公开(公告)号：US10466326B2

公开(公告)日：2019-11-05

申请号：US15574431

申请日：2016-05-13

Applicant: STC.UNM

Inventor： Laurel Sillerud

IPC: G01R33/56 ,  G01R33/465 ,  B82Y15/00 ,  G06T7/00

Abstract: A method of measuring the concentration of a magnetic material in an object using magnetic resonance imaging comprising administering magnetic material to the object; obtaining a set of T1-weighted and T2-weighted images of the object in order to determine a background magnetic resonance imaging signal intensity and measurements of the background nuclear magnetic relaxation times (T1, T2) of the object without magnetic material; and obtaining a set of T1-weighted and T2-weighted magnetic resonance images of the object with magnetic materials added; measuring effect of magnetic material on the relaxation times; and converting the T1-weighted and T2-weighted images into a set of contrast images which are subtracted from each other to yield a contrast difference image proportional to the concentration of the magnetic material.

公开(公告)号：US20190256827A1

公开(公告)日：2019-08-22

申请号：US16227279

申请日：2018-12-20

Applicant: STC.UNM

Inventor： Fu-Sen Liang ,  Tingjun Chen ,  Dan Gao

IPC: C12N9/10 ,  C12N9/22 ,  C12N15/11 ,  C12N15/85

Abstract: An epigenome editing system generally includes three exogenous coding regions. The first exogenous coding region encodes a first polypeptide that includes an epigenetic editing domain and a domain that, in the presence of an inducer, forms a complex with a second polypeptide. The second exogenous coding region encodes the second polypeptide, which includes a dCas9 domain and a domain that, in the presence of the inducer, forms a complex with the first polypeptide. The third exogenous coding region encodes an sgRNA sequence that targets the dCas9 domain to a genomic locus.

公开(公告)号：US10389745B2

公开(公告)日：2019-08-20

申请号：US15750236

申请日：2016-08-04

Applicant: STC.UNM

Inventor： Abdullah Mueen ,  Nikan Chavoshi

IPC: G06F11/00 ,  G06F12/14 ,  G06F12/16 ,  G08B23/00 ,  H04L29/06 ,  G06F16/22 ,  G06Q50/00 ,  G06F21/57

Abstract: Bots are detected real-time by correlating activity between users using a lag-sensitive hashing technique that captures warping-invariant correlation. Correlated users groups in social media may be found that represent bot behavior with thousands of bot accounts detected in a couple of hours.

公开(公告)号：US20190227226A1

公开(公告)日：2019-07-25

申请号：US16254970

申请日：2019-01-23

Applicant: STC.UNM

Inventor： Behnam ABAIE ,  Arash MAFI

IPC: G02B6/02

Abstract: A hollow core optical fiber guide is provided that comprises a body for reflecting light comprising a first end, a second end, a longitudinal dimension extending between the first end and the second end, an inner sidewall, an outer sidewall, and a transverse dimension extending radially between the inner sidewall and the outer sidewall, wherein the body comprises a plurality of optically dielectric material and each of the plurality of dielectric material having a different refractive index; and a light guiding core region disposed within the body.

公开(公告)号：US20190202922A1

公开(公告)日：2019-07-04

申请号：US16333898

申请日：2017-09-21

Applicant: STC.UNM ,  LOS ALAMOS NATIONAL SECURITY, LLC

Inventor： RENATA PASQUALINI ,  WADIH ARAP ,  FERNANDA IAMASSAKA STAQUICINI ,  FORTUNATO FERRARA ,  ANDREW R.M. BRADBURY

IPC: C07K16/28 ,  A61K47/68 ,  A61K38/07 ,  A61K39/395 ,  G01N33/574 ,  C07K16/18 ,  C12N15/10

CPC classification number: C07K16/2866 ,  A61K38/07 ,  A61K39/3955 ,  A61K47/6803 ,  A61K47/6817 ,  A61K47/6843 ,  A61K47/6849 ,  A61K2039/505 ,  A61P35/00 ,  C07K16/18 ,  C07K2317/21 ,  C07K2317/35 ,  C07K2317/55 ,  C07K2317/622 ,  C07K2317/73 ,  C07K2317/77 ,  C12N15/1037 ,  G01N33/57423

Abstract: Isolated or recombinant Eph A5 or GRP78 targeting antibodies are provided. In some cases, antibodies of the embodiments can be used for the detection, diagnosis and/or therapeutic treatment of human diseases, such as cancer. A method of rapidly identifying antibodies or antibody fragments for the treatment of cancer using a combination of in vitro and in vim methodologies is also provided.

公开(公告)号：US20190160021A1

公开(公告)日：2019-05-30

申请号：US16204085

申请日：2018-11-29

Applicant: STC.UNM

Inventor： David L. Vander Jagt ,  Lorraine M. Deck ,  Robert E. Royer

IPC: A61K31/035 ,  A61K31/09 ,  A61K31/05 ,  A61K31/122 ,  A61K45/06 ,  A61P35/00 ,  A61P17/00

Abstract: The present invention relates to substituted stilbenes and dienones which exhibit unexpected dual activity, as inhibitors of NFκB and as agonists (activators) of Nrf2. In particular, these compounds show dual activity and makes them particularly useful in the treatment of inflammation, including chronic inflammation and a number of related chronic disease states and conditions, including neurological diseases, including Alzheimer's, Alzheimer's prodrome and mild cognitive impairment, and other diseases and conditions, such as Parkinson's disease, depression, bipolar disorders and autism spectrum disorders. Compounds, pharmaceutical compositions and methods of treatment are described.

公开(公告)号：US20190138685A1

公开(公告)日：2019-05-09

申请号：US16096494

申请日：2017-05-01

Applicant: STC.UNM

Inventor： Joseph Costantine ,  Sergio A Pellegrino ,  Maria Sakovsky

IPC: G06F17/50 ,  H01Q1/36 ,  H01Q11/08 ,  H01Q1/28 ,  H01Q13/02

Abstract: A system and method for designing an antenna wherein a plurality of antenna designs are visually compared using performance metric plots that distinguish between geometries that meet all requirements and designs that do not.

公开(公告)号：US10279019B2

公开(公告)日：2019-05-07

申请号：US15118143

申请日：2015-02-11

Applicant: THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPT. OF HEALTH AND HUMAN SERVICES ,  STC.UNM

Inventor： Alan Remaley ,  John T. Schiller ,  Marcelo Amar ,  Bryce Chackerian

IPC: C07K11/00 ,  A61K38/10 ,  A61K39/00 ,  A61P9/10 ,  C12N9/64 ,  A61K45/06 ,  A61K47/69 ,  C07K14/47

Abstract: A vaccine construct comprising an antigenic PCSK9 peptide and an immunogenic carrier, and methods of using the same that are effective to lower blood cholesterol levels in a mammal and treat dyslipidemias and related disease states in a mammal without the frequency of administration required by passive immunity strategies.

公开(公告)号：US10251870B2

公开(公告)日：2019-04-09

申请号：US15556055

申请日：2016-03-02

Applicant: STC.UNM

Inventor： Eric R. Prossnitz ,  Matthias Barton ,  Matthias R. Meyer

IPC: A61K31/436 ,  A61K31/435 ,  A61K31/4355 ,  A61K31/437 ,  A61K31/16 ,  A61K31/7088 ,  A61K38/28

Abstract: The current invention is in the field of molecular biology/pharmacology and provides methods of using compounds that modulate the effects of GPR30/GPER for treating obesity and diabetes (preferably agonists) as well as disease states and/or conditions that result from excessive formation of reactive oxygen species (preferably antagonists). These compounds may function as agonists and/or antagonists of the disclosed estrogen receptor and/or modulate the expression/upregulation of nox and nox-associated reactive oxygen species (ROS).

公开(公告)号：US10249780B1

公开(公告)日：2019-04-02

申请号：US15424464

申请日：2017-02-03

Applicant: STC.UNM

Inventor： Ganesh Balakrishnan ,  Adam Alexander Hecht ,  Erin Ivey Vaughan

IPC: H01L21/00 ,  H01L31/08 ,  H01L31/18 ,  H01L31/0304 ,  H01L31/0216 ,  H01L31/0392

Abstract: Provided is a method of making a radiation detector, including: growing a thin film on a substrate. The substrate is a silicon substrate. The thin film includes aluminum antimony alloy (AlSb). The growing is epitaxial growth via ultra-high vacuum molecular beam epitaxy (UHV-MBE).