摘要:
A family of covalent kinetic stabilizer compounds that selectively and covalently react with the prominent plasma protein transthyretin in preference to more than 4000 other human plasma proteins is disclosed. A contemplated compound corresponds in structure to Formula I, below, where the various substituents are defined within, and reacts chemoselectively with one or two of four Lys-15 ε-amino groups within the transthyretin tetramer. The crystal structure confirms the binding orientation of the compound substructure and the conjugating amide bond. A covalent transthyretin kinetic stabilizer exhibits superior amyloid inhibition potency, compared to a non-covalent counterpart, and inhibits cytotoxicity associated with amyloidogenesis.
摘要:
An aqueous coloring composition for textile printing, the aqueous coloring composition being capable of forming an image which exhibits a high color optical density and excellent water resistance; a textile printing method and a kit, using the same; and a fabric, in which an image exhibiting both a high color optical density and excellent water resistance is formed, are provided. The aqueous coloring composition for textile printing includes a colorant and water, in which the molecule of the colorant contains both a chromophoric group and a dissociable group which is in a dissociated state, the chromophoric group and a negative electric charge generated by the dissociation of the dissociable group form a conjugated system, and the number of dissociable groups in the molecule of the colorant is the same as the number of chromophoric groups therein.
摘要:
A family of covalent kinetic stabilizer compounds that selectively and covalently react with the prominent plasma protein transthyretin in preference to more than 4000 other human plasma proteins is disclosed. A contemplated compound corresponds in structure to Formula I, below, where the various substituents are defined within, and reacts chemoselectively with one or two of four Lys-15 ε-amino groups within the transthyretin tetramer. The crystal structure confirms the binding orientation of the compound substructure and the conjugating amide bond. A covalent transthyretin kinetic stabilizer exhibits superior amyloid inhibition potency, compared to a non-covalent counterpart, and inhibits cytotoxicity associated with amyloidogenesis.
摘要:
A family of covalent kinetic stabilizer compounds that selectively and covalently react with the prominent plasma protein transthyretin in preference to more than 4000 other human plasma proteins is disclosed. A contemplated compound corresponds in structure to Formula I, below, where the various substituents are defined within, and reacts chemoselectively with one or two of four Lys-15 ε-amino groups within the transthyretin tetramer. The crystal structure confirms the binding orientation of the compound substructure and the conjugating amide bond. A covalent transthyretin kinetic stabilizer exhibits superior amyloid inhibition potency, compared to a non-covalent counterpart, and inhibits cytotoxicity associated with amyloidogenesis.
摘要:
An azo dye represented by the following formula (I): wherein, in formula (I), R1, R2, R3, and R4 each independently represent a hydrogen atom, an aliphatic group, an aryl group, a halogen atom, an acyl group, a cyano group, an acylamino group, an aliphatic oxycarbonyl group, an aryloxycarbonyl group, a carbamoyl group, an aliphatic sulfonyl group, an arylsulfonyl group, a sulfamoyl group, an aliphatic oxycarbonylamino group, an aryloxycarbonylamino group, a sulfo group, a carboxyl group, a carbamoylamino group, a sulfamoylamino group, or an aliphatic- or aromatic-sulfonylamino group, wherein R1 and R2 and/or R3 and R4 may be combined with each other to form a five- or six-membered aromatic ring or non-aromatic ring; X represents a carbon atom or a nitrogen atom, wherein n is 0 when X is a nitrogen atom and n is 1 when X is a carbon atom; A, B, C, and D each represent a carbon atom or a nitrogen atom, provided that at least one of A, B, C and D represents a nitrogen atom; Y represents a substituent; and m denotes an integer from 0 to 3.
摘要:
An azo dye represented by the following formula (I): wherein, in formula (I), R1, R2, R3, and R4 each independently represent a hydrogen atom, an aliphatic group, an aryl group, a halogen atom, an acyl group, a cyano group, an acylamino group, an aliphatic oxycarbonyl group, an aryloxycarbonyl group, a carbamoyl group, an aliphatic sulfonyl group, an arylsulfonyl group, a sulfamoyl group, an aliphatic oxycarbonylamino group, an aryloxycarbonylamino group, a sulfo group, a carboxyl group, a carbamoylamino group, a sulfamoylamino group, or an aliphatic- or aromatic-sulfonylamino group, wherein R1 and R2 and/or R3 and R4 may be combined with each other to form a five- or six-membered aromatic ring or non-aromatic ring; X represents a carbon atom or a nitrogen atom, wherein n is 0 when X is a nitrogen atom and n is 1 when X is a carbon atom; A, B, C, and D each represent a carbon atom or a nitrogen atom, provided that at least one of A, B, C and D represents a nitrogen atom; Y represents a substituent; and m denotes an integer from 0 to 3.
摘要:
Provided is the azobenzene derivative denoted by general formula (I). In general formula (I), R1 denotes a hydrogen atom or the like; Ar1 and Ar2 each independently denote an arylene group optionally comprising a substituent R or an aromatic heterocycle optionally comprising a substituent R, wherein Ar1 and Ar2 which are bonded through an azo group comprise at least two substituents denoted by R in total and multiple atoms and/or substituents denoted by R may be identical or different; R denotes a halogen atom or the like; X denotes an alkylene group optionally comprising a hetero atom; X1 denotes —NH— or the like; Y denotes a hydrogen atom or the like; a denotes an integer ranging from 0 to 2; and m and n each independently denote an integer ranging from 1 to 8.
摘要翻译:提供由通式(I)表示的偶氮苯衍生物。 在通式(I)中,R 1表示氢原子等; Ar 1和Ar 2各自独立地表示任选地包含取代基R的芳基或任选地包含取代基R的芳族杂环,其中Ar 1, 和通过偶氮基键合的Ar 2包括至少两个由R表示的取代基,R表示的多个原子和/或取代基可以相同或不同; R表示卤素原子等; X表示任选地包含杂原子的亚烷基; X 1表示-NH-等; Y表示氢原子等; a表示0〜2的整数, m和n各自独立地表示1〜8的整数。