Paul E. Linderson , Michael LeBeau , Wade P. Leveille , Michael R. Jackson
发明人： John Angelosanto , Charles T. Murphy , Kurt Joudrey , Kara O'Donnell , Paul E. Linderson , Michael LeBeau , Wade P. Leveille , Michael R. Jackson
CPC分类号： G01N30/32 , B01D15/166 , B29B7/007 , B29B7/385 , G01N30/24 , G01N30/34 , G01N2030/201 , G01N2030/326 , G01N2030/347
摘要： Low-pressure mixing of fluids includes a pumping system having a pump and a fluidic inlet port through which fluid is introduced to the pump. A fluid proportioning system is in fluidic communication with the fluidic inlet port of the pumping system to deliver thereto a fluid stream comprised of multiple different fluids. The fluid proportioning system includes a manifold having a plurality of inlet ports, an outlet port connected by tubing to the fluidic inlet port of the pumping system, and an outlet conduit providing an internal fluidic passageway to the outlet port. Each inlet port is fluidically coupled to a fluid source to receive one of the different fluids and to the outlet conduit to deliver thereto the received fluid for delivery out of the manifold through the outlet port to the fluidic inlet port of the pumping system.
摘要翻译： 液体的低压混合包括具有泵和流体入口的泵送系统，流体通过该入口进入泵。 流体配比系统与泵送系统的流体入口端口流体连通，以向其输送由多种不同流体组成的流体流。 流体分配系统包括具有多个入口端口的歧管，通过管道连接到泵送系统的流体入口端口的出口端口以及向出口端口提供内部流体通道的出口管道。 每个入口端口流体耦合到流体源以接收不同流体中的一种和出口管道，以将其接收到的流体输送到歧管通过出口到达泵送系统的流体入口端口。
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公开(公告)号：US5788465A
公开(公告)日：1998-08-04
申请号：US606149
申请日：1996-02-23
申请人： Joseph A. Luongo , Jeffrey Howard Stokes , Robert E. Reynolds , Wade P. Leveille , Robert J. Dumas
发明人： Joseph A. Luongo , Jeffrey Howard Stokes , Robert E. Reynolds , Wade P. Leveille , Robert J. Dumas
CPC分类号： F04B53/14 , F04B53/147 , F04B53/22 , F05C2201/0478 , F05C2203/0873
摘要： A pump configured so that tools are not required to remove the pump head and disassemble the plunger. A single large hand operated knob or head nut facilitates tool-less pump head removal. The pump head is guided into position in a manifold and held in place by the hand knob. The manifold is designed to receive all the external fluidic connections made to the pump head. Fluid paths to the pump head have been replaced with miniature face seals which facilitate high pressure sealing between the pump head and manifold. Low pressure tubing seals reside in a seal wash chamber or housing and are not attached to the head, eliminating the need for tooling to disconnect them during pump head removal. A tool-less plunger mechanism includes a nutcap assembly having a plunger socket receiving a plunger assembly including a sapphire plunger fixed to a plunger holder ball accommodated by the socket. The plunger assembly is captured within the socket by a plurality of cams. The cams are spring loaded to rotate and collapse onto the plunger holder ball, pulling the plunger assembly tightly into the socket. A restricting cone is actuated to rotate the cams away from the plunger holder ball for release and removal of the plunger assembly.
摘要翻译： 泵被配置为使得不需要工具来移除泵头并拆卸柱塞。 单个大型手动旋钮或头螺母便于无需泵头拆卸。 泵头被引导到歧管中的位置，并通过手柄保持在适当的位置。 歧管设计用于接收与泵头形成的所有外部流体连接。 泵头的流体路径已被替换为便于在泵头和歧管之间进行高压密封的微型面密封件。 低压油管密封件位于密封清洗室或外壳中，并且不连接到喷头上，因此无需在泵头拆卸过程中切割工具。 一种无需工具的柱塞机构包括一个具有活塞插座的螺母盖组件，所述活塞插座接收柱塞组件，所述活塞组件包括固定到由所述插座容纳的柱塞座球的蓝宝石柱塞。 柱塞组件通过多个凸轮捕获在插座内。 凸轮被弹簧加载以旋转并塌陷到柱塞保持器球上，将柱塞组件紧紧地拉入插座中。 致动限制锥以将凸轮转动离开活塞保持器球以释放和移除柱塞组件。
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公开(公告)号：US08035088B2
公开(公告)日：2011-10-11
申请号：US12593313
申请日：2008-03-19
CPC分类号： G01N30/724 , H01J49/0445 , Y10T29/49718 , Y10T137/85938
摘要： The invention comprises apparatus for use with atmospheric pressure ionization sources in which an aerosol is formed from a solution of a sample. The aerosol is received in a hollow member and discharged outside the chamber of the ionization source in order to reduce contamination of the ionization source itself by involatile material in the solution and by previously analysed samples. The hollow member is easily removable from the ionization source to facilitate cleaning and replacement. Ionization sources, mass spectrometers, and ion mobility spectrometers comprising the apparatus are also described.
摘要翻译： 本发明包括与大气压电离源一起使用的装置，其中气溶胶由样品溶液形成。 气溶胶被容纳在中空构件中并且排出到电离源的室外，以便通过溶液中的非挥发性材料和先前分析的样品来减少电离源本身的污染。 中空构件容易从电离源移除，以便于清洁和更换。 还描述了包括该装置的电离源，质谱仪和离子迁移谱仪。
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