公开(公告)号：US20240166729A1

公开(公告)日：2024-05-23

申请号：US17996013

申请日：2021-04-14

Applicant: Ramot at Tel-Aviv University Ltd. ,  B.G. Negev Technologies and Applications Ltd., at Ben-Gurion University

Inventor： Yariv WINE ,  Neta SAL-MAN ,  Yaron HILLMAN ,  Dan LUSTIGER ,  Jenia GERSHBERG ,  Dan EVEN

IPC: C07K16/12 ,  A61K39/00 ,  A61K45/06 ,  A61P31/04 ,  G01N33/569

CPC classification number: C07K16/1232 ,  A61K45/06 ,  A61P31/04 ,  G01N33/56916 ,  A61K2039/505 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/565 ,  G01N2333/245

Abstract: The invention relates to human antibodies specific for Type III secretion system (T3SS), variants and biosimilars thereof. The human antibodies of the invention are specifically directed at the EspB protein. The preset disclosure further provides compositions and uses of the disclosed antibodies in treatment and diagnosis of MDR pathogenic bacterial infections.

公开(公告)号：US20240150786A1

公开(公告)日：2024-05-09

申请号：US18281304

申请日：2022-03-10

Applicant: THE STATE OF ISRAEL, MINISTRY OF AGRICULTURE & RURAL DEVELOPMENT, AGRICULTURAL RESEARCH ORGANIZATION ,  RAMOT AT TEL AVIV UNIVERSITY LTD.

Inventor： Maya BAR ,  Meirav LEIBMAN ,  Adi AVNI

IPC: C12N15/82

CPC classification number: C12N15/8282 ,  C12N15/8281 ,  C12N15/8286

Abstract: This invention is related to a double mutant plant line that harbors impaired NRC4a (NLR required for cell death) and NRC4b genes. The said double mutant plant has an increased defense response and a reduction in disease levels compared to a non-mutated or a single mutation mutated plant of the same population. This invention is also related to the method for increasing a plant defense response and for reducing plant diseases levels, comprised by (a) configuring one or more nucleic acid sequences to target and impair at least two plant NRC (NLR required for cell death) or NRC ortholog genes, (b) applying a gene editing process utilizing said one or more nucleic acid sequences, (c) obtaining at least one double mutant plant line, harboring two impaired NRC (NLR required for cell death) genes, and (d) growing said plant.

公开(公告)号：US11962091B2

公开(公告)日：2024-04-16

申请号：US15734777

申请日：2019-06-05

Applicant: Ramot at Tel-Aviv University Ltd.

Inventor： Nadav Buadana ,  Eran Socher ,  Samuel Jameson

IPC: H01Q21/06 ,  H01Q3/30 ,  H01Q21/00

CPC classification number: H01Q21/061 ,  H01Q3/30 ,  H01Q21/0087

Abstract: There is described an integrated antenna for radiating an electromagnetic beam at a wavelength λ, for example, in a range of millimeter and submillimeter waves. The antenna is integrated in a dielectric die having specific dimensions, and is configured as a dense array comprising two or more radiating elements (transmitters). The proposed array is denser than a conventional 1D or 2D array, would such a conventional array be arranged on the same dielectric die with a spacing λ/2 between its neighbouring radiating elements.

公开(公告)号：US11891381B2

公开(公告)日：2024-02-06

申请号：US17334905

申请日：2021-05-31

Applicant: HADASIT MEDICAL RESEARCH SERVICES AND DEVELOPMENT LTD. ,  RAMOT AT TEL-AVIV UNIVERSITY LTD.

Inventor： Or Kakhlon ,  Miguel Enrique Weil ,  Leonardo Javier Solmesky

IPC: C07D409/12 ,  A61P25/28 ,  C07D487/08

CPC classification number: C07D409/12 ,  A61P25/28 ,  C07D487/08

Abstract: Compounds represented by general Formulae I to IV as described herein are disclosed. Further disclosed are composition utilizing the herein disclosed compounds and using the same for the treatment of glycogen storage disorders.

公开(公告)号：US20240002895A1

公开(公告)日：2024-01-04

申请号：US18209263

申请日：2023-06-13

Applicant: RAMOT AT TEL AVIV UNIVERSITY LTD.

Inventor： Avigail-Elah BARUCH LESHEM ,  Ayala LAMPEL ,  Tlalit MASSARANO

IPC: C12P21/02

CPC classification number: C12P21/02

Abstract: The invention relates to a composition comprising a polymer-based droplet, wherein the polymer-based droplet comprises one or more of melanin, a tyrosine substrate with a cleavable protecting group on the side chain, tyrosine, tyrosinase and any combination thereof. The composition further relates to a method of synthesizing melanin comprising the steps of: obtaining a polymer-based droplet containing a tyrosine substrate with a cleavable protecting group on the side chain (protected tyrosine) or a polymer-based droplet containing tyrosine (unprotected); wherein the tyrosine is oxidized by tyrosinase and polymerizes so as to obtain melanin.

公开(公告)号：US11851389B2

公开(公告)日：2023-12-26

申请号：US16347995

申请日：2017-11-07

Applicant: RAMOT AT TEL-AVIV UNIVERSITY LTD.

Inventor： Dan Peer ,  Srinivas Ramishetti

IPC: C07C211/22 ,  A61K47/18 ,  C07C215/08 ,  C07C229/12 ,  C07C243/00 ,  C07C243/16 ,  C07C243/28 ,  C07D295/15 ,  C12N15/113 ,  A61K48/00 ,  C07C243/04 ,  C07C59/01 ,  C07C333/10 ,  C07C219/04 ,  C07D233/64 ,  C07C229/02 ,  A61P29/00 ,  C07D295/13 ,  C07C243/26 ,  C07C233/00 ,  C07C243/14 ,  C07C279/04 ,  A61P35/00 ,  C07C229/10 ,  C07C243/10

CPC classification number: C07C211/22 ,  A61K47/18 ,  A61K48/00 ,  A61P29/00 ,  A61P35/00 ,  C07C59/01 ,  C07C215/08 ,  C07C219/04 ,  C07C229/02 ,  C07C229/10 ,  C07C229/12 ,  C07C233/00 ,  C07C243/00 ,  C07C243/10 ,  C07C243/14 ,  C07C243/16 ,  C07C243/26 ,  C07C243/28 ,  C07C279/04 ,  C07C333/10 ,  C07D233/64 ,  C07D295/13 ,  C07D295/15 ,  C12N15/113 ,  C12N2310/14

Abstract: The present invention provides cationic lipids and lipid nanoparticle formulations comprising these lipids, alone or in combination with other lipids. These lipid nanoparticles may be formulated with nucleic acids to facilitate their intracellular delivery both in vitro and for therapeutic applications. The present invention also provides methods of chemical synthesis of these lipids, lipid nanoparticle preparation and formulation with nucleic acids.

公开(公告)号：US11827687B2

公开(公告)日：2023-11-28

申请号：US17591620

申请日：2022-02-03

Applicant: TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD. ,  RAMOT AT TEL AVIV UNIVERSITY LTD.

Inventor： Genady Kostenich ,  Mor Oron-Herman ,  Arie Orenstein ,  Talia Shekhter Zahavi ,  Ehud Gazit ,  Yoseph Salitra ,  Ludmilla Buzhansky

IPC: C07K14/655 ,  A61K38/08 ,  A61K47/62 ,  A61K47/69 ,  A61K38/12 ,  A61K49/00

CPC classification number: C07K14/655 ,  A61K38/08 ,  A61K38/12 ,  A61K47/62 ,  A61K47/6923 ,  A61K47/6933 ,  A61K47/6937 ,  A61K49/0043 ,  A61K49/0056 ,  A61K49/0093

Abstract: Disclosed are Somatostatin receptor ligands comprising a peptide moiety, pharmaceutical compositions and uses thereof. Disclosed are also synthetic Somatostatin receptor ligands comprising a cyclic peptide moiety and an active agent moiety covalently bonded to the cyclic peptide moiety through a nitrogen atom of a side chain functional group of an internal residue of the cyclic peptide moiety, pharmaceutical compositions and uses thereof. Disclosed are also synthetic Somatostatin receptor ligands comprising a cyclic peptide moiety and a nanoparticle active agent moiety covalently bonded to the cyclic peptide moiety, pharmaceutical compositions and uses thereof.

公开(公告)号：US11821036B2

公开(公告)日：2023-11-21

申请号：US16493874

申请日：2018-03-15

Applicant: RAMOT AT TEL-AVIV UNIVERSITY LTD. ,  MOR RESEARCH APPLICATIONS LTD.

Inventor： Liron Yoffe ,  Noam Shomron ,  Moshe Hod

IPC: C12Q1/6883 ,  C12Q1/6851 ,  C12Q1/6834 ,  G01N33/53

CPC classification number: C12Q1/6883 ,  C12Q1/6834 ,  C12Q1/6851 ,  G01N33/5308 ,  C12Q2600/178 ,  G01N2496/00 ,  G01N2800/368

Abstract: Methods and kits for identifying an increased risk of developing preeclampsia in a pregnant woman based on expression pattern of non-coding RNAs in body fluids are provided. In particular, the methods provide information for identifying a pregnant woman as being at risk of developing preeclampsia by analyzing the pattern of non-coding RNAs in body fluids during early stages of pregnancy.

公开(公告)号：US20230368916A1

公开(公告)日：2023-11-16

申请号：US18027946

申请日：2021-09-23

Applicant: Ramot at Tel-Aviv University Ltd. ,  Mor Research Applications Ltd.

Inventor： Oded SHOR ,  Felix BENNINGER ,  Andrei KHRENNIKOV

IPC: G16H50/20

CPC classification number: G16H50/20

Abstract: There is provided a computer implemented method of diagnosing a medical state associated with a neuro-psychiatric disorder in a subject, comprising: receiving a plurality of EEG datasets, each respective EEG dataset from a respective EEG electrode of a plurality of EEG electrodes monitoring a head of the subject, clustering the plurality of EEG datasets into a plurality of clusters, computing a p-adic representation of the plurality of clusters, extracting a quantum potential value from p-adic representation of the plurality of clusters, and diagnosing the medical state associated with the neuro-psychiatric disorder according to the quantum potential relative to a threshold that separates between presence of the medical state and non-presence of the medical state.

公开(公告)号：US20230364302A1

公开(公告)日：2023-11-16

申请号：US18315891

申请日：2023-05-11

Applicant: Ramot at Tel-Aviv University Ltd.

Inventor： Nurit Bar-Shai ,  Alexander Golberg ,  Ayelet Lesman ,  Orna Sharabani-Yosef

IPC: A61L27/36

CPC classification number: A61L27/3637

Abstract: Cellulose-based scaffolds having fibrous structures, which include a decellularized macroalgae tissue from which cellular materials and nucleic acids are removed; implants including such cellulose-based scaffolds; and a decellularization process for the preparation thereof. The macroalgae tissue may be a green macroalgae tissue, a red macroalgae tissue, or a brown macroalgae tissue. The green macroalgae tissue may be a Cladophora sp. tissue; and the red macroalgae tissue may be a Bangia sp. tissue.