公开(公告)号：US20240402269A1

公开(公告)日：2024-12-05

申请号：US18798020

申请日：2024-08-08

Applicant: ENDOMAGNETICS LTD.

Inventor： Simon Richard Hattersley

IPC: G01R33/12 ,  A61B5/00 ,  A61B5/05 ,  A61B5/06 ,  A61B17/00 ,  A61K49/18 ,  B82Y5/00

Abstract: A system and method for locating magnetic material. In one embodiment the system includes a magnetic probe; a power module in electrical communication with the magnetic probe to supply current to the magnetic probe; a sense module in electrical communication with the magnetic probe to receive signals from the magnetic probe; and a computer in electrical communication with the power module and the sense module. The computer generates a waveform that controls the supply of current from the power module and receives a signal from the sense module that indicates the presence of magnetic material. The magnetic probe is constructed from a material having a coefficient of thermal expansion of substantially 10−6/° C. or less and a Young's modulus of substantially 50 GPa or greater. In one embodiment magnetic nanoparticles are injected into a breast and the lymph nodes collecting the particles are detected with the probe and deemed sentinel nodes.

公开(公告)号：US12092708B2

公开(公告)日：2024-09-17

申请号：US18103828

申请日：2023-01-31

Applicant: ENDOMAGNETICS LTD.

Inventor： Simon Richard Hattersley

IPC: A61B5/05 ,  A61B5/00 ,  A61B5/06 ,  A61K49/18 ,  B82Y5/00 ,  G01R33/12 ,  A61B17/00

CPC classification number: G01R33/1269 ,  A61B5/05 ,  A61B5/065 ,  A61B5/415 ,  A61B5/418 ,  A61B5/4312 ,  A61K49/1863 ,  B82Y5/00 ,  A61B2017/00876 ,  A61B2562/12

Abstract: A system and method for locating magnetic material. In one embodiment the system includes a magnetic probe; a power module in electrical communication with the magnetic probe to supply current to the magnetic probe; a sense module in electrical communication with the magnetic probe to receive signals from the magnetic probe; and a computer in electrical communication with the power module and the sense module. The computer generates a waveform that controls the supply of current from the power module and receives a signal from the sense module that indicates the presence of magnetic material. The magnetic probe is constructed from a material having a coefficient of thermal expansion of substantially 10−6/° C. or less and a Young's modulus of substantially 50 GPa or greater. In one embodiment magnetic nanoparticles are injected into a breast and the lymph nodes collecting the particles are detected with the probe and deemed sentinel nodes.

公开(公告)号：US20230329834A1

公开(公告)日：2023-10-19

申请号：US18138600

申请日：2023-04-24

Applicant: ENDOMAGNETICS LTD

Inventor： Tiziano Agostinelli ,  Kevin Lorimer ,  Quentin John Harmer

IPC: A61B90/00 ,  A61B5/06 ,  A61B34/20 ,  G01D5/20

CPC classification number: A61B90/39 ,  A61B5/064 ,  A61B34/20 ,  A61B5/062 ,  G01D5/20 ,  A61B2090/3908 ,  A61B2505/05 ,  A61B2034/2051 ,  A61B2090/3966 ,  A61B2017/00867

Abstract: A detection system and method uses an implantable magnetic marker comprising at least one piece of a large Barkhausen jump material (LBJ). The marker is deployed to mark a tissue site in the body for subsequent surgery, and the magnetic detection system includes a handheld probe to excite the marker below the switching field for bistable switching of the marker causing a harmonic response to be generated in a sub-bistable mode that allows the marker to be detected and localised. The marker implanted may also be shorter than the critical length required to initiate bistable switching of the LBJ material.

公开(公告)号：US09523748B2

公开(公告)日：2016-12-20

申请号：US14992682

申请日：2016-01-11

Applicant: ENDOMAGNETICS LTD

Inventor： Simon Richard Hattersley ,  Peter Georg Laitenberger

IPC: G01R33/12 ,  G01R33/035 ,  G01N27/72 ,  A61B5/05 ,  G01N27/74 ,  G01R33/02 ,  G01R33/10

CPC classification number: G01R33/1276 ,  A61B5/05 ,  G01N27/72 ,  G01N27/745 ,  G01R33/0213 ,  G01R33/10

Abstract: A probe for detecting magnetic particles. In one embodiment, the probe includes: a cylindrical probe core having a first end and a second end, the cylindrical probe core defining two channels for containing coils of wire, one of the channels being adjacent the first end of the cylindrical probe core; two sense coils, one each of the sense coils being located in a respective one of the channels; and two drive coils, one each of the drive coils being co-located with the respective sense coil in a respective one of the channels.

公开(公告)号：US20160354495A1

公开(公告)日：2016-12-08

申请号：US15171383

申请日：2016-06-02

Applicant: ENDOMAGNETICS LTD

Inventor： Quentin John Harmer ,  Eric Mayes

IPC: A61K49/18 ,  A61K41/00 ,  A61K49/06

CPC classification number: A61K49/1863 ,  A61K41/0052 ,  A61K47/6939 ,  B82Y5/00

Abstract: A multicore magnetic particle. In one embodiment, the magnetic particle includes a plurality of superparmagnetic cores embedded in a non-magnetic matrix. In another embodiment, the effective anisotropy energy barrier of the particle is larger than the sum of the anisotropy energy barriers of the individual superparamagnetic cores. In yet another embodiment, the superparamagnetic cores are close enough to interact magnetically by exchange coupling and dipole interaction. In still yet another embodiment, the specific loss power of the magnetic particle is greater than the specific loss power of an equivalent mass of individual superparamagnetic cores.

Abstract translation: 多核磁性颗粒。 在一个实施例中，磁性粒子包括嵌入非磁性矩阵中的多个超磁性核心。 在另一个实施方案中，颗粒的有效各向异性能势垒大于各个超顺磁核的各向异性能量势垒的总和。 在另一个实施例中，超顺磁核足够接近以通过交换耦合和偶极相互作用磁化地相互作用。 在另一个实施例中，磁性颗粒的比损耗功率大于单个超顺磁芯的等效质量的比损耗功率。

公开(公告)号：US20160354178A1

公开(公告)日：2016-12-08

申请号：US15172187

申请日：2016-06-03

Applicant: ENDOMAGNETICS LTD

Inventor： Eric Mayes ,  Quentin John Harmer ,  Kevin Lorimer ,  Quentin Andrew Pankhurst

IPC: A61B90/00 ,  A61B5/00 ,  A61B5/05

CPC classification number: A61B90/39 ,  A61B5/05 ,  A61B5/4312 ,  A61B2017/00862 ,  A61B2090/3908 ,  A61B2090/3925 ,  A61B2090/3954 ,  A61B2090/3966 ,  A61B2090/3987 ,  A61B2090/3995 ,  A61B2562/0223

Abstract: A magnetic marker for marking a site in tissue in the body. In one embodiment, the marker comprises a magnetic metallic glass. In another embodiment, the marker is in a non-spherical configuration having an anisotropy ratio less than 9. In yet another embodiment, the marker is in a non-spherical configuration having an anisotropy ratio less than 6. In yet another embodiment, the marker is in a non-spherical configuration having an anisotropy ratio less than 3.

Abstract translation: 用于标记身体组​​织中的部位的磁性标记。 在一个实施例中，标记包括磁性金属玻璃。 在另一个实施方案中，标记是具有小于9的各向异性比的非球形构型。在另一个实施方案中，标记是具有小于6的各向异性比的非球形构型。在另一个实施方案中，标记 是各向异性比小于3的非球形构型。

公开(公告)号：US09427186B2

公开(公告)日：2016-08-30

申请号：US12960746

申请日：2010-12-06

Applicant: Simon Richard Hattersley ,  Quentin Andrew Pankhurst

Inventor： Simon Richard Hattersley ,  Quentin Andrew Pankhurst

IPC: A61B5/00 ,  A61B5/05 ,  A61B5/06 ,  A61B10/00 ,  A61K49/18 ,  B82Y5/00

CPC classification number: A61B5/418 ,  A61B5/05 ,  A61B5/065 ,  A61B5/415 ,  A61B5/4312 ,  A61B10/0041 ,  A61K49/1863 ,  B82Y5/00

Abstract: A system and method for locating magnetic material. In one embodiment the system includes a magnetic probe; a power module in electrical communication with the magnetic probe to supply current to the magnetic probe; a sense module in electrical communication with the magnetic probe to receive signals from the magnetic probe; and a processing module in electrical communication with the power module and the sense module. The processing module generates a waveform that controls the supply of current from the power module and receives a signal from the sense module that indicates the presence of magnetic material. The magnetic probe is constructed from a material having a coefficient of thermal expansion of substantially 10−6/° C. or less and a Young's modulus of substantially 50 GPa or greater. In one embodiment magnetic nanoparticles collect in the lymph nodes. In one embodiment the particles have a mean hydrodynamic diameter of between 5-200 nm.

Abstract translation: 一种用于定位磁性材料的系统和方法。 在一个实施例中，系统包括磁探针; 电源模块，与所述磁探头电连通以向所述磁探头供电; 感测模块​​，与所述磁探头电连通以接收来自所述磁性探头的信号; 以及与电源模块和感测模块电连通的处理模块。 处理模块产生一个波形，该波形控制来自功率模块的电流供应，并接收来自感测模块的指示磁性材料的存在的信号。 磁性探针由热膨胀系数大致为10 -6 /℃以下，杨氏模量为50GPa以上的材料构成。 在一个实施方案中，磁性纳米颗粒收集在淋巴结中。 在一个实施方案中，颗粒的平均流体动力学直径在5-200nm之间。

公开(公告)号：US09234877B2

公开(公告)日：2016-01-12

申请号：US13799334

申请日：2013-03-13

Applicant: Endomagnetics Ltd. ,  University of Houston

Inventor： Simon Richard Hattersley ,  Peter Georg Laitenberger ,  Audrius Brazdeikis

IPC: G01R33/12 ,  G01R33/28 ,  A61B5/05 ,  G01N27/74 ,  G01R33/02 ,  G01R33/10

CPC classification number: G01R33/1276 ,  A61B5/05 ,  G01N27/72 ,  G01N27/745 ,  G01R33/0213 ,  G01R33/10

Abstract: A probe for detecting magnetic particles. In one embodiment, the probe includes: a cylindrical probe core having a first end and a second end, the cylindrical probe core defining two channels for containing coils of wire, one of the channels being adjacent the first end of the cylindrical probe core; two sense coils, one each of the sense coils being located in a respective one of the channels; and two drive coils, one each of the drive coils being co-located with the respective sense coil in a respective one of the channels.

Abstract translation: 用于检测磁性颗粒的探头。 在一个实施例中，探针包括：具有第一端和第二端的圆柱形探针芯，所述圆柱形探针芯限定用于容纳线圈的两个通道，所述通道中的一个与所述圆柱形探针芯的第一端相邻; 两个感测线圈，每个感测线圈位于相应的一个通道中; 和两个驱动线圈，每个驱动线圈与相应的一个通道中的相应感测线圈共同定位。