公开(公告)号：US20140222126A1

公开(公告)日：2014-08-07

申请号：US14170720

申请日：2014-02-03

Applicant: Shu Xiao ,  Andrei Pakhomov ,  Karl H. Schoenbach

Inventor： Shu Xiao ,  Andrei Pakhomov ,  Karl H. Schoenbach

IPC: A61N5/00

CPC classification number: A61N1/36014 ,  A61N1/40 ,  A61N2/006 ,  A61N5/02

Abstract: A system for treatment of biological tissues is provided. The system includes a lens having a hollow, substantially hemispherical shape with an outer surface and an inner surface, the inner surface defining a substantially hemispherical cavity for inserting the biological tissues. The system further includes an antenna assembly for generating and directing electromagnetic radiation towards the outer surface. In the system, the lens is configured to direct the electromagnetic energy to an area in the cavity, a dielectric constant of the lens at the inner surface substantially matches a dielectric constant of the biological tissues, the dielectric constant monotonically increases from the outer surface to the inner surface, and the electromagnetic energy is generated via a series of pulses having a transient of less than about 1 nanosecond.

Abstract translation: 提供了一种用于治疗生物组织的系统。 该系统包括具有中空的，基本上半球形的透镜，其具有外表面和内表面，内表面限定用于插入生物组织的基本上半球形的腔。 该系统还包括一个天线组件，用于产生和引导电磁辐射朝向外表面。 在该系统中，透镜被配置为将电磁能量引导到空腔中的区域，透镜在内表面的介电常数基本上与生物组织的介电常数相匹配，介电常数从外表面单调增加到 通过具有小于约1纳秒的瞬态的一系列脉冲来产生内表面和电磁能。

公开(公告)号：US08798705B2

公开(公告)日：2014-08-05

申请号：US13264729

申请日：2010-04-14

Applicant: Juergen F. Kolb ,  Karl H. Schoenbach ,  Stephen P. Beebe

Inventor： Juergen F. Kolb ,  Karl H. Schoenbach ,  Stephen P. Beebe

IPC: A61B5/04

CPC classification number: A61N1/325 ,  A61N1/0502 ,  A61N1/306 ,  A61N1/327

Abstract: An instrument 10 for delivering a high voltage pulse to tissue is disclosed. The instrument 10 can include an outer support member 12 with a liquid reservoir 14 that has a liquid-contacting interior surface 16, an opening 18 at a distal end 20 of the outer support member 12, and a ground electrode 22 extending in a longitudinal direction and having a lower surface 23 proximate the opening 18. The instrument 10 can also include a working electrode 26 extending longitudinally from the liquid-contacting interior surface 16 with a needle-shaped distal portion 28 proximate the distal end 20; and an inlet port 31 and an outlet port 34 in liquid communication with the liquid reservoir 14. The working electrode 26 can be electrically isolated from the ground electrode 22 by an insulating portion 30 of the outer support member 12, and a direct path can exist through the liquid reservoir 14 between the ground electrode 22 and the working electrode 26.

Abstract translation: 公开了一种用于将高电压脉冲传送到组织的器械10。 仪器10可以包括具有液体储存器14的外部支撑构件12，该储存器14具有液体接触内表面16，在外部支撑构件12的远端20处的开口18和沿纵向方向延伸的接地电极22 并且具有靠近开口18的下表面23.仪器10还可以包括从液体接触内表面16纵向延伸的工作电极26，其具有靠近远端20的针状远端部分28; 以及与液体储存器14液体连通的入口31和出口34.工作电极26可以通过外部支撑构件12的绝缘部分30与接地电极22电隔离，并且可以存在直接路径 通过接地电极22和工作电极26之间的液体贮存器14。

公开(公告)号：US08772004B2

公开(公告)日：2014-07-08

申请号：US12823696

申请日：2010-06-25

Applicant: Gary C. Schafran ,  Juergen F. Kolb ,  Aron Stubbins ,  Karl H. Schoenbach

Inventor： Gary C. Schafran ,  Juergen F. Kolb ,  Aron Stubbins ,  Karl H. Schoenbach

IPC: C12N13/00

CPC classification number: A01G1/00 ,  A01G2/00 ,  C12M33/00 ,  C12N1/12 ,  C12N13/00 ,  C12P7/649 ,  Y02E50/13 ,  Y02E50/17

Abstract: A method and device for aggregating algae in an aqueous solution is disclosed. The method can include providing an algae feed comprising a liquid and algae dispersed therein. The algae feed can be aggregated by applying a nanosecond pulsed electric field to the algae feed. The nanosecond pulsed electric field can include a plurality of electric pulses having a pulse duration ranging from 1 to 1,000 nanoseconds. The method can also include separating an aggregated algae stream from the algae feed and feeding the aggregated algae stream to a lipid extraction operation.

Abstract translation: 公开了一种在水溶液中聚集藻类的方法和装置。 该方法可以包括提供包含分散在其中的液体和藻类的藻类饲料。 藻类饲料可以通过将纳秒脉冲电场施加到藻类饲料来聚集。 纳秒脉冲电场可以包括具有1至1,000纳秒的脉冲持续时间的多个电脉冲。 该方法还可以包括从藻类饲料中分离聚集的藻类物流，并将聚集的藻类物流进行脂质提取操作。

公开(公告)号：US08646918B2

公开(公告)日：2014-02-11

申请号：US13492298

申请日：2012-06-08

Applicant: Declan G. De Paor

Inventor： Declan G. De Paor

IPC: G03B21/14 ,  G03B21/26

CPC classification number: G03B21/56 ,  G03B37/04 ,  G03B37/06

Abstract: A projection system having a set of projectors that cast images: (i) onto the concave surface of a hemispherical dome, as is usual in planetariums and (ii) onto the surface of a centrally located sphere. The images thus cast may be coordinated by a controlling computer program, so that changes in the content or orientation of the images on the sphere result in corresponding changes in the images on the dome and vice versa.

Abstract translation: 一种投影系统，具有投影图像的一组投影仪：（i）像在天文馆中通常的那样在半球形的圆顶的凹面上，和（ii）到位于中心的球体的表面上。 这样投射的图像可以通过控制计算机程序协调，使得球体上的图像的内容或取向的变化导致圆顶上的图像的相应变化，反之亦然。

公开(公告)号：US20130123469A1

公开(公告)日：2013-05-16

申请号：US13707754

申请日：2012-12-07

Applicant: OLD DOMINION UNIVERSITY RESEARCH FOUNDATION

Inventor： Sandeep Kumar ,  Patrick G. Hatcher

IPC: C07K1/12

CPC classification number: C07K1/12 ,  C05F5/004 ,  C05F5/006 ,  C08H1/00 ,  C08H8/00 ,  C10G1/065 ,  C12N1/12 ,  C12P7/62 ,  C12P7/6436 ,  C12P7/649 ,  C12P21/00 ,  Y02A40/209 ,  Y02A40/211 ,  Y02E50/13 ,  Y02P20/145

Abstract: Methods of fractionating proteins and lipids in algae are provided. The methods can extract peptides and amino acids from algae, can produce components used in food or fertilizer, and can improve algal biomass feed for biofuel production, as non-limiting examples. One embodiment of a method as disclosed herein comprises providing a feed material of algae saturated with water to a reactor, bringing the water saturating the algae to a subcritical temperature within the reactor and separating a reactor effluent into solids and liquid.

Abstract translation: 提供了在藻类中分离蛋白质和脂质的方法。 这些方法可以从藻类中提取肽和氨基酸，可以生产用于食品或肥料的成分，并且可以改善生物燃料生产的藻类生物质饲料作为非限制性实例。 本文公开的方法的一个实施方案包括向反应器提供饱和水的藻类的进料，使藻类饱和的水在反应器内达到亚临界温度，并将反应器流出物分离成固体和液体。

公开(公告)号：US20110004123A1

公开(公告)日：2011-01-06

申请号：US12459503

申请日：2009-07-02

Applicant: John A. Companion

Inventor： John A. Companion

IPC: A61B5/103

CPC classification number: A61B8/08 ,  A61B5/204

Abstract: A system and method are provided for monitoring bladder distention. Independently controllable acoustic transmitters are coupled to the surface of a user's abdomen region in a spaced-apart fashion. Each transmitter can introduce a broadband acoustic signal into a portion of the abdomen region. Acoustic receivers are also coupled to the surface of the abdomen region to detect acoustic reflections generated when the acoustic signals are introduced into the abdomen region. A controller is positioned on the user and is correlated to an orientation of the user. The controller stores a profile indicative of anatomical features of the user. The controller initiates periodic activations of selected ones of the transmitters based upon the profile and the orientation of the user. The controller uses a weighted combination of all of the acoustic reflections to determine bladder distention of the user. The weighted combination is defined by at least the profile and orientation of the user.

Abstract translation: 提供了一种用于监测膀胱膨胀的系统和方法。 独立可控的声发射器以间隔的方式联接到用户的腹部区域的表面。 每个发射机可以将宽带声信号引入腹部区域的一部分。 声学接收器还耦合到腹部区域的表面以检测当声信号被引入腹部区域时产生的声反射。 控制器位于用户身上并与用户的方向相关联。 控制器存储指示用户的解剖特征的简档。 控制器基于用户的简档和方向启动所选择的发射机的周期性激活。 控制器使用所有声反射的加权组合来确定用户的膀胱膨胀。 加权组合至少由用户的轮廓和方向定义。

公开(公告)号：US20110003350A1

公开(公告)日：2011-01-06

申请号：US12823696

申请日：2010-06-25

Applicant: Gary C. Schafran ,  Juergen F. Kolb ,  Aron Stubbins ,  Karl H. Schoenbach

Inventor： Gary C. Schafran ,  Juergen F. Kolb ,  Aron Stubbins ,  Karl H. Schoenbach

IPC: C12P7/64 ,  C12N13/00 ,  C12M1/42 ,  C12P7/16 ,  C12P7/06 ,  C12P7/04

CPC classification number: A01G1/00 ,  A01G2/00 ,  C12M33/00 ,  C12N1/12 ,  C12N13/00 ,  C12P7/649 ,  Y02E50/13 ,  Y02E50/17

Abstract: A method and device for aggregating algae in an aqueous solution is disclosed. The method can include providing an algae feed comprising a liquid and algae dispersed therein. The algae feed can be aggregated by applying a nanosecond pulsed electric field to the algae feed. The nanosecond pulsed electric field can include a plurality of electric pulses having a pulse duration ranging from 1 to 1,000 nanoseconds. The method can also include separating an aggregated algae stream from the algae feed and feeding the aggregated algae stream to a lipid extraction operation.

Abstract translation: 公开了一种在水溶液中聚集藻类的方法和装置。 该方法可以包括提供包含分散在其中的液体和藻类的藻类饲料。 藻类饲料可以通过将纳秒脉冲电场施加到藻类饲料来聚集。 纳秒脉冲电场可以包括具有1至1,000纳秒的脉冲持续时间的多个电脉冲。 该方法还可以包括从藻类饲料中分离聚集的藻类物流，并将聚集的藻类物流进行脂质提取操作。

公开(公告)号：US4267573A

公开(公告)日：1981-05-12

申请号：US915453

申请日：1978-06-14

Applicant: George M. Chaikin ,  Carl F. R. Weiman

Inventor： George M. Chaikin ,  Carl F. R. Weiman

IPC: G06T3/00 ,  G06F3/14

CPC classification number: G06K9/28 ,  G06K9/42 ,  G06T3/0006

Abstract: An image processing system is described in which an image is converted into a plurality of image elements or cells which are arranged in a predetermined pattern. These cells are then simultaneously rearranged into a second predetermined pattern to provide a transformed representation of the original image. In this transformed state, the positions of all of the cells may be simultaneously shifted in a manner which produces modifications of the original image, such as scaling or rotating. The highly parallel manner in which the present system manipulates the image cells allows the desired image modifications to be effected more simply and rapidly than has been previously possible. In a preferred embodiment of the invention these image cell manipulations are performed in a three dimensional shift register of novel design. A number of alternative embodiments of the invention are set forth which are of particular value in pattern recognition systems and in graphic display systems in which the ability to modify or animate images is desired.

Abstract translation: 描述了一种图像处理系统，其中图像被转换成以预定图案排列的多个图像元素或单元。 然后将这些单元重新排列成第二预定图案以提供原始图像的变换表示。 在这种变换状态下，可以以产生原始图像的修改的方式，例如缩放或旋转，同时移位所有单元的位置。 本系统操纵图像单元的高度平行的方式允许比以前可能更简单和快速地实现期望的图像修改。 在本发明的优选实施例中，这些图像单元操作在新颖设计的三维移位寄存器中执行。 阐述了本发明的多个替代实施例，其在模式识别系统和图形显示系统中是特别有价值的，其中需要对图像进行修改或者制作动画的能力。

公开(公告)号：US11951307B2

公开(公告)日：2024-04-09

申请号：US17306314

申请日：2021-05-03

Applicant: Old Dominion University Research Foundation

Inventor： Andrei G. Pakhomov ,  Olga N. Pakhomova ,  Shu Xiao

IPC: A61N1/32 ,  A61N1/04 ,  A61N1/36 ,  C12N13/00

CPC classification number: A61N1/323 ,  A61N1/327 ,  C12N13/00 ,  A61N1/0412 ,  A61N1/0476 ,  A61N1/36

Abstract: Provided herein are methods of generating a biologically effective unipolar nanosecond electric pulse by superposing two biologically ineffective bipolar nanosecond electric pulses and related aspects, such as electroporation and/or therapeutic applications of these methods to non-invasively target electrostimulation (ES) selectively to deep tissues and organs.

公开(公告)号：US20230277241A1

公开(公告)日：2023-09-07

申请号：US18307051

申请日：2023-04-26

Applicant: Old Dominion University Research Foundation

Inventor： Christian W. Zemlin

IPC: A61B18/14

CPC classification number: A61B18/1492 ,  A61B2018/00357

Abstract: An apparatus and methods for performing ablation of myocardial tissues are disclosed. The apparatus includes a plurality of ablation electrode configurations to which nanosecond pulsed electric fields are applied. The methods relate to therapies to treat cardiac arrhythmias, such as, atrial fibrillation and scar-related ventricular tachycardia, amongst others. The affected myocardial tissues are ablated creating a plurality of lesions enabled by the nanosecond pulsed electric fields applied to either penetrating electrodes, endo-endo electrodes, or endo-epi electrodes. Different electrophysiological tests are performed to assess the application of nanosecond pulsed electric field ablation to specific desired tissue location within the heart. Test results show the potential to overcome limitations of current ablation therapies, thereby providing patients and doctors a superior treatment for cardiac arrhythmias.