公开(公告)号：US20230073067A1

公开(公告)日：2023-03-09

申请号：US17763621

申请日：2021-02-23

Applicant: Institute of Microbiology, Chinese Academy of Science

Inventor： Jinghua YAN ,  Rui SHI ,  Qihui WANG ,  Fu GAO ,  Sufang MA

IPC: C07K16/10 ,  G01N33/577 ,  G01N33/569 ,  A61P31/14

Abstract: Provided in the present invention are a humanized monoclonal antibody for the 2019 novel coronavirus (2019-nCOV) and the use thereof. The antibody is capable of specifically binding with a receptor binding domain (RBD) of 2019-nCOV and blocking the binding between the RBD of 2019-nCOV and ACE2, and furthermore inhibiting the infection caused by 2019-nCOV.

公开(公告)号：US11585808B2

公开(公告)日：2023-02-21

申请号：US17174431

申请日：2021-02-12

Applicant: Siemens Healthcare Diagnostics Inc.

Inventor： David Ledden

IPC: G01N33/543 ,  G01N33/487 ,  G01N33/53 ,  G01N33/541 ,  G01N33/573 ,  G01N33/577 ,  G01N33/68 ,  G01N33/74

Abstract: Devices, methods, and kits for detecting at least two analytes present within a small volume single fluid sample obtained from patient for the creation of a multiplexed panel of the various analytes present within the single fluid sample are disclosed.

公开(公告)号：US20230045855A1

公开(公告)日：2023-02-16

申请号：US17936729

申请日：2022-09-29

Applicant: YEDA RESEARCH AND DEVELOPMENT CO., LTD.

Inventor： Rachel SOREK ,  Keren JAKOBI-BROOK ,  Pennina SAFER ,  Irun R. COHEN

IPC: G01N33/564 ,  G01N33/577

Abstract: Assays and methods for diagnosing and treating autoimmune diseases. Particularly, the invention provides methods for differential diagnosis of specific autoimmune diseases, including autoimmune rheumatic disorders.

公开(公告)号：US20230043289A1

公开(公告)日：2023-02-09

申请号：US17846302

申请日：2022-06-22

Applicant: AC Immune SA ,  Genentech, Inc.

Inventor： Oskar Adolfsson ,  Isidro Hotzel ,  Danielle DiCara

IPC: C07K16/18 ,  A61K47/68 ,  A61K39/395 ,  A61K45/06 ,  G01N33/577 ,  A61P25/00 ,  A61P25/16 ,  A61P25/28

Abstract: The invention provides anti-Tau antibodies and methods of using the same.

公开(公告)号：US11573223B2

公开(公告)日：2023-02-07

申请号：US16838889

申请日：2020-04-02

Applicant: SHANGHAI INZEX BIOTECHNOLOGY CO., LTD.

Inventor： Fengbo Wu ,  Yongyan Nie ,  Xiaojuan Shi

IPC: G01N33/53 ,  G01N33/94 ,  G01N33/50 ,  G01N33/543 ,  G01N33/487 ,  G01N33/577 ,  G01N1/44 ,  G01N1/40 ,  G01N1/28 ,  G01N33/533 ,  G01N33/537 ,  G01N1/38

Abstract: A reagent for extracting immunosuppressant drugs from a whole blood sample for immunoassay includes protein denaturant, proteolytic enzyme, surfactant and pH buffer. A method and an immunoassay kit for detection of the immunosuppressant concentration in a whole blood sample uses the extraction reagent. The extraction reagent doesn't need the use of organic solvent as that in the traditional extraction methods, therefore the adverse effects of the organic solvent on the antibody activity in a detection system and the other relative defects associated to its use are obviated. The drug extraction process doesn't need centrifugation, as the processed sample can be directly applied for immunoassay. The operation for drug extraction is simple, and the detection result based on this extraction method is accurate.

公开(公告)号：US11560424B2

公开(公告)日：2023-01-24

申请号：US17111159

申请日：2020-12-03

Applicant: MedImmune Limited

Inventor： Darren Schofield ,  Michael Perkinton ,  Lorraine Irving ,  George Thom

IPC: A61K45/00 ,  G01N33/567 ,  C07K16/18 ,  G01N33/537 ,  G01N33/543 ,  G01N33/577 ,  G01N33/68 ,  A61K39/00

Abstract: The invention provides antibodies that specifically bind human α-synuclein with a high affinity and reduces α-synuclein spreading in vivo, recombinant polypeptides comprising said antibodies or antigen-binding fragment thereof and methods for generating such polypeptides, as well as compositions and methods for generating α-synuclein antibodies, and methods of using α-synuclein antibodies for the treatment of diseases of the central nervous system, in particular alpha-synucleinopathies.

公开(公告)号：US20220349879A1

公开(公告)日：2022-11-03

申请号：US17778122

申请日：2020-11-04

Applicant: TOSOH CORPORATION

Inventor： Yu MUTO ,  Kouichi MISAWA

IPC: G01N33/543 ,  G01N33/577

Abstract: The invention provides an assay method for an assay system using an anti-immunocomplex antibody, which is able to increase reaction efficiency. The n immunoassay method uses: an anti-hapten rabbit monoclonal antibody immobilized on a water-insoluble carrier, and a labeled anti-immunocomplex antibody, wherein the method comprises the following steps (i) to (iii): (i) a step of reacting the anti-hapten rabbit monoclonal antibody immobilized on the water-insoluble carrier with a hapten in a solution to be measured, (ii) a step of reacting the labeled anti-immunocomplex antibody with the hapten-anti-hapten rabbit monoclonal antibody immune complex, and (iii) a step of detecting the signal from the label.

公开(公告)号：US11480568B2

公开(公告)日：2022-10-25

申请号：US16133295

申请日：2018-09-17

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： Rachel Sorek ,  Keren Jakobi-Brook ,  Pennina Safer ,  Irun R. Cohen

IPC: G01N33/564 ,  G01N33/577

Abstract: Assays and methods for diagnosing and treating autoimmune diseases. Particularly, the invention provides methods for differential diagnosis of specific autoimmune diseases, including autoimmune rheumatic disorders.

公开(公告)号：US11406976B2

公开(公告)日：2022-08-09

申请号：US16500190

申请日：2018-03-28

Applicant: Dublin City University

Inventor： Robert Forster ,  Elaine Spain ,  Kellie Adamson ,  Eadaoin Carthy ,  David Boyle

IPC: B01L3/00 ,  G01N27/07 ,  G01N33/543 ,  G01N33/569 ,  G01N33/577 ,  G01N35/00

Abstract: A microfluidic device for detection of an analyte in a fluid is described. The microfluidic device comprises a substrate having a first surface defining entrances to one or more chambers defined in the substrate, surfaces of the chambers defining a second surface of the substrate, the first surface being modified for selective targeting and capture of at least one analyte to operably effect a blocking of the entrance to at least one of the chambers, and wherein a response characteristic of the microfluidic device is operably varied by the blocking of the entrance to the at least one of the chambers, thereby providing an indication of the presence of the analyte within the fluid.

公开(公告)号：US20220211017A1

公开(公告)日：2022-07-07

申请号：US17668086

申请日：2022-02-09

Applicant: VERSITI BLOOD RESEARCH INSTITUTE FOUNDATION, INC.

Inventor： Peter J. Newman ,  Huiying Zhi

IPC: A01K67/027 ,  C07K14/705 ,  G01N33/50 ,  C12N15/89 ,  G01N33/577

Abstract: A transgenic mouse comprising T30A, S32P, Q33L, N39D, and M470Q mutations in GPIIIa, as well as methods for making the transgenic mouse and methods for using the transgenic mouse to screen test compounds are described.