公开(公告)号：US6161435A

公开(公告)日：2000-12-19

申请号：US358733

申请日：1999-07-21

Applicant: Leonard J. Bond ,  Guo Yong Chai ,  Alan Richard Greenberg ,  William Bernard Krantz

Inventor： Leonard J. Bond ,  Guo Yong Chai ,  Alan Richard Greenberg ,  William Bernard Krantz

IPC: B01D61/12 ,  B01D61/22 ,  B01D65/02 ,  B01D65/10 ,  G01N29/032 ,  G01N29/07 ,  G01N29/11 ,  G01N29/22 ,  G01N29/30 ,  G01N29/44 ,  G01N29/48 ,  G01D7/00 ,  B01D17/06 ,  B01D33/00

CPC classification number: G01N29/4436 ,  B01D61/12 ,  B01D61/22 ,  B01D65/02 ,  B01D65/10 ,  B01D2321/00 ,  G01N29/032 ,  G01N29/07 ,  G01N29/11 ,  G01N29/221 ,  G01N29/222 ,  G01N29/30 ,  G01N29/4427 ,  G01N29/48 ,  G01N2291/0231 ,  G01N2291/0237 ,  G01N2291/02416 ,  G01N2291/0251 ,  G01N2291/044

Abstract: The fouling state of a polymeric membrane within the high pressure housing of a spiral wound or a hollow fiber membrane module is determined. An ultra sonic transducer positioned with its emitting face in physical engagement with the outer surface of the housing is pulse energized by a pulser/receiver device. A membrane echo signal is detected by a receiver of the pulser/receiver device. A reference echo signal indicative of a fouled or an unfouled state of the membrane is compared to the echo signal to determine the membrane fouling state. The echo to reference comparing step can be based upon comparing amplitude domain signals, comparing time-domain signals, comparing combinations of amplitude domain and time-domain signals, and comparing transformations of amplitude domain and time-domain signals. A clean or a fouled reference echo can be provided from a clean or a fouled membrane and then stored for use during a liquid separation process, or a clean reference echo signal can be obtained on-line from a second transducer whose echo signal is derived from an area of the membrane known to remain relatively unfouled during the liquid separation process, or a clean or fouled reference echo signal can be provided for later use during a cleaning process or during a liquid separation process. Multiple transducers and a switching network can sample the fouling state at different positions within the membrane module.

Abstract translation: 确定螺旋卷绕或中空纤维膜组件的高压壳体内的聚合物膜的结垢状态。 定位在其发射面与壳体的外表面物理接合的超声波换能器由脉冲发生器/接收器装置脉冲激励。 膜回波信号由脉冲发生器/接收装置的接收器检测。 将指示膜的污浊或未结垢状态的参考回波信号与回波信号进行比较以确定膜污染状态。 回波到参考比较步骤可以基于比较幅度域信号，比较时域信号，比较幅度域和时域信号的组合，以及比较振幅域和时域信号的变换。 可以从干净的或污垢的膜提供干净或污垢的参考回波，然后在液体分离过程中存储以供使用，或者可以从其回波信号源自的第二换能器在线获得干净的参考回波信号 已知在液体分离过程中已知保持相对未分解的膜的区域，或清洁或污染的参考回波信号可以提供用于在清洁过程期间或在液体分离过程期间的后续使用。 多个换能器和开关网络可以在膜组件内的不同位置处取样结垢状态。

公开(公告)号：US6093809A

公开(公告)日：2000-07-25

申请号：US851843

申请日：1997-05-06

Applicant: Thomas R. Cech ,  Joachim Lingner

Inventor： Thomas R. Cech ,  Joachim Lingner

IPC: A61K38/00 ,  A61K39/00 ,  A61K48/00 ,  C12N9/12 ,  C12N15/113 ,  C07H21/04 ,  C07K5/00 ,  C07K7/00

CPC classification number: C12N15/113 ,  C12N15/1137 ,  C12N9/1241 ,  C12N9/1276 ,  C12Y207/07049 ,  A01K2217/05 ,  A61K38/00 ,  A61K39/00 ,  A61K48/00 ,  C07K2319/00 ,  C12N2310/15 ,  C12N2310/315

Abstract: The present invention is directed to novel telomerase nucleic acids and amino acids. In particular, the present invention is directed to nucleic acid and amino acid sequences encoding various telomerase protein subunits and motifs, including the 123 kDa and 43 kDa telomerase protein subunits of Euplotes aediculatus, and related sequences from Schizosaccharomyces, Saccharomyces sequences, and human telomerase. The present invention is also directed to polypeptides comprising these telomerase protein subunits, as well as functional polypeptides and ribonucleoproteins that contain these subunits.

Abstract translation: 本发明涉及新型端粒酶核酸和氨基酸。 特别地，本发明涉及编码各种端粒酶蛋白亚基和基序的核酸和氨基酸序列，包括Euplotes aediculatus的123kDa和43kDa端粒酶蛋白亚基，以及来自粟酒裂殖酵母，酵母属序列和人端粒酶的相关序列。 本发明还涉及包含这些端粒酶蛋白亚基的多肽，以及含有这些亚单位的功能性多肽和核糖核蛋白。

公开(公告)号：US6080703A

公开(公告)日：2000-06-27

申请号：US191566

申请日：1998-11-13

Applicant: Allen M. Hermann ,  Veeraraghavan Badri

Inventor： Allen M. Hermann ,  Veeraraghavan Badri

IPC: C01G29/00 ,  H01L39/12 ,  H01L39/24

CPC classification number: C01G29/006 ,  H01L39/126 ,  C01P2002/72 ,  C01P2002/77 ,  C01P2004/03 ,  C01P2006/32 ,  C01P2006/40 ,  C01P2006/42 ,  C01P2006/80 ,  Y10S505/782 ,  Y10S505/783

Abstract: A method for producing a high temperature superconductor system having the composition TlBiBaCaCuO. The system exhibits a T.sub.c of at least 116 K. The method includes the steps of mixing compounds including Tl, Bi, Ba, Ca, Cu, and O to create a mixture. The mixture is heated. The mixture is then cooled.

Abstract translation: 一种具有组成TlBiBaCaCuO的高温超导体系的制造方法。 该系统显示至少为116K的Tc。该方法包括混合包括Tl，Bi，Ba，Ca，Cu和O的化合物以产生混合物的步骤。 混合物加热。 然后将混合物冷却。

公开(公告)号：US5982549A

公开(公告)日：1999-11-09

申请号：US79489

申请日：1998-05-15

Applicant: Kenneth Kubala ,  Brian Hooker ,  Lindon Lewis ,  Andrew Hatch

Inventor： Kenneth Kubala ,  Brian Hooker ,  Lindon Lewis ,  Andrew Hatch

IPC: G02B23/12 ,  G02B27/10 ,  G02B21/18 ,  G02B23/00 ,  G02B27/02

CPC classification number: G02B23/12

Abstract: This invention provides a vision system that increases the field of view of an electronic binocular system without degrading image quality or requiring extremely large format sensors or displays. The vision system comprises an imaging device coupled with a viewing device. The imaging device comprises a compression lens and an image sensor. The viewing device comprises an image display and a decompression lens. The compression lens matches the optical distortion to the human visual acuity curve for field positions greater than an angle .theta.. Below angle .theta. there is substantially no distortion. The optimum angle .theta. depends on the application. For an average individual viewing a landscape the angle .theta. is about 10.degree.. For different viewing objects, the optimum angle .theta. varies from about 5.degree. to about 15.degree.. The image sensor can be infrared sensitive for infrared viewing. For low-light level viewing an image intensifier can be positioned between the compression lens and the image sensor. The imaging device can be connected to the viewing device in a unitary structure or the imaging device can be remote from the viewing device. The compression lens and the decompression lens are compound lenses, each comprising a plurality of component lenses. One or more surface of one or more component lens can be aspheric.

Abstract translation: 本发明提供一种增加电子双目系统的视野而不降低图像质量或需要极大格式的传感器或显示器的视觉系统。 视觉系统包括与观看装置耦合的成像装置。 成像装置包括压缩透镜和图像传感器。 观察装置包括图像显示器和减压透镜。 压缩透镜将光学畸变与大于角度θ的场位置的人视力曲线相匹配。 角度θ以下基本上没有失真。 最佳角度θ取决于应用。 对于观看景观的平均个体，角度θ约为10度。 对于不同的观察对象，最佳角度θ在约5°至约15°之间变化。 图像传感器可以对红外线进行红外检测。 对于低光级别的观看，图像增强器可以位于压缩透镜和图像传感器之间。 成像装置可以以单一结构连接到观察装置，或者成像装置可以远离观察装置。 压缩透镜和减压透镜是复合透镜，每个透镜包括多个分量透镜。 一个或多个组件透镜的一个或多个表面可以是非球面的。

公开(公告)号：US5981474A

公开(公告)日：1999-11-09

申请号：US98791

申请日：1998-06-17

Applicant: Mark C. Manning ,  Theodore W. Randolph ,  Eli Shefter ,  Richard F. Falk, III

Inventor： Mark C. Manning ,  Theodore W. Randolph ,  Eli Shefter ,  Richard F. Falk, III

IPC: A61K9/00 ,  A61K9/16 ,  A61K9/51 ,  A61K38/04 ,  A61K38/22 ,  A61K38/28 ,  A61K38/57 ,  A61K47/48 ,  B01F3/00 ,  C07K1/30 ,  A61K38/00 ,  A23J1/00

CPC classification number: A61K9/145 ,  A61K38/05 ,  A61K38/09 ,  A61K38/27 ,  A61K38/28 ,  A61K38/57 ,  A61K47/4803 ,  A61K47/48792 ,  A61K47/48876 ,  A61K9/0024 ,  A61K9/0078 ,  A61K9/08 ,  A61K9/1647 ,  A61K9/5123 ,  A61K9/5153 ,  B01F3/0092 ,  C07K1/30 ,  B01F2003/0064 ,  Y02P20/544

Abstract: Provided is a method for preparing a true, homogeneous solution of a pharmaceutical substance dissolved in an organic solvent in which the pharmaceutical substance is not normally soluble. Solubilization is obtained by forming a hydrophobic ion pair complex involving the pharmaceutical substance and an amphiphilic material. The resulting organic solution may be further processed to prepare pharmaceutical powders. A biodegradable polymer may be co-dissolved with the pharmaceutical substance and the amphiphilic material and may be incorporated into a pharmaceutical powder. A preferred method for preparing pharmaceutical powders is to subject the organic solution to gas antisolvent precipitation using a supercritical gas antisolvent such as carbon dioxide. Also provided is a method for making hollow particles having a fiber-like shape which would provide enhanced retention time in the stomach if ingested by a human or animal host.

Abstract translation: 提供了制备溶解在药物通常不溶于其中的有机溶剂中的药物的真实均匀溶液的方法。 通过形成涉及药物物质和两亲性物质的疏水性离子对络合物来获得溶解。 所得到的有机溶液可以进一步加工以制备药物粉末。 可生物降解的聚合物可以与药物物质和两亲物质共溶，并且可以并入药物粉末中。 用于制备药物粉末的优选方法是使用超临界气体反溶剂如二氧化碳对有机溶液进行气体反溶剂沉淀。 还提供了一种制备具有纤维状形状的中空颗粒的方法，其将在人或动物宿主摄入时提供增强的胃中的停留时间。

公开(公告)号：US5981259A

公开(公告)日：1999-11-09

申请号：US976838

申请日：1997-11-24

Applicant: Alex Franzusoff

Inventor： Alex Franzusoff

IPC: A61K47/48 ,  A61K48/00 ,  C07K14/16 ,  C12N9/60 ,  C12N9/64 ,  C12N15/113 ,  C12N15/12 ,  C12N15/81 ,  C12N15/82 ,  C12N15/74 ,  A61K31/70 ,  C12N15/80 ,  C12N15/85

CPC classification number: C12N15/1137 ,  A61K47/48776 ,  C07K14/005 ,  C12N15/81 ,  C12N15/8201 ,  C12N9/60 ,  C12N9/6454 ,  A61K48/00 ,  C12N2740/16122

Abstract: The present invention includes the identification and isolation of a nucleic acid molecule encoding a dibasic amino acid processing endoprotease from CD4+ T-lymphocytes as well as a protein encoded by that nucleic acid molecule. The present invention also includes related nucleic acid molecules and proteins encoded by such nucleic acid molecules as well as recombinant molecules and recombinant cells that include nucleic acid molecules of the present invention. The present invention also includes use of such nucleic acid molecules and proteins to develop therapeutic compositions that enhance or inhibit dibasic amino acid processing endoprotease activity.

Abstract translation: 本发明包括鉴定和分离编码来自CD4 + T淋巴细胞的二元氨基酸处理内蛋白酶的核酸分子以及由该核酸分子编码的蛋白质。 本发明还包括由此类核酸分子编码的相关核酸分子和蛋白质以及包含本发明的核酸分子的重组分子和重组细胞。 本发明还包括使用这种核酸分子和蛋白质来开发增强或抑制二元氨基酸处理内切蛋白酶活性的治疗组合物。

公开(公告)号：US5957866A

公开(公告)日：1999-09-28

申请号：US746738

申请日：1996-11-15

Applicant: Joseph Isaac Shapiro ,  Howard David Weinberger

Inventor： Joseph Isaac Shapiro ,  Howard David Weinberger

IPC: A61B5/0456 ,  A61B7/00 ,  A61B7/04 ,  G06F17/00

CPC classification number: A61B7/04 ,  A61B5/7257 ,  A61B7/003 ,  A61B5/0456 ,  A61B5/7203 ,  A61B5/726

Abstract: Apparatus for assisting an operator to diagnose physical conditions in a patient by collecting and analyzing cyclical body sounds such as heart beat, peripheral vessel sounds, or breath sounds. Several cycles of data are collected and digitized. Each cycle is converted to the frequency domain and phase fixed. Then all of the frequency converted and phase fixed cycles are signal averaged together, and the results displayed to the operator. The cycles may be sorted according to respiratory cycle and averaged in two groups. The cycles may be gated according to the patients ECG. The apparatus may suggest diagnoses or further maneuvers to be performed.

Abstract translation: 用于通过收集和分析周期性身体声音（例如心跳，外周血管声音或呼吸音）来辅助操作者诊断患者身体状况的装置。 收集和数字化数据的几个周期。 每个周期被转换为频域并相位固定。 然后将所有的频率转换和相位固定周期信号平均在一起，结果显示给操作员。 循环可根据呼吸周期进行分类，平均分为两组。 循环可以根据患者心电图进行门控。 该装置可以建议进行诊断或进一步操纵。

公开(公告)号：US5939306A

公开(公告)日：1999-08-17

申请号：US843530

申请日：1997-04-16

Applicant: Lisa A. Alex ,  Melvin I. Simon ,  Claude Selitrennikoff ,  Jacqueline Agnan

Inventor： Lisa A. Alex ,  Melvin I. Simon ,  Claude Selitrennikoff ,  Jacqueline Agnan

IPC: C07K14/37 ,  C07K14/395 ,  C07K14/40 ,  C12N1/21 ,  C12N9/12

CPC classification number: C12N9/1223 ,  C07K14/37 ,  C07K14/395 ,  C07K14/40

Abstract: The present invention relates to histidine kinases, including osmosensing fungal histidine kinases. In particular, the present invention provides amino acid and nucleic acid sequences of fungal histidine kinases from organisms such as Candida (e.g., C. albicans) and Neurospora (e.g., N. crassa). The present invention further provides compositions and methods for the development of antifungal compounds.

Abstract translation: 本发明涉及组氨酸激酶，包括渗透真菌组氨酸激酶。 特别地，本发明提供了来自生物如假丝酵母（例如白色念珠菌）和神经孢子虫（例如粗糙沙门氏菌）的真菌组氨酸激酶的氨基酸和核酸序列。 本发明还提供了用于开发抗真菌化合物的组合物和方法。

公开(公告)号：US5919606A

公开(公告)日：1999-07-06

申请号：US853463

申请日：1997-05-09

Applicant: Peter T. Kazlas ,  Douglas J. McKnight ,  Kristina M. Johnson

Inventor： Peter T. Kazlas ,  Douglas J. McKnight ,  Kristina M. Johnson

IPC: G02F1/1339

CPC classification number: G02F1/13394

Abstract: A method and apparatus for assembly of liquid crystal cells with a thin (

Abstract translation: 用于组装具有薄（<4μm），均匀（+/-100μm）单元间隙的液晶单元的方法和装置。 该方法可以用于在单个基板上组装单个或多个液晶单元。 该方法使用可光限定的聚合物树脂作为边缘密封和间隔物，并且具有几个重要步骤：旋涂限定单元间隙，图案化限定单元结构，并且热压粘合提供粘合。 用于组装具有薄的均匀单元间隙的液晶单元的方法包括以下步骤：用溶剂稀释光可定义的聚合物树脂; 将稀释的可光定影聚合物树脂施加在基材上; 通过选择性地暴露于光图案化稀释的可光定影聚合物树脂; 并且基于暴露于导致树脂图案的光而选择性地除去稀释的可光定影聚合物树脂的部分。

公开(公告)号：US5691183A

公开(公告)日：1997-11-25

申请号：US368852

申请日：1995-01-05

Applicant: Alex Franzusoff ,  Luis R. Miranda

Inventor： Alex Franzusoff ,  Luis R. Miranda

IPC: A61K36/064 ,  A61K38/00 ,  A61K39/39 ,  A61K47/48 ,  C07K14/16 ,  C12N9/60 ,  C12N9/64 ,  C12N15/113 ,  C12N15/57 ,  C12N15/81 ,  C12N15/82 ,  C12Q1/02 ,  C12Q1/37 ,  C12N15/74

CPC classification number: C12Q1/37 ,  A61K36/064 ,  A61K39/39 ,  A61K47/48776 ,  C07K14/005 ,  C12N15/1137 ,  C12N15/81 ,  C12N15/8201 ,  C12N15/8279 ,  C12N9/60 ,  C12N9/6454 ,  C12Q1/025 ,  A61K38/00 ,  C07K2319/00 ,  C12N2740/16122 ,  C12Q2337/22 ,  G01N2333/162 ,  G01N2333/395

Abstract: The present invention includes the identification and isolation of a nucleic acid molecule encoding a dibasic amino acid processing endoprotease from CD4+ T-lymphocytes as well as a protein encoded by that nucleic acid molecule. The present invention also includes related nucleic acid molecules and proteins encoded by such nucleic acid molecules as well as recombinant molecules and recombinant cells that include nucleic acid molecules of the present invention. The present invention also includes use of such nucleic acid molecules and proteins to develop therapeutic compositions that enhance or inhibit dibasic amino acid processing endoprotease activity.

Abstract translation: 本发明包括鉴定和分离编码来自CD4 + T淋巴细胞的二元氨基酸处理内蛋白酶的核酸分子以及由该核酸分子编码的蛋白质。 本发明还包括由此类核酸分子编码的相关核酸分子和蛋白质以及包含本发明的核酸分子的重组分子和重组细胞。 本发明还包括使用这种核酸分子和蛋白质来开发增强或抑制二元氨基酸处理内切蛋白酶活性的治疗组合物。