公开(公告)号：US10155718B2

公开(公告)日：2018-12-18

申请号：US15819646

申请日：2017-11-21

Applicant: FMC CORPORATION

Inventor： Donald J. Dumas

IPC: C07C201/12 ,  C07C253/14 ,  C07C231/02

Abstract: A method for preparing 3-methyl-2-nitrobenzoic acid is disclosed wherein 1,3-dimethyl-2-nitrobenzene is combined with an oxidation catalayst in the presence of an oxygen source and an initiator, provided that less than 99% of the 1,3-dimethyl-2-nitrobenzene is oxidized.A method for preparing compounds of Formula 7 and Formula 11 is also disclosed wherein the method is characterized by using 3-methyl-2-nitrobenzoic acid as prepared by the method disclosed above wherein R1 is C1-C7 alkyl, C3-C6 cycloalkyl or C4-C7 alkylcycloalkyl.

公开(公告)号：US20180345260A1

公开(公告)日：2018-12-06

申请号：US15778376

申请日：2016-11-21

Applicant: MICROBIAL CHEMISTRY RESEARCH FOUNDATION

Inventor： Masakatsu SHIBASAKI ,  Naoya KUMAGAI ,  Akihito NONOYAMA ,  Kazuki HASHIMOTO ,  Akira SAITO

IPC: B01J31/22 ,  B01J37/04 ,  C07C201/12 ,  C07C205/16 ,  C07C205/54 ,  C07C237/04

CPC classification number: B01J31/22 ,  B01J37/04 ,  B01J2231/341 ,  B01J2531/004 ,  B01J2531/12 ,  B01J2531/38 ,  C07B61/00 ,  C07C201/12 ,  C07C205/16 ,  C07C205/32 ,  C07C205/54 ,  C07C237/04 ,  C07C237/22 ,  C07F7/003

Abstract: A catalyst including: neodymium; sodium; and a ligand, which is a compound expressed by Structural Formula (1) below, wherein the neodymium and the ligand form a complex at a molar ratio of 1:2 (neodymium:ligand):

公开(公告)号：US20180334414A1

公开(公告)日：2018-11-22

申请号：US15580838

申请日：2016-06-01

Applicant: Oxford University Innovation Limted

Inventor： Stephen P. Fletcher ,  Mireia Sidera Portela

IPC: C07C1/32 ,  C07C41/30 ,  C07C17/263 ,  C07C67/343 ,  C07C201/12 ,  C07F7/18 ,  C07D309/18 ,  C07D333/08 ,  C07D307/79 ,  C07D231/56 ,  C07D213/61 ,  C07D209/08 ,  C07D211/70

Abstract: Processes of forming Csp2—Csp3 bonds at the allylic carbon of a cyclic allylic compound starting material are disclosed, in which a racemic mixture of a cyclic allylic compound having a leaving group attached to the allylic carbon is reacted with a compound having a nucleophilic carbon atom in the presence of a Rh(I), Pd(II) or Cu(I) pre-catalyst and a chiral ligand. The reaction products containing the newly-formed Csp2—Csp3 bond are generated in high stereoisomeric excess, and may therefore serve as important organic building blocks in the preparation of new agrochemicals and pharmaceuticals.

公开(公告)号：US20180326409A1

公开(公告)日：2018-11-15

申请号：US16044576

申请日：2018-07-25

Applicant: KING FAHD UNIVERSITY OF PETROLEUM AND MINERALS

Inventor： Bassam El ALI ,  Mansur B. Ibrahim

IPC: B01J31/22 ,  C07C201/12 ,  B01J35/02 ,  C07C51/377 ,  C07C51/06 ,  C07C51/09 ,  C07C51/353 ,  C07C51/367 ,  C07C51/373 ,  C07C57/44 ,  C07C59/64 ,  C07C59/84 ,  C07C205/53

CPC classification number: B01J31/2295 ,  B01J21/08 ,  B01J35/023 ,  B01J35/026 ,  B01J2231/4261 ,  B01J2531/824 ,  C07C51/06 ,  C07C51/09 ,  C07C51/353 ,  C07C51/367 ,  C07C51/373 ,  C07C51/377 ,  C07C201/12 ,  C07C57/44 ,  C07C59/64 ,  C07C59/84 ,  C07C205/53

Abstract: A solid-supported palladium(II) complex which catalyzes the Mizoroki-Heck coupling reaction efficiently and a method of employing the solid-supported palladium(II) complex to synthesize cinnamic acid and derivatives thereof. The solid-supported palladium(II) complex is also stable and can be recycled without significantly losing catalytic activity.

公开(公告)号：US10125159B2

公开(公告)日：2018-11-13

申请号：US15610269

申请日：2017-05-31

Applicant: KING FAHD UNIVERSITY OF PETROLEUM AND MINERALS

Inventor： M. Nasiruzzaman Shaikh ,  Md. Abdul Aziz ,  Aasif Helal

IPC: C07F15/02 ,  C07C45/50 ,  B01J31/28 ,  B01J31/22 ,  B01J35/00 ,  B01J35/02 ,  C07C41/30 ,  C07C201/12 ,  C07F17/02 ,  C07C2/86 ,  C07C17/269

Abstract: A functionalized magnetic nanoparticle including an organometallic sandwich compound and a magnetic metal oxide. The functionalized magnetic nanoparticle may be reacted with a metal precursor to form a catalyst for various C—C bond forming reactions. The catalyst may be recovered with ease by attracting the catalyst with a magnet.

公开(公告)号：US10099981B2

公开(公告)日：2018-10-16

申请号：US15809305

申请日：2017-11-10

Applicant: The University of Georgia Research Foundation, Inc.

Inventor： Eric Ferreira ,  Qiankun Li

IPC: C07C41/18 ,  C07C269/06 ,  C07C67/333 ,  C07D209/08 ,  C07C201/12 ,  C07D317/60 ,  C07C45/67 ,  C07C67/31 ,  C07C41/28 ,  C07C45/64

Abstract: Provided are methods for the meta-selective C—H arylations of arene alcohol-based substrates. The methods combine the transient norbornene strategy with a quinoline-based acetal scaffold to achieve the formation of biaryl compounds. These processes establish a foundation for catalytic polyfunctionalization of alcohol-based compounds. The method comprises attaching a heterocyclic hemiacetal scaffold to an aromatic alcohol or a substituted aromatic alcohol; reacting the aromatic or substituted aromatic alcohol having the heterocyclic hemiacetal scaffold attached with an alkyl or aryl iodide in a reaction mix comprising a palladium catalyst, a silver salt, and carboxymethyl norbornene to generate a meta-arylated arene conjugated to the heterocyclic hemiacetal scaffold; and then cleaving the heterocyclic hemiacetal scaffold from the meta-arylated arene alcohol.

公开(公告)号：US09957286B2

公开(公告)日：2018-05-01

申请号：US15427179

申请日：2017-02-08

Applicant: Universidad de Guanajuato

Inventor： Ignacio Rene Galindo Esquivel ,  Juan Manuel Juarez Ruiz ,  Orlando Regalado Oliva

IPC: C07C201/12 ,  C07F7/18 ,  B01J31/06 ,  C07D209/34

CPC classification number: C07F7/1804 ,  B01J31/061 ,  B01J31/062 ,  B01J31/069 ,  B01J2231/342 ,  B01J2231/346 ,  B01J2231/348 ,  C07C201/12 ,  C07D209/34

Abstract: This invention describes the methodology to produce solid heterogeneous chiral organocatalysts that can be used in condensation reactions. The catalysts can be recovered in a simple manner by filtration and can also be reused.

公开(公告)号：US09926270B2

公开(公告)日：2018-03-27

申请号：US14830638

申请日：2015-08-19

Applicant: Dermira, Inc.

Inventor： Anthony Adrian Shaw ,  Enrico Vigano ,  Renato Molteni

IPC: C07D207/12 ,  C07C309/73 ,  C07C303/22 ,  C07C201/12 ,  C07C309/30

CPC classification number: C07D207/12 ,  B01D9/00 ,  C07C63/24 ,  C07C67/08 ,  C07C69/608 ,  C07C201/12 ,  C07C303/22 ,  C07C309/30 ,  C07C309/73 ,  C07F11/005 ,  C07C205/57

Abstract: Provided herein are methods for the production of glycopyrronium tosylate and glycopyrronium tosylate compositions. Also provided herein are compositions useful in the production of glycopyrronium tosylate. Additionally provided herein are glycopyrronium tosylate compositions. Glycopyrronium tosylate is useful for the treatment of, among other conditions, hyperhidrosis.

公开(公告)号：US20180016211A1

公开(公告)日：2018-01-18

申请号：US15717327

申请日：2017-09-27

Applicant: Syngenta Crop Protection, LLC

Inventor： Denis GRIBKOV ,  Bjorn ANTELMANN ,  Fanny BOIS ,  Harald WALTER ,  Alain DE MESMAEKER

IPC: C07C17/32 ,  C07C205/12 ,  C07C205/11 ,  C07C201/12 ,  C07C205/06 ,  C07C22/04 ,  C07C17/26 ,  C07C17/23 ,  C07C17/266 ,  C07C209/36 ,  C07C22/02

CPC classification number: C07C17/32 ,  C07C17/23 ,  C07C17/26 ,  C07C17/266 ,  C07C22/02 ,  C07C22/04 ,  C07C201/12 ,  C07C205/06 ,  C07C205/11 ,  C07C205/12 ,  C07C209/365 ,  C07C2601/10 ,  C07C2603/66 ,  C07C211/61

Abstract: The present invention relates to a novel a process for the preparation of 9-dichloromethylene-1,2,3,4-tetrahydro-1,4-methano-naphthalen-5-ylamine which process comprises a) reacting cyclopentadiene in the presence of a radical initiator and CXCl3, wherein X is chloro or bromo, to a compound of formula II, or aa) reacting cyclopentadiene with CXCl3, wherein X is chloro, in the presence of a metal catalyst to a compound of formula II, wherein X is chloro, b) reacting the compound of formula II with a base in the presence of an appropriate solvent to the compound of formula III, c) and converting the compound of formula III in the presence of 1,2-dehydro-6-nitrobenzene to the compound of formula IV, and d) hydrogenating the compound of formula IV in the presence of a metal catalyst.

公开(公告)号：US09828328B2

公开(公告)日：2017-11-28

申请号：US15313365

申请日：2015-05-29

Applicant: E I DU PONT DE NEMOURS AND COMPANY

Inventor： Stephen Ernest Jacobson ,  Donald J. Dumas ,  Rupert Spence ,  Sarah May Crawford ,  Venkateswara Rao Surisetty

IPC: C07C201/12 ,  C07C231/02 ,  C07C253/14

CPC classification number: C07C201/12 ,  C07C231/02 ,  C07C253/14 ,  C07C205/57

Abstract: A method for preparing 3-methyl-2-nitrobenzoic acid is disclosed wherein 1,3-dimethyl-2-nitrobenzene is combined with an oxidation catalyst in the presence of an oxygen source and an initiator, provided that less than 99% of the 1,3-dimethyl-2-nitrobenzene is oxidized.A method for preparing compounds of Formula 7 and Formula 11 is also disclosed wherein the method is characterized by using 3-methyl-2-nitrobenzoic acid as prepared by the method disclosed above. wherein R1 is C1-C7 alkyl, C3-C6 cycloalkyl or C4-C7 alkylcycloalkyl.