公开(公告)号：US09771609B2

公开(公告)日：2017-09-26

申请号：US14460750

申请日：2014-08-15

申请人： Chung Yuan Christian University

发明人： Chean-Yeh Cheng ,  Chi-Ying Kao

IPC分类号： C12Q1/26 ,  C12Q1/58 ,  C12Q1/62 ,  G01N27/327 ,  C12Q1/00

CPC分类号： C12Q1/004 ,  C12Q1/005 ,  G01N27/3271 ,  G01N27/3277

摘要： Embodiments of this invention disclose new second generation uric acid-sensing electrodes at least characterized by chemically bonding both uricase and the redox mediator to an electrode. The produced electrodes can be long-term stably used without losing activity. The developed electrode has been successfully applied for the analysis of uric acid (UA) in healthy human urine specimens which exhibits very good analysis accuracy and precision without too much interference. Therefore, the developed electrodes have the potential for clinical applications.

公开(公告)号：US09734430B2

公开(公告)日：2017-08-15

申请号：US14854812

申请日：2015-09-15

申请人： Mackay Memorial Hospital ,  CHung Yuan Christian University

发明人： Wei-Chih Hu ,  Chung-Lieh Hung ,  Hung-I Yeh

IPC分类号： G06K9/00 ,  G06K9/62 ,  G06T7/00 ,  G06T7/60 ,  A61B6/03 ,  A61B6/00 ,  A61B5/026 ,  A61B5/029 ,  A61B8/06

CPC分类号： G06K9/6207 ,  A61B5/0263 ,  A61B5/029 ,  A61B6/032 ,  A61B6/503 ,  A61B8/065 ,  G06T7/0012 ,  G06T7/12 ,  G06T7/66 ,  G06T2207/10016 ,  G06T2207/10132 ,  G06T2207/30048

摘要： An evaluation system for determination of cardiovascular function parameters is provided. The evaluation system includes a data reading module, an image generating module, a contour determination module, an active contour module, a geometric center axis computing module, a view angle selection module and a function evaluation module. After reading cardiovascular graphic files with the data reading module, the image generating module displays 2D images or a 3D image constructed from the 2D images. Then, active contours are generated by the contour determination module and the active contour module, so as for the geometric center axis computing module to calculate geometric center axes. The view angle selection module then rotates the 3D image according to the view angle data received and modifies the 2D image files accordingly to generate plural cross-section images of the 3D image. Finally, the function evaluation module calculates evaluation parameters according to the geometric center axes. Thus, evaluation parameters can be derived from cardiovascular ultrasound images for clinical diagnosis in the evaluation of cardiovascular functions.

公开(公告)号：US09636633B2

公开(公告)日：2017-05-02

申请号：US15383278

申请日：2016-12-19

申请人： CHUNG YUAN CHRISTIAN UNIVERSITY

发明人： Yi-Feng Lin ,  Chia-Chieh Ko ,  Kuo-Lun Tung ,  Chien-Hua Chen ,  Kai-Shiun Chang

IPC分类号： B01D53/22 ,  B01D71/02 ,  B01D69/12 ,  B01D67/00 ,  B01J20/08 ,  B01J20/10 ,  B01J20/28

CPC分类号： B01D53/228 ,  B01D67/0048 ,  B01D69/12 ,  B01D69/125 ,  B01D71/025 ,  B01D71/027 ,  B01D2053/221 ,  B01D2257/504 ,  B01J20/08 ,  B01J20/103 ,  B01J20/28004 ,  B01J20/28035 ,  B01J20/28083 ,  B01J20/28085 ,  Y02C10/04 ,  Y02C10/08 ,  Y02C10/10

摘要： The present invention provides a method for making a porous silica aerogel composite membrane. The porous silicon oxide aerogel composite membrane includes a porous aluminum oxide membrane having a plurality of macro pores with an average diameter larger than 50 nm and a porous silica aerogel membrane formed on at least one side of the porous aluminum oxide membrane and the macro pores of surface layers of the porous aluminum oxide membrane where the porous silica aerogel membrane has a plurality of meso pores with an average diameter of 2˜50 nm and is derived from methyltrimethoxysilane precursor by a sol-gel synthetic method.

公开(公告)号：US09523032B2

公开(公告)日：2016-12-20

申请号：US14468355

申请日：2014-08-26

申请人： CHUNG YUAN CHRISTIAN UNIVERSITY

发明人： Cheng-An J. Lin ,  Walter Hong-Shong Chang ,  Chih-Hsien Lee ,  Wen-Kai Chuang

IPC分类号： A61B5/055 ,  C09K11/58 ,  A61K49/22 ,  C09K11/08 ,  A61K49/00

CPC分类号： C09K11/58 ,  A61K49/0017 ,  A61K49/0091 ,  A61K49/223 ,  C09K11/08

摘要： A medical contrast agent made of microbubbles containing Au nanoclusters is provided. The shell of the microbubbles contains fluorescent Au nanocluster-albumin complex, and the core contains air or fluorocarbons. The method for preparing the microbubbles is also disclosed.

摘要翻译： 提供由包含Au纳米团簇的微泡制成的医用造影剂。 微泡的壳含有荧光Au纳米簇 - 白蛋白复合物，核心包含空气或碳氟化合物。 还公开了制备微泡的方法。

公开(公告)号：US09522971B2

公开(公告)日：2016-12-20

申请号：US14587617

申请日：2014-12-31

申请人： CHUNG YUAN CHRISTIAN UNIVERSITY

发明人： Yung Chang ,  Yan-Wen Chen ,  Jheng-Fong Jhong

IPC分类号： C07K1/22 ,  C07K14/765 ,  C07K14/75 ,  C08F220/34

CPC分类号： C08F220/34 ,  C07K1/22 ,  C07K14/75 ,  C07K14/765 ,  C08F2220/286 ,  C08F222/385

摘要： The present invention discloses an amine modifying material which is a copolymer polymerized from an amine functional acrylate, a poly(ethylene glycol) functional acrylate and a cross-linker. The application of the amine modifying material in the bio-molecules separation area is also provided in the present invention.

摘要翻译： 本发明公开了一种胺改性材料，其是由胺官能丙烯酸酯，聚（乙二醇）官能丙烯酸酯和交联剂聚合的共聚物。 在本发明中还提供了胺改性材料在生物分子分离区域中的应用。

公开(公告)号：US09477258B2

公开(公告)日：2016-10-25

申请号：US14509055

申请日：2014-10-08

申请人： Industrial Technology Research Institute ,  Chung Yuan Christian University ,  National Tsing Hua University

发明人： Yow-Tyng Nieh ,  Shih-Hsu Huang ,  Shih-Chieh Chang ,  Chung-Han Chou

IPC分类号： G06F1/00 ,  G06F1/32 ,  G06F17/50 ,  G06F1/10

CPC分类号： G06F1/10

摘要： A clock tree in a circuit and an operation method thereof are provided. The clock tree includes at least two sub clock trees, at least two voltage-controllable power-mode-aware (PMA) buffers and a power-mode control circuit. The PMA buffers delay a system clock to serve as the delayed clock, and provide respectively the delayed clock to the sub clock trees. The power-mode control circuit provides at least two first power information to at least two function modules respectively, wherein a power mode of each of the function modules is determined according to the first power information respectively. The power-mode control circuit provides at least two second power information to the PMA buffers respectively, wherein a delay time of each of the PMA buffers is determined according to the second power information respectively.

摘要翻译： 提供电路中的时钟树及其操作方法。 时钟树包括至少两个子时钟树，至少两个电压可控功率模式感知（PMA）缓冲器和功率模式控制电路。 PMA缓冲器将系统时钟延迟用作延迟时钟，并分别向子时钟树提供延迟的时钟。 功率模式控制电路分别向至少两个功能模块提供至少两个第一功率信息，其中每个功能模块的功率模式分别根据第一功率信息来确定。 功率模式控制电路分别向PMA缓冲器提供至少两个第二功率信息，其中分别根据第二功率信息确定每个PMA缓冲器的延迟时间。

公开(公告)号：US09267113B2

公开(公告)日：2016-02-23

申请号：US14203489

申请日：2014-03-10

申请人： Chung Yuan Christian University

发明人： Tzong-Yuan Wu ,  Mean-Shine Chen ,  Chao-Yi Teng ,  Ying-Ju Chen ,  Chung-Hsiung Wang

IPC分类号： C12N7/00 ,  A01K67/02 ,  A01K67/027

CPC分类号： C12N7/00 ,  A01K67/0271 ,  A01K2227/706 ,  A01K2267/01 ,  C12N15/86 ,  C12N2710/14041 ,  C12N2710/14121 ,  C12N2710/14143 ,  C12N2710/14144 ,  C12N2840/203

摘要： Disclosed herein is an Autographa californica multiple nucleopolyhedrovirus (AcMNPV) based hybrid baculovirus and its uses thereof. The AcMNPV based hybrid baculovirus is capable of infecting different hosts, and comprises Maruca vitrata multiple nucleopolyhedrovirus (MaviMNPV) genes of lef1, orf1629, pk1, CDS1, CDS2, and lef2; and AcMNPV/MaviMNPV-hybrid genes of egt and orf152. The AcMNPV based hybrid baculovirus is therefore useful as a bio-insecticide by its capability of delivering genes of toxic proteins to be expressed in at least two different insect hosts.

摘要翻译： 本文公开了一种基于Autographa californica多核苷酸多角体病毒（AcMNPV）的杂交杆状病毒及其用途。 基于AcMNPV的杂种杆状病毒能够感染不同的宿主，并且包含lef1，orf1629，pk1，CDS1，CDS2和lef2的Maruca vitrata多核苷酸多角体病毒（MaviMNPV）基因; 和egt和orf152的AcMNPV / MaviMNPV杂交基因。 因此，基于AcMNPV的杂种杆状病毒通过其能够递送至少两种不同昆虫宿主中表达的毒性蛋白质的基因而可用作生物杀虫剂。

公开(公告)号：US09157072B2

公开(公告)日：2015-10-13

申请号：US14277892

申请日：2014-05-15

申请人： Chung Yuan Christian University

发明人： Tzong-Yuan Wu ,  Mean-Shine Chen ,  Chao-Yi Teng ,  Ying-Ju Chen

IPC分类号： C12N7/00

CPC分类号： C12N7/00 ,  C12N15/86 ,  C12N2710/14121 ,  C12N2710/14143 ,  C12N2710/14144 ,  C12N2840/203

摘要： Disclosed herein is an Autographa californica multiple nucleopolyhedrovirus (AcMNPV) based hybrid baculovirus and its uses thereof. The AcMNPV based hybrid baculovirus is capable of infecting different hosts, and comprises Bombyx mori nuclear polyhedrosis virus (BmNPV) genes of lef9, vlf1, p6.9, and vp80; Maruca vitrata multiple nucleopolyhedrovirus (MaviMNPV) genes of lef2, orf1629, and pe38; and AcMNPV/BmNPV/MaviMNPV-hybrid genes of pk1, lef8, DNA pol, GP41, helicase, orf94, VP1054, orf65, lef4, lef5, and orf99. The AcMNPV based hybrid baculovirus is therefore useful as a bio-tool or bio-insecticide for its capability of delivering genes for production or expression of toxic proteins in at least three different insect hosts.

摘要翻译： 本文公开了一种基于Autographa californica多核苷酸多角体病毒（AcMNPV）的杂交杆状病毒及其用途。 基于AcMNPV的杂交杆状病毒能够感染不同的宿主，并且包含lef9，vlf1，p6.9和vp80的家蚕核型多角体病毒（BmNPV）基因; 苜蓿叶绿体多核苷酸多角体病毒（MaviMNPV）基因lef2，orf1629和pe38; 和pk1，lef8，DNA pol，GP41，解旋酶，orf94，VP1054，orf65，lef4，lef5和orf99的AcMNPV / BmNPV / MaviMNPV杂交基因。 因此，基于AcMNPV的杂种杆状病毒作为生物工具或生物杀虫剂可用于其在至少三种不同昆虫宿主中递送基因以产生或表达毒性蛋白质的能力。

公开(公告)号：US20150252333A1

公开(公告)日：2015-09-10

申请号：US14277892

申请日：2014-05-15

申请人： Chung Yuan Christian University

发明人： Tzong-Yuan Wu ,  Mean-Shine Chen ,  Chao-Yi Teng ,  Ying-Ju Chen

IPC分类号： C12N7/00

CPC分类号： C12N7/00 ,  C12N15/86 ,  C12N2710/14121 ,  C12N2710/14143 ,  C12N2710/14144 ,  C12N2840/203

摘要： Disclosed herein is an Autographa californica multiple nucleopolyhedrovirus (AcMNPV) based hybrid baculovirus and its uses thereof. The AcMNPV based hybrid baculovirus is capable of infecting different hosts, and comprises Bombyx mori nuclear polyhedrosis virus (BmNPV) genes of lef9, vlf1, p6.9, and vp80; Maruca vitrata multiple nucleopolyhedrovirus (MaviMNPV) genes of lef2, orf1629, and pe38; and AcMNPV/BmNPV/MaviMNPV-hybrid genes of pk1, lef8, DNA pol, GP41, helicase, orf94, VP1054, orf65, lef4, lef5, and orf99. The AcMNPV based hybrid baculovirus is therefore useful as a bio-tool or bio-insecticide for its capability of delivering genes for production or expression of toxic proteins in at least three different insect hosts.

摘要翻译： 本文公开了一种基于Autographa californica多核苷酸多角体病毒（AcMNPV）的混合杆状病毒及其用途。 基于AcMNPV的杂交杆状病毒能够感染不同的宿主，并且包含lef9，vlf1，p6.9和vp80的家蚕核型多角体病毒（BmNPV）基因; 苜蓿叶绿体多核苷酸多角体病毒（MaviMNPV）基因lef2，orf1629和pe38; 和pk1，lef8，DNA pol，GP41，解旋酶，orf94，VP1054，orf65，lef4，lef5和orf99的AcMNPV / BmNPV / MaviMNPV杂交基因。 因此，基于AcMNPV的杂种杆状病毒作为生物工具或生物杀虫剂可用于其在至少三种不同昆虫宿主中递送基因以产生或表达毒性蛋白质的能力。

公开(公告)号：US20150252332A1

公开(公告)日：2015-09-10

申请号：US14203489

申请日：2014-03-10

申请人： Chung Yuan Christian University

发明人： Tzong-Yuan Wu ,  Mean-Shine Chen ,  Chao-Yi Teng ,  Ying-Ju Chen ,  Chung-Hsiung Wang

IPC分类号： C12N7/00 ,  A01K67/027

CPC分类号： C12N7/00 ,  A01K67/0271 ,  A01K2227/706 ,  A01K2267/01 ,  C12N15/86 ,  C12N2710/14041 ,  C12N2710/14121 ,  C12N2710/14143 ,  C12N2710/14144 ,  C12N2840/203

摘要： Disclosed herein is an Autographa californica multiple nucleopolyhedrovirus (AcMNPV) based hybrid baculovirus and its uses thereof. The AcMNPV based hybrid baculovirus is capable of infecting different hosts, and comprises Maruca vitrata multiple nucleopolyhedrovirus (MaviMNPV) genes of lef1, orf1629, pk1, CDS1, CDS2, and lef2; and AcMNPV/MaviMNPV-hybrid genes of egt and orf152. The AcMNPV based hybrid baculovirus is therefore useful as a bio-insecticide by its capability of delivering genes of toxic proteins to be expressed in at least two different insect hosts.

摘要翻译： 本文公开了一种基于Autographa californica多核苷酸多角体病毒（AcMNPV）的混合杆状病毒及其用途。 基于AcMNPV的杂种杆状病毒能够感染不同的宿主，并且包含lef1，orf1629，pk1，CDS1，CDS2和lef2的Maruca vitrata多核苷酸多角体病毒（MaviMNPV）基因; 和egt和orf152的AcMNPV / MaviMNPV杂交基因。 因此，基于AcMNPV的杂种杆状病毒通过其能够递送至少两种不同昆虫宿主中表达的毒性蛋白质的基因而可用作生物杀虫剂。