公开(公告)号：US20150276752A1

公开(公告)日：2015-10-01

申请号：US14665962

申请日：2015-03-23

Applicant: The Regents of the University of California

Inventor： Carolyn R. Bertozzi ,  Peyton Shieh

IPC: G01N33/58 ,  C09B11/08 ,  G01N33/68 ,  G01N33/50 ,  C12Q1/02 ,  C09B11/24 ,  C07B59/00

CPC classification number: G01N33/582 ,  C07F7/0816 ,  C09B11/08 ,  C09B11/24 ,  C09B11/28 ,  C09B69/008

Abstract: The present disclosure provides fluorogenic azide compounds. Also provided are methods of using the subject compounds for labelling a target biomolecule that includes an alkyne. In some embodiments, the method includes contacting the biomolecule with a fluorogenic azide compound, wherein the contacting results in covalent linkage of the compound with the alkyne moiety of the target biomolecule.

Abstract translation: 本公开提供荧光叠氮化合物。 还提供了使用本发明化合物标记包含炔烃的靶生物分子的方法。 在一些实施方案中，该方法包括使生物分子与荧光叠氮化合物接触，其中所述接触导致化合物与靶生物分子的炔部分共价连接。

公开(公告)号：US09139602B2

公开(公告)日：2015-09-22

申请号：US13673982

申请日：2012-11-09

Applicant: SAMSUNG DISPLAY CO., LTD.

Inventor： Jung-Sub Lee ,  Seung-Gak Yang

IPC: H01L51/50 ,  C07F7/10 ,  C07D491/048 ,  C07D495/04 ,  H01L51/00 ,  C07F7/08

CPC classification number: C07F7/10 ,  C07D491/048 ,  C07D495/04 ,  C07F7/0816 ,  H01L51/0032 ,  H01L51/0067 ,  H01L51/0071 ,  H01L51/0081 ,  H01L51/0085 ,  H01L51/5016 ,  H01L51/5056 ,  H01L51/5072 ,  H01L51/5088 ,  H01L51/5092

Abstract: A fused ring compound represented by Formula 1: In Formula 1, X1, X2, Y1 to Y6, Ar1 to Ar3, R1 to R11, L1 to L3, a, b, and c are as defined in the specification.

Abstract translation: 由式1表示的稠环化合物：在式1中，X1，X2，Y1至Y6，Ar1至Ar3，R1至R11，L1至L3，a，b和c如说明书中所定义。

公开(公告)号：US20150252023A1

公开(公告)日：2015-09-10

申请号：US14718296

申请日：2015-05-21

Applicant: Robert Murray McKinnell ,  Daniel D. Long

Inventor： Robert Murray McKinnell ,  Daniel D. Long

IPC: C07D401/14 ,  A61K31/496 ,  C07F7/08 ,  A61K45/06

CPC classification number: C07D401/14 ,  A61K31/496 ,  A61K45/06 ,  C07D405/14 ,  C07F7/0816

Abstract: The invention provides compounds of formulas (I) or (II): wherein the variables are defined in the specification, or a pharmaceutically-acceptable salt thereof, that are inhibitors of replication of the hepatitis C virus. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat hepatitis C viral infections, and processes and intermediates useful for preparing such compounds.

Abstract translation: 本发明提供式（I）或（II）的化合物：其中变量在说明书中定义，或其药学上可接受的盐，其是丙型肝炎病毒的复制抑制剂。 本发明还提供包含这些化合物的药物组合物，使用这些化合物治疗丙型肝炎病毒感染的方法，以及可用于制备这些化合物的方法和中间体。

公开(公告)号：US20150236271A1

公开(公告)日：2015-08-20

申请号：US14420539

申请日：2013-08-07

Applicant: DOOSAN CORPORATION

Inventor： Tae Hyung Kim ,  In Hyuk Lee ,  Hoe Moon Kim ,  Jin Yong Shin ,  Ho Cheol Park ,  Chang Jun Lee ,  Young Mi Beak ,  Eun Jung Lee

IPC: H01L51/00 ,  C07D495/04 ,  C09K11/06 ,  C07F7/08 ,  C07D517/04 ,  C07D403/14 ,  C07D487/04 ,  C07D491/048

CPC classification number: H01L51/0072 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D403/10 ,  C07D403/14 ,  C07D471/04 ,  C07D487/04 ,  C07D491/048 ,  C07D495/04 ,  C07D517/04 ,  C07D519/00 ,  C07F7/0816 ,  C09B57/00 ,  C09K11/06 ,  C09K2211/1007 ,  C09K2211/1011 ,  C09K2211/1029 ,  C09K2211/1033 ,  C09K2211/1037 ,  C09K2211/104 ,  C09K2211/1044 ,  C09K2211/1059 ,  C09K2211/1062 ,  C09K2211/1066 ,  C09K2211/107 ,  C09K2211/1074 ,  H01L51/0052 ,  H01L51/0058 ,  H01L51/0067 ,  H01L51/0094 ,  H01L51/5012 ,  H01L51/5016 ,  H01L51/5056 ,  H01L51/5088 ,  H01L51/5206 ,  H01L51/5221 ,  H01L2251/308 ,  H05B33/14

Abstract: The present invention relates to a novel compound and an organic electroluminescence device including the same, and the compound according to the present invention may be used in an organic material layer, preferably a light-emitting layer of an organic electroluminescence device, thereby enhancing the light-emitting efficiency, driving voltage, lifespan, and the like of the organic electroluminescence device.

Abstract translation: 本发明涉及一种新颖的化合物和包含该化合物的有机电致发光器件，根据本发明的化合物可以用于有机电致发光器件的有机材料层，优选发光层，从而增强光 - 有机电致发光器件的效率，驱动电压，寿命等。

公开(公告)号：US20150219676A1

公开(公告)日：2015-08-06

申请号：US14597408

申请日：2015-01-15

Applicant: Dan Yang ,  Nai-Kei Wong ,  Jun Hu

Inventor： Dan Yang ,  Nai-Kei Wong ,  Jun Hu

IPC: G01N33/84 ,  G01N33/58 ,  C07D491/20 ,  C07F7/08 ,  C07D493/10 ,  C07D311/82

CPC classification number: G01N33/84 ,  C07D311/82 ,  C07D491/20 ,  C07D493/10 ,  C07F7/0816 ,  C07F9/6561 ,  G01N33/582

Abstract: The invention provides fluorogenic compounds and probes that can be used as reagents for measuring, detecting and/or screening superoxide. The fluorogenic compounds of the invention can produce fluorescence colors, such as green, yellow, red, or far-red. The invention further provides fluorogenic compounds for selectively staining superoxide in the mitochondria of living cells. The invention also provides methods that can be used to measure, directly or indirectly, the presence and/or amount of superoxide in chemical samples and biological samples such as cells and tissues in living organisms, and a high-throughput screening methods for detecting or screening superoxide or compounds that can increase or decrease the level of superoxide in chemical and biological samples.

Abstract translation: 本发明提供可用作测量，检测和/或筛选超氧化物的试剂的荧光化合物和探针。 本发明的荧光化合物可以产生荧光颜色，例如绿色，黄色，红色或远红色。 本发明还提供了用于选择性染色活细胞线粒体中超氧化物的荧光化合物。 本发明还提供了可用于直接或间接测量化学样品和生物样品如生物体中的细胞和组织的超氧化物的存在和/或量的方法，以及用于检测或筛选的高通量筛选方法 超氧化物或可增加或降低化学和生物样品中超氧化物水平的化合物。

公开(公告)号：US20150057246A1

公开(公告)日：2015-02-26

申请号：US14345130

申请日：2012-09-11

Applicant: Michael P. Dwyer ,  Kartik M. Keertikar ,  Qingbei Zeng ,  Robert D. Mazzola, JR. ,  John P. Caldwell ,  Haiqun Tang ,  Anilkumar Gopinadhan Nair ,  Bandarpalle B. Shankar ,  Stuart B. Rosenblum ,  Joseph A. Kozlowski

Inventor： Michael P. Dwyer ,  Kartik M. Keertikar ,  Qingbei Zeng ,  Robert D. Mazzola, JR. ,  John P. Caldwell ,  Haiqun Tang ,  Anilkumar Gopinadhan Nair ,  Bandarpalle B. Shankar ,  Stuart B. Rosenblum ,  Joseph A. Kozlowski

IPC: C07F7/08 ,  A61K45/06 ,  A61K31/695

CPC classification number: C07F7/0816 ,  A61K31/695 ,  A61K45/06 ,  Y02A50/385 ,  Y02A50/387 ,  Y02A50/389 ,  Y02A50/395

Abstract: The present invention relates to novel Silyl-Containing Heterocyclic Compounds of Formula (I): (I) and pharmaceutically acceptable salts thereof, wherein A, B, C, D and R2 are as defined herein. The present invention also relates to compositions comprising at least one Silyl-Containing Heterocyclic Compound, and methods of using the Silyl-Containing Heterocyclic Compounds for treating or preventing HCV infection in a patient.

Abstract translation: 本发明涉及式（I）的新的含甲硅烷基的杂环化合物：（I）及其药学上可接受的盐，其中A，B，C，D和R2如本文所定义。 本发明还涉及包含至少一种含甲硅烷基的杂环化合物的组合物，以及使用含有甲硅烷基的杂环化合物治疗或预防患者HCV感染的方法。

公开(公告)号：US20150034161A1

公开(公告)日：2015-02-05

申请号：US14379468

申请日：2013-02-19

Applicant: Next Energy Technologies, Inc.

Inventor： Arnold B. Tamayo ,  Corey V. Hoven ,  Thomas K. Wood ,  Braden Smith

IPC: H01L51/00 ,  H01L51/42 ,  C08G61/12 ,  C07D513/04 ,  C07F7/10

CPC classification number: H01L51/0071 ,  B82Y10/00 ,  C07D513/04 ,  C07F7/0807 ,  C07F7/0816 ,  C07F7/10 ,  C08G61/126 ,  C08G2261/3243 ,  C08G2261/3246 ,  C08G2261/91 ,  H01L51/0035 ,  H01L51/0047 ,  H01L51/0068 ,  H01L51/0094 ,  H01L51/42 ,  H01L51/4253 ,  Y02E10/549

Abstract: Organic molecule semi-conducting chromophores containing a halogen-substituted core structure are disclosed. Such compounds can be used in organic heterojunction devices, such as organic molecule solar cells and transistors.

Abstract translation: 公开了含有卤素取代的核心结构的有机分子半导发色团。 这种化合物可用于有机异质结装置，例如有机分子太阳能电池和晶体管。

公开(公告)号：US20140314677A1

公开(公告)日：2014-10-23

申请号：US14215979

申请日：2014-03-17

Applicant: VisEn Medical, Inc.

Inventor： Kevin Groves ,  Ryan Buff

IPC: C07F7/08 ,  A61K49/00 ,  G01N33/569 ,  A61K47/48

CPC classification number: A61K47/48023 ,  A61K47/48092 ,  A61K47/48384 ,  A61K49/0019 ,  A61K49/0021 ,  A61K49/0052 ,  A61K49/0054 ,  C07F7/0816 ,  C09B11/28 ,  C09B69/008 ,  G01N33/56966

Abstract: The invention provides a family of fluorescent compounds. The compounds are substituted silaxanthenium compounds that can be chemically linked to one or more biomolecules, such as a protein, nucleic acid, and therapeutic small molecule. The compounds can be used for imaging in a variety of medical, biological and diagnostic applications. The dyes are particularly useful for in vitro, in vivo and ex vivo imaging applications.

Abstract translation: 本发明提供一系列荧光化合物。 这些化合物是可以与一种或多种生物分子如蛋白质，核酸和治疗性小分子化学连接的取代的硅氧烷henium化合物。 该化合物可用于各种医学，生物和诊断应用中的成像。 染料特别适用于体外，体内和离体成像应用。

公开(公告)号：US08853679B2

公开(公告)日：2014-10-07

申请号：US13387020

申请日：2010-08-05

Applicant: Sheena Zuberi ,  Tania Zuberi

Inventor： Sheena Zuberi ,  Tania Zuberi

IPC: H01L29/12

CPC classification number: C07D495/04 ,  C07D495/14 ,  C07D495/22 ,  C07F7/0816 ,  H01L51/0074 ,  H01L51/0545

Abstract: A semiconducting compound comprising the structure: where R1 to R4 independently comprise, but are not limited to, optionally substituted straight, branched or cyclic alkyl chains having 2 to 20 (e.g. 2 to 12) carbon atoms, alkoxy, amino, amido, silyl, alkyl, alkenyl, aryl or hetero aryl; where X1 and X2 independently comprise S, O, NR5 or SiR6R7 where R8 to R7 independently comprise C1 to C5 branched, straight or cyclic alkyl chains; and where Ar1 comprises a heterocyclic ring, and where n is an integer between 1 and 4.

Abstract translation: 包含以下结构的半导体化合物：其中R 1至R 4独立地包括但不限于任选取代的具有2至20（例如2至12）个碳原子的直链，支链或环状烷基链，烷氧基，氨基，酰胺基，甲硅烷基， 烷基，烯基，芳基或杂芳基; 其中X1和X2独立地包含S，O，NR5或SiR6R7，其中R8至R7独立地包含C1至C5支链的直链或环状烷基链; 并且其中Ar 1包含杂环，并且其中n是1和4之间的整数。

公开(公告)号：US20140296133A1

公开(公告)日：2014-10-02

申请号：US14350766

申请日：2012-10-11

Applicant: Council of Scientific & Industrial Research

Inventor： Dumbala Srinivasa Reddy ,  Seetharam Singh Balamkundu ,  Remya Ramesh

IPC: C07F7/10 ,  A61K45/06 ,  A61K31/695

CPC classification number: C07F7/10 ,  A61K31/695 ,  A61K45/06 ,  C07F7/0816 ,  Y02A50/473

Abstract: The invention discloses silaanalogs of oxazolidinone compounds, to pharmaceutical compositions and to the synthesis of the oxazolidinone derivatives of formula I. The invention further relates to methods of treating a subject suffering with gram positive pathogens including those resistant to methicillin and vancomycin using the compound(s) or modulation of coagulation properties of blood-clotting cascade or compositions of the oxazolidinone derivatives of the invention.

Abstract translation: 本发明公开了恶唑烷酮化合物的硅醛阴离子，药物组合物和式I的恶唑烷酮衍生物的合成。本发明还涉及使用化合物（s）治疗患有革兰氏阳性病原体的受试者，包括耐甲氧西林和万古霉素的受试者的方法 ）或调节血液凝固级联的凝血特性或本发明的恶唑烷酮衍生物的组合物。